Immunohistochemical Expression of Programmed Death-Ligand 1 Associated with Human Papillomavirus-Driven High-Grade Cervical Intraepithelial Neoplasia in South African Women
Jessica McIntyre; Rahaba Marima; Babatunde Alabi; Gopika Ramkilawon; Benny Mosoane · 2026 · Onco
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Background: Cervical cancer is the second most prevalent malignancy among South African women, with high-risk human papillomavirus (HPV) infection as a critical risk factor. HPV plays a central role in cervical carcinogenesis, particularly in high-grade squamous intraepithelial lesions (HSIL). Increased programmed death ligand 1 (PD-L1) expression has been implicated in cervical carcinoma tumorigenesis. Using immunohistochemistry, this study investigated the correlation between high-risk HPV-driven cervical intraepithelial neoplasia (CIN) and PD-L1 expression. Methods: An analytical cross-sect
Abstract by Jessica McIntyre; Rahaba Marima; Babatunde Alabi; Gopika Ramkilawon; Benny Mosoane, Onco (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/onco6010014