Negative / Null Result ReportOpen accessMedicine
Wagstaff KM, Stein MS, Herschtal A et al. · 2025 · Pharmaceutics
Background: The efficacy of a single oral dose of Ivermectin as prophylaxis for SARS-CoV-2 is uncertain. This trial sought to evaluate the effectiveness of a single oral low dose of Ivermectin to prevent SARS-CoV-2 infection or reduce…
View details →DOI: 10.3390/pharmaceutics17091205 Negative / Null Result ReportMedicine
Çevik N, Hazar Bodrumlu E · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials.…
View details →DOI: 10.1007/s40368-024-00894-7 Negative / Null Result ReportMedicine
Taguchi K, Chuang VTG, Ozawa M et al. · 2024 · Die Pharmazie
Urticaria is induced by the histamine released from mast cells which develops wheals (edema) as a visual feature. In clinical practice, second-generation histamine H 1 -receptor blockers are routinely used as the first-line symptomatic…
View details →DOI: 10.1691/ph.2024.4518 Failed Experiment Report
Medina E, Sanchez-Sandoval AL, Barrón-Palma EV et al. · 2024 · Preprint
Background Coronavirus disease 2019 (COVID-19) has created the need to evaluate drugs such as favipiravir (FPV), an antiviral inhibitor of RNA-dependent RNA-polymerase (RdRp), and Maraviroc (MVC), an antiretroviral that antagonizes the…
View details →DOI: 10.12688/f1000research.143776.2 Negative / Null Result ReportMedicine
Martins J, Eliseu A, Campos S et al. · 2024 · Animals : an open access journal from MDPI
The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their…
View details →DOI: 10.3390/ani14121732 Negative / Null Result ReportOpen accessMedicine
Wu H, Jin J, Zhou D et al. · 2025 · BMC anesthesiology
Background Liposomal bupivacaine (LB) provides prolonged analgesia, but it remains unclear whether it prevents rebound pain or merely delays its onset. This study investigated the effect of LB on rebound pain in a mouse model of peripheral…
View details →DOI: 10.1186/s12871-025-03430-2 Replication FailureOpen accessMedicine
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2025 · BMC cancer
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →DOI: 10.1186/s12885-025-13684-1 Negative / Null Result ReportMedicine
Pintus E, Scaringi M, Engelen J et al. · 2026 · Theriogenology
Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…
View details →DOI: 10.1016/j.theriogenology.2026.118051 Negative / Null Result ReportMedicine
de Lazzari E, Nomah DK, Blanco JL et al. · 2024 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives The prevalence and risk factors of SARS-CoV-2 infection among unvaccinated people living with HIV (PWH) are not well understood, and the protective role of tenofovir remains controversial. This study aimed to assess the…
View details →DOI: 10.1016/j.ijid.2024.107266 Negative / Null Result ReportOpen accessMedicine
Gabaldon-Albero A, Martin-Grau C, Marti-Masanet M et al. · 2024 · Pediatric rheumatology online journal
Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic…
View details →DOI: 10.1186/s12969-024-01036-5 Negative / Null Result ReportOpen accessMedicine
Tang F, Zhang L, Lu S et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background Hyperbaric oxygen therapy (HBOT) is widely used as a therapeutic intervention for various types of wounds. Studies have shown that in addition to improving local oxygen supply to the wound site, HBOT can also influence cytokine…
View details →DOI: 10.1002/cnr2.70563 Negative / Null Result Report
Eghbali A, Ghaffari K, Eghbali A et al. · 2024 · Preprint
Background: Magnesium oxide is proposed to be effective in prevention of nephrotoxic impact of carboplatin therapy. The aim was to evaluate the magnesium oxide supplementation effect on serum creatinine, blood urea nitrogen (BUN) and…
View details →DOI: 10.22541/au.170665409.99346891/v1 Negative / Null Result ReportOpen accessMedicine
Gao J, Mathias RT, Varadaraj K et al. · 2025 · Investigative ophthalmology & visual science
Purpose The lens has a feedback control system made by transient receptor potential vanilloid 4 (TRPV4) and TRPV1 to sense pressure and activate ion transport to maintain intracellular hydrostatic pressure close to zero at the lens…
View details →DOI: 10.1167/iovs.66.13.20 Negative / Null Result ReportMedicine
Cropper E, Riley P, Simon AG · 2024 · Journal of forensic sciences
There are many factors that may affect the longevity of or guide the use of canine training aids. Literature to date has mainly focused on identifying the headspace volatiles associated with training aids or odors and only minimal research…
View details →DOI: 10.1111/1556-4029.15507 Negative / Null Result ReportOpen accessMedicine
Carr JF, Basurto De Santiago C, Bhut SA et al. · 2026 · mBio
In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics. SanA, an inner membrane…
View details →DOI: 10.1128/mbio.00635-26 Negative / Null Result ReportMedicine
Bastia L, Garberi R, Querci L et al. · 2024 · Journal of clinical monitoring and computing
To determine how percutaneous tracheostomy (PT) impacts on respiratory system compliance (C rs ) and end-expiratory lung volume (EELV) during volume control ventilation and to test whether a recruitment maneuver (RM) at the end of PT may…
