A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Mohamed L. Sorror, Rainer Storb, Brenda M. Sandmaier et al. · 2014 · Journal of Clinical Oncology
PURPOSE: Age has long been used as a major factor for assessing suitability for allogeneic hematopoietic cell transplantation (HCT). The HCT-comorbidity index (HCT-CI) was developed as a measure of health status to predict mortality risk…
Lena Jingen Liang, HS Chris Choi, Marion Joppe · 2017 · Journal of Travel & Tourism Marketing
The purpose of this paper is to extend the research on consumer repurchase intention, perceived value, and perceived risk into the realm of the peer-to-peer economy, specifically in the context of Airbnb. A total of 395 surveys were…
Michael F. Green, Carrie E. Bearden, Tyrone D. Cannon et al. · 2011 · Schizophrenia Bulletin
Social cognitive impairments are consistently reported in schizophrenia and are associated with functional outcome. We currently know very little about whether these impairments are stable over the course of illness. In the current study,…
Jonathan Leeder, Mark Glaister, Kathleen Pizzoferro et al. · 2012 · Journal of Sports Sciences
Sleep is known to be an important component of recovery from training, yet little is known about the quality and quantity of sleep achieved by elite athletes. The aim of the present study was to quantify sleep in elite athletes using…
Alex R. Kemper, William T. Mahle, Gerard R. Martin et al. · 2011 · PEDIATRICS
BACKGROUND: Although newborn screening for critical congenital heart disease (CCHD) was recommended by the US Health and Human Services Secretary's Advisory Committee on Heritable Disorders in Newborns and Children to promote early…
Roland G. Fryer · 2011 · The Quarterly Journal of Economics
This article describes a series of school-based field experiments in over 200 urban schools across three cities designed to better understand the impact of financial incentives on student achievement. In Dallas, students were paid to read…
Cátia Laranjeira, Katarina Sandgren, Nicoletta Kessaris et al. · 2011 · Journal of Clinical Investigation
The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clonal cultures and in…
Stacia E. Rodenbusch, Paul R. Hernandez, Sarah Simmons et al. · 2016 · CBE—Life Sciences Education
National efforts to transform undergraduate biology education call for research experiences to be an integral component of learning for all students. Course-based undergraduate research experiences, or CUREs, have been championed for…
Suetonia C. Palmer, Dimitris Mavridis, Antonio Nicolucci et al. · 2016 · JAMA
IMPORTANCE: Numerous glucose-lowering drugs are used to treat type 2 diabetes. OBJECTIVE: To estimate the relative efficacy and safety associated with glucose-lowering drugs including insulin. DATA SOURCES: Cochrane Library Central…
Jay J. Van Bavel, Peter Mende‐Siedlecki, William J. Brady et al. · 2016 · Proceedings of the National Academy of Sciences
In recent years, scientists have paid increasing attention to reproducibility. For example, the Reproducibility Project, a large-scale replication attempt of 100 studies published in top psychology journals found that only 39% could be…
Ian M. Lyons, Gavin R. Price, Anniek Vaessen et al. · 2014 · Developmental Science
Math relies on mastery and integration of a wide range of simpler numerical processes and concepts. Recent work has identified several numerical competencies that predict variation in math ability. We examined the unique relations between…
Bruno Crépon, Florencia Devoto, Esther Duflo et al. · 2015 · American Economic Journal Applied Economics
We report results from a randomized evaluation of a microcredit program introduced in rural areas of Morocco in 2006. Thirteen percent of the households in treatment villages took a loan, and none in control villages did. Among households…
Nezih Altay, Angappa Gunasekaran, Rameshwar Dubey et al. · 2018 · Production Planning & Control
This study examines the effects of supply chain agility (SCAG) and supply chain resilience (SCRES) on performance under the moderating effect of organizational culture. We have used the dynamic capability view (DCV) to conceptualize our…
Marcel Fafchamps, Bart Minten · 2012 · The World Bank Economic Review
This study estimates the benefits that Indian farmers derive from market and weather information delivered to their mobile phones by a commercial service called Reuters Market Light (RML). We conduct a controlled randomized experiment in…
Hanne Vanheel, María Vicario, Tim Vanuytsel et al. · 2013 · Gut
OBJECTIVE: Functional dyspepsia (FD) is an extremely common functional gastrointestinal disorder, the pathophysiology of which is poorly understood. We hypothesised that impaired intestinal barrier function is involved in the onset and…
David Q. Rich, Howard M. Kipen, Wei Huang et al. · 2012 · JAMA
CONTEXT: Air pollution is a risk factor for cardiovascular diseases (CVD), but the underlying biological mechanisms are not well understood. OBJECTIVE: To determine whether markers related to CVD pathophysiological pathways (biomarkers for…
Alexandra C. Nica, Leopold Parts, Daniel Glass et al. · 2011 · PLoS Genetics
While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore in depth the role of cis-regulatory variation in three human tissues: lymphoblastoid cell lines (LCL), skin, and fat. The samples (156 LCL, 160 skin, 166 fat) were derived simultaneously from a subset of well-phenotyped healthy female twins of the MuTHER resource. We discover an abundance of cis-eQTLs in each tissue similar to previous estimates (858 or 4.7% of genes). In addition, we apply factor analysis (
