Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Tomáš Erban, Karel Harant, Martin Hubálek et al. · 2015 · Scientific Reports
We investigated pathogens in the parasitic honeybee mite Varroa destructor using nanoLC-MS/MS (TripleTOF) and 2D-E-MS/MS proteomics approaches supplemented with affinity-chromatography to concentrate trace target proteins. Peptides were detected from the currently uncharacterized Varroa destructor Macula-like virus (VdMLV), the deformed wing virus (DWV)-complex and the acute bee paralysis virus (ABPV). Peptide alignments revealed detection of complete structural DWV-complex block VP2-VP1-VP3, VDV-1 helicase and single-amino-acid substitution A/K/Q in VP1, the ABPV structural block VP1-VP4-VP2-
View details →DOI: 10.1038/srep13907Cited by 48 Negative / Null Result ReportOpen accessPhysics and Astronomy
Ben Yelverton, Grant M. Kennedy, K. Y. L. Su et al. · 2019 · Monthly Notices of the Royal Astronomical Society
Abstract We compile a sample of 341 binary and multiple star systems with the aim of searching for and characterizing Kuiper belt-like debris discs. The sample is assembled by combining several smaller samples studied in previously…
View details →DOI: 10.1093/mnras/stz1927Cited by 48 Negative / Null Result Report
Madeleine Selvander, Peter Åsman · 2012 · Acta Ophthalmologica
Abstract. Purpose: To investigate construct validity for modules hydromaneuvers and phaco on the Eyesi surgical simulator. Methods: Seven cataract surgeons and 17 medical students performed capsulorhexis, hydromaneuvers, phaco, navigation,…
View details →DOI: 10.1111/j.1755-3768.2012.02440.xCited by 48 Negative / Null Result ReportOpen accessHealth Professions
Anders Alm, AM. Hornmark, Per-Arne Fall et al. · 2026 · Acta Dermato Venereologica
An occlusive hydrocolloid dressing (Comfeel Ulcus) was compared with a conventional wet saline gauze dressing regarding the effect on ulcer cleansing and healing processes, experience of pain and the consumption of nursing time, in a…
View details →DOI: 10.2340/000155551989149110Cited by 48 Negative / Null Result ReportOpen accessPhysics and Astronomy
Michael W. Topping, Dan Stark, Peter Senchyna et al. · 2025 · The Astrophysical Journal
Abstract JWST has recently discovered a subset of reionization era galaxies with ionized gas that is metal-poor in oxygen and carbon but heavily enriched in nitrogen. This abundance pattern is almost never seen in lower-redshift galaxies but is commonly observed in globular cluster stars. We have recently demonstrated that this peculiar abundance pattern appears in a compact (≃20 pc) metal-poor galaxy undergoing a strong burst of star formation. This galaxy was originally selected based on strong C iv emission, indicating a hard radiation field rarely seen locally. In this paper, we present JW
View details →DOI: 10.3847/1538-4357/ada95cCited by 48 Negative / Null Result ReportOpen accessMedicine
Seo‐Young Park, Jong‐Mu Sun, Yoon‐La Choi et al. · 2022 · ESMO Open
•The adjuvant durvalumab therapy failed to demonstrate the survival benefit in ESCC who underwent neoadjuvant CCRT.•This is the first report on the role of adjuvant immunotherapy in both pathologic complete response (ypCR) and…
View details →DOI: 10.1016/j.esmoop.2022.100385Cited by 48 Negative / Null Result ReportOpen accessMedicine
Alexander Mihaescu, Mikaeel Valli, Carme Uribe et al. · 2022 · Molecular Brain
Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson’s disease patients and 30 healthy controls f
View details →DOI: 10.1186/s13041-022-00964-1Cited by 48 Negative / Null Result Report
Haiyang Yang, Amitava Chattopadhyay, Kuangjie Zhang et al. · 2012 · Journal of Consumer Psychology
Abstract Recent research suggests that unconscious thought is superior to conscious thought in many cognitive domains. In this article, we show that the duration of unconscious thought has an inverted‐U shaped relationship with creativity…
View details →DOI: 10.1016/j.jcps.2012.04.002Cited by 47 Negative / Null Result Report
Masaaki Sadakiyo, Teppei Yamada, Kenichi Kato et al. · 2016 · Chemical Science
We conducted a systematic study of the control of selective adsorption behaviour through the type of central metals in a series of analogous MOFs that show closed-open structural transformations.
