Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Matthias M. Engelen, Quentin Van Thillo, Albrecht Betrains et al. · 2022 · Research and Practice in Thrombosis and Haemostasis
Abstract Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein pathway activates both inflammatory pathways and contact‐mediated coagulation. We investigated if modulation of the thromboinflammatory response improves outcomes in hospitalized COVID‐19 patients. Methods In this multicenter open‐label randomized clinical trial (EudraCT 2020‐001739‐28), patients hospitalized with COVID‐19 were 1:2 randomized to receive standard of care (SOC) or SOC plus study intervention. The intervention consisted of aprotinin (2,000,000 IE IV four times daily) combined with low
View details →DOI: 10.1002/rth2.12826 Replication FailureOpen accessPsychology
Alba Massolo, Mariel Traversi, Matías Alfonso · 2024 · Europe's Journal of Psychology
In this paper, we investigate whether collaborative group performance is better than individual performance in solving a syllogism evaluation task. We hypothesise that collaborative group settings will outperform individual settings and that the belief bias effect will be mitigated in a group setting. Two empirical studies were conducted with Argentinian undergraduate students. Study 1 (N = 239) used a between-subjects design with two conditions: individual resolution and interactive group resolution. Overall, the group condition performed better than the individual condition, but there were n
View details →DOI: 10.5964/ejop.12041 Replication FailureOpen accessMedicine
Karina da Silva, Cristino Carneiro Oliveira, Leandro Ferracini Cabral et al. · 2023 · PLoS ONE
Pulmonary expansion manoeuvres are therapeutic techniques used to prevent and reverse atelectasis; however, no randomized controlled trials have provided evidence supporting the use of this intervention among individuals on mechanical ventilation. Objective To evaluate the effects of chest compression-decompression and chest block manoeuvres compared to usual care among patients on mechanical ventilation. Methods The current study was a randomized clinical trial of adult subjects on mechanical ventilation for 12 to 48 hours. The control group received usual care (passive or active mobilization
View details →DOI: 10.1371/journal.pone.0295775 Negative / Null Result ReportOpen accessPediatrics
Davene R. Wright, Karen Glanz, Trina Colburn et al. · 2018 · BMC Pediatrics
Abstract Background Previous studies have examined correlations between BMI calculated using parent-reported and directly-measured child height and weight. The objective of this study was to validate correction factors for parent-reported child measurements. Methods Concordance between parent-reported and investigator measured child height, weight, and BMI (kg/m2) among participants in the Neighborhood Impact on Kids Study (n = 616) was examined using the Lin coefficient, where a value of ±1.0 indicates perfect concordance and a value of zero denotes non-concordance. A correction model for par
View details →DOI: 10.1186/s12887-018-1042-x Negative / Null Result ReportMedicine
Chen, Si, Chen et al. · 2026 · Frontiers in medicine
This study aimed to evaluate the long-term effects of an automated eye position fixation training device (AEPFTD) on intraoperative cooperation, surgical efficiency, complications, and recurrence rates in patients undergoing pterygium…
View details →DOI: 10.3389/fmed.2026.1764636 Negative / Null Result ReportOpen accessPlant culture
David Matthew Deery, Greg J Rebetzke, Jose Antonio Jimenez-Berni et al. · 2016 · Frontiers in Plant Science
Lower canopy temperature (CT), resulting from increased stomatal conductance, has been associated with increased yield in wheat. Historically, CT has been measured with hand-held infrared thermometers. Using the hand-held CT method on large field trials is problematic, mostly because measurements are confounded by temporal weather changes during the time requiredto measure all plots. The hand-held CT method is laborious and yet the resulting heritability low, thereby reducing confidence in selection in large scale breeding endeavours.We have developed a reliable and scalable crop phenotyping m
View details →DOI: 10.3389/fpls.2016.01808 Negative / Null Result ReportOpen accessMedical technology
Mike J Crawford, Christian Gold, Helen Odell-Miller et al. · 2017 · Health Technology Assessment
Background: Preliminary studies have indicated that music therapy may benefit children with autism spectrum disorders (ASD). Objectives: To examine the effects of improvisational music therapy (IMT) on social affect and responsiveness of children with ASD. Design: International, multicentre, three-arm, single-masked randomised controlled trial, including a National Institute for Health Research (NIHR)-funded centre that recruited in London and the east of England. Randomisation was via a remote service using permuted blocks, stratified by study site. Setting: Schools and private, voluntary and
View details →DOI: 10.3310/hta21590 Negative / Null Result ReportOpen accessPediatrics
Jin Wha Choi, Jisook Kim, So Yoon Ahn et al. · 2018 · Neonatal Medicine
Purpose The aim of this study is to examine the tolerability and effect of early high-dose amino acid administration in extremely low birth weight infants (ELBWIs). Methods This retrospective cohort study included ELBWI (birth weight <1,000 g, n=142). Biochemical, nutritional, and neurodevelopmental data were compared between infants who received conventional low amino acid (LAA; 1.5 g/kg/day) and those who received high amino acid (HAA; 3 g/kg/day) within the first 48 hours after birth. Neurodevelopmental data included weight, height, and head circumference at discharge, 12 to 14 and 18 to 24
View details →DOI: 10.5385/nm.2018.25.4.153 Negative / Null Result ReportOpen accessAgriculture
Sindesi Olwetu A., Lewu Muinat N., Ncube Bongani et al. · 2021 · Agriculture
Vegetables are essential components in human diets because they are rich in vitamins, minerals, and dietary fibre. There is a growing interest in human nutrition enhancement through vegetable consumption to reduce micro mineral deficiencies, especially in households with low buying power. A greenhouse pot experiment was conducted to evaluate the effect of zeolite amendment on the mineral composition of cabbage (Brassica oleracea var. capitata L.), in relation to the soil chemical status. The experiment was carried out over two growing seasons (winter/spring) of 2018 and 2019. The treatments we
View details →DOI: 10.2478/agri-2021-0010 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Robert G Maki, Martina Bradic, Phillip Wong et al. · 2025 · Journal for ImmunoTherapy of Cancer
Background Objective responses to immune checkpoint inhibitors (ICI) in leiomyosarcoma (LMS) are rare. Response rates may be increased by combination with other drugs known to promote immune infiltration, such as poly(ADP-ribose) polymerase (PARP) inhibitors, which have led to benefit in BRCA-altered uterine LMS. We therefore evaluated the combination of a PARP inhibitor, rucaparib, and the anti-programmed death receptor-1 monoclonal antibody, nivolumab, in patients with advanced LMS and investigated its effects on the tumor immune microenvironment.Methods This was an open-label, single-center
View details →DOI: 10.1136/jitc-2025-012020 Negative / Null Result ReportOpen accessVeterinary medicine
Emily E. Bray, Emily E. Bray, Kerinne M. Levy et al. · 2019 · Frontiers in Veterinary Science
Assistance dogs can greatly improve the lives of people with disabilities. However, a large proportion of dogs bred and trained for this purpose are deemed unable to successfully fulfill the behavioral demands of this role. Often, this determination is not finalized until weeks or even months into training, when the dog is close to 2 years old. Thus, there is an urgent need to develop objective selection protocols that can identify dogs most and least likely to succeed, from early in the training process. We assessed the predictive validity of two candidate measures employed by Canine Companio
View details →DOI: 10.3389/fvets.2019.00049 Negative / Null Result ReportOpen accessMedicine
Kwak N, Kim JY, Kim HJ et al. · 2025 · Tuberculosis and respiratory diseases
Background This study aimed to determine whether a shorter high-dose rifampicin regimen is non-inferior to the standard 6-month tuberculosis regimen. Methods This multicenter, randomized, open-label, non-inferiority trial enrolled…
