Negative / Null Result ReportOpen accessEnvironmental Science
Melanie Nägeli, Patrick Scherler, Stephanie Witczak et al. · 2021 · Oecologia
The joint effects of interacting environmental factors on key demographic parameters can exacerbate or mitigate the separate factors' effects on population dynamics. Given ongoing changes in climate and land use, assessing interactions between weather and food availability on reproductive performance is crucial to understand and forecast population dynamics. By conducting a feeding experiment in 4 years with different weather conditions, we were able to disentangle the effects of weather, food availability and their interactions on reproductive parameters in an expanding population of the red
View details →DOI: 10.1007/s00442-021-05076-6Cited by 35 Negative / Null Result ReportOpen accessMedicine
Ilkka Koskivuo, Jukka Kemppainen, Salvatore Giordano et al. · 2016 · Acta Oncologica
BACKGROUND: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim…
View details →DOI: 10.1080/0284186x.2016.1213879Cited by 35 Negative / Null Result ReportOpen accessMedicine
Michael Stewart, Raj K. Maturi, Vincent Chen et al. · 2014 · Clinical ophthalmology
AIMS: To determine if intravitreal bevacizumab combined with the dexamethasone intravitreal implant 0.7 mg improves visual acuity and macular thickness more than bevacizumab monotherapy in eyes with macular edema due to branch and central…
View details →DOI: 10.2147/opth.s60159Cited by 35 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthew B. Lipner, Raoud Marayati, Yangmei Deng et al. · 2016 · PLoS ONE
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer cell metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin have a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, a drug with negligible toxicity, as a therapeutic modality in pancreatic cancer. Preclinical studies in cell line xenografts and one study in patient-derived xenograft (PDX) models were promising, while recently published clinical trials showed no benef
View details →DOI: 10.1371/journal.pone.0147113Cited by 35 Negative / Null Result ReportOpen accessNeuroscience
Simon Ruch, Flavio Jean Schmidig, Leona Knüsel et al. · 2022 · NeuroImage
Slow-wave sleep is the deep non-rapid eye-movement (NREM) sleep stage that is most relevant for the recuperative function of sleep. Its defining property is the presence of slow oscillations (<2 Hz) in the scalp electroencephalogram (EEG). Slow oscillations are generated by a synchronous back and forth between highly active UP-states and silent DOWN-states in neocortical neurons. Growing evidence suggests that closed-loop sensory stimulation targeted at UP-states of EEG-defined slow oscillations can enhance the slow oscillatory activity, increase sleep depth, and boost sleep's recuperative fun
View details →DOI: 10.1016/j.neuroimage.2022.119682Cited by 35 Negative / Null Result ReportOpen accessMathematics
Yook Kit Ow-Yeong, Ibrahim H. Yeter, Farhan Ali · 2023 · International Journal of STEM Education
Abstract Background Data literacy is increasingly important in today’s data-driven world. Students across many educational systems first formally learn about data in elementary school not as a separate subject but via the mathematics curriculum. This experience can create tensions in the priorities of learning and assessment given the presence of other foundational mathematics content domains such as numbers, algebra, measurement, and geometry. There is a need to study data literacy in comparison to these other content domains in elementary mathematics. To address this need, we developed a met
View details →DOI: 10.1186/s40594-023-00397-9Cited by 35 Negative / Null Result ReportEnvironmental Science
Rafiq Hamdi, Hans Van de Vyver, Piet Termonia · 2011 · International Journal of Climatology
Abstract We explore the use of high‐resolution dynamical downscaling as a means to simulate extreme values of summer maximum surface air temperature over Belgium ( T MAX ). We use the limited area version of the ARPEGE‐IFS model, ALADIN.…
View details →DOI: 10.1002/joc.2409Cited by 35 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Gareth Richards, Manuel C. Gomes, T. Ventura · 2018 · Journal of Developmental Origins of Health and Disease
Foetal sex hormones can have powerful and far-reaching effects on later phenotype. However, obtaining accurate measurements is difficult for ethical reasons, and researchers often employ proxy variables to examine their effects. The…
View details →DOI: 10.1017/s2040174418000752Cited by 35 Negative / Null Result ReportOpen accessMedicine
Joel Wight, Mimi Yue, Colm Keane et al. · 2019 · British Journal of Haematology
De novo diffuse large B-cell lymphoma (DLBCL) presenting with synchronous central nervous system (CNS) and systemic disease (synDLBCL) is not well described and is excluded from clinical trials. We performed a retrospective analysis of 80…
