Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tugba Nilay Kulaksız, Şükran Nazan Koşar, Süleyman Bulut et al. · 2016 · Nutrients
The carbohydrate (CHO) concentration of a mouth rinsing solution might influence the CHO sensing receptors in the mouth, with consequent activation of brain regions involved in reward, motivation and regulation of motor activity. The purpose of the present study was to examine the effects of maltodextrin mouth rinsing with different concentrations (3%, 6% and 12%) after an overnight fast on a 20 km cycling time trial performance. Nine recreationally active, healthy males (age: 24 ± 2 years; V ˙ O 2 m a x : 47 ± 5 mL·kg(-1)·min(-1)) participated in this study. A double-blind, placebo-controlled
View details →DOI: 10.3390/nu8050269Cited by 34 Negative / Null Result ReportOpen accessMedicine
Rokshana Parvin, Jan Schinkoethe, Christian Grund et al. · 2020 · Veterinary Research
An intravenous pathogenicity index (IVPI) of > 1.2 in chickens or, in case of subtypes H5 and H7, expression of a polybasic hemagglutinin cleavage site (HACS), signals high pathogenicity (HP). Viruses of the H9N2-G1 lineage, which spread across Asia and Africa, are classified to be of low pathogenicity although, in the field, they became associated with severe clinical signs and epizootics in chickens. Here we report on a pre-eminent trait of recent H9N2-G1 isolates from Bangladesh and India, which express a tribasic HACS (motif PAKSKR-GLF; reminiscent of an HPAIV-like polybasic HACS) and comp
View details →DOI: 10.1186/s13567-020-00771-3Cited by 34 Negative / Null Result Report
Ludo Waltman, Vincent A. Traag · 2021 · F1000Research
Most scientometricians reject the use of the journal impact factor for assessing individual articles and their authors. The well-known San Francisco Declaration on Research Assessment also strongly objects against this way of using the…
View details →DOI: 10.12688/f1000research.23418.2Cited by 34 Negative / Null Result ReportOpen accessMedicine
Yukiko Morimoto, Gertraud Maskarinec, Song‐Yi Park et al. · 2014 · British Journal Of Nutrition
Given the high intake levels of soya and low incidence rates of breast cancer in Asian countries, isoflavones, substances with an oestrogen-like structure occurring principally in soyabeans, are postulated to be cancer protective. In the…
View details →DOI: 10.1017/s0007114514001780Cited by 34 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Habiba S. Al Safar, Heather J. Cordell, Osman Jafer et al. · 2013 · Annals of Human Genetics
Twenty percent of people aged 20 to 79 have type 2 diabetes (T2D) in the United Arab Emirates (UAE). Genome-wide association studies (GWAS) to identify genes for T2D have not been reported for Arab countries. We performed a discovery GWAS…
View details →DOI: 10.1111/ahg.12036Cited by 34 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nana Ama Amissah, Sophie Gryseels, Nicholas J. Tobias et al. · 2014 · PLoS neglected tropical diseases
BACKGROUND: The reservoir and mode of transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer, still remain a mystery. It has been suggested that M. ulcerans persists with difficulty as a free-living organism due to its natural fragility and inability to withstand exposure to direct sunlight, and thus probably persists within a protective host environment. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the role of free-living amoebae as a reservoir of M. ulcerans by screening the bacterium in free-living amoebae (FLA) cultures isolated from environmental specimens using re
View details →DOI: 10.1371/journal.pntd.0003148Cited by 34 Negative / Null Result ReportOpen accessMedicine
Thomas Muelleman, Jeremy Peterson, Naweed I. Chowdhury et al. · 2015 · Journal of Neurological Surgery Part B Skull Base
Objectives To determine the utility of three-dimensional (3D) printed models in individualized petroclival tumor resection planning by measuring the fidelity of printed anatomical structures and comparing tumor exposure afforded by…