View details →DOI: 10.1039/c5sc03325jCited by 47 Negative / Null Result ReportOpen accessMedicine
Akiyoshi Hagiwara, Noriko Tanaka, Tatsuki Uemura et al. · 2016 · BMJ Open
OBJECTIVE: To determine whether treatment with recombinant human thrombomodulin (rhTM) increases survival among patients with severe septic-induced disseminated intravascular coagulation (DIC). DESIGN: Single-centre, open-label, randomised…
View details →DOI: 10.1136/bmjopen-2016-012850Cited by 47 Negative / Null Result ReportOpen accessMedicine
Marie Fallon, Maciej Sopata, Erika Dragon et al. · 2023 · The Oncologist
BACKGROUND: This phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid…
View details →DOI: 10.1093/oncolo/oyad188Cited by 47 Negative / Null Result ReportOpen accessMedicine
Mark Thalgott, Thomas Horn, Matthias Heck et al. · 2014 · Journal of Hematology & Oncology
BACKGROUND: Patients with locally advanced and high-risk prostate cancer (LAPC) are prone to experience biochemical recurrence despite radical prostatectomy (RP). We evaluated feasibility, safety and activity of a neoadjuvant chemohormonal therapy (NCHT) with 3-weekly full dose docetaxel and complete androgen blockade (CAB) in locally advanced and high-risk prostate cancer patients (LAPC) undergoing RP. METHODS: Patients (n = 30) were selected by Kattans' preoperative score and received trimestral buserelin 9,45 mg, bicalutamide 50 mg/day and 3 cycles docetaxel (75 mg/m²) followed by RP. Prima
View details →DOI: 10.1186/1756-8722-7-20Cited by 47 Negative / Null Result ReportOpen accessMedicine
Brigitte Leeners, Tillmann H. C. Krüger, Kirsten Geraedts et al. · 2017 · Frontiers in Behavioral Neuroscience
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational multisite study comprised data of n=88 menstruating women from Hannover, Germany, and Zurich, Switzerland, assessed during a first cycle and n=68 re-assessed during a second cycle to rule out practice effects and false-positive chance findings. We assessed visuospatial working memory, attention, cognitive bias and hormone levels at four consec
View details →DOI: 10.3389/fnbeh.2017.00120Cited by 47 Negative / Null Result ReportOpen accessSocial Sciences
Alexis V. Knaub, Kathleen Foote, Charles Henderson et al. · 2016 · International Journal of STEM Education
The characteristics of the classroom environment play an important role in shaping teaching practices and supporting research-based instructional strategies. One instructional strategy that has reimagined the classroom is the Student-Centered Active Learning Environment with Upside-Down Pedagogies (SCALE-UP). SCALE-UP uses studio-style instruction to facilitate student collaboration. Although there is significant interest in studio-style instruction, there is not much research-based guidance available for institutions interested in setting up a classroom, especially for secondary users interes
View details →DOI: 10.1186/s40594-016-0042-3Cited by 47 Negative / Null Result ReportOpen accessMedicine
Agatha Lenartowicz, Holly Truong, Giulia C. Salgari et al. · 2019 · Journal of Child Psychology and Psychiatry
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in…
View details →DOI: 10.1111/jcpp.13042Cited by 47 Failed Experiment ReportPhysics and Astronomy
V. K. Dixit, S. Porwal, S. D. Singh et al. · 2014 · Journal of Physics D Applied Physics
Temperature dependence of the photoluminescence (PL) peak energy of bulk and quantum well (QW) structures is studied by using a new phenomenological model for including the effect of localized states. In general an anomalous S-shaped…
View details →DOI: 10.1088/0022-3727/47/6/065103Cited by 47 Replication FailureDecision Sciences
Marc-André Goulet, Denis Cousineau · 2019 · Advances in Methods and Practices in Psychological Science
When running statistical tests, researchers can commit a Type II error, that is, fail to reject the null hypothesis when it is false. To diminish the probability of committing a Type II error (β), statistical power must be augmented.…
