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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 661 of 725

Negative / Null Result ReportMedicine

Similar water uptake depths in lianas and trees, but divergent functional trait coordination across organs in a seasonally dry tropical forest in Cambodia.

Hiiragi K, Sopheak T, Sophors C et al. · 2026 · Tree physiology

Although previous studies have suggested that lianas exhibit superior growth compared with trees during dry seasons, their strategies for acquiring water remain poorly understood. This study investigated the water uptake depth and…

View details →DOI: 10.1093/treephys/tpag057
Negative / Null Result ReportOpen accessMedicine

Management of endotracheal tube dislodgement during transoral oropharyngolaryngeal surgery: a multicenter cross-sectional survey study.

Li F, Huang D, Liang Z · 2026 · BMC anesthesiology

Objective To investigate the awareness, clinical management practices, and training needs of otolaryngologists and anesthesiologists regarding endotracheal tube dislodgement (ETTD) during transoral oropharyngolaryngeal surgery. Methods A…

View details →DOI: 10.1186/s12871-026-03958-x
Negative / Null Result ReportOpen accessMedicine

Impact of Junior Physicians' Resignation on Palliative Sedation Practices: A Retrospective Single-Center Study in South Korea.

Hong M, Lee SW, Jung M · 2026 · Journal of hospice and palliative care

Purpose This study aimed to evaluate changes in the proportion of patients receiving palliative sedation (PS) before and after the mass resignation of junior physicians in South Korea. Methods This single-center retrospective chart review…

View details →DOI: 10.14475/jhpc.2026.29.1.21
Negative / Null Result ReportOpen accessMedicine

Dental Health in Pediatric Patients With Different Types of Mucopolysaccharidosis: Retrospective Cross-Sectional Study.

Wang M, Liu R, Xia T et al. · 2026 · JMIR pediatrics and parenting

Background Patients with mucopolysaccharidosis (MPS) appear to have an increased risk of developing dental disease. Objective This study aimed to evaluate the status of dental caries and dental anomalies among Chinese patients with…

View details →DOI: 10.2196/87430
Negative / Null Result ReportOpen accessMedicine

Mitigation of salinity stress in Mentha piperita L. through foliar application of chitosan-salicylic acid encapsulated ZnO nanoparticles.

Al-Obaidi MHR, Mehrabani LV, Hassanpouraghdam MB et al. · 2026 · Scientific reports

Salinity stress harms plant growth and physiological characteristics. To investigate the effect of NaCl salinity stress (without salinity stress and 100 mM salinity) and foliar spray with: control (distilled water), zinc oxide…

View details →DOI: 10.1038/s41598-026-47421-w
Negative / Null Result ReportMedicine

Factors Associated With Surgical Outcomes in Medial Orbital Wall Fracture Reconstruction With Absorbable Plates.

Li B · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative imaging factors associated with absorbable plate reconstruction outcomes for medial orbital wall fractures are not well-established. The role of muscle cone integrity on computed tomography (CT) has not been…

View details →DOI: 10.1016/j.joms.2026.04.022
Negative / Null Result ReportOpen accessMedicine

The effect of <i>Lactiplantibacillus plantarum</i> probiotic supplement on rainbow trout challenged with <i>Aeromonas salmonicida</i>.

Mikulikova I, Lepkova Z, Bandouchova H et al. · 2026 · Veterinarni medicina

Two probiotic ( Lactiplantibacillus plantarum ) supplementation strategies (continuous and cyclic) were evaluated for their ability to enhance resistance of rainbow trout ( Oncorhynchus mykiss ) to Aeromonas salmonicida infection. Neither…

View details →DOI: 10.17221/101/2025-vetmed
Negative / Null Result ReportMedicine

[Efficacy of photodynamic therapy in extrahepatic cholangiocarcinoma].

