Negative / Null Result ReportOpen accessEnvironmental Science
Lars Gamfeldt, Helmut Hillebrand · 2011 · PLoS ONE
The study of the interrelationship between productivity and biodiversity is a major research field in ecology. Theory predicts that if essential resources are heterogeneously distributed across a metacommunity, single species may dominate productivity in individual metacommunity patches, but a mixture of species will maximize productivity across the whole metacommunity. It also predicts that a balanced supply of resources within local patches should favor species coexistence, whereas resource imbalance would favor the dominance of one species. We performed an experiment with five freshwater al
View details →DOI: 10.1371/journal.pone.0021972Cited by 35 Negative / Null Result ReportOpen accessEnvironmental Science
Thomas Galland, Carlos P. Carmona, Lars Götzenberger et al. · 2020 · Ecological Indicators
Functional redundancy is considered a major component of the insurance mechanism, which theoretically maintains ecosystem stability by preventing the loss of ecosystem functions with species loss. Over the past decades, examination of…
View details →DOI: 10.1016/j.ecolind.2020.106488Cited by 35 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Gareth Richards, Manuel C. Gomes, T. Ventura · 2018 · Journal of Developmental Origins of Health and Disease
Foetal sex hormones can have powerful and far-reaching effects on later phenotype. However, obtaining accurate measurements is difficult for ethical reasons, and researchers often employ proxy variables to examine their effects. The…
View details →DOI: 10.1017/s2040174418000752Cited by 35 Negative / Null Result ReportOpen accessComputer Science
Erkan Er, Eduardo Gómez‐Sánchez, Yannis Dimitriadis et al. · 2019 · Interactive Learning Environments
This paper presents the findings of a mixed-methods research that explored the potentials emerging from aligning learning design (LD) and learning analytics (LA) during the design of a predictive analytics solution and from involving the…
View details →DOI: 10.1080/10494820.2019.1610455Cited by 35 Negative / Null Result Report
Dhayana Dallmeier, Martin G. Larson, Na Wang et al. · 2012 · Journal of the American Heart Association
Background Prior studies have reported conflicting findings with regard to the association of biomarkers in the prediction of incident type 2 diabetes. We evaluated 12 biomarkers as possible diabetes predictors in the F ramingham H eart S…
View details →DOI: 10.1161/jaha.112.000869Cited by 35 Negative / Null Result ReportOpen accessMedicine
Xiaodong Huang, Xiaozhong Chen, Chong Zhao et al. · 2020 · Frontiers in Oncology
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy(IMRT) to treat stage II nasopharyngeal carcinoma (NPC). Methods and Materials: In this randomized phase 2 study (registered with ClinicalTrials.gov, (NCT01187238)), eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), d
View details →DOI: 10.3389/fonc.2020.01314Cited by 35 Negative / Null Result ReportOpen accessMedicine
Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
View details →DOI: 10.1080/0284186x.2016.1213879Cited by 35 Negative / Null Result ReportMedicine
Dhakshana Sivayoganathan, Deivanayagam Maruthini, Julie Glanville et al. · 2011 · Human Fertility
OBJECTIVE: This study aimed to compare the spectrum of polycystic ovary syndrome (PCOS) symptoms in patients from four different specialist clinics. DESIGN: A prospective cross-sectional observational study. SETTING: The study was…
View details →DOI: 10.3109/14647273.2011.632058Cited by 35 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthew B. Lipner, Raoud Marayati, Yangmei Deng et al. · 2016 · PLoS ONE
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benef
View details →DOI: 10.1371/journal.pone.0147113Cited by 35 Negative / Null Result ReportOpen accessMedicine
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →DOI: 10.2147/opth.s60159Cited by 35 Negative / Null Result ReportOpen accessMedicine
Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
View details →DOI: 10.1111/bjh.16064Cited by 35 Negative / Null Result ReportOpen accessEnvironmental Science
Melanie Nägeli, Patrick Scherler, Stephanie Witczak et al. · 2021 · Oecologia
The joint effects of interacting environmental factors on key demographic parameters can exacerbate or mitigate the separate factors' effects on population dynamics. Given ongoing changes in climate and land use, assessing interactions between weather and food availability on reproductive performance is crucial to understand and forecast population dynamics. By conducting a feeding experiment in 4 years with different weather conditions, we were able to disentangle the effects of weather, food availability and their interactions on reproductive parameters in an expanding population of the red
