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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21360 results · page 605 of 712

Negative / Null Result ReportMedicine

Association of Oral Contraceptives with Adverse Pregnancy Outcomes: A Mendelian Randomization and Colocalization Study.

Liu P, Dang C, Liu J et al. · 2026 · Current medicinal chemistry

Introduction This study aimed to investigate the causal relationship and biological mechanism between oral contraceptives (OCs) and adverse pregnancy outcomes using Mendelian randomization (MR) methods. Methods We conducted a drug-target…

View details →DOI: 10.2174/0109298673396130260330140027
Negative / Null Result ReportMedicine

Immersive Virtual Reality with Haptic Simulators for Dental Education: A User Acceptance Study in Poland.

Zadrożny Ł, Orlańska A, Ponto-Wolska M et al. · 2026 · European journal of dentistry

Objective This article aims to evaluate dental students' experiences, perceptions, and expectations related to training with virtual reality-based haptic simulators (VRHS) introduced into the preclinical and clinical dental curriculum.…

View details →DOI: 10.1055/s-0046-1824443
Negative / Null Result ReportMedicine

Beliefs in pregnancy: the psychometric properties of the German version of the birth beliefs scale (BBS).

Schmidt G, Dietsche S, Stoll K et al. · 2026 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective To evaluate the psychometric properties of the German Birth Beliefs Scale (G-BBS) in a large sample of pregnant women in Germany, and its potential utility for women-centred birth counselling, and respectful maternity care.…

View details →DOI: 10.1016/j.srhc.2026.101247
Negative / Null Result Report

Genetic Liability to Antidepressant Treatment and Risk of Female Infertility: A Two-Sample Bidirectional Mendelian Randomization Study

Wang M, Bai B, Yin T et al. · 2026 · Preprint

Abstract This study applied a two‑sample bidirectional Mendelian randomization (MR) design using genetic summary statistics from the FinnGen R9 database to examine the causal link between genetic predisposition to antidepressant treatment…

View details →DOI: 10.21203/rs.3.rs-9057307/v1
Negative / Null Result ReportMedicine

Association of Prophylactic Corticosteroids with Post-Extubation Outcomes in Pediatric Cardiac Critical Care: A Retrospective Propensity-Weighted Cohort Study.

Saengsin K, Jirattikanwong N, Wongyikul P et al. · 2026 · Journal of clinical medicine

Background/Objectives : Post-extubation stridor (PES) is common in pediatric critical care and may contribute to extubation failure, particularly in children with heart disease. Prophylactic corticosteroids are frequently used before…

View details →DOI: 10.3390/jcm15124762
Negative / Null Result ReportMedicine

Does a non-dipping heart rate profile predict adverse maternal-fetal outcomes? evidence from 24-h ambulatory monitoring in the second half of high-risk pregnancies.

Espeche W, Minetto J, Cerri G et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Hypertensive disorders of pregnancy are a leading cause of maternal-fetal morbidity and mortality, with preeclampsia representing a major contributor to adverse outcomes. Ambulatory blood pressure monitoring (ABPM) has improved risk…

View details →DOI: 10.1038/s41440-026-02687-5
Negative / Null Result ReportMedicine

Clinical Evaluation of a Real-Time Wearable System for Monitoring In-Hospital Ambulatory Patients With COVID-19: Retrospective Data Study.

Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics

Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…

View details →DOI: 10.2196/81304
Negative / Null Result Report

Physical activity during anthracycline chemotherapy: exploratory secondary analysis of a randomized trial of functional capacity, free-living activity, and ejection fraction

Appiah KN, Sharma N, Adu N et al. · 2026 · Preprint

Abstract Background: Anthracycline-based chemotherapy produces progressive functional decline and cardiotoxicity in adults with cancer. Physical activity interventions may attenuate these effects, yet evidence across multiple domains…

View details →DOI: 10.21203/rs.3.rs-9439431/v1
Negative / Null Result Report

Colocalization Reprioritizes the Major Depressive Disorder Druggable Genome: Demotion of the Top TWAS Signal (DRD2) and Nomination of SLC12A5/FURIN/DCC by Direction-Aware, Confirmation-Gated Analysis of 635 GWAS Loci

Kang B · 2026 · Preprint

Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS,…

View details →DOI: 10.21203/rs.3.rs-9880173/v1
Negative / Null Result ReportMedicine

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…

View details →DOI: 10.1002/ajhb.70291
Negative / Null Result Report

Within-person prospective associations between youth psychopathology and white matter development and the moderating role of parental mental health

Karl V, Beck D, Dall'Aglio L et al. · 2026 · Preprint

Background: Adolescence is a developmental period involving ongoing white matter (WM) maturation and rising risk for psychopathology. This risk is particularly elevated among youth whose parents have mental health problems. Methods:…

View details →DOI: 10.31234/osf.io/ksy2n_v1
Negative / Null Result ReportMedicine

Investigational Approaches in Treatment of Nonadvanced Mastocytosis.

