Negative / Null Result Report
Alshammari AK, Maina M, Alsuwat MA et al. · 2026 · Preprint
Respiratory viral-bacterial co-infections cause severe disease across species, yet the molecular mechanisms underlying enhanced pathogenesis remain poorly understood. This study characterised H3N8 equine influenza A virus (IAV) and…
View details →DOI: 10.64898/2026.05.19.724896 Negative / Null Result ReportMedicine
Saiz-Gonzalo G, Drouin G, Rao Y et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Non-nutritive sweeteners (NNS) are increasingly consumed during pregnancy, yet their distinct metabolic fates obscure a unified mechanism for developmental programming. We tested whether maternal NNS exposure acts upstream of metabolism by…
View details →DOI: 10.1016/j.fct.2026.116128 Negative / Null Result Report
Plouhinec L, Maresca M, Saget J et al. · 2026 · Preprint
Abstract As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high…
View details →DOI: 10.21203/rs.3.rs-9542962/v1 Negative / Null Result ReportMedicine
Magsi FH, Ullah A, Ma Y et al. · 2026 · Journal of chemical ecology
Fall armyworm (Spodoptera frugiperda) has emerged as a major pest of maize across the Americas, Africa and Asia. Current management relies heavily on synthetic insecticides, which are environmentally unsustainable. However, pheromone-based…
View details →DOI: 10.1007/s10886-026-01731-5 Negative / Null Result ReportMedicine
Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →DOI: 10.1016/j.exphem.2026.105458 Replication FailureMedicine
Sawatpanich T, Innoi S, Chaiyamoon A et al. · 2026 · Life (Basel, Switzerland)
Morus alba L. fruit extract (MFE), which is rich in cyanidin 3-glucoside (C3G), demonstrates antioxidant properties and pharmacological effects, but its reproductive safety remains poorly understood. Polyphenols modulate steroidogenesis,…
View details →DOI: 10.3390/life16060991 Replication FailureMedicine
Jeremic M, Jovanovic-Tucovic M, Martinovic T et al. · 2026 · Neurotoxicology
The mechanistic target of rapamycin complex 2 (mTORC2), a key regulator of cellular metabolism, growth, and survival, remains poorly characterized in the context of dopaminergic neurotoxicity. In this study, we investigated the role of…
View details →DOI: 10.1016/j.neuro.2026.103497 Replication FailureMedicine
Abdelmenam DS, Elshahawy WM, Ahmed RK · 2026 · Odontology
This study aimed to assess the effect of incorporating sodium fluoride (NaF) into an adhesive system on the microtensile bond strength of ceramic occlusal veneers. Eighty resin-dentin sticks (~ 1 mm 2 ) were obtained from 20 upper first…
View details →DOI: 10.1007/s10266-026-01374-8 Negative / Null Result Report
Nicholas M, Ianssen M, Costa D et al. · 2026 · Preprint
Abstract Purpose Psychosocial factors have been identified as risks for delayed recovery after work injuries but results from interventions for high-risk cases have been mixed. An earlier Australian study that matched care to assessed…
View details →DOI: 10.21203/rs.3.rs-9422704/v1 Negative / Null Result ReportMedicine
Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →DOI: 10.1113/ep093753 Negative / Null Result ReportMedicine
Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
Negative / Null Result ReportMedicine
Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →DOI: 10.1016/j.lungcan.2023.107355 Negative / Null Result ReportOpen accessMedicine
Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →DOI: 10.3390/ph19040605 Negative / Null Result ReportOpen accessMedicine
Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
View details →DOI: 10.1093/noajnl/vdag106 Negative / Null Result ReportMedicine
Chen B, Wang Q, Xue X et al. · 2026 · NPJ biofilms and microbiomes
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition arising from interactions between genetic and environmental factors. The interplay between the microbiota-gut-brain axis and epigenetics has been implicated in ASD,…
View details →DOI: 10.1038/s41522-026-01041-4 Negative / Null Result ReportMedicine
Takeuchi H, Akiba Y, Van Quang N et al. · 2026 · Journal of prosthodontic research
Purpose Osseointegration begins at the initial blood-implant contact; however, titanium-adhesive blood proteins remain incompletely defined. We used a structure-free, nano-smooth titanium substrate (Ra ≈ 0.6 nm) to identify…
View details →DOI: 10.2186/jpr.jpr_d_25_00199 Negative / Null Result ReportMedicine
Riancho-Zarrabeitia L, Barrena OI, Santos-Gomez M et al. · 2026 · Reumatologia clinica
Background/objectives Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease marked by diverse autoantibodies. While serological clusters have been associated with distinct clinical phenotypes, most existing studies rely…