View details →DOI: 10.1007/s00442-021-05076-6Cited by 35 Negative / Null Result ReportOpen accessMedicine
Pasquale F. Innominato, Abdoulaye Karaboué, C. Focan et al. · 2020 · International Journal of Cancer
The triplet combination of irinotecan, oxaliplatin and fluorouracil is an active frontline regimen in metastatic colorectal cancer, but scarce data exist on its use as salvage treatment. We aimed at assessing its safety and efficacy profiles with its circadian-based administration (chronoIFLO5) as either first- or second-line treatment, within the time-finding EORTC 05011 trial. Five-day chronoIFLO5 was administered every 3 weeks in patients with PS 0, 1 or 2. It consisted of chronomodulated irinotecan (180 mg/sqm), oxaliplatin (80 mg/sqm) and fluorouracil-leucovorin (2800 and 1200 mg/sqm, res
View details →DOI: 10.1002/ijc.33422Cited by 35 Negative / Null Result ReportOpen accessMedicine
Kseniia Chernyshova, Keiichi Inoue, Shun‐ichi Yamashita et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: Glaucoma results in progressive degeneration of the optic nerve and irreversible vision loss. Several mutations in the gene encoding optineurin (OPTN), the receptor for Parkin-dependent mitochondrial autophagy (mitophagy), are…
View details →DOI: 10.1167/iovs.19-27184Cited by 35 Negative / Null Result ReportOpen accessSocial Sciences
Heather N. Taussig, Sara E. Culhane, Edward F. Garrido et al. · 2012 · Child Maltreatment
Physically neglected youth are at increased risk of mental health problems, but there are few interventions that have demonstrated efficacy in reducing mental health symptoms for this vulnerable population. The Fostering Healthy Futures…
View details →DOI: 10.1177/1077559512461397Cited by 35 Negative / Null Result ReportEnvironmental Science
Rafiq Hamdi, Hans Van de Vyver, Piet Termonia · 2011 · International Journal of Climatology
Abstract We explore the use of high‐resolution dynamical downscaling as a means to simulate extreme values of summer maximum surface air temperature over Belgium ( T MAX ). We use the limited area version of the ARPEGE‐IFS model, ALADIN.…
View details →DOI: 10.1002/joc.2409Cited by 35 Negative / Null Result ReportSocial Sciences
Tyler Greer, Qiang Hao, Mengguo Jing et al. · 2019
This replication study aims at both quantifying the effects of active learning classrooms in introductory programming courses (CS1) and overcoming some design and methodological limits of prior studies on this topic. 156 students enrolled…
View details →DOI: 10.1145/3287324.3287345Cited by 35 Negative / Null Result ReportOpen accessDecision Sciences
Uğur Demirel, Handan Çam, Ramazan Ünlü · 2020 · GAZI UNIVERSITY JOURNAL OF SCIENCE
Stock market prediction in financial and commodity markets is a major challenge for speculators, investors, and companies but also profitable with an accurate prediction. Thus, obtaining accurate prediction results becomes extremely…
View details →DOI: 10.35378/gujs.679103Cited by 35 Negative / Null Result ReportOpen accessMedicine
Joseph Rigdon, Sanjay Basu · 2019 · BMJ Open
OBJECTIVES: We aimed to test whether or not adding (1) nutrition predictor variables and/or (2) using machine learning models improves cardiovascular death prediction versus standard Cox models without nutrition predictor variables.…
View details →DOI: 10.1136/bmjopen-2019-032703Cited by 35 Replication FailureOpen accessNeuroscience
Kevin van Schie, Arne Leer · 2019 · Clinical Psychological Science
In this direct replication of Houben, Otgaar, Roelofs, and Merckelbach ( Clinical Psychological Science, 6, 610–616, 2018), we tested whether making eye movements during memory recall increases susceptibility to creating false memories.…
View details →DOI: 10.1177/2167702619859335Cited by 35 Negative / Null Result ReportSocial Sciences
Matthew Rueben, Frank J. Bernieri, Cindy Grimm et al. · 2017
Privacy-sensitive robotics is an emerging area of HRI research. Judgments about privacy would seem to be context-dependent, but none of the promising work on contextual "frames" has focused on privacy concerns. This work studies the impact…
View details →DOI: 10.1145/2909824.3020218Cited by 35 Negative / Null Result ReportOpen accessNeuroscience
Simon Ruch, Flavio Jean Schmidig, Leona Knüsel et al. · 2022 · NeuroImage
Slow-wave sleep is the deep non-rapid eye-movement (NREM) sleep stage that is most relevant for the recuperative function of sleep. Its defining property is the presence of slow oscillations (<2 Hz) in the scalp electroencephalogram (EEG). Slow oscillations are generated by a synchronous back and forth between highly active UP-states and silent DOWN-states in neocortical neurons. Growing evidence suggests that closed-loop sensory stimulation targeted at UP-states of EEG-defined slow oscillations can enhance the slow oscillatory activity, increase sleep depth, and boost sleep's recuperative fun
