Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans
Brett Roberts; Aristotelis Antonopoulos; Stuart M. Haslam; Alison Dicker; Tom N. McNeilly; Stephanie L Johnston; Anne Dell; David P. Knox · 2013 · Veterinary Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, recombinant forms of these proteins have failed to replicate this protection.”
Abstract
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. However, recombinant forms of these proteins have failed to replicate this protection. This is thought to be due to differences in glycosylation and/or conformation between native and recombinant proteins. We have exploited the free-living nematode Caenorhabditis elegans to examine its suitability as an alternative system for recombinant expression of parasit
Abstract by Brett Roberts; Aristotelis Antonopoulos; Stuart M. Haslam; Alison Dicker; Tom N. McNeilly; Stephanie L Johnston; Anne Dell; David P. Knox, Veterinary Research (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1297-9716-44-111