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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 663 of 725

Negative / Null Result ReportOpen accessMedicine

Exploring horses' (Equus caballus) gaze and asymmetric ear position in relation to human attentional cues.

Barrera G, Albiach-Serrano A, Guillén-Salazar F · 2024 · Animal cognition

Studies have shown that horses are sensitive to human attentional cues. Also, there is some evidence that they might be able to infer the knowledge state of a human and communicate intentionally with us. However, this ability is not fully…

View details →DOI: 10.1007/s10071-024-01909-y
Negative / Null Result ReportMedicine

'July effect' in management and outcomes of patients admitted with pulmonary embolism in the United States, 2016 to 2021.

Bansal M, Mehta A, Morris DL et al. · 2025 · Proceedings (Baylor University. Medical Center)

Background This study sought to assess the outcomes of pulmonary embolism (PE) admissions at teaching and nonteaching hospitals in the month of July, when new trainees begin their training in the United States. Methods During 2016-2021,…

View details →DOI: 10.1080/08998280.2025.2520125
Negative / Null Result ReportMedicine

Assessing the in vivo impact of novel β-lactamase inhibitors on the efficacy of their partner β-lactams against serine carbapenemase-producing Pseudomonas aeruginosa using human-simulated exposures.

Ruiz VH, Gill CM, Nicolau DP · 2024 · The Journal of antimicrobial chemotherapy

Objectives To evaluate the efficacy of human-simulated regimens (HSRs) of ceftazidime, ceftazidime/avibactam, imipenem, imipenem/relebactam, meropenem and meropenem/vaborbactam in a murine thigh infection model against serine…

View details →DOI: 10.1093/jac/dkad412
Negative / Null Result ReportOpen accessMedicine

Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos.

Schaefer M, Liedtke C, Enge S · 2025 · Scientific reports

Recent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be…

View details →DOI: 10.1038/s41598-025-27622-5
Negative / Null Result ReportOpen accessMedicine

How different immersive environments affect intracortical brain computer interfaces.

Tortolani AF, Kunigk NG, Sobinov AR et al. · 2025 · Journal of neural engineering

Objective . As brain-computer interface (BCI) research advances, many new applications are being developed. Tasks can be performed in different virtual environments, and whether a BCI user can switch environments seamlessly will influence…

View details →DOI: 10.1088/1741-2552/adb078
Negative / Null Result ReportOpen accessMedicine

Longitudinal Changes in Sensory Processing and Clinical Outcomes During Spinal Cord and Dorsal Root Ganglion Stimulation to Treat Chronic Pain: A Pilot Study.

Rogers ER, Sankarasubramanian V, Kyi WHT et al. · 2025 · Journal of pain research

Purpose The analgesic mechanisms and neurophysiological effects of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) are poorly understood. In this pilot repeated-measures study, we used quantitative sensory testing…

View details →DOI: 10.2147/jpr.s519187
Negative / Null Result ReportMedicine

High Prevalence and Clinical Relevance of Intrapulmonary Vascular Dilatations in Patients Undergoing TIPS Implantation.

Mauz JB, Rieland H, Berliner D et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Considerate patient selection is vital to ensure the best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations…

View details →DOI: 10.1016/j.cgh.2024.04.027
Negative / Null Result ReportMedicine

Impact of morphine dependence and withdrawal on economic demand for fentanyl, cocaine, and methamphetamine in rats.

Seaman RW Jr, Shariatzadeh N, Salinas KA et al. · 2026 · Drug and alcohol dependence

Background Stimulant-opioid co-use has surged in the United States, with methamphetamine use among people who use opioids increasing 82.6 % from 2015 to 2017. This trend contributes to rising overdose deaths, marking a "fourth wave" of the…

View details →DOI: 10.1016/j.drugalcdep.2025.112992
Negative / Null Result ReportOpen accessMedicine

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential.

Lilley A, Chiapponi C, Prosperi A et al. · 2026 · Vaccines

Background/Objectives : Influenza A viruses cause seasonal epidemics of respiratory infections in humans, the severity of which can be mitigated by influenza vaccine use. Influenza A viruses circulating in pigs continue to pose a pandemic…

View details →DOI: 10.3390/vaccines14030211
Negative / Null Result ReportOpen accessMedicine

Semaglutide use before single-level lumbar fusion associated with fewer readmissions and 90-day costs.