View details →DOI: 10.1111/bjh.16064Cited by 35 Negative / Null Result ReportOpen accessDecision Sciences
Uğur Demirel, Handan Çam, Ramazan Ünlü · 2020 · GAZI UNIVERSITY JOURNAL OF SCIENCE
Stock market prediction in financial and commodity markets is a major challenge for speculators, investors, and companies but also profitable with an accurate prediction. Thus, obtaining accurate prediction results becomes extremely…
View details →DOI: 10.35378/gujs.679103Cited by 35 Negative / Null Result ReportOpen accessMedicine
Naveen Gupta, Ranjeet Sinha, Anna Krasnodembskaya et al. · 2018 · Stem Cells
Bone marrow derived mesenchymal stromal cells have been shown to have significant therapeutic effects in experimental models of pneumonia and lung injury. The current study examined the roles of the toll like receptor 4 (TLR4) and protease…
View details →DOI: 10.1002/stem.2796Cited by 34 Negative / Null Result ReportOpen accessMedicine
Maxwell Akanbi, Chad J. Achenbach, Babafemi Taiwo et al. · 2017 · BMC Pulmonary Medicine
BACKGROUND: Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB in Nigeria. METHODS: Adults with HIV being evaluated for pulmonary TB (PTB) were consecutively enrolled into the study cohort. At baseline, expectorated sputa were examined using Xpert and smear microscopy for Mycobacterium tuberculosis (MTB) and acid fast bacilli, respectively. Patients diagnosed with TB were followed-up until 6 months post TB diagnosis. TB was defined as spu
View details →DOI: 10.1186/s12890-017-0430-6Cited by 34 Negative / Null Result ReportOpen accessImmunology and Microbiology
Tzu‐Hsing Kuo, Julie A. Williams · 2014 · SLEEP
STUDY OBJECTIVES: Sleep is known to increase as an acute response to infection. However, the function of this behavioral response in host defense is not well understood. To address this problem, we evaluated the effect of acute sleep…
View details →DOI: 10.5665/sleep.3648Cited by 34 Negative / Null Result ReportBusiness, Management and Accounting
Andrew B. Speer, Neil Douglas Christiansen, Chet Robie et al. · 2021 · Journal of Applied Psychology
The use of personality measures to predict work-related outcomes has been of great interest over the past several decades. The present study used machine learning (ML) to examine the optimal level in the personality hierarchy to use in…
View details →DOI: 10.1037/apl0000618Cited by 34 Negative / Null Result ReportMedicine
Adrian T. Davis, Heidi Israel, Lisa K. Cannada et al. · 2012 · Journal of Orthopaedic Trauma
OBJECTIVES: The purpose of this study was to test the biomechanical properties of locking and nonlocking plates using one-third tubular and periarticular plate designs in an osteoporotic distal fibula fracture model. METHODS: Twenty-four…
View details →DOI: 10.1097/bot.0b013e318281a565Cited by 34 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jason L. Pugh, Alona S. Sukhina, Thomas M. Seed et al. · 2014 · The Journal of Immunology
Lymphocytes are sensitive to ionizing radiation and naive lymphocytes are more radiosensitive than their memory counterparts. Less is known about radiosensitivity of memory cell subsets. We examined the radiosensitivity of naive (TN),…
View details →DOI: 10.4049/jimmunol.1400434Cited by 34 Negative / Null Result ReportOpen accessMedicine
Tomoya Mizuno, Takao Kamai, Hideyuki Abe et al. · 2015 · BMC Cancer
BACKGROUND: The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (18F-FDG PET) in human renal cell carcinoma (RCC) has not been elucidated. On the other hand, overactivation of the phosphatidylinositol 3'kinase (PI3K), serine/threonine kinase Akt, and mammalian target of rapamycin (mTOR) pathway has been detected in a variety of human cancers, including RCC. So far, little is known about the relationship between the SUV and these proteins in
View details →DOI: 10.1186/s12885-015-1097-0Cited by 34 Negative / Null Result ReportOpen accessMedicine
Yukie Fujimoto, Natsuko Inoue, Koji Morimoto et al. · 2019 · Cancer Science
Analysis of anticancer immunity aids in assessing the prognosis of patients with breast cancer. From 250 operated breast cancers, we focused on serum levels of C-C motif chemokine ligand 5 (CCL5), which is involved in cancer immune…
View details →DOI: 10.1111/cas.14234Cited by 34 Negative / Null Result ReportOpen accessEnvironmental Science
Quentin J. Leclerc, Jodi A. Lindsay, Gwenan M. Knight · 2022 · PLoS Computational Biology
Bacteriophage (phage) are bacterial predators that can also spread antimicrobial resistance (AMR) genes between bacteria by generalised transduction. Phage are often present alongside antibiotics in the environment, yet evidence of their joint killing effect on bacteria is conflicted, and the dynamics of transduction in such systems are unknown. Here, we combine in vitro data and mathematical modelling to identify conditions where phage and antibiotics act in synergy to remove bacteria or drive AMR evolution. We adapt a published model of phage-bacteria dynamics, including transduction, to add
