A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21234 results · page 75 of 708
Samuel Murray, Nathan Liang, Nicholaus P. Brosowsky et al. · 2021 · Psychology of Aesthetics Creativity and the Arts
A primary aim of mind-wandering research has been to understand its influence on task performance. While this research has typically highlighted the costs of mind wandering, a handful of studies have suggested that mind wandering may be…
Changhee Park, Tae Min Kim, Jeong Mo Bae et al. · 2020 · Cancer Research and Treatment
PURPOSE: The treatment outcomes and genomic profiles of diffuse midline glioma (DMG) in adult patients are rarely characterized. We performed a retrospective study to evaluate the clinicogenomic profiles of adult patients with brain DMG.…
Andrew Orton, Jonathan Frandsen, Randy L. Jensen et al. · 2017 · Journal of neurosurgery
OBJECTIVE Anaplastic meningiomas represent 1%-2% of meningioma diagnoses and portend a poor prognosis. Limited information is available on practice patterns and optimal management. The purpose of this study was to define treatment patterns…
Brittany I Davidson, Heather Shaw, David A. Ellis · 2022 · Computers in Human Behavior
The mass adoption of digital technologies raises questions about how they impact people and society. Associations between technology use and negative correlates (e.g., depression and anxiety) remain common. However, pre-registered studies have failed to replicate these findings. Regardless of direction, many designs rely on psychometric scales that claim to define and quantify a construct associated with technology engagement. These often suggest clinical manifestations present as disorders or addictions. Given their importance for research integrity, we consider what these scales might be mea
Anders Alm, AM. Hornmark, Per-Arne Fall et al. · 2026 · Acta Dermato Venereologica
An occlusive hydrocolloid dressing (Comfeel Ulcus) was compared with a conventional wet saline gauze dressing regarding the effect on ulcer cleansing and healing processes, experience of pain and the consumption of nursing time, in a…
Michael W. Topping, Dan Stark, Peter Senchyna et al. · 2025 · The Astrophysical Journal
Abstract JWST has recently discovered a subset of reionization era galaxies with ionized gas that is metal-poor in oxygen and carbon but heavily enriched in nitrogen. This abundance pattern is almost never seen in lower-redshift galaxies but is commonly observed in globular cluster stars. We have recently demonstrated that this peculiar abundance pattern appears in a compact (≃20 pc) metal-poor galaxy undergoing a strong burst of star formation. This galaxy was originally selected based on strong C iv emission, indicating a hard radiation field rarely seen locally. In this paper, we present JW
Seo‐Young Park, Jong‐Mu Sun, Yoon‐La Choi et al. · 2022 · ESMO Open
•The adjuvant durvalumab therapy failed to demonstrate the survival benefit in ESCC who underwent neoadjuvant CCRT.•This is the first report on the role of adjuvant immunotherapy in both pathologic complete response (ypCR) and…
Alexander Mihaescu, Mikaeel Valli, Carme Uribe et al. · 2022 · Molecular Brain
Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson’s disease patients and 30 healthy controls f
Brian Martin, Beth A. Gabris-Weber, Rajiv P. Reddy et al. · 2018 · PLoS ONE
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive
Pradeesh Sivapalan, Charlotte Suppli Ulrik, Thérèse Lapperre et al. · 2021 · European Respiratory Journal
Background Combining the antibiotic azithromycin and hydroxychloroquine induces airway immunomodulatory effects, with the latter also having in vitro antiviral properties. This may improve outcomes in patients hospitalised for coronavirus…
J Prazák, Luca G. Valente, Manuela Iten et al. · 2021 · The Journal of Infectious Diseases
BACKGROUND: The optimal method for delivering phages in the context of ventilator-associated pneumonia (VAP) is unknown. In the current study, we assessed the utility of aerosolized phages (aerophages) for experimental…
Hiroki Nishikawa, Akira Arimoto, Tomoko Wakasa et al. · 2012 · International Journal of Oncology
The aim of the present study was to evaluate the influence of preoperative transcatheter arterial chemoembolization (TACE) on survival after surgical resection (SR) for hepatocellular carcinoma (HCC). Two hundred and thirty-five HCC…
Maria Juárez, Nieves Díaz, Geoffrey I. Johnston et al. · 2020 · Lara D. Veeken
OBJECTIVES: This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary…
Wei Qiu, Sonja Raven, Jing-Kun Wu et al. · 2010 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: To determine the frequency of hypothalamic lesions in patients with multiple sclerosis (MS) using conventional MRI (cMRI) protocols. METHODS: Brain cMRI (1.5 Tesla) scans of 105 Caucasian patients with classical MS (50 with…
Antoine Bouquegneau, Emmanuelle Vidal‐Petiot, François Vrtovsnik et al. · 2013 · Nephrology Dialysis Transplantation
BACKGROUND: Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD). Accurate estimation of glomerular filtration rate (GFR) is thus important in these patients. We tested the…
Swati Agarwal, Faisal A Alzahrani, Asif Ahmed · 2018 · International Journal of Molecular Sciences