View details →DOI: 10.1055/s-0035-1566253Cited by 34 Negative / Null Result ReportMedicine
Adrian T. Davis, Heidi Israel, Lisa K. Cannada et al. · 2012 · Journal of Orthopaedic Trauma
OBJECTIVES: The purpose of this study was to test the biomechanical properties of locking and nonlocking plates using one-third tubular and periarticular plate designs in an osteoporotic distal fibula fracture model. METHODS: Twenty-four…
View details →DOI: 10.1097/bot.0b013e318281a565Cited by 34 Negative / Null Result ReportOpen accessMedicine
Tomoya Mizuno, Takao Kamai, Hideyuki Abe et al. · 2015 · BMC Cancer
BACKGROUND: The relationship between the clinicopathological features and molecular changes associated with standardized uptake value (SUV) determined by Positron emission tomography (PET) with [18F] fluorodeoxyglucose (18F-FDG PET) in human renal cell carcinoma (RCC) has not been elucidated. On the other hand, overactivation of the phosphatidylinositol 3'kinase (PI3K), serine/threonine kinase Akt, and mammalian target of rapamycin (mTOR) pathway has been detected in a variety of human cancers, including RCC. So far, little is known about the relationship between the SUV and these proteins in
View details →DOI: 10.1186/s12885-015-1097-0Cited by 34 Negative / Null Result ReportOpen accessMedicine
Yukie Fujimoto, Natsuko Inoue, Koji Morimoto et al. · 2019 · Cancer Science
Analysis of anticancer immunity aids in assessing the prognosis of patients with breast cancer. From 250 operated breast cancers, we focused on serum levels of C-C motif chemokine ligand 5 (CCL5), which is involved in cancer immune…
View details →DOI: 10.1111/cas.14234Cited by 34 Negative / Null Result ReportBusiness, Management and Accounting
Andrew B. Speer, Neil Douglas Christiansen, Chet Robie et al. · 2021 · Journal of Applied Psychology
The use of personality measures to predict work-related outcomes has been of great interest over the past several decades. The present study used machine learning (ML) to examine the optimal level in the personality hierarchy to use in…
View details →DOI: 10.1037/apl0000618Cited by 34 Negative / Null Result ReportOpen accessMedicine
Weijun Wang, Zong‐Han Liu, Kang Wang et al. · 2023 · Cancer Medicine
BACKGROUND: There is no consensus on the optimal regimen for unresectable recurrent hepatocellular carcinoma (HCC), so this retrospective study aimed to evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib and PD-1 inhibitors (T-L-P) versus TACE combined with lenvatinib (T-L) or TACE alone. METHOD: Data were collected from 204 patients with unresectable recurrent HCC who received T-L-P, T-L, or TACE alone at three medical centers from January, 2019 to December, 2020 for analysis. The survival outcomes, tumor response, and adverse events were compa
View details →DOI: 10.1002/cam4.5880Cited by 34 Negative / Null Result ReportOpen accessMedicine
Lucinda L. van Stee, Sarah E. Boston, Ameet Singh et al. · 2015 · Veterinary Surgery
OBJECTIVE: To assess the outcome of canine splenic lymphoma treated with splenectomy and to evaluate prognostic factors, including involvement of other sites, adjuvant chemotherapy, and the effect of World Health Organization (WHO)…
View details →DOI: 10.1111/vsu.12405Cited by 34 Negative / Null Result ReportOpen accessMedicine
Javier Pereda, Salvador Pérez, Javier Escobar et al. · 2012 · PLoS ONE
BACKGROUND: Obesity is a prognostic factor for severity in acute pancreatitis in humans. Our aim was to assess the role of oxidative stress and abdominal fat in the increased severity of acute pancreatitis in obese rats. METHODOLOGY: Taurocholate-induced acute pancreatitis was performed in lean and obese Zucker rats. Levels of reduced glutathione, oxidized glutathione, L-cysteine, cystine, and S-adenosylmethionine were measured in pancreas as well as the activities of serine/threonine protein phosphatases PP1 and PP2A and tyrosin phosphatases. Isoprostane, malondialdehyde, triglyceride, and fr
View details →DOI: 10.1371/journal.pone.0044383Cited by 34 Negative / Null Result ReportOpen accessMedicine
