Negative / Null Result ReportOpen accessMedicine
GamalEl Din SF, Nabil NI, Khalil MA et al. · 2025 · Urology research & practice
Objective The present study examined the impact of measuring penile girth and length in the erect state on reassuring individuals with small penis anxiety (SPA) in the flaccid state. Methods This study included 200 potent men aged 25-40…
View details →DOI: 10.5152/tud.2025.24133 Negative / Null Result ReportOpen accessMedicine
Sköld C, Hailer NP, Mallmin H · 2026 · Acta orthopaedica
Background and purpose Denosumab may preserve periprosthetic bone mineral density (pBMD) around uncemented total hip arthroplasty (THA) components. This exploratory analysis of a previously published randomized controlled trial (RCT) aimed…
View details →DOI: 10.2340/17453674.2026.45695 Negative / Null Result ReportOpen accessMedicine
Lin YH, Tsai IJ, Chang YA et al. · 2026 · Therapeutics and clinical risk management
Background Traumatic brain injury (TBI) is a major risk factor for subsequent neurodegenerative disorders. Emerging evidence suggests that statins may mitigate neuroinflammation and lipid dysregulation after TBI. This study aimed to…
View details →DOI: 10.2147/tcrm.s591742 Negative / Null Result ReportOpen accessMedicine
Dos Santos LC, da Cunha VB, Ribeiro JM et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Cocaine use disorder (CUD) remains a major public health challenge with limited effective therapeutic options. Cannabidiol (CBD) has been proposed as a potential treatment due to its neuroprotective and anti-craving properties. This…
View details →DOI: 10.1007/s00210-026-05037-x Failed Experiment ReportOpen accessMedicine
Zamalloa N, Rose J, Lap CJ et al. · 2026 · Current oncology (Toronto, Ont.)
Human epidermal growth factor receptor 2 (HER2) is a molecular target of interest in prostate cancer due to its association with poor prognosis and its potential role in androgen receptor signaling. However, earlier clinical trials…
View details →DOI: 10.3390/curroncol33020091 Negative / Null Result ReportOpen accessMedicine
Samson T, Aali M, McBride D et al. · 2026 · Current oncology (Toronto, Ont.)
Surgical resection combined with chemotherapy offers the best chance of survival in pancreatic ductal adenocarcinoma (PDAC), but many will experience recurrence and early mortality. We examined soluble AXL (sAXL), a blood protein, for its…
View details →DOI: 10.3390/curroncol33020088 Negative / Null Result ReportOpen accessMedicine
Ghiringhelli F, Rébé C · 2026 · Frontiers in immunology
Emerging preclinical evidence challenges the long-standing assumption that Interleukin-1β (IL-1β) uniformly promotes non-small cell lung cancer (NSCLC). We show that, in the context of chemo-immunotherapy, IL-1β enhances anti-tumor…
View details →DOI: 10.3389/fimmu.2026.1773253 Negative / Null Result ReportOpen accessMedicine
Schweiger L, Raggam RB, Toth-Gayor G et al. · 2025 · PloS one
Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk…
View details →DOI: 10.1371/journal.pone.0321491 Negative / Null Result ReportOpen accessMedicine
Bespalov A, Swartz J, Knowles N et al. · 2025 · Alzheimer's research & therapy
Agitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer's disease (AD) dementia. It is associated with poor outcomes, including reduced functional ability, reduced…
View details →DOI: 10.1186/s13195-025-01780-0 Negative / Null Result ReportOpen accessMedicine
Kim JH, Song M, Lee KW et al. · 2026 · Life (Basel, Switzerland)
Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to…
View details →DOI: 10.3390/life16050712 Negative / Null Result ReportMedicine
Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology
Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…
View details →DOI: 10.1097/dad.0000000000002771 Negative / Null Result ReportOpen accessMedicine
Misawa A, Kimura E, Inoue M et al. · 2025 · Journal of surgical case reports
Tension-free vaginal mesh repair surgery (TVM) has decreased due to complications related to mesh use and the lack of superiority compared to native tissue repair (NTR). In japan it is still performed as a treatment for pelvic organ…
View details →DOI: 10.1093/jscr/rjaf537 Negative / Null Result ReportMedicine
Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines
Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…
View details →DOI: 10.3390/biomedicines12061201 Negative / Null Result ReportOpen accessMedicine
Samatoshenkov I, Zakirova E, Samatoshenkova J et al. · 2026 · Cells
Peripheral arterial disease and critical limb-threatening ischemia remain major clinical challenges, particularly in patients who are not candidates for surgical or endovascular revascularization. These limitations have stimulated…
View details →DOI: 10.3390/cells15121104 Negative / Null Result ReportOpen accessMedicine
Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus
Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…
View details →DOI: 10.7759/cureus.104675 Replication FailureMedicine
Sonnick MA, Laothamatas K, Furfaro D et al. · 2024 · Transplantation proceedings
Background In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is…
View details →DOI: 10.1016/j.transproceed.2024.08.025 Replication FailureMedicine
Pradhan A, Bhandari M, Vishwakarma P et al. · 2024 · European review for medical and pharmacological sciences
Heart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the…
View details →DOI: 10.26355/eurrev_202404_35929 Replication FailureOpen accessMedicine
Sabben C, Charbonneau F, Obadia M et al. · 2026 · European stroke journal
Introduction Acute ischaemic strokes (AIS) due to proximal anterior cerebral artery (ACA) occlusions are rare. Their clinical outcomes following medical management alone have been scarcely described. Patients and methods We conducted a…
View details →DOI: 10.1093/esj/aakag014 Negative / Null Result ReportOpen accessMedicine
Massardier E, Manchec O, Bérard E et al. · 2025 · Journal of experimental orthopaedics
Purpose Numerous studies have been published on the optimal management of the patella during total knee arthroplasty (TKA), but controversy remains. The aim of this study was to compare survivorship and functional outcomes with or without…
View details →DOI: 10.1002/jeo2.70448 Negative / Null Result ReportMedicine
Jung JC, Ju JW, Chang HW et al. · 2024 · Journal of cardiothoracic and vascular anesthesia
Objectives This study evaluated the performances of the age, creatinine, and ejection fraction (ACEF) I and II scores and compare them with that of the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II score in patients…
View details →DOI: 10.1053/j.jvca.2024.08.011 Negative / Null Result ReportOpen accessMedicine
Tambaro FP, Fabozzi F, Masetti R et al. · 2026 · Frontiers in oncology
Deterioration of nutritional status in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is associated with increased morbidity. Enteral nutrition (EN) has been associated with more favorable outcomes than total…
View details →DOI: 10.3389/fonc.2026.1778224 Negative / Null Result ReportOpen accessMedicine
Higuchi T, Igarashi K, Miwa S et al. · 2025 · Medicine
The clinical utility of P-glycoprotein (P-gp) in osteosarcoma remains controversial. This retrospective cohort study aimed to investigate the association between P-gp expression and clinicopathological factors, chemotherapy (CTx) response,…
View details →DOI: 10.1097/md.0000000000043472 Negative / Null Result ReportOpen accessMedicine
Kim GH, Fass R · 2025 · Journal of neurogastroenterology and motility
Extraesophageal symptoms and signs of gastroesophageal reflux disease (GERD), such as throat clearing, globus sensation, hoarseness, cough, asthma, pulmonary fibrosis, otitis, sinusitis, and dental erosions, are common and pose diagnostic…
View details →DOI: 10.5056/jnm24159 Negative / Null Result ReportOpen accessMedicine
Hirayama H, Ishida K, Kodama H et al. · 2026 · OTO open
Objective This study aimed to evaluate the benefits of recipient site of closed incision negative pressure therapy (ciNPT) on postoperative complications in head and neck reconstruction. Study design A single-center retrospective…
View details →DOI: 10.1002/oto2.70249 Negative / Null Result ReportOpen accessMedicine
Abbas AE, Kaneko T, Khalili H et al. · 2026 · Circulation. Cardiovascular interventions
Background Lower ( Methods Patients who underwent aortic valve-in-valve replacement with a balloon-expandable valve from July 2015 to December 2023 in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve…
View details →DOI: 10.1161/circinterventions.125.015945 Negative / Null Result ReportMedicine
Prior D, Yang J, Nuño MM et al. · 2025 · Pediatric blood & cancer
Background Cisplatin, etoposide, and bleomycin (PEb) have been the standard of care for patients with germ cell tumors (GCT). In the 1990s, an intergroup trial (POG9049/CCG8882) randomized patients with high-risk GCT, as defined by the…
View details →DOI: 10.1002/pbc.31665 Negative / Null Result Report
Lavaire T, McLaughlin D, Liu S et al. · 2026 · Preprint
CoverCress is a new winter annual oilseed crop developed from field pennycress within the past 20 years. Field pennycress is commonly considered to be self-pollinated but little basic research has been published and there is some…
View details →DOI: 10.64898/2026.04.08.716402 Negative / Null Result ReportOpen accessMedicine
Lee HS, Kang SH, Eun HS et al. · 2026 · The Korean journal of helicobacter and upper gastrointestinal research
Objectives Metformin has been suggested to exert chemopreventive effects against gastric cancer. However, epidemiologic evidence remains inconsistent, and its impact on histologically confirmed precursor lesions, such as gastric dysplasia,…
View details →DOI: 10.7704/kjhugr.2025.0090 Negative / Null Result Report
Ion RM, Hutanu A, Sala DT et al. · 2024 · Preprint
Abstract Background: Bariatric surgery plays an impotant role in immnological modulation by reducing levels of systemic inflammatory markers, such as interkleukin-6 and tumor necrosis factor alpha. The goal of this study is to establish…
View details →DOI: 10.21203/rs.3.rs-4263046/v1 Negative / Null Result ReportOpen accessMedicine
Dong X, Liu Y, Chu X et al. · 2024 · CNS neuroscience & therapeutics
Background The ideal blood pressure (BP) target in patients who undergo endovascular thrombectomy (EVT) with successful reperfusion is uncertain. Observational studies show that elevated BP during this period is associated with a higher…
View details →DOI: 10.1111/cns.14907 