TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
Sruti Rayaprolu; Bianca Mullen; Matt Baker; Timothy Lynch; Elizabeth Finger; William W. Seeley; Kimmo J. Hatanpaa; Catherine Lomen‐Hoerth · 2013 · Molecular Neurodegeneration
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene has been reported to be a genetic risk factor for Alzheimer's disease by two independent groups (Odds ratio between 2.9-4.5). Given the key role of TREM2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of TREM2 may play a more generalized role in neurodegeneration. With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative dis
Abstract by Sruti Rayaprolu; Bianca Mullen; Matt Baker; Timothy Lynch; Elizabeth Finger; William W. Seeley; Kimmo J. Hatanpaa; Catherine Lomen‐Hoerth, Molecular Neurodegeneration (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1750-1326-8-19