A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21165 results · page 9 of 706
Nicole Koenig‐Lewis, Morgan Marquet, Adrian Palmer et al. · 2015 · Service Industries Journal
Models of technology adoption, notably the Technology Acceptance Model and the Unified Theories of Acceptance and Use of Technology, provide good theoretical foundations for understanding mobile payment adoption. This study extends these…
Zarek Brot-Goldberg, Amitabh Chandra, Benjamin Handel et al. · 2017 · The Quarterly Journal of Economics
Abstract Measuring consumer responsiveness to medical care prices is a central issue in health economics and a key ingredient in the optimal design and regulation of health insurance markets. We leverage a natural experiment at a large…
Qi Guoyou, Zeng Sai-xing, Tam Chiming et al. · 2011 · Corporate Social Responsibility and Environmental Management
ABSTRACT Facing the challenge of environmental degradation in China, a growing number of firms have begun to integrate environmental management systems into their business strategies and develop green innovation strategies. Based on the…
Matthijs Rooduijn, Sarah L. de Lange, Wouter van der Brug · 2012 · Party Politics
In this article, we examine the programmatic reactions to the rise of populist parties. It has been argued that populism is not necessarily the prerogative of populist parties; it has been adopted by mainstream parties as well. The article…
Amélie C. M. Gaudin, Tor N. Tolhurst, Alan P. Ker et al. · 2015 · PLoS ONE
Cropping sequence diversification provides a systems approach to reduce yield variations and improve resilience to multiple environmental stresses. Yield advantages of more diverse crop rotations and their synergistic effects with reduced tillage are well documented, but few studies have quantified the impact of these management practices on yields and their stability when soil moisture is limiting or in excess. Using yield and weather data obtained from a 31-year long term rotation and tillage trial in Ontario, we tested whether crop rotation diversity is associated with greater yield stabili
Peter Oehen, Rafael Traber, Verena Widmer et al. · 2012 · Journal of Psychopharmacology
Psychiatrists and psychotherapists in the US (1970s to 1985) and Switzerland (1988-1993) used MDMA legally as a prescription drug, to enhance the effectiveness of psychotherapy. Early reports suggest that it is useful in treating…
Damon Jones, David Molitor, Julian Reif · 2019 · The Quarterly Journal of Economics
Workplace wellness programs cover over 50 million U.S. workers and are intended to reduce medical spending, increase productivity, and improve well-being. Yet limited evidence exists to support these claims. We designed and implemented a…
Charles E. Vejnar, Evgeny M. Zdobnov · 2012 · Nucleic Acids Research
MicroRNAs, or miRNAs, post-transcriptionally repress the expression of protein-coding genes. The human genome encodes over 1000 miRNA genes that collectively target the majority of messenger RNAs (mRNAs). Base pairing of the so-called miRNA 'seed' region with mRNAs identifies many thousands of putative targets. Evaluating the strength of the resulting mRNA repression remains challenging, but is essential for a biologically informative ranking of potential miRNA targets. To address these challenges, predictors may use thermodynamic, evolutionary, probabilistic or sequence-based features. We dev
Aris Alea Lapada, Frosyl F. Miguel, Dave Arthur Robledo et al. · 2020 · International Journal of Learning Teaching and Educational Research
Amidst the threat of COVID-19 pandemic in the Philippines, the educators, students, and the school are still coping and adjusting to the distance learning education. This study explored teachers' awareness about the COVID-19 pandemic and…
Adam Brufsky, Musa Mayer, Hope S. Rugo et al. · 2011 · Clinical Cancer Research
PURPOSE: registHER is a prospective, observational study of 1,023 newly diagnosed HER2-positive metastatic breast cancer (MBC) patients. EXPERIMENTAL DESIGN: Baseline characteristics of patients with and without central nervous system…
Gijsbert Stoet, David C. Geary · 2013 · PLoS ONE
We analyzed one decade of data collected by the Programme for International Student Assessment (PISA), including the mathematics and reading performance of nearly 1.5 million 15 year olds in 75 countries. Across nations, boys scored higher than girls in mathematics, but lower than girls in reading. The sex difference in reading was three times as large as in mathematics. There was considerable variation in the extent of the sex differences between nations. There are countries without a sex difference in mathematics performance, and in some countries girls scored higher than boys. Boys scored l
Michele T. Cole, Daniel J. Shelley, Louis B. Swartz · 2014 · The International Review of Research in Open and Distributed Learning
<p>This article presents the results of a three-year study of graduate and undergraduate students’ level of satisfaction with online instruction at one university. The study expands on earlier research into student satisfaction with e-learning. Researchers conducted a series of surveys over eight academic terms. Five hundred and fifty-three students participated in the study. Responses were consistent throughout, although there were some differences noted in the level of student satisfaction with their experience. There were no statistically significant differences in the level of satisf
Xian‐Hu Zha, Kan Luo, Qiuwu Li et al. · 2015 · Europhysics Letters (EPL)
The two-dimensional material MXene has recently attracted interest for its excellent performance in diverse perspectives. Etched from the parental MAX phase with hydrofluoric acid, the synthesized MXene surface is normally functionalized…
M. Ackermann, M. Ajello, A. Allafort et al. · 2012 · The Astrophysical Journal
Recent detections of the starburst galaxies M82 and NGC 253 by gamma-ray telescopes suggest that galaxies rapidly forming massive stars are more luminous at gamma-ray energies compared to their quiescent relatives. Building upon those…
Horacio J. Asbun, John Stauffer · 2012 · Journal of the American College of Surgeons
BACKGROUND: Minimal access surgery techniques have evolved to include complex surgical procedures. Laparoscopic pancreaticoduodenectomy (LPD) is a complex operation that pancreas surgeons have been slow to adopt. This article reviews our…
