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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21374 results · page 662 of 713

Negative / Null Result ReportMedicine

Microbiome responses to anthelmintic treatment depend on pre-treatment helminth infection status in young Ethiopian children.

Tikhonova P, Mekonnen Z, Belanger KD et al. · 2026 · Communications medicine

Background Mass deworming programs using anthelmintic drugs are a common public health strategy for controlling soil-transmitted helminth (STH) infections in high-risk, low-income countries. However, whether routine deworming induces…

View details →DOI: 10.1038/s43856-026-01625-3
Negative / Null Result ReportMedicine

Evaluating a specialty-specific objective structured clinical examination and workplace-based assessment curriculum for radiation oncology postgraduate training: a prospective educational intervention study.

Ma CY, Chen J, Fu Y et al. · 2026 · BMC medical education

Background Competence in radiation oncology is still commonly expected to emerge through apprenticeship, although essential tasks such as target delineation, treatment-plan review, and multidisciplinary reasoning are not reliably sampled…

View details →DOI: 10.1186/s12909-026-09554-4
Negative / Null Result ReportMedicine

Efficacy of Short Course Cognitive Behavioral Therapy on Stress Reduction Among First-Year Surgical Residents.

Burnet G, Vasic I, Sauaia A et al. · 2026 · Journal of surgical education

Objective To determine the efficacy of cognitive behavioral therapy (CBT) on stress, anxiety, burnout, and depression in surgical interns and to determine the optimal timing of CBT. Our hypothesis was that CBT could improve each of these…

View details →DOI: 10.1016/j.jsurg.2026.103957
Negative / Null Result ReportOpen accessMedicine

Effects of Premolar Extraction on the Dimensions of the Airway Through Cephalometric Appraisal: A Retrospective Study.

Mehraj F, Bhat MA, Mangulkar A et al. · 2025 · Journal of pharmacy & bioallied sciences

Introduction In recent years, there has been a great deal of interest in research because of the changes that the extraction of premolars has caused to the structures surrounding of the upper airway. This is because it's thought that these…

View details →DOI: 10.4103/jpbs.jpbs_1340_25
Negative / Null Result ReportMedicine

The challenge of data scarcity and imbalanced classes in radiomics performance.

Rodriguez-Belenguer P, Beser-Robles M, Marfil-Trujillo M et al. · 2026 · Computer methods and programs in biomedicine

Background and objectives Radiomics-based machine learning models are increasingly used for clinical decision-making, yet their reliability is often constrained by limited sample sizes and class imbalance in imaging datasets. While prior…

View details →DOI: 10.1016/j.cmpb.2026.109435
Negative / Null Result ReportMedicine

Three-Year Changes in Health-Related Quality of Life after Laparoscopic Hysterectomy: A Registry-Based Cohort Study.

Denstad SE, Volløyhaug I, Lieng M et al. · 2026 · Journal of minimally invasive gynecology

Study objective To evaluate changes in health-related quality of life (HRQoL) 3 years after laparoscopic hysterectomy (LH) for benign, prophylactic, and malignant indications, and to identify baseline factors associated with these changes.…

View details →DOI: 10.1016/j.jmig.2026.03.036
Negative / Null Result ReportMedicine

Cortico-cortical paired associative stimulation increases SMA-M1 facilitation in tremor-dominant Parkinson's disease.

Tan J, Rurak BK, Helmich RC et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Objective Tremor is a common motor symptom of Parkinson's disease (PD) that reduces quality of life. Cortico-cortical paired associative stimulation (ccPAS) is a transcranial magnetic stimulation protocol that induces connective…

View details →DOI: 10.1016/j.clinph.2026.2111928
Negative / Null Result ReportMedicine

Interactive Alignment After Communication Partner Training in Adults With Traumatic Brain Injury.

Bode-Akinboye E, Rietdijk R, Dale R et al. · 2026 · American journal of speech-language pathology

Purpose Adults with moderate-severe traumatic brain injury (TBI) often have significant communication challenges, particularly in interpersonal conversations. Most research aiming to understand these challenges has used static measures of…

View details →DOI: 10.1044/2025_ajslp-25-00226
Negative / Null Result ReportMedicine

Acetaminophen inhibits denitrification in Paracoccus denitrificans: Bioenergetic constraint and periplasmic electron transfer impairment.

Dong ZH, Zhang Y, Lu J et al. · 2026 · Journal of hazardous materials

Acetaminophen (APAP) is frequently detected in municipal wastewater, yet its effect on heterotrophic denitrification remains insufficiently resolved. Here, Paracoccus denitrificans was exposed to 0.5 and 7.5 ppm APAP, representing lower…

View details →DOI: 10.1016/j.jhazmat.2026.142260
Negative / Null Result ReportMedicine

Topical Cetirizine in Androgenetic Alopecia: A Preliminary Study.