Background: Throughout history, menopause has been regarded as a transition in a woman’s life. With the increase in life expectancy, women now spend more than a third of their lives in menopause. During these years, women may experience…
Fabio Morgante, Wen Huang, Peter Sørensen et al. · 2020 · G3 Genes Genomes Genetics
Abstract The ability to accurately predict complex trait phenotypes from genetic and genomic data are critical for the implementation of personalized medicine and precision agriculture; however, prediction accuracy for most complex traits is currently low. Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. We found that expression levels (r
Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić et al. · 2023 · Blood Cancer Journal
Currently, the International Prognostic Index (IPI) is the most used and reported model for prognostication in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). IPI-like variations have been proposed, but only a few have been validated in different populations (e.g., revised IPI (R-IPI), National Comprehensive Cancer Network IPI (NCCN-IPI)). We aimed to validate and compare different IPI-like variations to identify the model with the highest predictive accuracy for survival in newly diagnosed DLBCL patients. We included 5126 DLBCL patients treated with immunochemotherapy wit
Jack Cavanaugh, Michael Whittaker, Derk Joester · 2019 · Chemical Science
In situ observation of amorphous calcium carbonate (ACC) confined in ∼500 pL emulsion droplets allows determination of the timing of individual crystal nucleation events. Statistical analysis of events in hundreds of droplets establishes…
Jacob Schewe, Anders Levermann · 2012 · Environmental Research Letters
Abstract Indian monsoon rainfall is vital for a large share of the world’s population. Both reliably projecting India’s future precipitation and unraveling abrupt cessations of monsoon rainfall found in paleorecords require improved…
Zhen Wang, Shuangshan Wang, Qingmin Wu · 2014 · FEMS Microbiology Letters
Brucella melitensis is a facultative intracellular pathogen that mainly resides within macrophages. The mechanisms employed by Brucella to adapt to harsh intracellular environments and survive within host macrophages are not clearly…
Martin Urner, Peter Jüni, L. Paloma Rojas-Saunero et al. · 2023 · Critical Care Medicine
OBJECTIVES: Previous studies reported an association between higher driving pressure (∆P) and increased mortality for different groups of mechanically ventilated patients. However, it remained unclear if sustained intervention on ∆P, in…
M.B. Ogunniyi, Christiana Ogonna Igberi · 2014 · VNU Journal of Science: Natural Sciences and Technology (Vietnam National University)
Many developing countries are competing to attract foreign direct investment with a belief that it can be a tool for poverty reduction because it serves as supplements to domestic savings and it is often accompanied with technology and…
Tomáš Erban, Karel Harant, Martin Hubálek et al. · 2015 · Scientific Reports
We investigated pathogens in the parasitic honeybee mite Varroa destructor using nanoLC-MS/MS (TripleTOF) and 2D-E-MS/MS proteomics approaches supplemented with affinity-chromatography to concentrate trace target proteins. Peptides were detected from the currently uncharacterized Varroa destructor Macula-like virus (VdMLV), the deformed wing virus (DWV)-complex and the acute bee paralysis virus (ABPV). Peptide alignments revealed detection of complete structural DWV-complex block VP2-VP1-VP3, VDV-1 helicase and single-amino-acid substitution A/K/Q in VP1, the ABPV structural block VP1-VP4-VP2-
Ben Yelverton, Grant M. Kennedy, K. Y. L. Su et al. · 2019 · Monthly Notices of the Royal Astronomical Society
Abstract We compile a sample of 341 binary and multiple star systems with the aim of searching for and characterizing Kuiper belt-like debris discs. The sample is assembled by combining several smaller samples studied in previously…
Madeleine Selvander, Peter Åsman · 2012 · Acta Ophthalmologica
Abstract. Purpose: To investigate construct validity for modules hydromaneuvers and phaco on the Eyesi surgical simulator. Methods: Seven cataract surgeons and 17 medical students performed capsulorhexis, hydromaneuvers, phaco, navigation,…
Haiyang Yang, Amitava Chattopadhyay, Kuangjie Zhang et al. · 2012 · Journal of Consumer Psychology
Abstract Recent research suggests that unconscious thought is superior to conscious thought in many cognitive domains. In this article, we show that the duration of unconscious thought has an inverted‐U shaped relationship with creativity…
Masaaki Sadakiyo, Teppei Yamada, Kenichi Kato et al. · 2016 · Chemical Science
We conducted a systematic study of the control of selective adsorption behaviour through the type of central metals in a series of analogous MOFs that show closed-open structural transformations.
Akiyoshi Hagiwara, Noriko Tanaka, Tatsuki Uemura et al. · 2016 · BMJ Open
OBJECTIVE: To determine whether treatment with recombinant human thrombomodulin (rhTM) increases survival among patients with severe septic-induced disseminated intravascular coagulation (DIC). DESIGN: Single-centre, open-label, randomised…
Marie Fallon, Maciej Sopata, Erika Dragon et al. · 2023 · The Oncologist
BACKGROUND: This phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid…