Polymorphism analysis of estrogen receptor β Gene RsaI and AluI in girls with idiopathic central precocious puberty: investigating the relationship and implications for early risk prediction
Peipei Liu; Guoqing Dong; Mingzhu Li; Miao Huang; Xiyan Lu; Jianxu Li · 2026 · Frontiers in Endocrinology
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Abstract
ObjectiveTo investigate the association between estrogen receptor β (ERβ) gene RsaI (rs1256049) and AluI (rs4986938) polymorphisms and the risk of idiopathic central precocious puberty (ICPP) in girls, and to provide potential molecular genetic references for early risk prediction and individualized management of ICPP.MethodsA total of 100 girls with ICPP from the Pediatric Endocrinology Clinic and Inpatient Ward of Shenzhen Maternity & Child Healthcare Hospital were enrolled, and 100 agematched healthy girls undergoing routine physical examinations during the same period served as controls. T
Abstract by Peipei Liu; Guoqing Dong; Mingzhu Li; Miao Huang; Xiyan Lu; Jianxu Li, Frontiers in Endocrinology (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fendo.2026.1809152