Pongdee T · 2026 · Current allergy and asthma reports

PURPOSE OF REVIEW: Recent strategies to treat nonadvanced SM have focused on targeted therapies to inhibit mast cell activation and/or proliferation. Several investigational approaches are being explored to treat nonadvanced SM in this…

View details →DOI: 10.1007/s11882-026-01263-8
Negative / Null Result ReportMedicine

Acoustic Measures of Articulation and Vocal Quality in Transgender People Completing Vocal Feminization Therapy.

McKenna VS, Gustin RL, Novak VD et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Acoustic outcomes documented following gender-affirming voice and communication therapy (GAVT) for vocal feminization often include measures of vocal pitch and resonance; however, it is likely that other aspects of speech and…

View details →DOI: 10.1016/j.jvoice.2026.04.008
Negative / Null Result ReportOpen accessMedicine

Magnetocardiography Combined With the SYNTAX Score for Exploratory Modeling of Clinician-Selected Revascularization Category in Three-Vessel Coronary Artery Disease: A Single-Center Pilot Study.

An Z, Wang S, Zhang M et al. · 2026 · Cardiology research and practice

Background Three-vessel coronary artery disease (3V-CAD) often requires revascularization with either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The SYNTAX score is widely used for anatomical risk…

View details →DOI: 10.1155/crp/9497660
Negative / Null Result ReportMedicine

A Telerehabilitation-Based Fine Motor Training Program for Children with Inattentive ADHD: Randomized Controlled Trial.

Zhu F, Sun Y, Kuang D et al. · 2026 · Journal of medical Internet research

Background Children with inattentive attention-deficit/hyperactivity disorder (ADHD) often present with impairments in executive functions and fine motor skills in addition to core inattentive symptoms. However, evidence remains limited…

View details →DOI: 10.2196/97365
Negative / Null Result ReportMedicine

Systems-Level Plant Responses Reveal Pseudomonas-Mediated Growth Promotion in Brachypodium Under Nitrogen Limitation.

Sanow S, Mantz M, Wissel H et al. · 2026 · Plant, cell & environment

Plant growth-promoting bacteria can enhance plant performance under nutrient limitation, yet the underlying plant molecular responses remain incompletely resolved. We investigated growth promotion by Pseudomonas koreensis in Brachypodium…

View details →DOI: 10.1111/pce.70615
Negative / Null Result ReportMedicine

Auxin response and PIN-mediated transport in chlorophyte algae.

Smoljan A, Koutnik-Abele S, Vladimirtsev D et al. · 2026 · Journal of integrative plant biology

Auxin, primarily indole-3-acetic acid (IAA), is a central regulator of growth and development in land plants, but its physiological role in chlorophyte algae remains unclear. Here, we show that exogenous IAA modulates growth in Chlorella…

View details →DOI: 10.1111/jipb.70309
Negative / Null Result ReportMedicine

The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis: a randomised, double-blind, placebo-controlled clinical trial.

Mohy N, Sanaie S, Rahnemayan S et al. · 2026 · Beneficial microbes

Oxidative stress is a significant contributor to neuronal damage in multiple sclerosis (MS), marked by an imbalance in reactive oxygen species and antioxidant defences. Probiotics may modulate oxidative stress and improve antioxidant…

View details →DOI: 10.1163/18762891-bja00115
Negative / Null Result ReportMedicine

Voxel-wise case-control analysis of dose, linear energy transfer and symptomatic brainstem necrosis in pediatric brain tumors treated with proton therapy.

Handeland AH, Indelicato DJ, Engeseth GM et al. · 2026 · International journal of radiation oncology, biology, physics

Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…

View details →DOI: 10.1016/j.ijrobp.2026.05.054
Negative / Null Result ReportMedicine

Functional stupidity in Danish intersectoral pathways: An institutional ethnographic text analysis of documentary practices.

Kamionka SL, Sodemann M, Bilenberg N et al. · 2026 · Health (London, England : 1997)

Written information exchange is widely used to share information and coordinate care across services. Yet, its coordinating effects remain unclear. The aim of the study was to explore the textually mediated practices through which…

View details →DOI: 10.1177/13634593261419400
Negative / Null Result ReportMedicine

Fragmentation as a population rate-changer: A field experiment.

Nichols JD, Hines JE, Hinz RL et al. · 2026 · Ecology

Experimental and observational studies of effects of fragmentation on biodiversity and population dynamics have produced mixed results, with some reviews concluding strong evidence of negative effects and others concluding small positive…

View details →DOI: 10.1002/ecy.70327
Negative / Null Result Report

From Silos to Flows by Redesigning Regional Care for System-Wide Coordination: A Qualitative Study of Organizational Capabilities and Governance in Sweden

Carlsson KS, Brommels M, Ohrling M · 2026 · Preprint

Abstract Background Decentralised and market-inspired health system reforms have increased organisational plurality and local autonomy but often intensify fragmentation and complicate system-wide coordination. This study explored how…

View details →DOI: 10.21203/rs.3.rs-8703981/v1