View details →DOI: 10.1371/journal.pcbi.1010746Cited by 34 Negative / Null Result ReportOpen accessMedicine
Sabine Rauth, Dominik Hinz, Michael A. Borger et al. · 2016 · Biochemical Journal
Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease…
View details →DOI: 10.1042/bcj20160114Cited by 34 Negative / Null Result ReportOpen accessMedicine
Lucinda L. van Stee, Sarah E. Boston, Ameet Singh et al. · 2015 · Veterinary Surgery
OBJECTIVE: To assess the outcome of canine splenic lymphoma treated with splenectomy and to evaluate prognostic factors, including involvement of other sites, adjuvant chemotherapy, and the effect of World Health Organization (WHO)…
View details →DOI: 10.1111/vsu.12405Cited by 34 Negative / Null Result ReportOpen accessMedicine
Yukiko Morimoto, Gertraud Maskarinec, Song‐Yi Park et al. · 2014 · British Journal Of Nutrition
Given the high intake levels of soya and low incidence rates of breast cancer in Asian countries, isoflavones, substances with an oestrogen-like structure occurring principally in soyabeans, are postulated to be cancer protective. In the…
View details →DOI: 10.1017/s0007114514001780Cited by 34 Negative / Null Result ReportOpen accessMedicine
Weijun Wang, Zong‐Han Liu, Kang Wang et al. · 2023 · Cancer Medicine
BACKGROUND: There is no consensus on the optimal regimen for unresectable recurrent hepatocellular carcinoma (HCC), so this retrospective study aimed to evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib and PD-1 inhibitors (T-L-P) versus TACE combined with lenvatinib (T-L) or TACE alone. METHOD: Data were collected from 204 patients with unresectable recurrent HCC who received T-L-P, T-L, or TACE alone at three medical centers from January, 2019 to December, 2020 for analysis. The survival outcomes, tumor response, and adverse events were compa
View details →DOI: 10.1002/cam4.5880Cited by 34 Negative / Null Result Report
Stephanie Seneff, Robert Davidson, Jingjing Liu · 2012 · Entropy
Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This…
View details →DOI: 10.3390/e14112227Cited by 34 Negative / Null Result ReportOpen accessMedicine
Felicia C. Goldstein, Angela F. Caveney, Vicki Hertzberg et al. · 2016 · Journal of Neurotrauma
A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with…
View details →DOI: 10.1089/neu.2015.4313Cited by 34 Negative / Null Result ReportOpen accessMathematics
Marlin D Figgins, Trevor Bedford · 2026 · eLife
Accurately estimating relative transmission rates of SARS-CoV-2 variants remains a scientific and public health priority. Recent studies have used the sample proportions of different variants from genetic sequence data to describe variant frequency dynamics and relative transmission rates, but frequencies alone cannot capture the rich epidemiological behavior of SARS-CoV-2. Here, we extend methods for inferring the effective reproduction number of an epidemic using confirmed case data to jointly estimate variant-specific effective reproduction numbers and frequencies of co-circulating variants
View details →DOI: 10.7554/elife.104802.2Cited by 34 Replication FailureOpen accessMedicine
M. Roupret, Aurélie Bertaut, G. Pignot et al. · 2025 · Annals of Oncology
BACKGROUND: Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
View details →DOI: 10.1016/j.annonc.2025.09.017Cited by 34 Negative / Null Result ReportOpen accessMedicine
Catarina S. Lobo, Maria Inês P. Mendes, Diogo A. Pereira et al. · 2023 · Scientific Reports
Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune
View details →DOI: 10.1038/s41598-023-38862-8Cited by 34 Negative / Null Result ReportOpen accessEngineering
Tomáš Suchý, Martin Bartoš, Radek Sedláček et al. · 2021 · Materials
This study aims to point out the main drawback with respect to the design of simulated body environments. Three media commonly used for the simulation of the identical body environment were selected, i.e., Kokubo's simulated body fluid that simulates the inorganic component of human blood plasma, human blood plasma, and phosphate buffer saline. A comparison was performed of the effects of the media on collagen scaffolds. The mechanical and structural effects of the media were determined via the application of compression mechanical tests, the determination of mass loss, and image and micro-CT
View details →DOI: 10.3390/ma14164388Cited by 34 Negative / Null Result ReportOpen accessMedicine
James L. Alexander, Hajir Ibraheim, Bhavisha P. Sheth et al. · 2021 · Journal for ImmunoTherapy of Cancer
INTRODUCTION: Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) is used in corticosteroid-refractory cases. However, robust outcome data for these patients are scarce. METHODS: We conducted a multicenter (six cancer centers), cohort study of outcomes in patients treated with IFX for corticosteroid-refractory CPI-induced enterocolitis between 2007 and 2020. The primary outcome was corticoster
View details →DOI: 10.1136/jitc-2021-002742Cited by 34 