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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 572 of 712

Negative / Null Result ReportMedicine

Predicting parents' HPV vaccination intentions and behaviors across countries and time.

Schulz JV, Doerflinger JT, Behm C et al. · 2026 · Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Objective This study compares three models of parental human papillomavirus (HPV) vaccination intentions across United States, United Kingdom, and Germany: A model based on the theory of planned behavior (TPB), a model incorporating…

View details →DOI: 10.1037/hea0001596
Negative / Null Result ReportOpen accessMedicine

Combined Detection of Preoperative Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Carcinoma: A Retrospective Multicenter Cohort Study.

Yang Y, He Y, Lin B et al. · 2026 · Health care science

Background The aim of this study was to investigate the clinical value of combined detection of preoperative serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) for diagnosing medullary thyroid carcinoma (MTC), as well as predicting…

View details →DOI: 10.1002/hcs2.70074
Negative / Null Result ReportMedicine

A novel approach to the clinical assessment of juvenile fibromyalgia syndrome: the Juvenile Fibromyalgia Multidimensional Assessment Report.

Drago E, Lavarello C, Alongi A et al. · 2026 · Clinical and experimental rheumatology

Objectives Development and psychometric evaluation of a disease-specific, paediatric-targeted multidimensional questionnaire for the assessment of juvenile fibromyalgia syndrome (JFS) in routine clinical practice. Methods The Juvenile…

View details →DOI: 10.55563/clinexprheumatol/0v4aqh
Negative / Null Result ReportMedicine

Does Platelet-Rich Plasma Speed Recovery After Acute Lateral Ankle Sprain? A Prospective Comparative Study Among Athletes.

Genuth G, Stavrou P, Brown C et al. · 2026 · Foot & ankle international

Background Acute lateral ankle sprains are among the most common musculoskeletal injuries, accounting for up to 20% of all sports-related injuries and a leading cause of time lost from athletic participation. Although most cases respond to…

View details →DOI: 10.1177/10711007261422252
Negative / Null Result ReportMedicine

The effect of mitomycin-C on 3 snip punctoplasty.

Dertsiz Kozan B, Utlu B · 2026 · International ophthalmology

Purpose To investigate the effects of Mitomycin-C (MMC) use and duration of application on surgical outcomes in patients who underwent 3 snip punctoplasty for epiphora. Material and methods Demographic characteristics, follow-up period,…

View details →DOI: 10.1007/s10792-026-03970-7
Negative / Null Result ReportMedicine

Patient-Level Modeling of Ménière's Disease vs. Vestibular Migraine: Performance of Speech Discrimination and Caloric-vHIT Dissociation.

Pérez-Fernández N, Arbizu L · 2026 · Journal of clinical medicine

Background : Differentiating Ménière's disease (MD) from vestibular migraine (VM) remains difficult because current diagnostic frameworks are predominantly clinical and incorporate pure-tone thresholds, risking incorporation bias. We asked…

View details →DOI: 10.3390/jcm15051908
Negative / Null Result ReportMedicine

The utility of global versus domain-specific neuropsychological test score dispersion as markers of cognitive impairment.

Fatima H, Schaffert J, Carlew AR et al. · 2025 · The Clinical neuropsychologist

Objective Cognitive dispersion (CD) or neuropsychological test score variability has been associated with more rapid cognitive decline, and the development of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The predictive…

View details →DOI: 10.1080/13854046.2025.2577149
Negative / Null Result ReportMedicine

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir-ritonavir in patients with COVID-19.

Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology

Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…

View details →DOI: 10.1002/bcp.70507
Negative / Null Result ReportMedicine

Vocal Fundamental Frequency and Generalized Anxiety Disorder: Insights from a Large Multi-Country Cohort in Africa.

Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…

View details →DOI: 10.1016/j.jvoice.2026.03.014
Negative / Null Result ReportMedicine

Impact of Bariatric Surgery on Gout Medication: a Nationwide Cohort Study.

Kwon Y, Park J, Kim D et al. · 2026 · Obesity surgery

Background While bariatric surgery (BS) is an effective treatment for gout in patients with morbid obesity, little is known about how BS influences subsequent use of gout medications. We investigated the impact of BS on gout medication…

View details →DOI: 10.1007/s11695-025-08445-9
Negative / Null Result ReportMedicine

Inter-joint coordination and coordination variability during gait differentiate copers from noncopers in males with anterior cruciate ligament deficiency.

Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics

Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…

View details →DOI: 10.1016/j.jbiomech.2026.113416
Negative / Null Result ReportMedicine

Relationship Between Changes in Intestinal Desulfovibrio Levels and Oxygen Desaturation in Patients With Obstructive Sleep Apnea Syndrome.