Chenxi Wu, Alison L. Spongberg, Jason D. Witter et al. · 2010 · Environmental Science & Technology
Many pharmaceuticals and personal care products (PPCPs) are commonly found in biosolids and effluents from wastewater treatment plants. Land application of these biosolids and the reclamation of treated wastewater can transfer those PPCPs…
Sruti Rayaprolu, Bianca Mullen, Matt Baker et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer's disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of TREM2 may play a more generalized role in neurodegeneration. With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative dis
Z. Arzoumanian, P. T. Baker, A. Brazier et al. · 2018 · The Astrophysical Journal
Abstract We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a…
Kai Liu, Ying Chen, Duozhi Wu et al. · 2020 · Complementary Therapies in Clinical Practice
BACKGROUND: Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. Some sleep-improving drugs may inhibit the respiratory system and worsen the condition.…
Lama Qasem, Antonia S. Cardew, Alexis Wilson et al. · 2012 · PLoS ONE
Dynamic body acceleration (DBA) has been used as a proxy for energy expenditure in logger-equipped animals, with researchers summing the acceleration (overall dynamic body acceleration--ODBA) from the three orthogonal axes of devices. The vector of the dynamic body acceleration (VeDBA) may be a better proxy so this study compared ODBA and VeDBA as proxies for rate of oxygen consumption using humans and 6 other species. Twenty-one humans on a treadmill ran at different speeds while equipped with two loggers, one in a straight orientation and the other skewed, while rate of oxygen consumption (V
David P. Baker, Juan León, Emily G. Smith Greenaway et al. · 2011 · Population and Development Review
Demographic research frequently reports consistent and significant associations between formal educational attainment and a range of health risks such as smoking, drug abuse, and accidents, as well as the contraction of many diseases, and…
Diane Del Guercio, Jonathan Reuter · 2013 · The Journal of Finance
ABSTRACT To rationalize the well‐known underperformance of the average actively managed mutual fund, we exploit the fact that retail funds in different market segments compete for different types of investors. Within the segment of funds…
Fang Fang Zhang, Roberto Cardarelli, Joan F. Carroll et al. · 2011 · Epigenetics
Reduced levels of global DNA methylation are associated with genomic instability and are independent predictors of cancer risk. Little is known about the environmental determinants of global DNA methylation in peripheral blood. We examined…
Dawn Waterworth, Sally L. Ricketts, Kijoung Song et al. · 2010 · Arteriosclerosis Thrombosis and Vascular Biology
OBJECTIVE: Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density…
David R. Mandel, Katy Eichas, J Holmes · 2010 · BMC Complementary and Alternative Medicine
BACKGROUND: Lactic acid-producing bacteria (LAB) probiotics demonstrate immunomodulating and anti-inflammatory effects and the ability to lessen the symptoms of arthritis in both animals and humans. This randomized, double-blind, placebo-controlled, parallel-design, clinical pilot trial was conducted to evaluate the effects of the LAB probiotic preparation, Bacillus coagulans GBI-30, 6086, on symptoms and measures of functional capacity in patients with rheumatoid arthritis (RA) in combination with pharmacological anti-arthritic medications. METHODS: Forty-five adult men and women with symptom
Ibán Amenabar, Simon Poly, Wiwat Nuansing et al. · 2013 · Nature Communications
Mid-infrared spectroscopy is a widely used tool for material identification and secondary structure analysis in chemistry, biology and biochemistry. However, the diffraction limit prevents nanoscale protein studies. Here we introduce…
Javier Cerrato Allende, Eva Cifré · 2018 · Frontiers in Psychology
The fact that the permeability between family and work scopes produces work-family conflict (WFC) is well established. As such, this research aims to check whether the unequal involvement in household chores between men and women is associated with increased WFC in women and men, interpreting the results also from the knowledge that arise from gender studies. A correlational study was carried out by means a questionnaire applied to 515 subjects (63% men) of two independent samples of Spanish men and women without emotional relationship, who lived with their heterosexual partner. As expected, r
L. A. Smith, Natalia Price, Vanessa Simonite et al. · 2013 · BMC Pregnancy and Childbirth
BACKGROUND: Our aim was to describe the range of perineal trauma in women with a singleton vaginal birth and estimate the effect of maternal and obstetric characteristics on the incidence of perineal tears. METHODS: We conducted a prospective observational study on all women with a planned singleton vaginal delivery between May and September 2006 in one obstetric unit, three freestanding midwifery-led units and home settings in South East England. Data on maternal and obstetric characteristics were collected prospectively and analysed using univariable and multivariable logistic regression. Th