A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 71 of 660
Matias Lindgren · 2020 · Aaltodoc (Aalto University)
This thesis applies deep learning based classification techniques to identify natural languages from speech. The primary motivation behind this thesis is to implement accurate techniques for segmenting multimedia materials by the languages…
M.P.L. Calus, Michael E. Goddard, Yvonne C. J. Wientjes et al. · 2018 · Journal of Dairy Science
Genomic prediction is applicable to individuals of different breeds. Empirical results to date, however, show limited benefits in using information on multiple breeds in the context of genomic prediction. We investigated a multitask…
Daniel Skupski, John Owen, Sungduk Kim et al. · 2017 · Obstetrics and Gynecology
OBJECTIVE: To compare the accuracy of a new formula with one developed in 1984 (and still in common use) and to develop and compare racial and ethnic-specific and racial and ethnic-neutral formulas. METHODS: The Eunice Kennedy Shriver…
Andrew Orton, Jonathan Frandsen, Randy L. Jensen et al. · 2017 · Journal of neurosurgery
OBJECTIVE Anaplastic meningiomas represent 1%-2% of meningioma diagnoses and portend a poor prognosis. Limited information is available on practice patterns and optimal management. The purpose of this study was to define treatment patterns…
Changhee Park, Tae Min Kim, Jeong Mo Bae et al. · 2020 · Cancer Research and Treatment
PURPOSE: The treatment outcomes and genomic profiles of diffuse midline glioma (DMG) in adult patients are rarely characterized. We performed a retrospective study to evaluate the clinicogenomic profiles of adult patients with brain DMG.…
Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luíz Felipe Pinho Moreira et al. · 2018 · Scientific Reports
Transforming growth factor-β1 (TGF-β1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling. Fibroblast growth factor-2 (FGF-2) is a growth factor secreted by adipose tissue-derived stromal cells (ASC) which can antagonize TGF-β1 signaling. We hypothesized that TGF-β1-induced cardiac fibroblast to myofibroblast differentiation is abrogated by FGF-2 and ASC conditioned medium (ASC-CMed). Our experiments demonstrated that TGF-β1 treatment-induced cardiac fibroblast differentiation into myofibroblasts, as
Loes F.M. van der Zanden, Iris A.L.M. van Rooij, Wout Feitz et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in…
Valentina Lanteri, Gianguido Cossellu, Marco Farronato et al. · 2020 · Scientific Reports
The Palatal Rugae are considered a useful human identification marker for both orthodontists and forensic personnel. The principal aim of the present study was to evaluate the stability of palatal rugae with a 3D-3D superimposition procedure following Slow Maxillary Expansion (SME), in order to assess whether they kept their uniqueness and validity for human identification, even after a specific dental treatment. For this purpose, a sample of 27 digital dental models - belonging to growing patients (13 males and 14 females), aged between 8.5 and 15 years, who underwent SME therapy - was retros
Troy MacAvelia, Meisam Salahi, Michael Olsen et al. · 2012 · Journal of Biomechanical Engineering
Few experimental studies have examined surgical drilling in human bone, and no studies have inquired into this aspect for a popular commercially-available artificial bone used in biomechanical studies. Sixteen fresh-frozen human femurs and…
Samuel Murray, Nathan Liang, Nicholaus P. Brosowsky et al. · 2021 · Psychology of Aesthetics Creativity and the Arts
A primary aim of mind-wandering research has been to understand its influence on task performance. While this research has typically highlighted the costs of mind wandering, a handful of studies have suggested that mind wandering may be…
Kristin M. Burkart, Tamar Sofer, Stephanie J. London et al. · 2018 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. Objectives Perform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. Methods GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. Measurements and Main Results Among 11,
Dajana Radujković, Erik Verbruggen, Bjarni D. Sigurðsson et al. · 2017 · FEMS Microbiology Ecology
Global change is expected to affect soil microbial communities through their responsiveness to temperature. It has been proposed that prolonged exposure to elevated temperatures may lead to progressively larger effects on soil microbial…
Bahaaldin Alsoufi, Cedric Manlhiot, Bahaa M. Fadel et al. · 2010 · European Journal of Cardio-Thoracic Surgery
OBJECTIVES: The Ross procedure is the aortic valve-replacement procedure of choice in children. Nonetheless, late autograft re-operation for dilatation and/or valve regurgitation is of concern. We examined whether preoperative haemodynamic…
Josh Kinsler · 2012 · Quantitative Economics
Value-added models of teacher effectiveness yield consistent estimates of teacher quality under the assumption that students are randomly assigned to classrooms conditional on ability. Rothstein (2010) tested and rejected this underlying…
Nolwazi Z. Khumalo, Melusi Sibanda · 2019 · Sustainability
Regardless of the steady increase in the economic growth of South Africa, poverty levels and food insecurity have not declined as one would have anticipated. Urban and peri-urban agriculture (UPA) presents an opportunity as a livelihood strategy to alleviate poverty and ensure household food security within the urban and peri-urban spheres. However, less research has been done in this area to discover the contribution of UPA on households’ food security. This paper assesses the food security status of households that practised any form of UPA activities (later on referred to the rest of this p