Chen C, Liu HC, Wang RF et al. · 2026 · Zhonghua wai ke za zhi [Chinese journal of surgery]

Objective: To investigate the safety and efficacy of photodynamic therapy(PDT) combined with biliary stent implantation in the treatment of extrahepatic cholangiocarcinoma. Methods: A retrospective cohort analysis was conducted based on…

View details →DOI: 10.3760/cma.j.cn112139-20251104-00519
Negative / Null Result ReportOpen accessMedicine

Finite element analysis of the pedicle screw in lumbar transpedicular dynamic stabilization that penetrates the lateral cortex of the vertebral pedicle.

Zhao C, Zhang M, Li P et al. · 2026 · BMC musculoskeletal disorders

BACKGROUND: The mechanical stability of lumbar transpedicular dynamic stabilization (LTDS) was determined by simulating the degree to which the pedicle screws penetrated the lateral pedicle cortex. METHODS: A finite element model of the…

View details →DOI: 10.1186/s12891-026-09701-4
Negative / Null Result ReportMedicine

Preoperative radiotherapy negatively affects early hypertrophy but has no effect on graft survival and union in patients treated with vascularized fibular grafts for bone tumors.

Bayram S, Atasoy İT, Salduz A et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Preoperative radiotherapy may impair bone healing and remodeling after wide resection and reconstruction using vascularized fibular grafts for bone tumors. This study evaluated whether preoperative radiotherapy affected union,…

View details →DOI: 10.1016/j.jos.2026.05.004
Negative / Null Result ReportOpen accessMedicine

Axial Length Asymmetry in Patients with Unilateral Retinal Detachment.

Wang H, Loke JY, Chan WO et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Increased axial length is a major risk factor for retinal detachment. This study explored whether, in individuals presenting with unilateral disease, the longer eye was more likely to have rhegmatogenous disease.…

View details →DOI: 10.3390/medicina62030514
Negative / Null Result ReportMedicine

Cold-knife conization versus loop electrosurgical excision for cervical adenocarcinoma in situ: a retrospective cohort study.

Abudurehemu S, Wang X, Wang J et al. · 2026 · BMC women's health

Objective The purpose of this study was to compare the efficacy of cold-knife conization (CKC) and loop electrosurgical excision procedure (LEEP) in treating cervical adenocarcinoma in situ (AIS) and identify relevant risk factors within a…

View details →DOI: 10.1186/s12905-026-04540-w
Negative / Null Result ReportOpen accessMedicine

Dexmedetomidine and Apigenin Combination Mitigates Memory Deficits Caused by Microglial Activation and Hippocampal Neurogenesis Impairment in Methotrexate-Induced Chemo-Brain in Rats.

Yousef EM, Eldemerdash OM, Senousy MA et al. · 2026 · Neural plasticity

Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, and apigenin (Api), a naturally occurring bioflavonoid, have recently shown neuroprotective effects in experimental models of methotrexate (MTX)-induced neurotoxicity; however, the…

View details →DOI: 10.1155/np/9434180
Negative / Null Result ReportOpen accessMedicine

Can Lactate Values Predict Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery? A Prospective Observational Study.

Temiztürk Z, Beyazal OF, Topçu AC et al. · 2026 · Brazilian journal of cardiovascular surgery

Introduction The aim of our study is to investigate the relationship and predictive significance of routinely measured serum lactate values with postoperative atrial fibrillation (POAF) in patients following isolated coronary artery bypass…

View details →DOI: 10.21470/1678-9741-2024-0440
Negative / Null Result ReportMedicine

Computed tomography based distal femoral morphology and comparative multi-implant total knee replacement fit analysis in a South East London population.

Eveson TE, Davis TP, Tindall AJ · 2026 · Journal of orthopaedics

Background Accurate medio-lateral sizing of the distal femur during total knee replacement (TKR) is essential to optimise implant fit and avoid over- or under-hang, which have been associated with suboptimal outcomes. National guidance…

View details →DOI: 10.1016/j.jor.2026.04.018
Negative / Null Result ReportOpen accessMedicine

Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.