Ng MK, Mastrokostas PG, Rodriguez AN et al. · 2025 · Journal of craniovertebral junction & spine

Context Semaglutide, a glucagon-like protein-1 receptor agonist used in diabetes and obesity management, has demonstrated perioperative benefits in other surgical populations. However, its role in spine surgery remains unclear. Aims This…

View details →DOI: 10.4103/jcvjs.jcvjs_156_25
Negative / Null Result ReportOpen accessMedicine

The brief pain inventory-Interference Subscale has acceptable reliability but questionable validity in acute back and neck pain populations.

Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy

Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…

View details →DOI: 10.1016/j.bjpt.2024.101150
Negative / Null Result ReportMedicine

Finland's Flexible Partial Pension - A Bridge to Full-Time Retirement, a Pathway Out of Paid Employment, or an Income Supplement?

Ilmakunnas I, Sten-Gahmberg S · 2026 · Journal of aging & social policy

Flexible partial retirement schemes are intended to give individuals the opportunity to reduce working hours before moving into full retirement, the expectation being that the reduced workload will contribute to postponed old-age…

View details →DOI: 10.1080/08959420.2026.2643643
Negative / Null Result ReportOpen accessMedicine

Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.

Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…

View details →DOI: 10.1111/opo.13460
Negative / Null Result ReportOpen accessMedicine

Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.

Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…

View details →DOI: 10.1177/10556656241234599
Negative / Null Result ReportOpen accessMedicine

Pre-operative planning for reverse shoulder arthroplasty in low-resource centres: A modified Delphi study in South Africa.

Rachuene PA, Dey R, Kauta NJ et al. · 2024 · SICOT-J

Background Pre-operative planning for reverse shoulder arthroplasty (RSA) poses challenges, particularly when dealing with glenoid bone loss. This modified Delphi study aimed to assess expert consensus on RSA planning processes and…

View details →DOI: 10.1051/sicotj/2024021
Negative / Null Result ReportOpen accessMedicine

The Localization Accuracy of Electrically Evoked Dental Sensations.

Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research

Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…

View details →DOI: 10.1002/cre2.70012
Negative / Null Result Report

Bluetooth Noise-Canceling Headphones Improve the Quality of Ophthalmic Exam in Hearing-Loss Patients – A Randomized Controlled Trial

Glanzer BM, Ladki MS, Chea M et al. · 2023 · Preprint

This study tests the utilization of Bluetooth noise-canceling headphones in improving the quality of eye exams in patients with hearing loss. University of Texas Medical Branch patients above 55 years of age were screened for hearing loss…

View details →DOI: 10.20944/preprints202310.1157.v1
Negative / Null Result ReportOpen accessMedicine

The association between Nutrient-Rich food score (NRFS) and the odds of lung cancer risk: a case-control study in Iran.

Mohammadzadeh M, Abdi F, Hadi S et al. · 2026 · BMC nutrition

Background A high-quality diet is an important strategy for preventing chronic diseases, including cancer. The Nutrient Rich Food Score (NRFS) is a very useful index that can compare the value of key micronutrients and macronutrients per…

View details →DOI: 10.1186/s40795-026-01243-1
Negative / Null Result ReportOpen accessMedicine

Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury.

Soufi R, Salamzadeh J, Alavi Darazam I et al. · 2025 · Iranian journal of pharmaceutical research : IJPR

Background Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney injury (AKI) remains uncertain. This study aimed to evaluate vancomycin's pharmacokinetic and pharmacodynamic…

View details →DOI: 10.5812/ijpr-159089
Negative / Null Result ReportOpen accessMedicine

Cognitive and Behavioral Effects of Levetiracetam in Juvenile Rats.

Ullal SD, Thomas AG, Acharya SD et al. · 2026 · Pharmacology research & perspectives

Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and…

View details →DOI: 10.1002/prp2.70226
Negative / Null Result ReportMedicine

Persisting neurobehavioral consequences of gestational exposure to cadmium and benzo[a]pyrene in rats.

Hawkey AB, Fan R, Nwachukwu K et al. · 2025 · Neurotoxicology and teratology

Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure…

View details →DOI: 10.1016/j.ntt.2025.107546
Negative / Null Result ReportOpen accessMedicine

Elevated Carcinoembryonic Antigen Levels Predict Failure to Reach Surgery in Patients with Borderline Resectable Pancreatic Cancer Referred to Neoadjuvant Therapy.

Jacover A, Beller T, Mahamid N et al. · 2025 · Annals of surgical oncology

Introduction Neoadjuvant therapy (NT) is generally preferred over upfront surgery for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), but many patients fail to reach surgical resection. This study evaluates real-world…

View details →DOI: 10.1245/s10434-025-17433-3