View details →DOI: 10.1016/j.neuroimage.2022.119682Cited by 35 Negative / Null Result ReportMaterials Science
Ahmed M. Eissa, Flavio Barros, Pavle Vrljicak et al. · 2018 · Biomacromolecules
Novel approaches for culturing primary human cells in vitro are increasingly needed to study cell and tissue physiology and to grow replacement tissue for regenerative medicine. Conventional 2D monolayer cultures of endometrial epithelial…
View details →DOI: 10.1021/acs.biomac.8b00635Cited by 35 Negative / Null Result ReportOpen accessMathematics
Xinwu Qian, Lijun Sun, Satish V. Ukkusuri · 2021 · Scientific Reports
Improved mobility not only contributes to more intensive human activities but also facilitates the spread of communicable disease, thus constituting a major threat to billions of urban commuters. In this study, we present a multi-city investigation of communicable diseases percolating among metro travelers. We use smart card data from three megacities in China to construct individual-level contact networks, based on which the spread of disease is modeled and studied. We observe that, though differing in urban forms, network layouts, and mobility patterns, the metro systems of the three cities
View details →DOI: 10.1038/s41598-021-83878-7Cited by 35 Negative / Null Result ReportOpen accessMedicine
Thit Mynster Kronborg, Robert Schierwagen, Kajetan Trôst et al. · 2023 · Hepatology Communications
BACKGROUND: Patients with cirrhosis and portal hypertension face a high risk of complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce portal pressure and thus the risk of complications and mortality.…
View details →DOI: 10.1097/hc9.0000000000000332Cited by 35 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ruhul Salim, Kamrul Hassan, Sanzidur Rahman · 2019 · Applied Economics
This study aims to investigate dynamic relationships between research and development (R&D) expenditure, climate change (measured by annual rainfall and temperature variations), human capital (proxied by literacy) and total factor…
View details →DOI: 10.1080/00036846.2019.1697422Cited by 35 Negative / Null Result ReportOpen accessEnvironmental Science
Quentin J. Leclerc, Jodi A. Lindsay, Gwenan M. Knight · 2022 · PLoS Computational Biology
Bacteriophage (phage) are bacterial predators that can also spread antimicrobial resistance (AMR) genes between bacteria by generalised transduction. Phage are often present alongside antibiotics in the environment, yet evidence of their joint killing effect on bacteria is conflicted, and the dynamics of transduction in such systems are unknown. Here, we combine in vitro data and mathematical modelling to identify conditions where phage and antibiotics act in synergy to remove bacteria or drive AMR evolution. We adapt a published model of phage-bacteria dynamics, including transduction, to add
View details →DOI: 10.1371/journal.pcbi.1010746Cited by 34 Negative / Null Result ReportOpen accessEnvironmental Science
Mark J. Ducey, John Gunn, Andrew A. Whitman · 2013 · Forests
Restoration of old-growth forest structure is an emerging silvicultural goal, especially in those regions where old-growth abundance falls below the historic range of variability. However, longitudinal studies of old-growth dynamics that can inform silvicultural and policy options are few. We analyzed the change in structure, including stand density, diameter distribution, and the abundance of large live, standing dead, and downed dead trees on 58 late-successional and old-growth plots in Maine, USA, and compared these to regional data from the U.S. Forest Inventory and Analysis program. Struc
View details →DOI: 10.3390/f4041055Cited by 34 Negative / Null Result ReportMedicine
Alan L. Ho, Eric J. Sherman, Shrujal S. Baxi et al. · 2016 · Journal of Clinical Oncology
6096 Background: Recurrent/metastatic adenoid cystic carcinoma (R/M ACC) is incurable. Regorafenib (BAY 73-4506; Bayer) is a tyrosine kinase inhibitor (TKI) that targets receptor tyrosine kinases (RTKs), including vascular endothelial…
View details →DOI: 10.1200/jco.2016.34.15_suppl.6096Cited by 34 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tugba Nilay Kulaksız, Şükran Nazan Koşar, Süleyman Bulut et al. · 2016 · Nutrients
The carbohydrate (CHO) concentration of a mouth rinsing solution might influence the CHO sensing receptors in the mouth, with consequent activation of brain regions involved in reward, motivation and regulation of motor activity. The purpose of the present study was to examine the effects of maltodextrin mouth rinsing with different concentrations (3%, 6% and 12%) after an overnight fast on a 20 km cycling time trial performance. Nine recreationally active, healthy males (age: 24 ± 2 years; V ˙ O 2 m a x : 47 ± 5 mL·kg(-1)·min(-1)) participated in this study. A double-blind, placebo-controlled
View details →DOI: 10.3390/nu8050269Cited by 34 