Failed Experiment ReportOpen accessMedicine
Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…
View details →DOI: 10.1073/pnas.2601563123 Negative / Null Result ReportMedicine
Lee HL, Choi SM, Cho SH et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Head trauma (HT) has been suggested as a risk factor for Parkinson's disease (PD), but its impact on the motor and non-motor manifestations remains unclear. We investigated whether patients with early PD and a…
View details →DOI: 10.3390/medicina62061058 Negative / Null Result Report
Tripathy S, Crilley N, Morgan TK et al. · 2026 · Preprint
ABSTRACT Preterm birth before 28 weeks remains a leading cause of neonatal mortality and long-term morbidity. Intrauterine infection-driven chorioamnionitis is strongly associated with preterm labor, fetal inflammatory response syndrome,…
View details →DOI: 10.64898/2026.06.06.730594 Failed Experiment ReportMedicine
Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications
This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…
View details →DOI: 10.1016/j.bbrc.2026.154130 Negative / Null Result ReportMedicine
Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation
Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…
View details →DOI: 10.1186/s13102-026-01818-2 Negative / Null Result ReportOpen accessMedicine
Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports
Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…
View details →DOI: 10.1038/s41598-026-56181-6 Negative / Null Result Report
Khwanbua E, Lappe RR, Bierl AA et al. · 2026 · Preprint
Plant virus-based gRNA delivery systems offer a rapid alternative to stable transformation for CRISPR-mediated genome editing, but potyvirus-based platforms in Cas9-expressing plants are still underexplored. Here, we developed a turnip…
View details →DOI: 10.64898/2026.04.22.720221 Failed Experiment ReportMedicine
Wang Y, Chen Y, Wang K et al. · 2026 · Vaccines
Background/Objectives: Canine papillomavirus (CPV) is an important viral pathogen associated with papillomatosis in dogs, with canine papillomavirus type 1 (CPV1) and type 2 (CPV2) among the most prevalent and clinically relevant…
View details →DOI: 10.3390/vaccines14060512 Negative / Null Result ReportOpen accessMedicine
Oliveira YIL, Couto A, Sá PG et al. · 2025 · JBRA assisted reproduction
Objective To evaluate the association between antithyroid antibodies detectability and positivity and ovarian reserve. Additionally, we aimed to evaluate the correlation between TSH levels and parameters of ovarian reserve [anti-Mullerian…
View details →DOI: 10.5935/1518-0557.20250032 Negative / Null Result Report
Nagahori H, Liang JN, Keefer I et al. · 2026 · Preprint
Abstract This study conducted a secondary analysis of a previous study to evaluate the test-retest reliability, standard error of measurement (SEM), and minimal detectable change (MDC) of frontal plane projection angles across five…
View details →DOI: 10.21203/rs.3.rs-8183647/v1 Methods Dead-EndMedicine
Yamasaki R, Inoue Y · 2026 · Archives of physical medicine and rehabilitation
Objective To determine the minimal detectable change (MDC) of the 10-meter walk test (10MWT) and Timed Up and Go test (TUG) across different stages of Parkinson's disease (PD) severity as classified by the Hoehn & Yahr scale (H&Y). Design…
View details →DOI: 10.1016/j.apmr.2026.01.010 Negative / Null Result ReportMedicine
Requena-Tutusaus L, Anselmo I, Coll S et al. · 2026 · Journal of pharmacological and toxicological methods
Objectives Dried blood spot (DBS) micro-sampling is gaining prominence in anti-doping testing, particularly for the detection of erythropoietin-receptor agonists (ERAs) such as recombinant erythropoietin (rEPO). However, detecting…
View details →DOI: 10.1016/j.vascn.2026.108423 Negative / Null Result ReportOpen accessMedicine
Yamagata F, Yoshihara K, Nannya Y et al. · 2026 · EJHaem
TP53 -altered myeloid neoplasms are associated with an extremely high risk of relapse even after allogeneic hematopoietic cell transplantation (allo-HCT), and the optimal pretransplant and posttransplant strategies remain undefined. We…
View details →DOI: 10.1002/jha2.70315 Negative / Null Result ReportOpen accessMedicine
Bienvenue I, Roux O, Coilly A et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background & aims Liver transplantation (LT) is indicated for liver complications related to hepatitis B virus (HBV) infection: acute liver failure (ALF), decompensated cirrhosis or hepatocellular carcinoma (HCC). The present study aimed…
View details →DOI: 10.1111/liv.70737 Negative / Null Result ReportMedicine
Oliveira FADS, Santos LRH, Silva HAD et al. · 2026 · Journal of sport rehabilitation
Context Scapular dyskinesis is frequently associated with subacromial pain syndrome (SAPS), and clinicians increasingly use inertial sensors as a portable, low-cost option to assess scapular kinematics. However, the reliability of these…
View details →DOI: 10.1123/jsr.2026-0055 Negative / Null Result Report