View details →DOI: 10.1007/s10877-024-01174-x Negative / Null Result ReportOpen accessMedicine
Nemets VV, Grinevich VP, Petrunina EN et al. · 2025 · Cells
Recent studies indicated a connection between trace amine-associated receptor 5 (TAAR5) and emotional behaviors related to anxiety and depression; however, the neurobiological basis of this link is still unclear. Using mutant TAAR5…
View details →DOI: 10.3390/cells15010039 Negative / Null Result ReportMedicine
Yurttutan S, Geçkil E · 2026 · Journal of pediatric nursing
Aim This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). Method A…
View details →DOI: 10.1016/j.pedn.2026.05.008 Negative / Null Result Report
Matsuda S, Katsura Y, Shirata M et al. · 2026 · Preprint
Abstract Background: Pediatric seizures are low-frequency, high-risk events in primary care clinics. However, structured interprofessional simulation training in this setting remains rare. Evidence of the effectiveness of such training on…
View details →DOI: 10.21203/rs.3.rs-9619343/v1 Negative / Null Result ReportMedicine
Matta G, Edwards A, Roelands B et al. · 2026 · Research quarterly for exercise and sport
The physiological and placebo effects of beetroot juice remain unclear in settings outside traditional laboratory environments. Using a randomized, between-participant balanced placebo design, we asked 67 trained cyclists to complete…
View details →DOI: 10.1080/02701367.2026.2625878 Negative / Null Result ReportMedicine
Pokhrel P, Phillips KT, Phillips MM et al. · 2026 · Addiction (Abingdon, England)
Background and aims Co-use of cannabis and e-cigarettes for nicotine is increasing among younger adults in the United States (US). This study aimed to determine (1) the patterns of cannabis and e-cigarette use and co-use over time and (2)…
View details →DOI: 10.1111/add.70501 Methods Dead-EndMedicine
Fiebig N, Bartsch L, Klötzer C et al. · 2026 · Headache
Objective To evaluate the effects of a short, structured multimodal day-clinic program on health-related quality of life and disability in patients with primary headache disorders. Background Although monoclonal antibodies targeting the…
View details →DOI: 10.1111/head.70133 Methods Dead-EndMedicine
Jean J, Klein JI, Karashchuk N et al. · 2026 · Headache
Objective To determine if there is increased headache burden and disability among women with and without migraine during an in vitro fertilization (IVF) cycle. Background Migraine and infertility commonly impact women of childbearing age.…
View details →DOI: 10.1111/head.70111 Negative / Null Result ReportMedicine
Arko L, Nguyen TH, Stoffel M et al. · 2026 · AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Documentation burden and cognitive load contribute to clinician burnout, and ambient AI scribes offer a promising solution, though real-world evaluations remain limited. This study evaluated the impact of an ambient AI scribe on…
Negative / Null Result ReportMedicine
Gambale C, Faranda A, Ambrogio A et al. · 2026 · European journal of endocrinology
Objective Several patients with medullary thyroid carcinoma (MTC) are not cured after surgery. Disease persistence/recurrence is monitored by measuring calcitonin (CTN) and carcinoembryonic antigen (CEA) and by imaging. The role of…
View details →DOI: 10.1093/ejendo/lvag078 Negative / Null Result Report
Kröber P, Wolf F, Saliger J et al. · 2026 · Preprint
Background Gait training incorporating visual feedback or rhythmic auditory cueing has shown promising results in neurological conditions but has rarely been investigated in clinical rehabilitation for persons with Multiple Sclerosis…
View details →DOI: 10.64898/2026.06.18.26356023 Replication Failure
Wang Y, Zhang M, Qian N · 2026 · Preprint
Summary Forward receptive-field (RF) remapping, a mechanism for transsaccadic updating of retinal positions and perceptual stability, transiently changes cells’ eccentricities and thus could also change their RF sizes, yet few studies…
View details →DOI: 10.64898/2026.05.25.727689 Negative / Null Result ReportOpen accessMedicine
Zhang W, Guh DP, Tam ACT et al. · 2026 · Health affairs scholar
Introduction Evidence on the launch and diffusion of therapeutically important new medicines is limited. We examined the launch and diffusion of new patented medicines in 14 countries by therapeutic value. Methods We analyzed IQVIA MIDAS®…
View details →DOI: 10.1093/haschl/qxag119 Negative / Null Result ReportMedicine
Xiao J, Choi HM, Yim G et al. · 2026 · American journal of epidemiology
Epidemiological evidence on whether cesarean delivery influences offspring neurodevelopment remains inconsistent. We evaluated the associations between maternal cesarean delivery and childhood autism spectrum disorder (ASD) and…
View details →DOI: 10.1093/aje/kwag150 Negative / Null Result Report
Mevliyaoğulları E · 2026 · Preprint
Abstract Background The present study evaluated a technology-driven approach for producing a plant-protein-rich bird food based on colloid-mill-modified zein suspension and compared its first-clutch reproductive performance with an…
View details →DOI: 10.21203/rs.3.rs-9904294/v1 