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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21368 results · page 648 of 713

Negative / Null Result ReportOpen accessMedicine

Instructing participants about the random assignment of patients to treated and non-treated conditions does not diminish causal illusions.

Barreiro A, Rodríguez-Ferreiro J, Barberia I · 2025 · Royal Society open science

People sometimes perceive causal relationships between non-contingent events. When having to assess the contingency between a putative cause and an outcome, it is vital to ensure that all other causal forces are held constant whether the…

View details →DOI: 10.1098/rsos.251004
Negative / Null Result ReportOpen accessMedicine

Risk Factors for Endoscopic Gastric Mucosal Lesions: Analysis of Lifestyle, Dietary, and Clinical Determinants in 361 Patients.

Chiciudean PL, Filip AM, Munteanu SN et al. · 2025 · Life (Basel, Switzerland)

Background/objectives Gastric mucosal lesions represent a significant health burden, with Helicobacter pylori infection being the primary cause of chronic gastritis worldwide. However, the role of modifiable lifestyle factors in modulating…

View details →DOI: 10.3390/life15091474
Negative / Null Result ReportOpen accessMedicine

Tipping the scale: Effects of physical activity and body composition on cardiac parameters in postmenopausal females.

Fischer M, Tamariz-Ellemann A, Egelund J et al. · 2024 · Physiological reports

The risk of cardiovascular disease increases significantly after menopause. We sought to assess the impact of different activity levels on cardiac structure and function in postmenopausal women. We grouped age-similar, postmenopausal women…

View details →DOI: 10.14814/phy2.70144
Negative / Null Result ReportMedicine

The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.

Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity

Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…

View details →DOI: 10.1016/j.bbi.2024.03.016
Negative / Null Result ReportMedicine

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…

View details →DOI: 10.1152/japplphysiol.00052.2026
Negative / Null Result ReportMedicine

Light exposure impact on cardiac autonomic control before and following exercise.

Marin TC, Oliveira GF, Azevêdo LM et al. · 2025 · Chronobiology international

We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL…

View details →DOI: 10.1080/07420528.2025.2556841
Negative / Null Result Report

Brain Glutathione and GABA+ levels in autistic children

Song Y, Hupfeld KE, Davies-Jenkins CW et al. · 2023 · Preprint

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA),…

View details →DOI: 10.1101/2023.09.28.559718
Negative / Null Result ReportMedicine

Tell Me about yourself: Analyzing self-referential language use in borderline personality disorder.

Welch JE, Luo W, Ambroise KJ et al. · 2024 · Journal of psychiatric research

Depression and some other illnesses are associated with increased self-reference and negative emotion in language. Research findings on lexical patterns in Borderline Personality Disorder (BPD) have been inconsistent. We conducted two…

View details →DOI: 10.1016/j.jpsychires.2024.11.011
Negative / Null Result ReportMedicine

The Contemporary Probability of Occult Colorectal Cancer in Patients With Colitis-Related Dysplasia Undergoing Colectomy.

Boparai ES, Lee JK, Zhu S et al. · 2023 · The American journal of gastroenterology

Occult colorectal cancer (CRC) has historically driven recommendations for colectomy in patients with inflammatory bowel disease with dysplasia . We defined the contemporary risk of occult CRC at colectomy among 93 patients with…

View details →DOI: 10.14309/ajg.0000000000002291
Negative / Null Result ReportOpen accessMedicine

Effect of Ramp Lesions on Outcomes After Anterior Cruciate Ligament Reconstruction.

Ishibashi HK, Sasaki E, Chiba D et al. · 2025 · Orthopaedic journal of sports medicine

Background Ramp lesions (RLs) associated with anterior cruciate ligament (ACL) injury increase knee instability. However, whether RLs should be treated surgically remains unclear. Purpose/hypothesis This study aimed to investigate the…

View details →DOI: 10.1177/23259671241308015
Negative / Null Result ReportOpen accessMedicine

Participants with restricted dominant shoulder internal rotation range of motion demonstrate no side-to-side difference in humeral head translation; and no difference before and after joint mobilization: a pilot study.

Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science

[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…

View details →DOI: 10.1589/jpts.36.259
Negative / Null Result ReportOpen accessMedicine

Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.

Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience

Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…

View details →DOI: 10.3389/fnhum.2025.1516721
Negative / Null Result ReportMedicine

The liver-heart axis in patients with severe obesity: The association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease.

Young J, Seeberg KA, Aakre KM et al. · 2024 · Clinical biochemistry

Background Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would be predictive of…

View details →DOI: 10.1016/j.clinbiochem.2023.110688
Negative / Null Result Report

Feeding ecology of the obligate urchin symbiont Dactylopleustes yoshimurai (Crustacea: Amphipoda: Pleustidae) revealed by DNA metabarcoding analysis.

