Hearing loss in a whirlin mouse mutant is not reversed by activating the Whrn gene.
Pentland DR; Treder N; Najjar S; Kirwin DA; Goodyear R; Ingham NJ; Steel KP · 2026 · Hearing research
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
WHRN gene mutations underlie several forms of deafness in humans and mice. It is not known whether WHRN-associated hearing loss can be reversed after its onset and we aimed to address this using a genetic approach. We show that a knockdown…
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Metadata source: Europe PMC · DOI 10.1016/j.heares.2026.109682