View details →DOI: 10.1177/2515245919849434Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Marco Roccetti, Giovanni Delnevo, Luca Casini et al. · 2021 · Journal Of Big Data
Abstract Deep learning models are tools for data analysis suitable for approximating (non-linear) relationships among variables for the best prediction of an outcome. While these models can be used to answer many important questions, their utility is still harshly criticized, being extremely challenging to identify which data descriptors are the most adequate to represent a given specific phenomenon of interest. With a recent experience in the development of a deep learning model designed to detect failures in mechanical water meter devices, we have learnt that a sensible deterioration of the
View details →DOI: 10.1186/s40537-021-00428-8Cited by 47 Replication FailureOpen accessMedicine
Benjamin Baker, Ashish Bhalla, Brett Doleman et al. · 2016 · Medical Teacher
INTRODUCTION: Simulation-based training (SBT) has become an increasingly important method by which doctors learn. Stress has an impact upon learning, performance, technical, and non-technical skills. However, there are currently no studies that compare stress in the clinical and simulated environment. We aimed to compare objective (heart rate variability, HRV) and subjective (state trait anxiety inventory, STAI) measures of stress theatre with a simulated environment. METHODS: HRV recordings were obtained from eight anesthetic trainees performing an uncomplicated rapid sequence induction at pr
View details →DOI: 10.1080/0142159x.2016.1230188Cited by 47 Replication FailureSocial Sciences
John P. Crowley, Ryan Allred, Julianna Follon et al. · 2018 · Communication Studies
Research on the mere presence hypothesis shows mixed findings for the effects of cell phone presence on various conversation outcomes. The current study performed a partial replication of Przybylski and Weinstein’s (2013) study, which…
View details →DOI: 10.1080/10510974.2018.1467941Cited by 47 Failed Experiment ReportOpen accessMedicine
Arafat Tfayli, Majd Al Assaad, Ghina Fakhri et al. · 2020 · Cancer Medicine
Multiple randomized studies have shown that combination of chemotherapy and immune checkpoint inhibitors (ICIs) leads to better response rates and survival as compared to chemotherapy alone in the advanced stage of NSCLC. Data suggesting a benefit to using ICIs in the neoadjuvant therapy of patients with early stage NSCLC are emerging. Eligible subjects were treatment naïve patients with stage IB, II, and resectable IIIA NSCLC. Patients received three cycles of neoadjuvant chemotherapy with four doses of avelumab every 2 weeks. Patients with squamous cell cancer received cisplatin or carboplat
View details →DOI: 10.1002/cam4.3456Cited by 47 Negative / Null Result ReportOpen accessMedicine
Kayleigh N. McCarty, David H. Morris, Laura E. Hatz et al. · 2017 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: The UPPS-P model posits that impulsivity comprises five factors: positive urgency, negative urgency, lack of planning, lack of perseverance, and sensation seeking. Negative and positive urgency are the traits most consistently…
View details →DOI: 10.15288/jsad.2017.78.617Cited by 47 Negative / Null Result ReportPsychology
Stephen R. Shirk, Anne P. DePrince, Patrice S. Crisostomo et al. · 2013 · Psychotherapy
Four clinical trials have shown that a history of interpersonal trauma is associated with diminished response to cognitive-behavioral therapy (CBT) for adolescent depression. An efficacious CBT protocol for adolescent depression was…
View details →DOI: 10.1037/a0034845Cited by 47 Negative / Null Result ReportOpen accessMedicine
Sara Galimberti, Mario Petrini, Claudia Baratè et al. · 2020 · Frontiers in Oncology
SARS-CoV-2 is the viral agent responsible for the pandemic that in the first months of 2020 caused about 400,000 deaths. Among compounds proposed to fight the SARS-CoV-2-related disease (COVID-19), tyrosine kinase inhibitors (TKIs), already effective in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML), have been proposed on the basis of their antiviral action already demonstrated against SARS-CoV-1. Very few cases of COVID-19 have been reported in Ph+ ALL and in CML Italian cohorts; authors suggested that this low rate of infections might depend f
