Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo
Hanna K. Frost; Tomas Andersson; Sebastian Johansson; Ulrica Englund-Johansson; Per Ekström; Lars B. Dahlin; Fredrik Johansson · 2018 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). For control, we compared to hollow silicone tubes; or autologous nerve grafts. PCL nerve guides had
Abstract by Hanna K. Frost; Tomas Andersson; Sebastian Johansson; Ulrica Englund-Johansson; Per Ekström; Lars B. Dahlin; Fredrik Johansson, Scientific Reports (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-018-34699-8