Katrina L. Kaposi, Benjamin Mos, Brendan P. Kelaher et al. · 2013 · Environmental Science & Technology
There is increasing concern about the impacts of microplastics (<1 mm) on marine biota. Microplastics may be mistaken for food items and ingested by a wide variety of organisms. While the effects of ingesting microplastic have been…
James J. Goedert, Gieira S. Jones, Xing Hua et al. · 2015 · JNCI Journal of the National Cancer Institute
We investigated whether the gut microbiota differed in 48 postmenopausal breast cancer case patients, pretreatment, vs 48 control patients. Microbiota profiles in fecal DNA were determined by Illumina sequencing and taxonomy of 16S rRNA genes. Estrogens were quantified in urine. Case-control comparisons employed linear and unconditional logistic regression of microbiota α-diversity (PD_whole tree) and UniFrac analysis of β-diversity, with two-sided statistical tests. Total estrogens correlated with α-diversity in control patients (Spearman Rho = 0.37, P = .009) but not case patients (Spearman
James H. Cole · 2020 · Neurobiology of Aging
The brain-age paradigm is proving increasingly useful for exploring aging-related disease and can predict important future health outcomes. Most brain-age research uses structural neuroimaging to index brain volume. However, aging affects multiple aspects of brain structure and function, which can be examined using multimodality neuroimaging. Using UK Biobank, brain-age was modeled in n = 2205 healthy people with T1-weighted MRI, T2-FLAIR, T2∗, diffusion-MRI, task fMRI, and resting-state fMRI. In a held-out healthy validation set (n = 520), chronological age was accurately predicted (r = 0.78,
Ingmar Schäfer, Eike-Christin von Leitner, Gerhard Schön et al. · 2010 · PLoS ONE
OBJECTIVE: Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality, increased disability and functional decline. Information about interactions of chronic diseases can help to facilitate diagnosis, amend prevention and enhance the patients' quality of life. The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity. METHODS: Multimorbidity patterns were identified by exploratory tetrachoric factor ana
US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Pancreatic cancer is an uncommon cancer with an age-adjusted annual incidence of 12.9 cases per 100 000 person-years. However, the death rate is 11.0 deaths per 100 000 person-years because the prognosis of pancreatic cancer is…
Gary Cook, Connie Yip, Muhammad Siddique et al. · 2012 · Journal of Nuclear Medicine
UNLABELLED: There is evidence in some solid tumors that textural features of tumoral uptake in (18)F-FDG PET images are associated with response to chemoradiotherapy and survival. We have investigated whether a similar relationship exists…
Kevin C. Soares, Agnieszka A. Rucki, Annie A. Wu et al. · 2014 · Journal of Immunotherapy
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to late detection and resistance to conventional therapies. Published studies show that the PDA tumor microenvironment is predominantly infiltrated with immune suppressive…
Amy Chesser, Nikki Keene Woods, Kyle Smothers et al. · 2016 · Gerontology and Geriatric Medicine
Objective: The objective of this review was to assess published literature relating to health literacy and older adults. Method: The current review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta…
Hansong Chen, Zhen Tian · 2021 · Journal of Business Research
Digital transformation is essential if enterprises are to obtain a competitive advantage in the digital economy. However, successful transformation is a problem for both academia and industry. The literature mainly focuses on the net…
Matthew J. Ward, Stephen M. Thirdborough, Toby Mellows et al. · 2013 · British Journal of Cancer
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared with HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there is no…
Rachel E. McNeish, L. H. Kim, Heather A. Barrett et al. · 2018 · Scientific Reports
Abstract Microplastic is a contaminant of concern worldwide. Rivers are implicated as major pathways of microplastic transport to marine and lake ecosystems, and microplastic ingestion by freshwater biota is a risk associated with microplastic contamination, but there is little research on microplastic ecology within freshwater ecosystems. Microplastic uptake by fish is likely affected by environmental microplastic abundance and aspects of fish ecology, but these relationships have rarely been addressed. We measured the abundance and composition of microplastic in fish and surface waters from
Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren et al. · 2012 · Journal of Clinical Oncology
PURPOSE: To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced…
Georgina Mansell, T.J. Gorrie-Stone, Yanchun Bao et al. · 2019 · BMC Genomics
There has been a steady increase in the number of studies aiming to identify DNA methylation differences associated with complex phenotypes. Many of the challenges of epigenetic epidemiology regarding study design and interpretation have been discussed in detail, however there are analytical concerns that are outstanding and require further exploration. In this study we seek to address three analytical issues. First, we quantify the multiple testing burden and propose a standard statistical significance threshold for identifying DNA methylation sites that are associated with an outcome. Second
Gerhard Kling, Ulrich Volz, Victor Murinde et al. · 2020 · World Development
This article presents the first systematic investigation of the effects of climate-related vulnerability on firms’ cost of capital and access to finance and sheds light on a hitherto under-appreciated cost of climate change for climate vulnerable developing economies. We first show theoretically how climate vulnerability could affect firms’ cost of capital and access to finance. Apart from a possible impact on cost of debt and equity, which drive cost of capital, firms in countries with high exposure to climate risk might be more financially constrained. The latter results in low levels of deb
Qiaohong Sun, Xuebin Zhang, Francis W. Zwiers et al. · 2020 · Journal of Climate
Abstract This paper provides an updated analysis of observed changes in extreme precipitation using high-quality station data up to 2018. We examine changes in extreme precipitation represented by annual maxima of 1-day (Rx1day) and 5-day…