Naveen Gupta, Ranjeet Sinha, Anna Krasnodembskaya et al. · 2018 · Stem Cells
Bone marrow derived mesenchymal stromal cells have been shown to have significant therapeutic effects in experimental models of pneumonia and lung injury. The current study examined the roles of the toll like receptor 4 (TLR4) and protease…
View details →DOI: 10.1002/stem.2796Cited by 34 Negative / Null Result ReportOpen accessMedicine
James L. Alexander, Hajir Ibraheim, Bhavisha P. Sheth et al. · 2021 · Journal for ImmunoTherapy of Cancer
INTRODUCTION: Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) is used in corticosteroid-refractory cases. However, robust outcome data for these patients are scarce. METHODS: We conducted a multicenter (six cancer centers), cohort study of outcomes in patients treated with IFX for corticosteroid-refractory CPI-induced enterocolitis between 2007 and 2020. The primary outcome was corticoster
View details →DOI: 10.1136/jitc-2021-002742Cited by 34 Negative / Null Result ReportOpen accessMedicine
Shota Hamada, Martin Gulliford · 2016 · Journal of the American Geriatrics Society
OBJECTIVES: To evaluate whether low glycosylated hemoglobin (HbA1c), blood pressure (BP), and total cholesterol (TC) are associated with lower risk of all-cause mortality in very old individuals with type 2 diabetes mellitus. DESIGN:…
View details →DOI: 10.1111/jgs.14215Cited by 34 Negative / Null Result ReportOpen accessImmunology and Microbiology
Tzu‐Hsing Kuo, Julie A. Williams · 2014 · SLEEP
STUDY OBJECTIVES: Sleep is known to increase as an acute response to infection. However, the function of this behavioral response in host defense is not well understood. To address this problem, we evaluated the effect of acute sleep…
View details →DOI: 10.5665/sleep.3648Cited by 34 Negative / Null Result ReportOpen accessMedicine
Maxwell Akanbi, Chad J. Achenbach, Babafemi Taiwo et al. · 2017 · BMC Pulmonary Medicine
BACKGROUND: Xpert MTB/Rif (Xpert) is described as a game changer in tuberculosis (TB) control. We evaluated the impact of Xpert on diagnosis, time to treatment, and treatment outcome among patients with HIV associated TB in Nigeria. METHODS: Adults with HIV being evaluated for pulmonary TB (PTB) were consecutively enrolled into the study cohort. At baseline, expectorated sputa were examined using Xpert and smear microscopy for Mycobacterium tuberculosis (MTB) and acid fast bacilli, respectively. Patients diagnosed with TB were followed-up until 6 months post TB diagnosis. TB was defined as spu
View details →DOI: 10.1186/s12890-017-0430-6Cited by 34 Negative / Null Result ReportOpen accessMedicine
Catarina S. Lobo, Maria Inês P. Mendes, Diogo A. Pereira et al. · 2023 · Scientific Reports
Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune
View details →DOI: 10.1038/s41598-023-38862-8Cited by 34 Negative / Null Result ReportOpen accessMedicine
Sabine Rauth, Dominik Hinz, Michael A. Borger et al. · 2016 · Biochemical Journal
Amyloid beta (Aβ) peptides, in particular Aβ42 and Aβ40, exert neurotoxic effects and their overproduction leads to amyloid deposits in the brain, thus constituting an important biomolecular target for treatments of Alzheimer's disease…
View details →DOI: 10.1042/bcj20160114Cited by 34 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jason L. Pugh, Alona S. Sukhina, Thomas M. Seed et al. · 2014 · The Journal of Immunology
Lymphocytes are sensitive to ionizing radiation and naive lymphocytes are more radiosensitive than their memory counterparts. Less is known about radiosensitivity of memory cell subsets. We examined the radiosensitivity of naive (TN),…
View details →DOI: 10.4049/jimmunol.1400434Cited by 34 Negative / Null Result ReportOpen accessEngineering
Tomáš Suchý, Martin Bartoš, Radek Sedláček et al. · 2021 · Materials
