Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1
Andrea Botticelli; Silvia Mezi; Giulia Pomati; Bruna Cerbelli; Edoardo Cerbelli; Michela Roberto; Raffaele Giusti; Alessio Cortellini · 2020 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Backgrounds. Clinical trials showed that only a subset of patients benefits from immunotherapy suggesting the need to identify new predictive biomarker of resistance.. Indolamine 2,3-dioxygenase (IDO) has been proposed as a mechanism of resistance to anti-PD1 treatment and serum kyn/trp ratio represent a possible marker of IDO activity. Methods. Metastatic NSCLC, RCC and HNSCC treated in second line with nivolumab were included in this prospective study. Baseline serum kynurenine and tryptophan levels were measured by high-performance liquid chromatography to define the kyn/trp ratio. The 2–t
Abstract by Andrea Botticelli; Silvia Mezi; Giulia Pomati; Bruna Cerbelli; Edoardo Cerbelli; Michela Roberto; Raffaele Giusti; Alessio Cortellini, Frontiers in Immunology (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2020.01243