HMGB1-induced perturbations in the uterine immune microenvironment and implantation failure in rats.
Rajendran R; Singhania S; Suthar A; Metkari S; Patel V; Chaudhari U; Adiga SK; Sachdeva G · 2026 · Reproduction (Cambridge, England)
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
In brief: An excess of extracellular High-Mobility Group Box 1 protein, an alarmin, in the uterine cavity alters the proportion and phenotype of uterine immune cells. These derangements impair decidualization and adversely impact the…
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Metadata source: Europe PMC · DOI 10.1093/reprod/xaag046