View details →DOI: 10.4046/trd.2024.0099 Negative / Null Result ReportOpen accessMedicine
José María Paredes, Tomás Ripollés, Ángela Algarra et al. · 2022 · Intestinal Research
Background/Aims Tight control of inflammation and adjustment of treatment if activity persists is the current strategy for the management of Crohn’s disease (CD). The usefulness of fecal calprotectin (FC) in isolated involvement of the small intestine in CD is controversial. To assess the usefulness of FC to determine the inflammatory activity detected by intestinal ultrasonography (IUS) in ileal CD. Methods Patients with exclusively ileal involvement CD who underwent IUS and an FC were prospectively included. Simple ultrasound index was used to determine inflammatory activity. The usual stati
View details →DOI: 10.5217/ir.2021.00126 Negative / Null Result ReportOpen accessPathology
Menk M, Graw JA, von Haefen C et al. · 2018 · Journal of Inflammation Research
Mario Menk, Jan Adriaan Graw, Clarissa von Haefen, Hendrik Steinkraus, Burkhard Lachmann, Claudia D Spies, David Schwaiberger Department of Anesthesiology and Operative Intensive Care Medicine, Charité – University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany Purpose: Although the role of the angiotensin II type 2 (AT2) receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury
Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Pannipa Suwannasom, Tasalak Thonghong, Krit Leemasawat et al. · 2024 · Journal of Diabetes Investigation
Abstract Aims/Introduction Individuals with diabetes are at high risk of developing cardiovascular events. The present study investigated the predictive value of the cardio‐ankle vascular index (CAVI) when added to the Systematic Coronary Risk Evaluation 2‐Diabetes (SCORE2‐Diabetes) risk algorithm to predict cardiovascular events in the Asian population. Materials and Methods The SCORE2‐Diabetes risk was assessed in 1,502 patients with diabetes, aged 40–69 years. Then, we further stratified each 10‐year risk category with a CAVI value of 9.0. The primary outcomes (composite of all causes of de
View details →DOI: 10.1111/jdi.14231 Negative / Null Result ReportOpen accessMedicine
Sung Yoon Lim, Kyu Jin Lee, Yeonhoon Jang et al. · 2025 · The Korean Journal of Internal Medicine
Background/Aims Despite some evidence supporting its utility, the role of adjunctive dobutamine in the management of septic shock remains unclear. Methods The nationwide prospective sepsis cohort of the Korean Sepsis Alliance was analyzed. Adult patients with septic shock receiving norepinephrine were enrolled over a 29-month period. Patients given a dobutamine infusion within 3 days of intensive care unit (ICU) admission were compared with patients who received no infusion. To balance baseline characteristics, propensity score matching (PSM) was used. Results Of 11,981 patients with sepsis, 1
View details →DOI: 10.3904/kjim.2024.432 Negative / Null Result ReportOpen accessPediatrics
Sheldon R. Garrison, Sophie A. Schweinert, Matthew W. Boyer et al. · 2025 · Child and Adolescent Psychiatry and Mental Health
Abstract Background This study evaluated pharmacogenomic (PGx) testing in children and adolescents with autism spectrum disorder (ASD). ASD frequently presents with co-occurring depression and anxiety. This complex phenotype often results in psychotropic medication polypharmacy. Incorporating PGx testing into the medical work-up may reduce polypharmacy and improve quality of life with symptom reduction. Methods A retrospective electronic health record (EHR) review between January 2017 and May 2023. Individuals either received PGx testing or treatment as usual (TAU). The co-primary outcomes wer
View details →DOI: 10.1186/s13034-025-00915-3 Negative / Null Result ReportOpen accessMedicine
Julie Faverial, Denis Cornet, Jacky Paul et al. · 2016 · PLoS ONE