Mieke Metzemaekers, Seppe Cambier, Marfa Blanter et al. · 2021 · Clinical & Translational Immunology
OBJECTIVES: Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID-19). We isolated neutrophils from the blood of COVID-19 patients receiving…
Brittany I Davidson, Heather Shaw, David A. Ellis · 2022 · Computers in Human Behavior
The mass adoption of digital technologies raises questions about how they impact people and society. Associations between technology use and negative correlates (e.g., depression and anxiety) remain common. However, pre-registered studies have failed to replicate these findings. Regardless of direction, many designs rely on psychometric scales that claim to define and quantify a construct associated with technology engagement. These often suggest clinical manifestations present as disorders or addictions. Given their importance for research integrity, we consider what these scales might be mea
Seo‐Young Park, Jong‐Mu Sun, Yoon‐La Choi et al. · 2022 · ESMO Open
•The adjuvant durvalumab therapy failed to demonstrate the survival benefit in ESCC who underwent neoadjuvant CCRT.•This is the first report on the role of adjuvant immunotherapy in both pathologic complete response (ypCR) and…
Alexander Mihaescu, Mikaeel Valli, Carme Uribe et al. · 2022 · Molecular Brain
Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms. Some studies have found increased beta amyloid burden is associated with worsening cognitive impairment in Parkinson’s disease, especially in cases where dementia occurs, while other studies failed to replicate this finding. To better understand this relationship, we examined a cohort of 25 idiopathic Parkinson’s disease patients and 30 healthy controls f
Anders Alm, AM. Hornmark, Per-Arne Fall et al. · 2026 · Acta Dermato Venereologica
An occlusive hydrocolloid dressing (Comfeel Ulcus) was compared with a conventional wet saline gauze dressing regarding the effect on ulcer cleansing and healing processes, experience of pain and the consumption of nursing time, in a…
Michael W. Topping, Dan Stark, Peter Senchyna et al. · 2025 · The Astrophysical Journal
Abstract JWST has recently discovered a subset of reionization era galaxies with ionized gas that is metal-poor in oxygen and carbon but heavily enriched in nitrogen. This abundance pattern is almost never seen in lower-redshift galaxies but is commonly observed in globular cluster stars. We have recently demonstrated that this peculiar abundance pattern appears in a compact (≃20 pc) metal-poor galaxy undergoing a strong burst of star formation. This galaxy was originally selected based on strong C iv emission, indicating a hard radiation field rarely seen locally. In this paper, we present JW
Zhen Wang, Shuangshan Wang, Qingmin Wu · 2014 · FEMS Microbiology Letters
Brucella melitensis is a facultative intracellular pathogen that mainly resides within macrophages. The mechanisms employed by Brucella to adapt to harsh intracellular environments and survive within host macrophages are not clearly…
Jacob Schewe, Anders Levermann · 2012 · Environmental Research Letters
Abstract Indian monsoon rainfall is vital for a large share of the world’s population. Both reliably projecting India’s future precipitation and unraveling abrupt cessations of monsoon rainfall found in paleorecords require improved…
Ben Yelverton, Grant M. Kennedy, K. Y. L. Su et al. · 2019 · Monthly Notices of the Royal Astronomical Society
Abstract We compile a sample of 341 binary and multiple star systems with the aim of searching for and characterizing Kuiper belt-like debris discs. The sample is assembled by combining several smaller samples studied in previously…
Tomáš Erban, Karel Harant, Martin Hubálek et al. · 2015 · Scientific Reports
We investigated pathogens in the parasitic honeybee mite Varroa destructor using nanoLC-MS/MS (TripleTOF) and 2D-E-MS/MS proteomics approaches supplemented with affinity-chromatography to concentrate trace target proteins. Peptides were detected from the currently uncharacterized Varroa destructor Macula-like virus (VdMLV), the deformed wing virus (DWV)-complex and the acute bee paralysis virus (ABPV). Peptide alignments revealed detection of complete structural DWV-complex block VP2-VP1-VP3, VDV-1 helicase and single-amino-acid substitution A/K/Q in VP1, the ABPV structural block VP1-VP4-VP2-
M.B. Ogunniyi, Christiana Ogonna Igberi · 2014 · VNU Journal of Science: Natural Sciences and Technology (Vietnam National University)
Many developing countries are competing to attract foreign direct investment with a belief that it can be a tool for poverty reduction because it serves as supplements to domestic savings and it is often accompanied with technology and…
Jack Cavanaugh, Michael Whittaker, Derk Joester · 2019 · Chemical Science
In situ observation of amorphous calcium carbonate (ACC) confined in ∼500 pL emulsion droplets allows determination of the timing of individual crystal nucleation events. Statistical analysis of events in hundreds of droplets establishes…
Martin Urner, Peter Jüni, L. Paloma Rojas-Saunero et al. · 2023 · Critical Care Medicine
OBJECTIVES: Previous studies reported an association between higher driving pressure (∆P) and increased mortality for different groups of mechanically ventilated patients. However, it remained unclear if sustained intervention on ∆P, in…
Brian Martin, Beth A. Gabris-Weber, Rajiv P. Reddy et al. · 2018 · PLoS ONE
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive
J Prazák, Luca G. Valente, Manuela Iten et al. · 2021 · The Journal of Infectious Diseases
BACKGROUND: The optimal method for delivering phages in the context of ventilator-associated pneumonia (VAP) is unknown. In the current study, we assessed the utility of aerosolized phages (aerophages) for experimental…