Kodama M, Yamazaki R, Hayakawa J et al. · 2023 · Preprint

Abstract Symbiosis includes commensalism, mutualism, and parasitism, however in many symbiotic relationships, it is difficult to determine which type they are in. Since trophic-linkage is a necessary factor to determine this, data on…

View details →DOI: 10.21203/rs.3.rs-2655652/v1
Negative / Null Result Report

Effects of voluntary orienting of attention on temporal estimation

Ranzini M, Romeo Z, Zorzi M et al. · 2023 · Preprint

Exogenous orienting of attention can affect the mental processing of time, suggesting the existence of a spatial representation for temporal durations, with shorter and longer durations represented on the left and on the right of a mental…

View details →DOI: 10.21203/rs.3.rs-2556334/v1
Negative / Null Result ReportOpen accessMedicine

Re-evaluating heart rate variability biomarkers for glucose sensing: the impact of age normalisation and subject-independent validation.

Azam MB, Singh SI · 2026 · BMC medical informatics and decision making

Background Heart rate variability (HRV) derived from electrocardiogram (ECG) signals offers a promising non-invasive window into glycemic status; however, existing studies frequently combine distinct glucose measurements and employ…

View details →DOI: 10.1186/s12911-026-03455-8
Negative / Null Result ReportMedicine

Salsalate negatively impacts microvascular function in women with endometriosis.

Williams AC, Content VG, Alexander LM · 2025 · American journal of physiology. Heart and circulatory physiology

Women with endometriosis, an inflammatory disease, are at increased risk of cardiovascular disease and demonstrate impaired microvascular endothelial function, characterized by reduced nitric oxide (NO)-mediated vasodilation. In some…

View details →DOI: 10.1152/ajpheart.00012.2025
Negative / Null Result ReportOpen accessMedicine

Relationship between survival outcomes in patients with colorectal liver metastasis undergoing hepatectomy and significance of fibrotic markers for liver injury assessment.

Nanashima A, Hiyoshi M, Imamura N et al. · 2025 · Translational cancer research

Background Progression of chronic liver dysfunction influenced by long-term chemotherapy or repeated hepatectomy might be related to patient overall survival as well as tumor factors in colorectal liver metastasis (CLM) patients. Our aim…

View details →DOI: 10.21037/tcr-24-1138
Negative / Null Result ReportMedicine

Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression.

Chida K, Oshi M, Roy AM et al. · 2024 · Breast cancer research and treatment

Purpose While comprehensive research exists on the mutation of the DNA repair gene BRCA1, limited information is available regarding the clinical significance of BRCA1 gene expression. Given that cancer cell proliferation is aggrevated by…

View details →DOI: 10.1007/s10549-024-07421-8
Negative / Null Result ReportOpen accessMedicine

Differences in firing patterns along the dorsal-intermediate hippocampal axis in a fixed route during a change in emotional context.

Troha R, Lee SLT, Anam M et al. · 2025 · Frontiers in systems neuroscience

The hippocampus plays a prominent role in spatial navigation and memory. However, differences exist along the hippocampus longitudinal axis in function and connectivity. The current study focuses on the dorsal and intermediate subregions…

View details →DOI: 10.3389/fnsys.2025.1632849
Negative / Null Result ReportOpen accessMedicine

No effects of respiratory muscle endurance exercises on postprandial glucose excursions.

Beltrami FG, Mullarkey J, Spengler CM · 2026 · Frontiers in sports and active living

Introduction Whole-body exercise can attenuate postprandial glucose (PPG) excursions, one of the three main components in glucose control. Respiratory muscle endurance exercises (RMEE) based on resisted hyperpnea could offer an alternative…

View details →DOI: 10.3389/fspor.2026.1831908
Negative / Null Result ReportOpen accessMedicine

Parental political engagement and self-efficacy: An exploratory study.

Randolph C, Needlman R, Hutchinson E · 2024 · American journal of community psychology

Political engagement (PE) is associated with a sense of empowerment. PE by parents affects children's lives. This study explored parents' attitudes about inclusion of political engagement discussion in well-child care. Because voting is an…

View details →DOI: 10.1002/ajcp.12761
Negative / Null Result ReportMedicine

Patterns of Symptom Change in Behaviors and Cognitions During 10-Session Cognitive Behavioral Therapy (CBT-T) for Non-Underweight Eating Disorders.

Kambanis PE, Graver H, Palmer LP et al. · 2025 · The International journal of eating disorders

Objective Little is known about the timing of behavioral versus cognitive change in 10-session cognitive-behavioral therapy for non-underweight eating disorders (CBT-T). We aimed to: (a) evaluate the magnitude of behavioral and cognitive…

View details →DOI: 10.1002/eat.24429
Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

View details →DOI: 10.1016/j.mbplus.2025.100181
Negative / Null Result ReportMedicine

Rete ridges are decreased in dyschromic burn hypertrophic scar: A histological study.

Carney BC, Travis TE, Keyloun JW et al. · 2024 · Burns : journal of the International Society for Burn Injuries

Dyschromic hypertrophic scar (HTS) is a common sequelae of burn injury, however, its mechanism has not been elucidated. This work is a histological study of these scars with a focus on rete ridges. Rete ridges are important for normal skin…

View details →DOI: 10.1016/j.burns.2023.09.005