Zeloni R, Amaolo A, Morez Jacobs A et al. · 2026 · Preprint
Neanderthal introgression contributed a small fraction of genetic variants to present-day non-African genomes. While differences in cranial globularity between Neanderthal and modern humans are well documented from endocasts, the…
View details →DOI: 10.64898/2026.04.14.718380 Negative / Null Result ReportOpen accessMedicine
Kim D, Yang H, An J · 2026 · Cureus
Background Surgical stress alters cytokine concentrations, triggering systemic inflammatory responses and immune defense mechanisms. Interleukin-6 (IL-6) and interleukin-10 (IL-10) play important roles in perioperative inflammatory…
View details →DOI: 10.7759/cureus.109249 Negative / Null Result ReportOpen accessMedicine
Vlachou M, Solomakos N, Govaris A et al. · 2026 · Toxins
This study aimed to assess the occurrence and contamination levels of OTA in edible tissues of slaughtered pigs in Greece using high-performance liquid chromatography with fluorescence detection (HPLC-FD). Kidney, liver, muscle, and fat…
View details →DOI: 10.3390/toxins18040181 Negative / Null Result ReportOpen accessMedicine
Iannuzzi S, Müller M, Yu Y et al. · 2026 · Nature communications
The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited settings threaten treatment access. Cost-effective and widely…
View details →DOI: 10.1038/s41467-026-72907-6 Negative / Null Result ReportMedicine
Ho LYW, Lai CKY, Ng SSM · 2026 · Topics in stroke rehabilitation
Background The performance fatigue index provides objective measures for assessing the impact of fatigue on performance and it may be utilized for monitoring functional outcomes in individuals with stroke; however, its psychometric…
View details →DOI: 10.1080/10749357.2026.2648213 Negative / Null Result ReportMedicine
Templado S, Almela-Rojo M, Barceló MD et al. · 2026 · Hearing research
Background Pigs are increasingly used as translational models for auditory research due to anatomical and physiological similarities with humans. However, normative auditory brainstem response (ABR) parameters in commercial pig breeds…
View details →DOI: 10.1016/j.heares.2026.109655 Negative / Null Result ReportOpen accessMedicine
Kavanagh EW, Joynt AT, Pion AR et al. · 2026 · JCI insight
Cystic fibrosis (CF) is a life-limiting genetic disorder caused by deleterious variants in the CFTR gene that results in altered mucus impairing the airway epithelia. Durable correction of these variants in airway cells remains a…
View details →DOI: 10.1172/jci.insight.198563 Negative / Null Result ReportMedicine
Yin LX, Hidalgo CM, Bogan AW et al. · 2025 · JAMA otolaryngology-- head & neck surgery
Importance Circulating tumor human papillomavirus DNA (ctHPVDNA) is an important biomarker for the presence of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but little is known about early postoperative kinetics of ctHPVDNA…
View details →DOI: 10.1001/jamaoto.2025.1606 Negative / Null Result ReportOpen accessMedicine
Chawana-Mutingwende TD, Ngara B, Mudadi LS et al. · 2026 · Journal of the International AIDS Society
Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir-based regimens and psychosocial peer motivation may improve viral…
View details →DOI: 10.1002/jia2.70117 Negative / Null Result ReportMedicine
Giampaolo T, Liotard MG, Cadoré JL et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Diagnosis of canine bacterial bronchopneumonia (bBP) is challenging and mostly based on bronchoalveolar lavage fluid (BALF) cytology and bacterial culture (BC) results. However, bacterial contamination of BALF is frequent, intracellular…
View details →DOI: 10.1177/10406387261432645 Negative / Null Result ReportOpen accessMedicine
Gleichenhagen J, Kaiser N, Brüning T et al. · 2026 · Journal of clinical laboratory analysis
Background Microsampling using filter cards for dried blood spots (DBS) and dried plasma spots (DPS) is a well-established technique offering practical advantages for blood collection and subsequent processing. For DBS/DPS, only a small…
View details →DOI: 10.1002/jcla.70271 Negative / Null Result ReportOpen accessMedicine
Kashiv P, Balwani M, Pasari AS et al. · 2026 · Cureus
Antibody-mediated rejection (ABMR) is conventionally defined by the presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA), characteristic microvascular injury on allograft biopsy, and evidence of complement…
View details →DOI: 10.7759/cureus.104798 Negative / Null Result ReportOpen accessMedicine
Ifeh C, Allan E, Ndiaye A et al. · 2026 · Journal of food science
This study utilized collaborations with Senegalese women farmers to investigate the impact of lactic acid bacteria (LAB) fermentation of sorghum, baobab, and milk on nutritional and sensory qualities for plant-enriched yogurt. Using a…
View details →DOI: 10.1111/1750-3841.70978 Methods Dead-EndOpen accessMedicine
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
View details →DOI: 10.3390/foods15071130 Methods Dead-End
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
View details →DOI: 10.64898/2026.02.16.706088 