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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 571 of 712

Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

View details →DOI: 10.1007/s10633-025-10060-z
Failed Experiment ReportMedicine

Is physical pain causally related to suicidal behavior: An experimental test.

Park EC, Harris LM, Sigel AN et al. · 2023 · Behaviour research and therapy

Existing evidence suggests a link between physical pain and suicide, but the nature of this relationship remains unknown. To address this critical gap in knowledge, the present study leveraged a validated virtual reality (VR) suicide…

View details →DOI: 10.1016/j.brat.2023.104321
Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

View details →DOI: 10.1136/bmjment-2025-301598
Negative / Null Result ReportOpen accessMedicine

Clinical Impact of Flow-Adjusted Transprosthetic Pressure Gradient After Aortic Valve Replacement.

Ohmori T, Hiraoka A, Totsugawa T et al. · 2025 · Annals of thoracic surgery short reports

Background It is still controversial whether prosthesis-patient mismatch (PPM) adversely affects long-term outcomes after aortic valve replacement (AVR). The aim of this study was to examine whether flow-adjusted pressure gradient is a…

View details →DOI: 10.1016/j.atssr.2024.07.008
Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

View details →DOI: 10.1111/opo.13313
Failed Experiment ReportMedicine

Morphea after Silicone Implants.

Wollina U, Schönlebe J · 2023 · Acta dermatovenerologica Croatica : ADC

Dear Editor, Silicone is a hydrophobic polymer containing silicon. Silicon is an essential compound of soft tissue proteoglycans. Reports about morphea and other autoimmune connective tissue disorders in association with silicone implants…

Negative / Null Result ReportOpen accessMedicine

Dietary inflammatory index and objective disease activity in IBD: no association found.

de Oliveira RMV, Vasques ACJ, Romero SA et al. · 2026 · European journal of clinical nutrition

Background Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear. Objective To investigate the association between…

View details →DOI: 10.1038/s41430-026-01713-6
Negative / Null Result Report

When and why moral exemplars fail to motivate intergroup reconciliation

Péter SZ, Witkowska M-, Szekeres H · 2022 · Preprint

In societies with collective memories of their group’s historical victimization, the modes of conflict resolution conventionally proposed in social psychology may be ineffective. The present study aimed to examine the effectiveness of…

View details →DOI: 10.31234/osf.io/h37ae
Negative / Null Result ReportOpen accessMedicine

Lack of effect of cyclic adenosine monophosphate modulation during prematuration in vitro on development to the blastocyst stage and expression of specific genes associated with lineage commitment.

Desenzi R, Cuellar CJ, Hoorn QA et al. · 2025 · JDS communications

Pharmacological elevation of cyclic AMP (cAMP) of cultured cumulus-oocyte complexes (COC) before or coincident with initiation of maturation has been reported to improve outcomes for various systems for in vitro production of embryos. Here…

View details →DOI: 10.3168/jdsc.2024-0625
Negative / Null Result ReportMedicine

First evidence for the existence of Simkania negevensis in the genitalia of human females.

Abu-Saif RA, Al-Basha AS, Al-Younes HM · 2023 · Enfermedades infecciosas y microbiologia clinica (English ed.)

Introduction Simkania negevensis has been linked to some respiratory and non-respiratory diseases. However, there is still a serious lack of clinical investigations that attempt to determine possible body sites that could be inhabited by…

View details →DOI: 10.1016/j.eimce.2022.11.015
Negative / Null Result ReportOpen accessMedicine

Circulating microRNA-219 in stroke: Lack associations with clinical parameters and post-stroke epilepsy risk.

Fahimi Z, Kazemi M, Rahimi H et al. · 2025 · IBRO neuroscience reports

Background Post-stroke epilepsy (PSE) is a significant complication in stroke survivors, yet early diagnostic biomarkers remain unclear. This study investigated whether circulating microRNA-219 (miR-219) could serve as a reliable biomarker…

View details →DOI: 10.1016/j.ibneur.2025.11.013
Negative / Null Result ReportOpen accessMedicine

The impact of meteorological conditions on the occurrence of low back pain in a retrospective registry based population study.

Ochal M, Lewczuk KG, Dragańska E et al. · 2026 · Scientific reports

Low back pain (LBP) is one of the most prevalent musculoskeletal complaints and a leading cause of disability worldwide. Although patients frequently attribute symptom exacerbation to adverse weather, the scientific evidence for a direct…

View details →DOI: 10.1038/s41598-026-40669-2
Negative / Null Result ReportMedicine

Perioperative N-acetylcysteine: evidence and indications.

Wilson PR, Bridges KH, Scofield M et al. · 2024 · Pain management

Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia.…

View details →DOI: 10.1080/17581869.2024.2388504
Negative / Null Result ReportMedicine

Has stopping stopped making sense? Disentangling the processes elicited by complex action cancellation paradigms.

Weber S, Kemp SA, Hinder MR · 2026 · Cognitive, affective & behavioral neuroscience

Action cancellation represents a fundamental aspect of human motor control. Nonetheless, the behavioural paradigms used to study it are methodologically diverse and capture an incompletely understood combination of processes. Advancing…

View details →DOI: 10.3758/s13415-026-01440-2
Negative / Null Result Report

Re-examining the effect of inoculation messages on anti-vaccine conspiracy attitudes: A conceptual replication of Banas et al (2023)

Adinugroho I, Bentall R, Stafford T · 2025 · Preprint

This is the first study to attempt replication of Banas et al (2023) on inoculation messages. The original experiment demonstrated that inoculation messages could stimulate resistance to anti-vaccine conspiracy theories. However, a gap was…

View details →DOI: 10.31234/osf.io/d3x9p_v2
Negative / Null Result Report

Ranschburg Unrepeated

Remouchamps R, Majerus S, Kowialiewski B · 2025 · Preprint

In verbal working memory (WM), the second occurrence of an item in a memory list generally leads to impaired recall performance, a phenomenon called the “Ranschburg effect”. One explanation for this effect is response suppression, by which…

View details →DOI: 10.31234/osf.io/3zmje_v1