Role of ER Stress in Ventricular Contractile Dysfunction in Type 2 Diabetes
Akifumi Takada; Takayuki Miki; Atsushi Kuno; Hidemichi Kouzu; Daisuke Sunaga; Takahito Itoh; Masaya Tanno; Toshiyuki Yano · 2012 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Diabetes mellitus (DM) is associated with an increased risk of ischemic heart disease and of adverse outcomes following myocardial infarction (MI). Here we assessed the role of endoplasmic reticulum (ER) stress in ventricular dysfunction and outcomes after MI in type 2 DM (T2DM). METHODOLOGY AND PRINCIPAL FINDINGS: In hearts of OLETF, a rat model of T2DM, at 25∼30 weeks of age, GRP78 and GRP94, markers of ER stress, were increased and sarcoplasmic reticulum calcium ATPase (SERCA)2a protein was reduced by 35% compared with those in LETO, a non-diabetic control. SERCA2a mRNA levels w
Abstract by Akifumi Takada; Takayuki Miki; Atsushi Kuno; Hidemichi Kouzu; Daisuke Sunaga; Takahito Itoh; Masaya Tanno; Toshiyuki Yano, PLoS ONE (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0039893