A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 63 of 660
Matthias Reeh, Michael F. Nentwich, Dean Bogoevski et al. · 2011 · World Journal of Surgery
BACKGROUND: High surgical morbidity following distal pancreatectomy, especially pancreatic fistula, remains an unsolved problem. The aim of this study was to identify potential risk factors for surgical morbidity with a focus on the…
P T W Kim, Alice C. Wei, Eshetu G. Atenafu et al. · 2013 · British journal of surgery
BACKGROUND: The management of portal vein (PV) involvement by pancreatic adenocarcinoma during pancreaticoduodenectomy (PD) is controversial. The aim of this study was to compare the outcomes of unplanned and planned PV resections as part…
Benjamin J. Lee, Chi‐yuan Hsu, Rishi Parikh et al. · 2019 · Kidney International Reports
INTRODUCTION: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma. METHODS: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Candidate predictors included demographic characteristics, comorbidities, laboratory values, and medication use. We used logist
Qiang Wang, Claudia Wekerle, Sergey Danilov et al. · 2018 · Journal of Climate
Abstract The freshwater stored in the Arctic Ocean is an important component of the global climate system. Currently the Arctic liquid freshwater content (FWC) has reached a record high since the beginning of the last century. In this…
Nahdiya Zainal Abidin, Mohd Bakri Adam · 2013 · PubMed
BACKGROUND: Vertical jump is an index representing leg/kick power. The explosive movement of the kick is the key to scoring in martial arts competitions. It is important to determine factors that influence the vertical jump to help…
Jessica D. Petersen, Stephen Reiners, Brian A. Nault · 2013 · PLoS ONE
Pollinators provide an important service in many crops. Managed honey bees (Apis mellifera L.) are used to supplement pollination services provided by wild bees with the assumption that they will enhance pollination, fruit set and crop yield beyond the levels provided by the wild bees. Recent declines in managed honey bee populations have stimulated interest in finding alternative managed pollinators to service crops. In the eastern U.S., managed hives of the native common eastern bumble bee (Bombus impatiens Cresson) may be an excellent choice. To examine this issue, a comprehensive 2-yr stud
Duncan Murdock, Sarah E. Gabbott, Georg Mayer et al. · 2014 · BMC Evolutionary Biology
BACKGROUND: Fossil lobopodians, including animals proposed to have close affinity to modern onychophorans, are crucial to understanding the evolution of the panarthropod body plan and the phylum-level relationships between the ecdysozoan groups. Unfortunately, the key features of their anatomy are un-mineralized and subject to biases introduced during death, decay and preservation, yet the extent to which these fossils have been affected by the processes of post-mortem decay is entirely untested. Recent experimental work on chordates has highlighted a profound bias caused by decay, resulting i
Athula Naranpanawa · 2011 · Griffith Research Online (Griffith University, Queensland, Australia)
Abstract: The link between trade openness and environmental quality has become one of the most debated topics in recent years. Yet, limited empirical investigations have been carried out in this area. This paper examines the relationship…
Kaihui Li, Yanming Gong, Wei Song et al. · 2012 · Global Change Biology
Abstract A recent study (Wolf et al ., 2010) suggests that short—lived pulses of N 2 O emission during spring thaw dominate the annual N 2 O budget and that grazing decreases N 2 O emissions during the spring thaw. To verify this we…
Patricia O'Campo, Vicky Stergiopoulos, Pam Nir et al. · 2016 · BMJ Open
Objectives We studied the impact of a Housing First (HF) intervention on housing, contact with the justice system, healthcare usage and health outcomes among At Home/Chez Soi randomised trial participants in Toronto, a city with an…
J. Suzuki, Tomoki Horie, Yoshiyuki Inoue et al. · 2015 · Journal of Cosmology and Astroparticle Physics
A search for hidden photon cold dark matter (HP CDM) using a new technique with a dish antenna is reported. From the result of the measurement, we found no evidence for the existence of HP CDM and set an upper limit on the photon-HP mixing parameter $\chi$ of $\sim 6\times 10^{-12}$ for the hidden photon mass $m_\gamma = 3.1 \pm 1.2$ eV.
