A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21681 results · page 72 of 723
Toru Ishikawa · 2012 · The Professional Geographer
Abstract This study examined the relationships between geospatial thinking and spatial ability, focusing on knowledge and reasoning about fundamental concepts in geospatial science. Scores on a geospatial thinking test had low correlations…
Britta Jänicke, Fred Meier, Daniel Fenner et al. · 2016 · International Journal of Climatology
ABSTRACT Model‐based studies on urban heat islands can be seriously affected by errors in near‐surface air temperature ( T 2), especially if errors differ between cities and their rural surroundings. Furthermore, errors in T 2 strongly…
Chun‐Yen Tsai · 2014 · International Journal of Science Education
The scientific competencies advocated by the Programme for International Student Assessment (PISA) focus on the abilities needed in students' adult lives. This study investigated how such scientific competencies could be improved by using…
Yinxue Liu, Paul Bates, Jeffrey Neal et al. · 2021 · Water Resources Research
Abstract Accurate terrain representation is critical to estimating flood risk in urban areas. However, all current global elevation data sets can be regarded as digital surface models in urban areas as they contain building artifacts that…
Simone Baldi, Marta Menicatti, Giulia Nannini et al. · 2021 · Nutrients
Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs), medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with metabolic, gastrointestinal, and malignant diseases. Hence, we compared the serum FFA profile of patients with celiac disease (CD), adenomatous polyposis (AP), and colorectal cancer (CRC) to healthy controls (HC). We enrolled 44 patients (19 CRC, 9 AP, 16 CD) and 16 HC. We performed a quantitative FFA evaluation with the gas chromatography-mass spectrometry method (GC-MS), and we performed Dirichlet-multinomial
Yong‐Hao Pua, Hakmook Kang, Julian Thumboo et al. · 2019 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Machine-learning methods are flexible prediction algorithms with potential advantages over conventional regression. This study aimed to use machine learning methods to predict post-total knee arthroplasty (TKA) walking limitation,…
Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
Hassan Mohammadi, Yuting Tan · 2015 · Econometrics
Examinations of the dynamics of daily returns and volatility in stock markets of the U.S., Hong Kong and mainland China (Shanghai and Shenzhen) over 2 January 2001 to 8 February 2013 suggest: (1) evidence of unidirectional return spillovers from the U.S. to the other three markets; but no spillover between Hong Kong and either of the two mainland China markets; (2) evidence of unidirectional ARCH and GARCH effects from the U.S. to the other three markets; (3) correlations of returns vary across markets, with the highest correlation of 93.5% between the two Chinese markets, medium correlation o
Konrad Neumann, Ulrike Grittner, Sophie K. Piper et al. · 2017 · PLoS Biology
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials. Using simulation of data, we demonstrate that group sequential designs have t
Tom Koeman, Pauline Slottje, Leo J. Schouten et al. · 2017 · Occupational and Environmental Medicine
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69…
I. A. G. Snellen, L. Guzman-Ramirez, M. R. Hogerheijde et al. · 2020 · Astronomy & Astrophysics
Context. ALMA observations of Venus at 267 GHz that show the apparent presence of phosphine (PH 3 ) in its atmosphere have been presented in the literature. Phosphine currently has no evident production routes on the planet’s surface or in…
Patrick Kline, Christopher Walters · 2021 · Econometrica
This paper develops methods for detecting discrimination by individual employers using correspondence experiments that send fictitious resumes to real job openings. We establish identification of higher moments of the distribution of…
Susan C. Kleiman, Emily Bulik-Sullivan, Elaine M. Glenny et al. · 2017 · PLoS ONE
OBJECTIVE: This study examined associations between the composition and diversity of the intestinal microbiota and measures of depression, anxiety, eating disorder psychopathology, stress, and personality in a group of healthy adult females. METHODS: Female participants (n = 91) ages 19-50 years with BMI 18.5-25 kg/m2 were recruited from central North Carolina between July 2014 and March 2015. Participants provided a single fecal sample and completed an online psychiatric questionnaire that included five measures: (i) Beck Anxiety Inventory; (ii) Beck Depression Inventory-II; (iii) Eating Diso
Sae‐Won Han, Hyun‐Jung Lee, Jeong Mo Bae et al. · 2012 · International Journal of Cancer
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We…
Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
Shigeyuki Tamura, Atsushi Takeno, Hirofumi Miki · 2011 · International Journal of Surgical Oncology
