Characterizing non-hallucinogenic psychedelics beyond the head twitch response: phenotypic fingerprinting of lisuride and LSD.
King JL; Effinger DP; Basquez-Pfeifer C; Wallingford JR; Calderon JR; O'Connell CK; Thompson SM · 2026 · Translational psychiatry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…
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Metadata source: Europe PMC · DOI 10.1038/s41398-026-04174-4