View details →DOI: 10.3389/fonc.2020.01428Cited by 47 Negative / Null Result ReportOpen accessNeuroscience
Colin Quirk, Kirsten Adam, Edward K. Vogel · 2020 · eNeuro
Visual working memory is the ability to hold visual information temporarily in mind. A key feature of working memory is its starkly limited capacity, such that only a few simple items can be remembered at once. Prior work has shown that this capacity limit cannot be circumvented by providing additional encoding time, whether providing just 200 ms or up to 1300 ms, capacity is still limited to only three to four items. In contrast, Brady et al. (2016) hypothesized that real-world objects, but not simple items used in prior research, benefit from additional encoding time and are not subject to t
View details →DOI: 10.1523/eneuro.0150-20.2020Cited by 47 Negative / Null Result ReportOpen accessMedicine
Charles Sharp, Huzaifa Adamali, Ann Millar · 2017 · ERJ Open Research
Idiopathic pulmonary fibrosis (IPF) has an unpredictable course and prognostic factors are incompletely understood. We aimed to identify prognostic factors, including multidimensional indices from a significant IPF cohort at the Bristol…
View details →DOI: 10.1183/23120541.00096-2016Cited by 47 Negative / Null Result ReportMedicine
Soenke Böettger, David García Núñez, Rafael Meyer et al. · 2017 · Palliative & Supportive Care
BACKGROUND: In the intensive care setting, delirium is a common occurrence that comes with subsequent adversities. Therefore, several instruments have been developed to screen for and detect delirium. Their validity and psychometric…
View details →DOI: 10.1017/s1478951516001176Cited by 47 Negative / Null Result ReportOpen accessMedicine
Karin Bammann, Nicola K. Thomson, Birte Marie Albrecht et al. · 2021 · PLoS ONE
The study of physical activity in older adults is becoming more and more relevant. For evaluation of physical activity recommendations, intensity-specific accelerometer cut-points are utilized. However, research on accelerometer cut-points for older adults is still scarce. The aim of the study was to generate placement-specific cut-points of ActiGraph GT3X+ activity counts and raw measures of acceleration to determine physical activity intensity in older adults. A further aim was to compare the validity of the generated cut-points for a range of different physical activities. The study was a s
View details →DOI: 10.1371/journal.pone.0252615Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Xinsong Du, John Novoa-Laurentiev, Joseph M. Plasek et al. · 2024 · EBioMedicine
BACKGROUND: Large language models (LLMs) have shown promising performance in various healthcare domains, but their effectiveness in identifying specific clinical conditions in real medical records is less explored. This study evaluates LLMs for detecting signs of cognitive decline in real electronic health record (EHR) clinical notes, comparing their error profiles with traditional models. The insights gained will inform strategies for performance enhancement. METHODS: This study, conducted at Mass General Brigham in Boston, MA, analysed clinical notes from the four years prior to a 2019 diagn
View details →DOI: 10.1016/j.ebiom.2024.105401Cited by 47 Negative / Null Result ReportOpen accessComputer Science
Zongyao Li, Kazuhiro Kitajima, Kenji Hirata et al. · 2021 · EJNMMI Research
Abstract Background To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[ 18 F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep-learning technologies. Materials and methods Two clinicians and the new AI system retrospectively analyzed and diagnosed 414 axillae of 407 patients with biopsy-proven breast cancer who had undergone 2-[ 18 F]FDG-PET/CT before a mastectomy or breast-conserving surgery with a sentinel lymph node (LN) biopsy and/or axillary LN dissection. We designed and trained a
View details →DOI: 10.1186/s13550-021-00751-4Cited by 47 