Sınır B, Ortan P, Sayin SS et al. · 2026 · Respiratory medicine

Purpose Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and sleep fragmentation, which may alter gut microbiota composition. We primarily aimed to compare intestinal Desulfovibrio detection/abundance between patients…

View details →DOI: 10.1016/j.rmed.2026.108986
Negative / Null Result Report

Behavioral and Physiological Welfare Responses of Rhode Island Red Hens Reared in Individual Cage, Colony Cage and Deep-Litter Systems

Kumar A, Sinha RRK, Sahu SP et al. · 2026 · Preprint

Abstract The present experiment was conducted to compare three housing systems Individual cages, Colony cages and Deep litter on welfare, behaviour, and physiological traits in Rhode Island Red laying hens under tropical conditions. A…

View details →DOI: 10.21203/rs.3.rs-9950223/v1
Negative / Null Result ReportMedicine

Impact of application repetition on Joule heating and lesion formation using a circular-shaped pulsed field catheter.

Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…

View details →DOI: 10.1007/s10840-026-02379-7
Negative / Null Result ReportMedicine

Clinical study of the superthin anterolateral thigh flap for reconstruction of post-traumatic ankle joint soft-tissue defects.

Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…

View details →DOI: 10.1053/j.jfas.2026.06.019
Negative / Null Result ReportMedicine

Exploring iridotrabecular contact index and related factors in primary angle closure disease: a swept-source anterior segment OCT study.

Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology

Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…

View details →DOI: 10.1136/bjo-2024-326725
Negative / Null Result ReportMedicine

Impact of a Prenatal Nutrition Package with Balanced Energy Supplementation on Gestational Weight Gain in Amhara, Ethiopia.

Kang Y, Workneh F, Yibeltal K et al. · 2026 · The Journal of nutrition

Background Suboptimal gestational weight gain (GWG) is associated with adverse pregnancy outcomes; however, evidence on the impact of nutritional interventions on GWG in low-income settings remains limited. Objectives This study aims to…

View details →DOI: 10.1016/j.tjnut.2026.101653
Negative / Null Result ReportOpen accessMedicine

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.

Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open

Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…

View details →DOI: 10.1136/bmjno-2026-001547
Negative / Null Result Report

Addressing Unanswered Questions About the Shift of Strategy Approach: A Multi-Study Investigation of Approach Variations, Repeated Interviews, and Innocent Versus Guilty Responses

Nyström L, Granhag A, Neofotistos E et al. · 2026 · Preprint

Introduction. The Shift-of-Strategy (SoS) approach aims to obtain concealed information from semi-cooperative suspects by prompting them to shift toward more forthcoming counter-interrogation strategies. While previous studies on the…

View details →DOI: 10.31234/osf.io/8uzbn_v2
Negative / Null Result ReportMedicine

IgA nephropathy occurrence, treatment, and prognosis in the last two decades in Denmark.

Ystrøm IK, Jensen SK, Andersen IT et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences vary substantially across countries. This study assessed the epidemiology of IgAN including…

View details →DOI: 10.1093/ndt/gfag021
Negative / Null Result ReportMedicine

Intravenous IRON supplementation in Heart Failure with Preserved Ejection Fraction and iron deficiency (IRON-HFpEF): a comprehensive phase II multicentre placebo-controlled randomised clinical trial.

van de Bovenkamp AA, Nassiri S, de Man FS et al. · 2026 · European journal of heart failure

Aims Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementation on cardiovascular function and…

View details →DOI: 10.1093/ejhf/xuag162
Negative / Null Result ReportMedicine

Cranial-to-caudal approach in laparoscopic surgery for left-sided colon cancer: Longer specimens and higher lymph node yield.

Goksoy B, Ofluoglu CB, Azamat IF et al. · 2026 · Surgical oncology

Background Medial-to-lateral (ML) approach is the standard technique in laparoscopic surgery for left-sided colon cancer. However, it can be technically challenging; such as in patients with intra-abdominal adhesions or during splenic…

View details →DOI: 10.1016/j.suronc.2026.102354
Negative / Null Result ReportMedicine

Effects of guanidinoacetic acid and methionine supplementation in low-forage diets on ruminal fermentation and performance of feedlot-finished steers

Andriotti NM, Paris W, Maia FJ et al. · 2026 · Animal Feed Science and Technology.

Feed additives that improve energy metabolism efficiency can enhance cattle performance and nitrogen use. This study evaluated the effects of guanidinoacetic acid (GAA) and methionine (MET) supplementation, alone or combined, on…

Negative / Null Result ReportMedicine

Circulating immune cell biomarkers in Psoriatic Arthritis: associations with clinical manifestations and treatment response in the TOFA-PREDICT trial.

Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy

Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…

View details →DOI: 10.1186/s13075-026-03833-7