Negative / Null Result ReportMedicine
Lee HW, Harris AN, Wall SM et al. · 2026 · American journal of physiology. Renal physiology
Hypokalemia activates intercalated cell acid secretion, but because hypokalemia is typically associated with metabolic alkalosis, this activation cannot be ascribed to extracellular pH. Metabolic acidosis induces responses similar to those…
View details →DOI: 10.1152/ajprenal.00043.2026 Negative / Null Result ReportMedicine
King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry
The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…
View details →DOI: 10.1038/s41398-026-04174-4 Negative / Null Result ReportMedicine
Donate APG, Cousijn J, Rømer Thomsen K · 2026 · Psychopharmacology
Rationale People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD content, which may…
View details →DOI: 10.1007/s00213-026-07103-x Negative / Null Result ReportMedicine
Brown KA, Max LNF, Struble SE et al. · 2026 · American journal of veterinary research
Objective Determine the acute effects of xylazine and detomidine on concentrations of selected growth factors, cytokines, and α2-macroglobulin (A2M) in platelet-rich plasma (PRP) and autologous protein solution (APS) and the long-term…
View details →DOI: 10.2460/ajvr.26.02.0055 Negative / Null Result ReportMedicine
Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…
View details →DOI: 10.1038/s41386-026-02454-7 Failed Experiment ReportMedicine
Strandberg E, Vikmoen O, Svindland KV et al. · 2026 · European journal of sport science
To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy- and heat-shock-related proteins in women with breast cancer. Exploratory analyses assessed associations between changes…
View details →DOI: 10.1002/ejsc.70213 Failed Experiment Report
Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…
View details →DOI: 10.20944/preprints202604.2084.v1 Failed Experiment ReportMedicine
García-Mendoza A, González-Hernández M, Vega-Manriquez DX et al. · 2026 · Veterinary sciences
This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves. Early consumption of high-quality colostrum is critical for effective…
View details →DOI: 10.3390/vetsci13060600 Negative / Null Result Report
Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
View details →DOI: 10.64898/2026.04.19.719088 Negative / Null Result Report
Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
View details →DOI: 10.21203/rs.3.rs-9073032/v1 Negative / Null Result Report
Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
View details →DOI: 10.31234/osf.io/bpxcj_v2 Negative / Null Result ReportMedicine
Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
View details →DOI: 10.1007/s00213-026-07105-9 Negative / Null Result Report
Ben-Chetrit E, Zilberstein Z, Levin PD · 2026 · Preprint
Abstract Background Obtaining blood cultures at IV insertion is common practice, but is probably associated with greater contamination. Whether use of first-aliquot-diversion (diversion) reduces contamination in this context is not clear.…
View details →DOI: 10.21203/rs.3.rs-9162422/v1 Methods Dead-EndMedicine
Jiang Y, Zanganeh M, Waugh N et al. · 2026 · Gastrointestinal endoscopy
Background and aims Endoscopy units are increasingly being encouraged to consider replacing multiple-use (MU) endoscopes with single-use (SU) endoscopes, largely due to reduction in cross-infection. While evidence suggests comparable…
View details →DOI: 10.1016/j.gie.2026.06.033 Negative / Null Result ReportMedicine
Abrahams M, Bunting BP, Frewer LJ et al. · 2026 · Food & function
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small. Behaviour change theory implies the importance of goal setting to successful health intervention. This…
View details →DOI: 10.1039/d5fo03197d Negative / Null Result ReportMedicine
Ben-Zeev T, Levi C, Ratamess NA et al. · 2026 · Hormones and behavior
This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were…
View details →DOI: 10.1016/j.yhbeh.2026.105948 Negative / Null Result Report
dela Cruz PC, Benson B, Jayavelu ND et al. · 2025 · Preprint
ABSTRACT Background Rhinovirus (RV) is the most common trigger of viral-induced pediatric asthma exacerbations. The impact of IL-13-driven inflammation, common in pediatric asthma, on airway epithelial antiviral and inflammatory responses…
