Negative / Null Result ReportOpen accessMedicine· cited by 50

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study

Brian J. Anderson; Carolyn S. Calfee; Kathleen D. Liu; John P. Reilly; Kirsten N. Kangelaris; M.G.S. Shashaty; Aili L. Lazaar; Andrew I. Bayliffe · 2019 · Critical Care

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors. METHODS: In a multicenter prospective cohort study of 400 critically ill septic patients, we derived and validated thresholds for each marker and expressed prognostic enrichment using risk differences (RD) of 30-day mortal

Abstract by Brian J. Anderson; Carolyn S. Calfee; Kathleen D. Liu; John P. Reilly; Kirsten N. Kangelaris; M.G.S. Shashaty; Aili L. Lazaar; Andrew I. Bayliffe, Critical Care (2019) — licensed CC BY 4.0.

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