Hu Z, Ma R, Wen Y et al. · 2026 · Cancer medicine

Background The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0…

View details →DOI: 10.1002/cam4.71555
Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

View details →DOI: 10.1007/s00784-026-06847-2
Negative / Null Result ReportOpen accessMedicine

Clinical characteristics and prognostic differences between elderly-onset and adult-onset ulcerative colitis: a two-center retrospective cohort study.

Li H, Ding S, Li J et al. · 2026 · Frontiers in medicine

Background The incidence of elderly-onset ulcerative colitis (EO-UC) has been gradually increasing. The unique characteristics of clinical manifestations, therapeutic strategies, and prognosis in EO-UC patients compared with adult-onset…

View details →DOI: 10.3389/fmed.2026.1847513
Negative / Null Result ReportMedicine

[Mechanism of vitamin K2 in modulating matrix Gla protein to inhibit tumor growth in inflammation-associated colorectal cancer model mice].

Zhang HM, Wu MX, Wang HY et al. · 2026 · Zhonghua yi xue za zhi

Objective: To explore the mechanism of vitamin K2 (VitK2) regulating matrix Gla protein (MGP) in inhibiting tumor growth in inflammation-associated colorectal cancer (CAC) model mice. Methods: Twenty-six C57BL/6 male mice, 6-8 weeks old…

View details →DOI: 10.3760/cma.j.cn112137-20250708-01661
Negative / Null Result ReportOpen accessMedicine

Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.

Pusdekar VP, Dare G, Bhojwani P et al. · 2026 · Turkish journal of surgery

Objective Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen…

View details →DOI: 10.47717/turkjsurg.2026.2025-9-30
Negative / Null Result ReportMedicine

The effects of repetitive transcranial magnetic stimulation over the lateral parietal region on episodic future thinking and episodic memory.

Toufexis C, Grant JB, van Boxtel JJA et al. · 2026 · Consciousness and cognition

The left angular gyrus (AG) has been implicated in the level of detail elicited during both episodic memory (EM) and episodic future thinking (EFT). This study aimed to investigate whether repetitive transcranial magnetic stimulation…

View details →DOI: 10.1016/j.concog.2026.104070
Negative / Null Result ReportOpen accessMedicine

Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferroptosis?

Brzóska K, Carpenter AD, Petrus SA et al. · 2026 · International journal of molecular sciences

Gamma-tocotrienol (GT3) is one of the constituents of vitamin E that demonstrated significant radioprotective efficacy in murine and nonhuman primate (NHP) models. Considering the antioxidant activity of GT3 and its role in terminating…

View details →DOI: 10.3390/ijms27083387
Negative / Null Result ReportOpen accessMedicine

Robotic-assisted <i>versus</i> laparoscopic cholecystectomy: a matched study in pediatric cases at a single center.

Ha S, Kwon H, Namgoong JM et al. · 2026 · Annals of surgical treatment and research

Purpose In the past decade, advancements in robotic surgery have significantly expanded its application into diverse fields, including urological, gastrointestinal, hepatobiliary, and gynecological procedures. However, comparative outcome…

View details →DOI: 10.4174/astr.2026.110.3.188
Methods Dead-EndMedicine

A novel engineered vector for TA cloning of PCR products.

Samiei A, Najafabadi ZH, Akbari N et al. · 2026 · Journal of applied genetics

INTRODUCTION: Optimized vectors are crucial in modern molecular biology because they greatly enhance the efficiency of the DNA cloning procedure. This study aimed to design a novel engineered vector containing an HphI cassette to enhance…

View details →DOI: 10.1007/s13353-026-01050-1
Methods Dead-EndOpen accessMedicine

Comparison of Three Behavior Modification Techniques for Management of Anxious Pediatric Dental Patients Aged 4-6 Years during Cavity Preparation Using Airotor: A Randomized Controlled Trial.

Safoora AK, Vadakkepurayil K, Santhakumar M · 2026 · International journal of clinical pediatric dentistry

Background and objectives Dental anxiety is frequently observed in children and often poses a significant challenge to providing effective and high-quality dental care. Managing a child's anxiety in the clinical setting is a critical…

View details →DOI: 10.5005/jp-journals-10005-3475