CANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy
Beatriz G. Armendariz, PhD; Ulrich F.O. Luhman, PhD; Brian Berger, MD; Jules Hernandez-Sanchez, PhD; Katrijn Bogman, PhD; Nikolaos Mitrousis, PhD; Martina Wollenhaupt, MD; David Kent, MD · 2025 · Ophthalmology Science
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Abstract
Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro
Abstract by Beatriz G. Armendariz, PhD; Ulrich F.O. Luhman, PhD; Brian Berger, MD; Jules Hernandez-Sanchez, PhD; Katrijn Bogman, PhD; Nikolaos Mitrousis, PhD; Martina Wollenhaupt, MD; David Kent, MD, Ophthalmology Science (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.xops.2024.100650