This study aims to point out the main drawback with respect to the design of simulated body environments. Three media commonly used for the simulation of the identical body environment were selected, i.e., Kokubo's simulated body fluid that simulates the inorganic component of human blood plasma, human blood plasma, and phosphate buffer saline. A comparison was performed of the effects of the media on collagen scaffolds. The mechanical and structural effects of the media were determined via the application of compression mechanical tests, the determination of mass loss, and image and micro-CT
View details →DOI: 10.3390/ma14164388Cited by 34 Negative / Null Result Report
Stephanie Seneff, Robert Davidson, Jingjing Liu · 2012 · Entropy
Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This…
View details →DOI: 10.3390/e14112227Cited by 34 Replication FailureOpen accessMedicine
M. Roupret, Aurélie Bertaut, G. Pignot et al. · 2025 · Annals of Oncology
BACKGROUND: Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
View details →DOI: 10.1016/j.annonc.2025.09.017Cited by 34 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Roberts, Philip Joseph William · 2026 · CaltechAUTHORS (California Institute of Technology)
The three-dimensional flow field created by a simple line plume of finite length in a steady current of uniform density was investigated in a laboratory basin. The results can be used to aid in the prediction of dispersion of buoyant waste…
View details →DOI: 10.7907/5bjx-sh58Cited by 34 Negative / Null Result ReportOpen accessMathematics
Marlin D Figgins, Trevor Bedford · 2026 · eLife
Accurately estimating relative transmission rates of SARS-CoV-2 variants remains a scientific and public health priority. Recent studies have used the sample proportions of different variants from genetic sequence data to describe variant frequency dynamics and relative transmission rates, but frequencies alone cannot capture the rich epidemiological behavior of SARS-CoV-2. Here, we extend methods for inferring the effective reproduction number of an epidemic using confirmed case data to jointly estimate variant-specific effective reproduction numbers and frequencies of co-circulating variants
View details →DOI: 10.7554/elife.104802.2Cited by 34 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Oisín Ryan, Jonas M B Haslbeck, Lourens Waldorp · 2025 · Multivariate Behavioral Research
Time series analysis is increasingly popular across scientific domains. A key concept in time series analysis is stationarity, the stability of statistical properties of a time series. Understanding stationarity is crucial to addressing frequent issues in time series analysis such as the consequences of failing to model non-stationarity, how to determine the mechanisms generating non-stationarity, and consequently how to model those mechanisms (i.e., by differencing or detrending). However, many empirical researchers have a limited understanding of stationarity, which can lead to the use of in
View details →DOI: 10.1080/00273171.2024.2436413Cited by 33 Negative / Null Result ReportOpen accessComputer Science
Anne Lohr, Michael Sailer, Matthias Stadler et al. · 2024 · Teaching and Teacher Education
We investigated factors that are potentially associated with teaching and learning with digital technology, by replicating and extending Sailer, Murböck, and Fischer's (2021) study with a representative sample of 407 German secondary school teachers. In line with the replicated study, teachers' technology-related teaching skills were crucial for different forms of students' active learning, whereas the digital technology equipment available in a school was less important. School support was positively related to successful digital teaching and learning at schools. The success of Bring-Your-Own
View details →DOI: 10.1016/j.tate.2024.104788Cited by 33 Negative / Null Result ReportPsychology
Yongliang Wang, Yumeng Guo · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background The rise of artificial intelligence (AI) has reshaped English as Foreign Language (EFL) instruction, offering new opportunities for language learning. While much of the existing research focuses on AI integration in…
View details →DOI: 10.1002/jcal.70189Cited by 33 