Previous studies indicated that the quality of tropical composts is poorer than that of composts produced in temperate regions. The aim of this study was to test the type of manure, the use of co-composting with green waste, and the stabilization method for their ability to improve compost quality in the tropics. We produced 68 composts and vermicomposts that were analysed for their C, lignin and NPK contents throughout the composting process. Bayesian networks were used to assess the mechanisms controlling compost quality. The concentration effect, for C and lignin, and the initial blend qual
View details →DOI: 10.1371/journal.pone.0157884 Negative / Null Result ReportOpen accessMedicine
Cardona PJ · 2026 · Frontiers in immunology
Tuberculosis (TB) vaccine development is hindered by the absence of validated correlates of protection, the low proportion of infected individuals who progress to disease, and the pervasive impact of reinfection in endemic settings.…
View details →DOI: 10.3389/fimmu.2026.1807344 Negative / Null Result ReportOpen accessForestry
Basave Villalobos E, Alcalá Cetina Víctor M, López López Miguel A et al. · 2015 · iForest - Biogeosciences and Forestry
Swietenia humilis is a valued tree species for its high-quality wood, among other commercial interests. Attempts to plant the species in southwest Mexico have often failed due to poor quality seedlings combined with low soil fertility and dry environments. Nursery top-pruning and fertilization are practices previously reported to improve seedling quality, and facilitate rapid establishment under poor site conditions. In the present study, the effects of three top-pruning intensities (0%, 25%, and 50%), and two fertilizer regimes (traditional and exponential) on several S. humilis seedling morp
View details →DOI: 10.3832/ifor1179-007 Failed Experiment ReportOpen accessPublic aspects of medicine
Susan C. Wright, Titilayo T. Biya, Majapi E. Chokwe · 2014 · Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Pregnancy-related health education conveys basic information regarding healthy lifestyle choices and preventive healthcare in order to promote the health of the mother and foetus. Verbal education is supplemented frequently by means of healthpromotion leaflts. A pregnancy-related leaflt used in primary care clinics in Tshwane, South Africa titled: ‘Are you pregnant or planning to have a baby?’ was the focus of this research. Objectives: The study had two objectives, the fist of which was to explore whether the English pregnancy leaflt improved the knowledge of young female adults w
View details →DOI: 10.4102/hsag.v19i1.764 Failed Experiment ReportOpen accessOphthalmology
Nereyda G. Martínez Suárez, Ileana A. Agramonte Centelles, Ileana A. Agramonte Centelles · 2008 · Revista Cubana de Oftalmología
OBJETIVO: Evaluar clínicamente de pacientes portadores de queratoconjuntivitis seca posterior a puntoplastia con la técnica de parche del punto lagrimal. MÉTODOS: Se realizó puntoplastia con la técnica de parche del punto lagrimal a 31 pacientes (62 ojos) portadores de queratoconjuntivitis seca grado 2, que acudieron a la consulta en el año 2006, y se utilizó conjuntiva autóloga en 16 pacientes (32 ojos) y mucosa labial, en 15 casos (30 ojos), y se les evaluó clínicamente al mes y a los tres meses de realizada la cirugía. RESULTADOS: En 26 pacientes se observó una mejoría subjetiva y objetiva
Failed Experiment ReportOpen accessOphthalmology
Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD et al. · 2025 · Ophthalmology Science
Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro
View details →DOI: 10.1016/j.xops.2024.100650 Failed Experiment ReportOpen accessMedicine
Tahar Gargah, Majda Cherif, Rim Goucha-Louzir et al. · 2012 · Saudi Journal of Kidney Diseases and Transplantation
The hemolytic uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, represents one of the major causes of acute renal failure in infancy and childhood. The typical form occurring after an episode of diarrhea caused by Escherichia coli is the most frequent in children. Other microorganisms also may be responsible for HUS, such as Streptococcus pneumoniae, which causes more severe forms of the disease. We report an 8-month-old girl who presented with pneumonia and subsequently developed HUS. Renal biopsy showed characteristic lesion
View details →DOI: 10.4103/1319-2442.100885 Negative / Null Result ReportOpen accessAnimal culture
Giovanni Martemucci, Angela Gabriella D’Alessandro · 2010 · Italian Journal of Animal Science