View details →DOI: 10.64898/2025.12.06.692776 Negative / Null Result ReportMedicine
Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…
View details →DOI: 10.1016/j.ejogrb.2026.115242 Negative / Null Result ReportMedicine
Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
View details →DOI: 10.1038/s41598-026-56373-0 Negative / Null Result Report
Lalunio H, Goodman CA, Stupka N et al. · 2026 · Preprint
Abstract Aims Chronic inflammation and oxidative stress are key components in Duchenne muscular dystrophy (DMD) pathology. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in…
View details →DOI: 10.21203/rs.3.rs-9507119/v1 Negative / Null Result ReportMedicine
Wu J, Li G, Pen J et al. · 2026 · Journal of environmental management
Saline-alkali grassland ecosystems are essential methane (CH 4 ) sinks, playing a significant role in global CH 4 budgets. However, our understanding of the CH 4 uptake potential in saline-alkali grasslands and its response to climate…
View details →DOI: 10.1016/j.jenvman.2026.130030 Negative / Null Result Report
Pirillo V, Barca F, Bruno D et al. · 2026 · Preprint
Insects offer promising opportunities for organic waste bioconversion; however, they cannot efficiently degrade synthetic polymers such as polyethylene terephthalate (PET). Here, we generated transgenic Drosophila melanogaster lines to…
View details →DOI: 10.64898/2026.06.04.729872 Negative / Null Result ReportMedicine
Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology
Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…
View details →DOI: 10.1152/ajpheart.00277.2026 Negative / Null Result Report
Nutter NA, Costa-Terryll A, Miller LM et al. · 2026 · Preprint
Streptococcus pneumoniae ( Spn ) asymptomatically colonizes the upper respiratory tract (URT), a niche from which it can transmit to another host or cause invasive disease in the same host. The in vivo transcriptional adaptations that Spn…
View details →DOI: 10.64898/2026.05.19.726214 Negative / Null Result Report
DiLeone R, Trinko JR, Atangana E et al. · 2026 · Preprint
Binge eating disorder (BED) is characterized by episodic overconsumption of palatable food and involves dysregulated motivational and arousal processes. The orexin (hypocretin) system, through its widespread projections to mesolimbic…
View details →DOI: 10.64898/2026.04.24.720455 Negative / Null Result ReportMedicine
Plouhinec L, Maresca M, Saget J et al. · 2026 · Applied microbiology and biotechnology
As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high protein…
View details →DOI: 10.1007/s00253-026-13925-8 Negative / Null Result Report
Pearson AL, Tomaszewska MA, Brown CD et al. · 2026 · Preprint
Abstract Exposure to heat in urban settings is a significant and growing public health concern. Yet, few studies have longitudinally measured everyday heat exposure using GPS-derived activity space data, paired with fine resolution…
View details →DOI: 10.21203/rs.3.rs-9734906/v1 Negative / Null Result ReportMedicine
Ki SY, Jeong YT · 2026 · Biochemical and biophysical research communications
Peripheral sensory nerve injury triggers Wallerian degeneration, a process characterized by axonal fragmentation, myelin breakdown, and robust macrophage infiltration. While macrophages are widely implicated in debris clearance and repair…
View details →DOI: 10.1016/j.bbrc.2026.153878 Negative / Null Result ReportMedicine
Schmid JA, Hogue M, Aguilar-Cardoza J et al. · 2026 · Environmental toxicology and chemistry
Agricultural run-off is one of the leading sources of environmental pollution in the United States. Insecticides and neonicotinoids have become the most used insecticide class across the world and act as an agonist on the nicotinic…
View details →DOI: 10.1093/etojnl/vgag119 Negative / Null Result Report
Riviere JC, Marty V, Cavaillé J et al. · 2026 · Preprint
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of paternally expressed genes within the imprinted 15q11-q13 locus, which includes clusters of box C/D small nucleolar RNAs (SNORDs), notably the SNORD115 and…
View details →DOI: 10.64898/2026.04.28.720143 