A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Yngvar Krukhaug, Stein Atle Lie, Leif I Havelin et al. · 2014 · Journal of Hand Surgery (European Volume)
In this study we report the results of thumb carpometacarpal (CMC) joint replacements in the Norwegian population over a 17-year period. In total, 479 primary replacements performed from 1994 to 2011 were identified in the Norwegian…
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty et al. · 2019 · PLoS ONE
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8+ T cells from cancer cells, upregulation of immune checkpoint ligand expression, immunosuppressive cytokine production, and polarization of tumor infiltrating inflammatory cells. FAP is a post-proline peptidase selectively expressed during tissue remodeling and repair, such as with wound healing, and in the tumor
Yi‐Hsuan Huang, Meei‐Shyuan Lee, Yu-Sheng Lou et al. · 2019 · PLoS ONE
BACKGROUND: Breast cancer is the most common cancer in women and several perioperative factors may account for tumor recurrence and metastasis. The anesthetic agents employed during cancer surgery might play a crucial role in cancer cell survival and patient outcomes. We conducted a retrospective cohort study to investigate the relationship between the type of anesthesia and overall survival in patients who underwent breast cancer surgery performed by one experienced surgeon. METHODS: All patients who underwent breast cancer surgery by an experienced surgeon between January 2006 and December 2
Haixia Xie, LU Jin-fang, Ying Zhou et al. · 2015 · Infection and Immunity
Edwardsiella tarda is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish and gastro- and extraintestinal infections in humans. The type III secretion system (T3SS) of E. tarda has been identified as a key virulence…
Donald C. Hood, Emmanouil Tsamis, Nikhil Bommakanti et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods: Wide-field spectral-domain OCT scans, including the disc and macula, and 24-2 and 10-2 VFs were obtained from 45 healthy control (H) eyes/individuals, and 53 eyes/patients with 24-2 mean deviation (MD) better than -6 dB diagnosed as "definite glaucoma" (DG) by experts. Abnormal structure-abnormal function (aS-aF) agreement was assessed with
David F. Feldon, Soojeong Jeong, James Peugh et al. · 2017 · Proceedings of the National Academy of Sciences
Many PhD programs incorporate boot camps and summer bridge programs to accelerate the development of doctoral students' research skills and acculturation into their respective disciplines. These brief, high-intensity experiences span no…
Jessica D. Petersen, Stephen Reiners, Brian A. Nault · 2013 · PLoS ONE
Pollinators provide an important service in many crops. Managed honey bees (Apis mellifera L.) are used to supplement pollination services provided by wild bees with the assumption that they will enhance pollination, fruit set and crop yield beyond the levels provided by the wild bees. Recent declines in managed honey bee populations have stimulated interest in finding alternative managed pollinators to service crops. In the eastern U.S., managed hives of the native common eastern bumble bee (Bombus impatiens Cresson) may be an excellent choice. To examine this issue, a comprehensive 2-yr stud
Qiang Wang, Claudia Wekerle, Sergey Danilov et al. · 2018 · Journal of Climate
Abstract The freshwater stored in the Arctic Ocean is an important component of the global climate system. Currently the Arctic liquid freshwater content (FWC) has reached a record high since the beginning of the last century. In this…
Duncan Murdock, Sarah E. Gabbott, Georg Mayer et al. · 2014 · BMC Evolutionary Biology
BACKGROUND: Fossil lobopodians, including animals proposed to have close affinity to modern onychophorans, are crucial to understanding the evolution of the panarthropod body plan and the phylum-level relationships between the ecdysozoan groups. Unfortunately, the key features of their anatomy are un-mineralized and subject to biases introduced during death, decay and preservation, yet the extent to which these fossils have been affected by the processes of post-mortem decay is entirely untested. Recent experimental work on chordates has highlighted a profound bias caused by decay, resulting i
Nahdiya Zainal Abidin, Mohd Bakri Adam · 2013 · PubMed
BACKGROUND: Vertical jump is an index representing leg/kick power. The explosive movement of the kick is the key to scoring in martial arts competitions. It is important to determine factors that influence the vertical jump to help…
Athula Naranpanawa · 2011 · Griffith Research Online (Griffith University, Queensland, Australia)
Abstract: The link between trade openness and environmental quality has become one of the most debated topics in recent years. Yet, limited empirical investigations have been carried out in this area. This paper examines the relationship…
P T W Kim, Alice C. Wei, Eshetu G. Atenafu et al. · 2013 · British journal of surgery
BACKGROUND: The management of portal vein (PV) involvement by pancreatic adenocarcinoma during pancreaticoduodenectomy (PD) is controversial. The aim of this study was to compare the outcomes of unplanned and planned PV resections as part…
Constantine Mavroudis, Tiffany S. Ko, Ryan W. Morgan et al. · 2020 · Critical Care
BACKGROUND: Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. The primary objectives of this study were to determine if (1) epinephrine doses have a significant acute effect on CBF and cerebral tissue oxygenation during CPR and (2) if the effect of each
Matthias Reeh, Michael F. Nentwich, Dean Bogoevski et al. · 2011 · World Journal of Surgery
BACKGROUND: High surgical morbidity following distal pancreatectomy, especially pancreatic fistula, remains an unsolved problem. The aim of this study was to identify potential risk factors for surgical morbidity with a focus on the…
Benjamin J. Lee, Chi‐yuan Hsu, Rishi Parikh et al. · 2019 · Kidney International Reports
INTRODUCTION: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma. METHODS: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Candidate predictors included demographic characteristics, comorbidities, laboratory values, and medication use. We used logist
Patricia O'Campo, Vicky Stergiopoulos, Pam Nir et al. · 2016 · BMJ Open
Objectives We studied the impact of a Housing First (HF) intervention on housing, contact with the justice system, healthcare usage and health outcomes among At Home/Chez Soi randomised trial participants in Toronto, a city with an…
Kaihui Li, Yanming Gong, Wei Song et al. · 2012 · Global Change Biology
Abstract A recent study (Wolf et al ., 2010) suggests that short—lived pulses of N 2 O emission during spring thaw dominate the annual N 2 O budget and that grazing decreases N 2 O emissions during the spring thaw. To verify this we…
Brett Roberts, Aristotelis Antonopoulos, Stuart M. Haslam et al. · 2013 · Veterinary Research
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. However, recombinant forms of these proteins have failed to replicate this protection. This is thought to be due to differences in glycosylation and/or conformation between native and recombinant proteins. We have exploited the free-living nematode Caenorhabditis elegans to examine its suitability as an alternative system for recombinant expression of parasit
Dóra Kampis, Petra Karman, Gergely Csibra et al. · 2021 · Royal Society Open Science
, 587-592. (doi:10.1111/j.1467-9280.2007.01944.x)) has been widely cited as evidence for false-belief attribution in young children. Recent replication attempts of this paradigm have yielded mixed results: several studies did not replicate the original findings, raising doubts about the suitability of the paradigm to assess non-verbal action prediction and Theory of Mind. In a preregistered collaborative study including two of the original authors, we tested one hundred and sixty 24- to 26-month-olds across two locations using the original stimuli, procedure and analyses as closely as possible
J. Suzuki, Tomoki Horie, Yoshiyuki Inoue et al. · 2015 · Journal of Cosmology and Astroparticle Physics
A search for hidden photon cold dark matter (HP CDM) using a new technique with a dish antenna is reported. From the result of the measurement, we found no evidence for the existence of HP CDM and set an upper limit on the photon-HP mixing parameter $\chi$ of $\sim 6\times 10^{-12}$ for the hidden photon mass $m_\gamma = 3.1 \pm 1.2$ eV.
Cheng-Shiun He, Xin Hui Aw Yong, Neil P. Walsh et al. · 2026 · PubMed
Vitamin D is mainly obtained through sunlight ultraviolet-B (UVB) exposure of the skin, with a small amount typically coming from the diet.It is now clear that vitamin D has important roles beyond its well-known effects on calcium and bone…
Elvis Dze Achuo, Simplice Asongu, Vanessa S. Tchamyou · 2026 · Climatic Change
Abstract This study examines whether and how women’s socioeconomic empowerment affects environmental quality in African countries using the system Generalised Method of Moments. The empirical findings show that environmental sustainability is associated with the socioeconomic empowerment of women. The result remains robust when controlled for women’s political inclusion and female labour force participation. The results equally show that foreign direct investment (FDI) and gross domestic product (GDP) moderate the positive influence of the socioeconomic empowerment of women on greenhouse gas (
Michihiro Kon, Fuminori Kimura, Takayuki Akimoto et al. · 2026 · PubMed
AIM: We aimed to examine the effect of Coenzyme Q10 (CoQ10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver. METHODS: Rats were divided into four groups: rest group [control…
Siddharth Chandra, Goran Kuljanin, Jennifer M. Wray · 2012 · Demography
Estimates of worldwide mortality from the influenza pandemic of 1918-1919 vary widely, from 15 million to 100 million. In terms of loss of life, India was the focal point of this profound demographic event. In this article, we calculate…
Abdulrahman M. El‐Sayed, Lars Seemann, Peter Scarborough et al. · 2013 · American Journal of Epidemiology
Recent research suggests that social networks may present an avenue for intervention against obesity. By using a simulation model in which artificial individuals were nested in a social network, we assessed whether interventions targeting…
Hanna K. Frost, Tomas Andersson, Sebastian Johansson et al. · 2018 · Scientific Reports
Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). For control, we compared to hollow silicone tubes; or autologous nerve grafts. PCL nerve guides had
Andrew C. Chang, Phillip Li · 2017 · American Economic Review
We attempted to replicate 67 macroeconomic papers using author-provided data and code files by following a preanalysis plan. Excluding 6 papers that used confidential data, we obtained data and code replication files for 29 of 35 papers…
Akifumi Takada, Takayuki Miki, Atsushi Kuno et al. · 2012 · PLoS ONE
BACKGROUND: Diabetes mellitus (DM) is associated with an increased risk of ischemic heart disease and of adverse outcomes following myocardial infarction (MI). Here we assessed the role of endoplasmic reticulum (ER) stress in ventricular dysfunction and outcomes after MI in type 2 DM (T2DM). METHODOLOGY AND PRINCIPAL FINDINGS: In hearts of OLETF, a rat model of T2DM, at 25∼30 weeks of age, GRP78 and GRP94, markers of ER stress, were increased and sarcoplasmic reticulum calcium ATPase (SERCA)2a protein was reduced by 35% compared with those in LETO, a non-diabetic control. SERCA2a mRNA levels w
Weiyi Guo, Li Zhu, Sijun Meng et al. · 2017 · Journal of the American Society of Nephrology
IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of…
Sedigheh Asgary, Mahtab Keshvari, Amirhossein Sahebkar et al. · 2013 · PubMed
BACKGROUND: Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers…