Development to Term of Cloned Cattle Derived from Donor Cells Treated with Valproic Acid
Juliano Rodrigues Sangalli; Marcos Roberto Chiaratti; Tiago Henrique Camara De; R.R. Araújo; Fabiana Fernandes Bressan; Rafael Vilar Sampaio; Felipe Perecin; Lawrence C. Smith · 2014 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. In this regard, most factors that promote chromatin decondensation, including histone deacetylase inhibitors (HDACis), have been found to increase nuclear reprogramming efficiency, making their use common to improve SCNT rates. Herein we used valproic acid (VPA) in SCNT to test whether the treatment
Abstract by Juliano Rodrigues Sangalli; Marcos Roberto Chiaratti; Tiago Henrique Camara De; R.R. Araújo; Fabiana Fernandes Bressan; Rafael Vilar Sampaio; Felipe Perecin; Lawrence C. Smith, PLoS ONE (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0101022