Brett Roberts, Aristotelis Antonopoulos, Stuart M. Haslam et al. · 2013 · Veterinary Research
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. However, recombinant forms of these proteins have failed to replicate this protection. This is thought to be due to differences in glycosylation and/or conformation between native and recombinant proteins. We have exploited the free-living nematode Caenorhabditis elegans to examine its suitability as an alternative system for recombinant expression of parasit
Cheng-Shiun He, Xin Hui Aw Yong, Neil P. Walsh et al. · 2026 · PubMed
Vitamin D is mainly obtained through sunlight ultraviolet-B (UVB) exposure of the skin, with a small amount typically coming from the diet.It is now clear that vitamin D has important roles beyond its well-known effects on calcium and bone…
Michihiro Kon, Fuminori Kimura, Takayuki Akimoto et al. · 2026 · PubMed
AIM: We aimed to examine the effect of Coenzyme Q10 (CoQ10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver. METHODS: Rats were divided into four groups: rest group [control…
Abdulrahman M. El‐Sayed, Lars Seemann, Peter Scarborough et al. · 2013 · American Journal of Epidemiology
Recent research suggests that social networks may present an avenue for intervention against obesity. By using a simulation model in which artificial individuals were nested in a social network, we assessed whether interventions targeting…
Hanna K. Frost, Tomas Andersson, Sebastian Johansson et al. · 2018 · Scientific Reports
Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). For control, we compared to hollow silicone tubes; or autologous nerve grafts. PCL nerve guides had
Andrew C. Chang, Phillip Li · 2017 · American Economic Review
We attempted to replicate 67 macroeconomic papers using author-provided data and code files by following a preanalysis plan. Excluding 6 papers that used confidential data, we obtained data and code replication files for 29 of 35 papers…
Akifumi Takada, Takayuki Miki, Atsushi Kuno et al. · 2012 · PLoS ONE
BACKGROUND: Diabetes mellitus (DM) is associated with an increased risk of ischemic heart disease and of adverse outcomes following myocardial infarction (MI). Here we assessed the role of endoplasmic reticulum (ER) stress in ventricular dysfunction and outcomes after MI in type 2 DM (T2DM). METHODOLOGY AND PRINCIPAL FINDINGS: In hearts of OLETF, a rat model of T2DM, at 25∼30 weeks of age, GRP78 and GRP94, markers of ER stress, were increased and sarcoplasmic reticulum calcium ATPase (SERCA)2a protein was reduced by 35% compared with those in LETO, a non-diabetic control. SERCA2a mRNA levels w
Sedigheh Asgary, Mahtab Keshvari, Amirhossein Sahebkar et al. · 2013 · PubMed
BACKGROUND: Pomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers…
Weiyi Guo, Li Zhu, Sijun Meng et al. · 2017 · Journal of the American Society of Nephrology
IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of…
Eric Rassin, Anita Eerland, Ilse Kuijpers · 2010 · Journal of Investigative Psychology and Offender Profiling
Abstract People involved in criminal proceedings (e.g. police officers, district attorneys, judges, and jury members) may run the risk of developing confirmation bias, or tunnel vision. That is, these parties may readily become convinced…
Siddharth Chandra, Goran Kuljanin, Jennifer M. Wray · 2012 · Demography
Estimates of worldwide mortality from the influenza pandemic of 1918-1919 vary widely, from 15 million to 100 million. In terms of loss of life, India was the focal point of this profound demographic event. In this article, we calculate…
Basheer A. Elubid, Tao Huang, Ekhlas H. Ahmed et al. · 2019 · International Journal of Environmental Research and Public Health
The observation of groundwater quality elements is essential for understanding the classification and distribution of drinking water. Geographic Information System (GIS) and remote sensing (RS), are intensive tools for the performance and analysis of spatial datum associated with groundwater sources control. In this study, groundwater quality parameters were observed in three different aquifers including: sandstone, alluvium and basalt. These aquifers are the primary source of national drinking water and partly for agricultural activity in El Faw, El Raha (Fw-Rh), El Qalabat and El Quresha (Qa
Gyrd Skraaning, Greg A. Jamieson · 2019 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: Test the automation transparency design principle using a full-scope nuclear power plant simulator. BACKGROUND: Automation transparency is a long-held human factors design principle espousing that the responsibilities,…
Manoeli Lupatini, Afnan Khalil Ahmad Suleiman, Rodrigo Josemar Seminoti Jacques et al. · 2013 · PLoS ONE
The Pampa biome is considered one of the main hotspots of the world's biodiversity and it is estimated that half of its original vegetation was removed and converted to agricultural land and tree plantations. Although an increasing amount of knowledge is being assembled regarding the response of soil bacterial communities to land use change, to the associated plant community and to soil properties, our understanding about how these interactions affect the microbial community from the Brazilian Pampa is still poor and incomplete. In this study, we hypothesized that the same soil type from the s
Axel Finckh, Geraldine M Mc Carthy, Anne Madigan et al. · 2014 · Arthritis Research & Therapy
INTRODUCTION: Calcium pyrophosphate deposition (CPPD) may cause severe arthropathy, major joint destruction and treatment options are limited. The aim of this study was to test the therapeutic efficacy of methotrexate (MTX) in chronic or recurrent CPPD arthropathy. METHODS: Patients with CPPD arthropathy were randomized to receive either weekly subcutaneous injections of 15 mg/week of MTX or placebo (PBO) for three months, in a double-blind, crossover randomized controlled trial. Inclusion criteria comprised definite CPPD disease, recurrent arthritis or persistent polyarthritis, and an insuffi
Ariel Kalil, Kathleen M. Ziol‐Guest, Jodie Levin Epstein · 2010 · Journal of Marriage and the Family
This article replicated and extended Harriet Presser's (2000) investigation of the linkages between nonstandard work and marital instability. We reexplored this question using data from a sample of 2,893 newlywed couples from the National…
Jong‐Min Kim, Soo-Heon Hong, Jong‐Min Kim et al. · 2014 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The aim of this study was to determine (1) variations in the shape of the proximal, middle, and distal femur in a series of Korean patients who had undergone total knee arthroplasty (TKA), (2) the preoperative relationship between…
Joyce O’Shaughnessy, Hartmut Koeppen, Yuanyuan Xiao et al. · 2015 · Clinical Cancer Research
PURPOSE: We conducted a randomized phase III study to determine whether patients with early breast cancer would benefit from the addition of capecitabine (X) to a standard regimen of doxorubicin (A) plus cyclophosphamide (C) followed by…
Shannon Rhodes, Janet S. Sinsheimer, Yvette Bordelon et al. · 2010 · Annals of Human Genetics
In the investigation of disease aetiology, the genome-wide association study (GWAS) provides a hypothesis-free investigation of the broader human genome and, as with all scientific investigations, replication is essential to validate any…