A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21742 results · page 604 of 725
Huffman J, Chapple AG, Armbruster P et al. · 2026 · European oral research
Purpose This study sought to compare mechanical properties of beta titanium orthodontic wires to stainless steel and NiTi archwires under different pH conditions and for different time intervals. Materials and methods Twenty samples of 5…
Saber S, Rifat MMI, Rahimi F et al. · 2026 · Genetics
The rate, molecular spectrum, and fitness effects of mutations vary at all levels of the biological hierarchy, from within individual genomes to among taxonomic domains. Understanding the evolutionary factors underpinning that variation is…
Pizarro DM, Crooks A, Wattiaux MA et al. · 2026 · Translational animal science
Kernza intermediate wheatgrass ( Thinopyrum intermedium [Host] Barkworth & D.R. Dewey) is a novel dual-use perennial grain and forage crop with environmental and economic benefits for farmers. Perennial crop byproducts, such as Kernza…
Zanesco AP, Spivey DJ, Horn LF et al. · 2026 · Attention, perception & psychophysics
Sustaining the focus of our attention is effortful and cannot be maintained indefinitely. Our minds naturally wander, necessitating effortful control of attention to maintain focus and resist distraction from external events or internally…
Nazar PHO, Reis FCC, Barbosa HE et al. · 2026 · Journal of inorganic biochemistry
Complexes of the μ-oxo-bis(μ-acetate)diruthenium class exhibit ligand lability at the positions trans to the μ-oxo bridge. Lability is an important property for numerous drugs, such as cis-[Pt(NH 3 ) 2 Cl 2 ], given that its biological…
Gomez NG, Gomez MA, MacWilliams BA et al. · 2026 · Journal of applied biomechanics
Minimum toe clearance (MTC) location relative to the stance-phase foot, as well as how this location changes with walking speed, helps in better understanding the circumstances when MTC is most relevant. This study helps define where MTC…
Semeraro A, Chialà A, Carafa A et al. · 2026 · Preprint
Abstract Background Romosozumab/AMG785 (Evenity®, Amgen and UCB pharma, RMZ) is a sclerostin-neutralizing antibody that rapidly increases BMD, but very short-term monitoring in clinical routine is limited by specific issues of available…
Barbaro K, Candida E, Biavati FS et al. · 2026 · Orthodontics & craniofacial research
Objective Traditional biocompatibility assessments primarily address cytotoxicity and bulk material properties but often overlook molecular responses that occur below toxicity thresholds. Detecting these subtle effects is crucial for…
Incontri D, Kellner CP, Polymeris A et al. · 2026 · Journal of neurointerventional surgery
Background The results of the Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH) trial have renewed interest in minimally invasive hematoma evacuation (MIE) as a treatment option for intracerebral hemorrhage (ICH).…
Mai K, Salim SR, Tilstra-Ferrell E et al. · 2026 · Journal of forensic nursing
Aims To examine data from an early intervention program for mental health following recent sexual assault (SA) to compare referral and service utilization rates before and after a community-based outreach model was implemented. Methods In…
Mesquita JAC, Diniz ACS, Araujo MR et al. · 2026 · International journal of dental hygiene
Dental materials with the potential for caries progression prevention have been an attractive alternative to minimally invasive treatments. Objectives This randomized controlled split-mouth clinical trial aimed to assess, after 18 months,…
Rajendran R, Singhania S, Suthar A et al. · 2026 · Reproduction (Cambridge, England)
In brief: An excess of extracellular High-Mobility Group Box 1 protein, an alarmin, in the uterine cavity alters the proportion and phenotype of uterine immune cells. These derangements impair decidualization and adversely impact the…
Schumacher KR, Dillman J, Goldberg DJ et al. · 2026 · Pediatric cardiology
Fontan-associated liver disease (FALD) is a fibrotic liver disease in individuals with Fontan physiology. This study sought to determine the efficacy of treatment with udenafil, a phosphodiesterase type 5 inhibitor, for reducing liver…
Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research
Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…
Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…
Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.
Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…
McQueen K, Sivle LD, Khodabandeloo B et al. · 2025 · Marine environmental research
Sparkers are seismic sources commonly used to survey the seabed in areas planned for offshore wind farms. The almost continuous sounds produced by sparkers, with most energy in the frequency range 50Hz - 4 kHz, are audible to both fish and…
Béllo Carvalho R, Frangos C, Sonawane C et al. · 2026 · Journal of mammalogy
Animals in urban preserves experience both the security of protected habitats and the persistent anthropogenic disturbances of surrounding human-dominated landscapes. During the COVID-19 pandemic, lockdowns temporarily reduced human…
Halleran M, Balsom AA, Gordon JL · 2026 · Journal of integrative and complementary medicine
Objectives Women experiencing infertility report heightened levels of anxiety, depression, and distress. However, access to affordable mental health care is limited in most areas of the world. Self-directed interventions, including…
Kuroda K, Miyoshi H, Hamamoto K et al. · 2026 · The journal of obstetrics and gynaecology research
Aim More than half of patients with pelvic organ prolapse (POP) complain of lower urinary tract symptoms (LUTS), especially voiding difficulty. Surgical approaches such as laparoscopic sacrocolpopexy (LSC) and transvaginal mesh surgery…
Roosimaa M, Ilumets H, Kaha T et al. · 2026 · Journal of wound care
Objective The objective of this trial was to compare the clinical performance and safety of a novel wound dressing containing silver and copper nanoparticles (Nanordica; Nanordica Medical OÜ, Estonia) (Ag/Cu) with the ionic silver-based…
Rue I, Jones S, Soltaninejad M et al. · 2025 · Preprint
Abstract Serum neurofilament light (sNfL) is a biomarker of axonal integrity which is elevated in neurodegenerative diseases. Although common psychiatric disorders are not neurodegenerative, some studies have found slightly higher levels…
Agarwal R · 2026 · American journal of hypertension
Background The mechanism of hypertension associated with erythropoiesis-stimulating agents in chronic kidney disease (CKD) is complex and remains poorly understood. Methods Here, anemic hypertensive patients with CKD and well-controlled or…
Tamburro MK, Carlson JA, Yen WK et al. · 2026 · Matrix biology : journal of the International Society for Matrix Biology
Tendon injuries account for considerable and escalating clinical burden. After injury, tendons heal poorly with persistent fibrovascular scar. Unlike healthy tendon which is type I collagen (COL1)-rich and highly-aligned, fibrovascular…
Lisco A, Borgognone A, Vanpouille C et al. · 2026 · The Journal of infectious diseases
Background The cervicovaginal microbiome may affect HIV-1 susceptibility and can in turn influence the prevalence and clinical course of HIV-1 and other sexually transmitted diseases. As the determinants, immunological correlates and…
Yin TK, Sengar N, Fang TY et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
PURPOSE: Fluctuating hearing loss in Ménière’s disease (MD) presents a key clinical challenge due to lack of reliable prognostic markers. The clinical value of transient-evoked otoacoustic emissions (TEOAEs) low-frequency components…
Gkirgkiris K, Charalampaki E, Margioula E et al. · 2026 · Anaesthesia, critical care & pain medicine
Background stive heart failure may coexist and aggravate the non-cardiogenic pulmonary edema of acute respiratory distress syndrome (ARDS). Yet, patients with congestive heart failure are likely under-represented in ARDS trials. We aimed…
Bhattarai S, Baral S, Bhowmick M et al. · 2026 · Preprint
Abstract Objective: Malnutrition is a common complication of acute pancreatitis (AP), and it may adversely affect outcomes. This study aimed to evaluate short-term changes in body composition and the development of sarcopenia in patients…
Holian JA, Bolton MD, Wilson DI · 2025 · Current Research in Food Science
Addition of small amounts of glycerol to milk chocolate during the tempering stage can yield a product which exhibits enhanced mechanical strength and retards motion of the continuous phase (cocoa butter, a mixture of fats) of this dense…
Janicijevic D, Cuevas-Aburto J, Zhang X et al. · 2026 · Journal of sports sciences
This randomised study compared mid-term effects of supersets (SS) and cluster sets (CL) on neuromuscular performance in amateur male basketball players. Thirty participants were allocated to SS (n = 15) or CL (n = 15) and completed a…