Negative / Null Result ReportMedicine
Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma
Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…
View details →DOI: 10.1016/j.jcot.2025.103145 Negative / Null Result Report
Isezaki T, Yuyama H, Yasumuro O et al. · 2025 · Preprint
Abstract Background: This study evaluated the impact of the combined use of pazopanib hydrochloride (PAZ) and gastric acid suppressants (AS) on the progression-free survival and safety of Japanese patients with sarcoma. Methods: A…
View details →DOI: 10.21203/rs.3.rs-6368835/v1 Negative / Null Result ReportOpen accessMedicine
Hassan M, Al Balah O, Hegazy A et al. · 2026 · Journal of the Saudi Heart Association
Background Transcranial photobiomodulation (TPBM) using near-infrared (NIR) light is a novel, non-invasive neuromodulation strategy with potential to enhance neurorecovery. While preclinical studies are promising, clinical evidence in…
View details →DOI: 10.37616/2212-5043.1481 Negative / Null Result ReportOpen accessMedicine
MacMillan MB, Neath I, Roodenrys S · 2024 · Memory & cognition
A word's orthographic neighborhood is the set of words that differ from the target word by one letter. Both Roodenrys (2009) and Robert et al. (Journal of Psycholinguistic Research, 44, 119-125, 2015) posit that orthographic neighbors are…
View details →DOI: 10.3758/s13421-024-01658-w Negative / Null Result ReportOpen accessMedicine
Woodbury J, Offerdahl E · 2024 · CBE life sciences education
Team-based learning (TBL) is a highly intense active learning pedagogy that uses a cycle of preclass preparation, formative assessment for readiness, mini-lectures, and complex team exercises. Consistent with the literature on active…
View details →DOI: 10.1187/cbe.24-02-0090 Negative / Null Result ReportOpen accessMedicine
Bickerstaff L, Trinkl J, Munkwitz S et al. · 2025 · F1000Research
Background The photic sneeze reflex (PSR) is a common but underexplored phenomenon where bright light triggers sneezing, affecting ~30% of the population. This study aimed to characterise the light conditions inducing PSR. Methods One male…
View details →DOI: 10.12688/f1000research.167964.2 Negative / Null Result ReportOpen accessMedicine
Bahadoran S, Vaeznia S, Hassanpour H · 2026 · Veterinary and animal science
This study evaluated the effects of dietary Echinacea purpurea supplementation on immune regulation, oxidative stress, and cellular aging in broiler chickens reared at high altitude (2100 m). One hundred and eight day-old male Ross 308…
View details →DOI: 10.1016/j.vas.2026.100675 Negative / Null Result Report
Klaiman T, Ianotte L, Josephs M et al. · 2023 · Preprint
Abstract Background : Heart failure (HF) is one of the most common reasons for hospital admission and is a major cause of morbidity, mortality, and increasing health care costs. The EMPOWER study was a randomized trial that used remote…
View details →DOI: 10.21203/rs.3.rs-2206783/v1 Negative / Null Result ReportOpen accessMedicine
Leger K, Dong J, DeBruine LM et al. · 2023 · Scientific reports
Perceptions of the trustworthiness of faces predict important social outcomes, including economic exchange and criminal sentencing decisions. However, the specific facial characteristics that drive trustworthiness perceptions remain poorly…
View details →DOI: 10.1038/s41598-023-42990-6 Negative / Null Result ReportOpen accessMedicine
Yoon S, Rottenberg J · 2025 · BMC psychology
Background Does what a person desires to feel (affect valuation) predict their future affective reaction to salient life events? We tested this idea in the context of an exam, a key achievement-oriented event for college students. Methods…
View details →DOI: 10.1186/s40359-025-03759-w Negative / Null Result ReportOpen accessMedicine
Singstock M, Abdul Khader AHS, Wayant C et al. · 2026 · The oncologist
Background Oncology clinical trials, regardless of success in meeting their primary endpoint, often suffer from spin-the misrepresentation of research findings. Despite dramatic improvements in myeloma outcomes, numerous recent myeloma…
View details →DOI: 10.1093/oncolo/oyag221 Negative / Null Result ReportOpen accessMedicine
Cusimano C, Kim J, Wong J · 2025 · Proceedings of the National Academy of Sciences of the United States of America