Gastric cancer is one of the most common causes of cancer-related death worldwide. Surgical resection with lymph node dissection is the only potentially curative therapy for gastric cancer. However, the appropriate extent of lymph node dissection accompanied by gastrectomy for cancer remains controversial. In East Asian countries, especially in Japan and Korea, D2 lymph node dissection has been regularly performed as a standard procedure. In Western countries, surgeons perform gastrectomy with D1 dissection only because D2 is associated with high mortality and morbidity compared to those assoc
Ton Wang, Brooke C. Bredbeck, Brandy Sinco et al. · 2021 · JAMA Surgery
Importance: Through the Choosing Wisely campaign, surgical specialties identified 4 low-value breast cancer operations. Preliminary data suggest varying rates of deimplementation and have identified patient-level and clinician-level…
Hyehyun Jeong, Kyu‐pyo Kim, Jae Ho Jeong et al. · 2023 · Hepatology
BACKGROUND AND AIMS: The effectiveness of gemcitabine-based adjuvant chemotherapy is unclear in cholangiocarcinoma. We investigated the role of adjuvant gemcitabine plus cisplatin (GemCis) in a homogeneous group of high-risk patients with…
Heidi Lynch, Matthew P. Buman, Jared M. Dickinson et al. · 2020 · International Journal of Environmental Research and Public Health
There are conflicting reports regarding the efficacy of plant versus animal-derived protein to support muscle and strength development with resistance training. The purpose of this study was to determine whether soy and whey protein supplements matched for leucine would comparably support strength increases and muscle growth following 12 weeks of resistance training. Sixty-one untrained young men (n = 19) and women (n = 42) (18–35 year) enrolled in this study, and 48 completed the trial (17 men, 31 women). All participants engaged in supervised resistance training 3×/week and consumed 19 grams
Joseph F. Sobanko, Julia Dai, Joel M. Gelfand et al. · 2018 · Dermatologic Surgery
BACKGROUND: Minimally invasive cosmetic injectable procedures are increasingly common. However, a few studies have investigated changes in psychosocial functioning following these treatments. OBJECTIVE: To assess changes in body image,…
Kevin J. McHale, Joshua C. Rozell, Andrew H. Milby et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: Tarsometatarsal (Lisfranc) joint injuries commonly occur in National Football League (NFL) competition; however, the career effect of these injuries is unknown. PURPOSE: To define the time to return to competition for NFL…
Ann M. Farese, Cassandra R. Brown, Cassandra P. Smith et al. · 2013 · Health Physics
The identification of the optimal administration schedule for an effective medical countermeasure is critical for the effective treatment of individuals exposed to potentially lethal doses of radiation. The efficacy of filgrastim…
Richard Stansfield, Thomas J. Mowen, Thomas P. O’Connor et al. · 2016 · Journal of Research in Crime and Delinquency
Objective: Research on the relationship between religion and criminal recidivism has produced encouraging but ultimately inconclusive findings. This study offers a new direction for studying the role of religious support in reentry,…
Patrick G M Bolton, Marcin T. Kacperczyk · 2026 · European Accounting Review
We link voluntary and mandatory disclosure of carbon emissions with stock returns and volatility in a global cross-section of publicly listed firms. We find that voluntary disclosure of scope 1 emissions predicts lower stock returns…
David J. Cohen, Tara A. Lavelle, Ben van Hout et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To evaluate the cost-effectiveness of alternative approaches to revascularization for patients with three-vessel or left main coronary artery disease (CAD). BACKGROUND: Previous studies have demonstrated that, despite higher…
Małgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses et al. · 2017 · BMC Cancer
BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases)
Kristi McIntyre, Joyce O’Shaughnessy, Lee S. Schwartzberg et al. · 2014 · Breast Cancer Research and Treatment
Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have…
Juliana C.N. Chan, Béatrice Sauvé, Sonya Tokmakejian et al. · 2014 · Experimental and Clinical Endocrinology & Diabetes
OBJECTIVE: Hair analysis has been demonstrated to accurately reflect exposure to drug abuse, environmental toxins and exogenous hormones. We tested the feasibility of measuring cortisol and testosterone in hair of healthy and obese…
Abhishek Mathur, Sharona Ross, Kenneth Luberice et al. · 2014 · The American Surgeon
Negative margins are the goal with pancreaticoduodenectomy for pancreatic adenocarcinoma. Thereby, margins are assessed intraoperatively with frozen section analysis and negative margins are pursued. This study was undertaken to determine…
Haijie Liu, Yang Hu, Yan Zhang et al. · 2022 · Alzheimer s Research & Therapy
BACKGROUND: Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it currently remains unclear about the consistency of MR estimates across these GWAS, GWAX, and GWAS+GWAX datasets. METHODS: Here, we first selected 162 independent educational attainment genetic variants as the potential instrumental variables (N = 405,072). We then selected one AD GWAS dataset (N = 63