A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology
Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…
Christian K, Moritz C, Skelton K et al. · 2024 · Preprint
1. Reptiles are challenged with maintaining stable hydric states and viable body temperatures in a variable terrestrial environment. Reptiles can use behaviour to select favourable microhabitats as well as physiological adaptations, such…
Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports
Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…
Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…
van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
Soffer GK, Feinberg T, Kroll H et al. · 2025 · The Journal of asthma : official journal of the Association for the Care of Asthma
Objectives To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma…
Zhou C, Cui GY, Tang YH et al. · 2025 · World journal of diabetes
Background The association between ambient air pollution and glycolipid metabolic disorders (GMDs, including diabetes mellitus and dyslipidemia) is still not well understood, especially when it comes to the different effects of long-term…
Mayntz SP, Warncke S, Ladefoged LG et al. · 2025 · Journal of cardiology
Background Cardiovascular disease is a leading cause of mortality globally, with air pollution, particularly fine particulate matter (PM 2.5 ), recognized as a significant risk factor. While long-term accumulated exposure to PM 2.5 has…
Toklu E, Göknar G, Adıyeke SK · 2026 · BMC ophthalmology
BACKGROUND: Idiopathic epiretinal membrane (iERM) is a common age-related vitreoretinal disorder characterized by fibrocellular proliferation on the inner limiting membrane. Although systemic inflammation has been suggested to play a…
Schiemer C, Horswill MS, Hill A et al. · 2025 · Journal of safety research
Introduction As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors in medicinal populations.…
Yang Y, Li Z, Zhu Y et al. · 2025 · Diagnostic pathology
Background Triple-negative breast cancer (TNBC) is aggressive and has limited therapeutic options due to the absence of targeted therapies, highlighting the urgent need for prognostic biomarkers linked to cancer stemness and…
Kobayashi S · 2025 · World journal of hepatology
Carteri et al reaffirmed the value of the Child-Turcotte-Pugh score in predicting survival in patients with cirrhosis. However, the lack of association with nutritional markers warrants careful interpretation. In cirrhosis, complex…
Yigit S, Nursal AF, Celik A et al. · 2024 · Revista da Associacao Medica Brasileira (1992)
Objective Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity.…
Takanaga S, Matsumoto N, Kadowaki T et al. · 2024 · Acta medica Okayama
Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a…
Yang X, Liu W, Mao Z et al. · 2026 · GigaScience
Background Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association studies (EWAS) of preeclampsia produced inconsistent results in cord…
Alroba R, Alfakhri A, Badreldin H et al. · 2024 · Pharmacoepidemiology and drug safety
Purpose Previous research and pharmacovigilance monitoring activities have suggested a potential association between indapamide use and rhabdomyolysis. This study aims to investigate the potential causal relationship between the use of…
Barcia Aguilar C, Amengual-Gual M, Brenton JN et al. · 2024 · Seizure
Purpose Evaluate the relationship between first and second-line medication dosing and progression to refractory status epilepticus (RSE) in children. Methods This is a retrospective analysis of prospectively collected data from September…
Bhushan A, Dexter F, Brindeiro C et al. · 2026 · Anesthesiology and perioperative science
Purpose Earlier, patients developed surgical site infection for 2.0% of cases without Staphylococcus aureus transmission through anesthesia work areas, 11% with S. aureus transmitted susceptible to prophylactic antibiotic, and 18% with…
Szczuko M, Szmigiel O, Szczuko U et al. · 2026 · Journal of clinical medicine
Background : Hashimoto's thyroiditis (HT) is the result of a complex interplay between genetic, environmental, and epigenetic factors. The role of cellular and humoral immunity in the pathogenesis of the disease is well-established.…
Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry
Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…
Gao Z, Yuan Y, Oleson JJ et al. · 2024 · Preprint
ABSTRACT Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users.…
Lipschultz R, Salunga A, Castaneda P · 2024 · Preprint
Intro: To investigate if there is a relationship between the number of prenatal visits and the age at which hip dysplasia is diagnosed in infants. Methods: We conducted a retrospective chart review between January 2017 and December 2021,…
Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle
Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…
Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine
Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…
Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open
Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…
Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes
Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…
Fleece H, Teglasi H · 2025 · Children (Basel, Switzerland)
Background/Objectives : Behavioral inhibition (BI) has been extensively studied as an early-appearing risk factor for adverse developmental outcomes. One pathway through which BI may confer risk is via reduced competence to interact…
Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN
Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…
Alharazy S · 2024 · Pakistan journal of medical sciences
Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…
Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…