It is common to say that people feel entitled to rewards-they think they have earned or deserve them-based on their effort and achievement. However, effort and achievement draw on different principles to justify reward. They can also…
View details →DOI: 10.1073/pnas.2409131122 Negative / Null Result ReportOpen accessMedicine
Nakata Y, Watanabe Y, Ozaki A · 2026 · Cureus
Background The purpose of this study was to evaluate whether the workstyle reform, aimed at improving physician health and safety, achieved a secondary goal of enhancing surgical productivity by applying the Malmquist Index (MI) model. We…
View details →DOI: 10.7759/cureus.102095 Negative / Null Result ReportOpen accessMedicine
Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
View details →DOI: 10.3390/cancers15205073 Replication FailureOpen accessMedicine
Levy MM · 2013 · Critical care (London, England)
During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small…
View details →DOI: 10.1186/cc13060 Replication FailureMedicine
Rodrigue JR, Fleishman A, Fitzpatrick S et al. · 2015 · Progress in transplantation (Aliso Viejo, Calif.)
Context Since nearly all registered organ donors in the United States signed up via a driver's license transaction, motor vehicle (MV) offices represent an important venue for organ donation education. Objective To evaluate the impact of…
View details →DOI: 10.7182/pit2015166 Negative / Null Result ReportMedicine
Howland RH · 2015 · Journal of psychosocial nursing and mental health services
Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…
View details →DOI: 10.3928/02793695-20141222-01 Failed Experiment ReportOpen accessMedicine
Jones SA, Morand EF · 2024 · Drugs
The development of new medicines for systemic lupus erythematosus (SLE) has not addressed unmet clinical need, with only three drugs receiving regulatory approval for SLE in the last 60 years, one of which was specifically licensed for…
View details →DOI: 10.1007/s40265-024-02043-2 Failed Experiment ReportMedicine
Saraceni F, Scortechini I, Mancini G et al. · 2021 · Transplant infectious disease : an official journal of the Transplantation Society
Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in…
View details →DOI: 10.1111/tid.13401 Replication FailureOpen accessMedicine
Kim JK, Karp JM, Gerber NK · 2023 · Clinical and translational radiation oncology
Background/purpose The optimal management of residual micrometastases and isolated tumor cells (ITC) in patients with invasive breast cancer who undergo neoadjuvant chemotherapy (NAC) followed by definitive surgery is not well-studied. We…
View details →DOI: 10.1016/j.ctro.2022.11.014 Negative / Null Result ReportOpen accessMedicine
Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…
View details →DOI: 10.1016/j.esmoop.2024.103604 Negative / Null Result ReportMedicine
Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →DOI: 10.1377/hlthaff.2011.0159 Negative / Null Result ReportOpen accessMedicine
Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →DOI: 10.3389/fonc.2018.00423 Negative / Null Result ReportMedicine
Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →DOI: 10.1016/j.jsat.2014.11.007 Negative / Null Result ReportOpen accessMedicine
Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →DOI: 10.1093/ijnp/pyy051 Failed Experiment ReportMedicine
Scheperjans F, Levo R, Bosch B et al. · 2024 · JAMA neurology
Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models. Objective To assess the safety and symptomatic efficacy of…
View details →DOI: 10.1001/jamaneurol.2024.2305 Negative / Null Result ReportMedicine
Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →DOI: 10.1016/j.visres.2021.107965 Failed Experiment ReportMedicine
Black PC, Tangen CM, Singh P et al. · 2023 · European urology
Background Although radical cystectomy (RC) is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), many patients are ineligible for surgery or elect…
View details →DOI: 10.1016/j.eururo.2023.08.004 Failed Experiment ReportMedicine
Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
Failed Experiment ReportOpen accessMedicine
Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations
Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…
View details →DOI: 10.1097/cce.0000000000000742 