Dhurat RS, Sharma R, Shetty C et al. · 2025 · Skin appendage disorders

Introduction Prostaglandin D2 (PGD2) is elevated in the bald scalp of men with androgenetic alopecia (AGA) and inhibits hair growth. Cetirizine, an H1-antihistamine, reduces PGD2 production and has anti-inflammatory effects, making it a…

View details →DOI: 10.1159/000550279
Negative / Null Result ReportMedicine

Calm in the Chaos: A Mixed-Methods Pilot Study Using a Mobile Mindfulness App to Manage Stress and Burnout Among Emergency Department Nurses.

Kober M, Livingston JA, Barrick C et al. · 2026 · Journal of holistic nursing : official journal of the American Holistic Nurses' Association

Background: Emergency department (ED) nurses are routinely exposed to high-stress clinical environments, increasing their risk for burnout and emotional exhaustion. In holistic nursing, self-care is viewed as a professional and ethical…

View details →DOI: 10.1177/08980101261424557
Negative / Null Result ReportMedicine

The effect of discharge education provided with two different teaching techniques on nursing students' knowledge, self-efficacy and satisfaction: A randomized controlled trial.

Kayin Y, Oztas B · 2026 · Nurse education in practice

Aim This study examined the effects of PechaKucha and Teach-Back teaching techniques on nursing students' knowledge, self-efficacy and satisfaction regarding discharge education. Background Effective discharge education requires strategies…

View details →DOI: 10.1016/j.nepr.2026.104807
Negative / Null Result Report

Current Evidence on the Effects of Non-Nutritive Sweeteners on the Gut Microbiota-Incretin Axis and Metabolic Outcomes in Adult Human Populations: A Scoping Review

Sharma V, Verma Y · 2026 · Preprint

Abstract Non‑nutritive sweeteners (NNS) are widely consumed under the assumption of metabolic inertness, but emerging evidence suggests they may affect the gut microbiome, incretin hormones, and glucose homeostasis. This scoping review…

View details →DOI: 10.21203/rs.3.rs-10106611/v1
Negative / Null Result ReportMedicine

Sinonasal microbiome remains stable during dupilumab therapy in chronic rhinosinusitis: a pilot study.

Hirsch T, Moser U, Wolf A et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose This prospective pilot study aimed to evaluate whether dupilumab therapy induces measurable changes in the sinonasal microbiome of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods Eight CRSwNP patients…

View details →DOI: 10.1007/s00405-026-10378-7
Negative / Null Result ReportMedicine

Anterior maxillary distraction for maxillary advancement in growing patients with cleft lip and palate : Soft and hard tissue changes.

Parakkal T, Kuriakose MJ, Natarajan PV et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Surgically facilitated anterior maxillary distraction (AMD) is used for the treatment of maxillary hypoplasia secondary to cleft lip and palate (CLP). In this study, the soft and hard tissue changes following AMD in growing patients with…

View details →DOI: 10.1007/s00056-026-00676-4
Negative / Null Result ReportMedicine

Incline and decline treadmill trotting produce electromyographic changes in specific canine shoulder muscle activity: implications for therapeutic exercise.

Stanford K, Cain RM, Millis D et al. · 2026 · American journal of veterinary research

Objective To identify the effects of incline and decline treadmill trotting on forelimb muscle activity in dogs using electromyography (EMG). Methods Data were collected for a prospective within-subject, repeated-measures study in January…

View details →DOI: 10.2460/ajvr.26.04.0180
Negative / Null Result ReportMedicine

Ultrasound processing induces mild protein oxidation and significant changes in physicochemical properties of milk proteins.

Bhavya ML, Bayati M, Poojary MM et al. · 2026 · Food chemistry

Ultrasound (US) processing is a promising food technology to improve protein solubility, reduce particle size, and modify functional properties. However, concerns exist regarding US-induced protein oxidation due to reactive oxygen species…

View details →DOI: 10.1016/j.foodchem.2026.149898
Negative / Null Result ReportMedicine

Safety of Co-Administered Cannabidiol (CBD) and alcohol: a Phase I study.

Wolinsky D, Blaine S, Strickland JC et al. · 2026 · Journal of cannabis research

Background This Phase I randomized controlled trial aimed to assess the safety and tolerability of cannabidiol (CBD) and alcohol co-administration among moderate alcohol consumers in acute laboratory and chronic outpatient settings.…

View details →DOI: 10.1186/s42238-026-00457-1