Three experiments were carried out with the aim of evaluating the efficiency of techniques of in vivo production, storage and transfer of embryos in dairy sheep. Experiment I - For embryo production, thirty-one ewes were synchronized with FGA (vaginal sponges, 40 mg, 9 d) and PGF2α (ICI; 50 μg, 7th d), and subdivided into three groups corresponding to the following superovulatory treatments over 3 days with purified gonadotrophic preparations: A) control, FSH/LH ratio = 1 (250 IU p-FSH : 250 UI p-LH); B) FSH/LH ratio = 2 (250 IU p-FSH : 125 IU p-LH) and daily FSH/LH ratio of 3.4 &ndas
View details →DOI: 10.4081/ijas.2003.131 Negative / Null Result ReportOpen accessMedicine
Rosamund Chapman, Michiel van Diepen, Shireen Galant et al. · 2020 · Vaccines
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral glycoproteins has been shown to increase Env spike density on the cell membrane and surface of virus-like particles (VLPs). In this study, chimeric Env antigens were generated by replacing the transmembrane and cytoplasmic domains of HIV-1 Env with the corresponding regions from the influenza H5 hemagglutinin (HA) (gp140HA 2 tr) and by replaci
View details →DOI: 10.3390/vaccines8010054 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Sriyanti Sriyanti, Evy Damayanthi, Faisal Anwar · 2019 · Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition
Background : Rosela (Hibiscus sabdariffa L.) is an anthocyanin-rich plant that has good antioxidant capacity. However, the utilization was limited to red roselle, while previous studies showed that anthocyanin content was found to be higher in the thick roselle.therefore, this is an opportunity to develop purple roselle products as a preventive effort for degenerative diseases in men with fatness. Subjects in this study were male by considering the effect of estrogen on women which could play a role in suppressing oxidative stress. Objectives : This study aimed to analyze antioxidant (SOD/Supe
View details →DOI: 10.14710/jgi.7.2.75-85 Negative / Null Result ReportOpen accessMedicine
Duangdee Trangsuwan, Malai Wongchanchailert, Ladda Mo-suwan et al. · 2018 · Journal of Health Science and Medical Research (JHSMR)
Objective: To evaluate the volume of blood transfusion requirements as well as hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E. Material and Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 and September, 2014 in the Pediatric Clinic of Songklanagarind Hospital. The participants were β-thalassemia major and Hb E/β-thalassemia patients aged between 5 and 18 years. A random allocation sequence was generated to receiving either 6 months of vitamin E
View details →DOI: 10.31584/jhsmr.2018.36.3.19 Negative / Null Result ReportOpen accessAnimal culture
S. Lürzel, K. Barth, I. Windschnurer et al. · 2018 · Animal
Cattle’s relationship with humans is a crucial factor regarding their welfare. In dairy cows, interactions with humans occur regularly during milking. We tested the effect of gentle interactions (stroking, talking in a gentle voice) during milking on avoidance distance and milk composition, yield and flow characteristics as well as behaviour during milking. Over the course of 15 days, an experimenter interacted gently with 14 German Holstein cows for 2 min during morning and evening milkings, totalling 60 min; the experimenter stayed at a similar distance to 12 control cows of the same breed f
View details →DOI: 10.1017/s1751731117001495 Negative / Null Result ReportOpen accessBotany
Xiang-Gui Chen, Yi-Hua Wu, Neng-Qi Li et al. · 2022 · BMC Plant Biology
Abstract Background Orchids require specific mycorrhizal associations for seed germination. During symbiotic germination, the seed coat is the first point of fungal attachment, and whether the seed coat plays a role in the identification of compatible and incompatible fungi is unclear. Here, we compared the effects of compatible and incompatible fungi on seed germination, protocorm formation, seedling development, and colonization patterns in Dendrobium officinale; additionally, two experimental approaches, seeds pretreated with NaClO to change the permeability of the seed coat and fungi incub
View details →DOI: 10.1186/s12870-022-03760-0 