View details →DOI: 10.1016/j.reumae.2026.502172 Negative / Null Result ReportMedicine
Bonthrone AF, Cromb D, Javed SA et al. · 2026 · Placenta
Objectives To assess if maternal stress is higher in pregnancies with congenital heart disease (CHD) compared to low-risk pregnancies and if maternal stress is associated with placental microstructure and function. To explore if CHD alters…
View details →DOI: 10.1016/j.placenta.2026.05.027 Negative / Null Result Report
Pagano R, Kruashvili L, Puchalska M et al. · 2026 · Preprint
ABSTRACT Alcohol craving and consumption fluctuate across the reproductive cycle in females with alcohol use disorder (AUD), suggesting that estrogen signaling contributes to disease vulnerability. Here, we investigated the role of…
View details →DOI: 10.64898/2026.06.03.729849 Negative / Null Result ReportMedicine
Li J, de Vries HD, Ustyantsev K et al. · 2026 · Journal of lipid research
Farnesoid-x-receptor (FXR), a bile acid (BA)-activated nuclear receptor, is a therapeutic target for cholestatic and metabolic liver diseases. However, species differences in BA metabolism and FXR signaling hamper translation from mice to…
View details →DOI: 10.1016/j.jlr.2026.101088 Negative / Null Result ReportMedicine
Kirk C, Smith E, Wozniak A et al. · 2026 · Cutaneous and ocular toxicology
Purpose Emerging evidence supports a protective role of statins at preventing the progression of early-intermediate stage non-neovascular (dry) AMD. Clinical findings, however, remain equivocal as to the beneficial effects of statin use…
View details →DOI: 10.1080/15569527.2026.2646451 Negative / Null Result ReportMedicine
Mattke AC, Schlapbach LJ, Takashima M et al. · 2026 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a) sweep flow…
View details →DOI: 10.1097/mat.0000000000002709 Negative / Null Result ReportMedicine
Gu C, Xu R, Yin B et al. · 2025 · Integrative zoology
Predator cues have profound impacts on the behavior and physiology of prey animals. However, the mechanisms underlying stress responses induced by chronic exposure to predator cues in mammals, particularly the role of the gut microbiota,…
View details →DOI: 10.1111/1749-4877.13014 Negative / Null Result ReportMedicine
Luo Y, Wei K · 2026 · Experimental brain research
Motor adaptation arises from multiple learning mechanisms, including use-dependent learning (UDL) driven by repetition and implicit error-based learning (EBL) driven by motor prediction errors. Although both mechanisms contribute…
View details →DOI: 10.1007/s00221-026-07268-z Negative / Null Result ReportMedicine
Gaebel L, Gerhardt T, Khamhoung A et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundClonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear.ObjectiveWe tested the association…
View details →DOI: 10.1177/13872877261458734 Negative / Null Result ReportMedicine
Zubareva OE, Melik-Kasumov TB, Sinyak DS et al. · 2026 · Neurochemistry international
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
View details →DOI: 10.1016/j.neuint.2026.106206 Negative / Null Result ReportMedicine
Prakash V, Barnes BG, Windorff CJ · 2026 · Communications chemistry
Uranium-nitrogen compounds (U x N y ) pose interesting structural and electronic questions. Understanding the formation and speciation of U x N y may provide insights in nitrogen fixation as well as the preparation of potential uranium…
View details →DOI: 10.1038/s42004-026-02000-y Negative / Null Result ReportMedicine
Lawrence AG, Murangi T, Chevalier A et al. · 2026 · Journal of thrombosis and haemostasis : JTH
Background Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia, leading to joint degeneration despite prophylactic treatment. The CX3CL1 (fractalkine)-CX3CR1 chemokine axis…
View details →DOI: 10.1016/j.jtha.2026.04.035 Negative / Null Result ReportMedicine
Chiusaroli L, Chiusaroli L, Boustany M et al. · 2026 · The Pediatric infectious disease journal
Background Routine blood cultures (BCs) are frequently obtained in hospitalized children with suspected infection. Although bacterial pathogens are the primary concern, fungal infections remain a consideration in high-risk populations,…
View details →DOI: 10.1097/inf.0000000000005282 Negative / Null Result ReportMedicine
Lerma-Clavero A, Kopsida M, Arendt N et al. · 2026 · FEBS open bio
The unfolded protein response (UPR) plays an important role in tumor progression and cellular stress adaptation. In hepatocellular carcinoma (HCC), pharmacological inhibition of the protein kinase R-like endoplasmic reticulum kinase (PERK)…
View details →DOI: 10.1002/2211-5463.70252 