The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study
Alexandra C. Nica; Leopold Parts; Daniel Glass; James Nisbet; Amy Barrett; Magdalena Sekowska; Mary E. Travers; Simon Potter · 2011 · PLoS Genetics
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
While there have been studies exploring regulatory variation in one or more tissues, the complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore in depth the role of cis-regulatory variation in three human tissues: lymphoblastoid cell lines (LCL), skin, and fat. The samples (156 LCL, 160 skin, 166 fat) were derived simultaneously from a subset of well-phenotyped healthy female twins of the MuTHER resource. We discover an abundance of cis-eQTLs in each tissue similar to previous estimates (858 or 4.7% of genes). In addition, we apply factor analysis (
Abstract by Alexandra C. Nica; Leopold Parts; Daniel Glass; James Nisbet; Amy Barrett; Magdalena Sekowska; Mary E. Travers; Simon Potter, PLoS Genetics (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pgen.1002003