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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21346 results · page 550 of 712

Negative / Null Result ReportMedicine

Circulating immune cell biomarkers in Psoriatic Arthritis: associations with clinical manifestations and treatment response in the TOFA-PREDICT trial.

Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy

Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…

View details →DOI: 10.1186/s13075-026-03833-7
Negative / Null Result ReportMedicine

Stigma in functional neurological disorder; a longitudinal study.

Mcloughlin C, Ramsay N, Tak L et al. · 2026 · Journal of psychosomatic research

Background Stigma in Functional Neurological Disorder has been consistently reported by patient organisations as one of their biggest challenges. We aimed to longitudinally evaluate different components of stigma, namely perceived,…

View details →DOI: 10.1016/j.jpsychores.2026.112550
Negative / Null Result ReportMedicine

Effects of Acute Caffeine Supplementation on Integrated Biathlon Performance in Elite Male Athletes.

Engel H, Yilmaz C, Appelhans D et al. · 2026 · International journal of sport nutrition and exercise metabolism

Caffeine enhances endurance performance but may impair shooting accuracy, creating a potential trade-off for overall biathlon performance. In a randomized, placebo-controlled, crossover study, seven elite male biathletes consumed caffeine…

View details →DOI: 10.1123/ijsnem.2025-0138
Negative / Null Result ReportMedicine

Accuracy of thoracolumbar pedicle screw placement using intraoperative CT navigation versus 3D-printed patient-specific guides integrated with virtual surgical planning: a comparative study.

Pairojboriboon S, Charakorn K, Promoppatum P · 2026 · Expert review of medical devices

Background 3D-printed patient-specific pedicle screw guides (3DPSG) may provide accuracy comparable to intraoperative CT navigation (CTNav). Our 3DPSG workflow incorporates a virtual surgical planning (VSP) platform that uses deep-learning…

View details →DOI: 10.1080/17434440.2026.2687808
Negative / Null Result ReportMedicine

Outcome after cardiac surgery in Jehovah's Witnesses.

Karlsson E, Dalén M, Svenarud P et al. · 2026 · Scandinavian cardiovascular journal : SCJ

Objectives Jehovah's Witnesses categorically refuse allogenic blood transfusions on religious grounds, a major challenge if intervention for heart disease is required. We retrospectively analyzed outcome after open-heart surgery in 26…

View details →DOI: 10.1080/14017431.2026.2690764
Negative / Null Result ReportMedicine

Correlation between viral load and cervical squamous lesion severity in single and multiple infections: a large-scale analysis.

Xu T, Zhao J, Wu J et al. · 2026 · Infectious agents and cancer

Objective This study examined the association between high risk human papillomavirus viral load and cervical squamous lesions using the Cobas 4800 assay and evaluated its potential as an indicator for identifying CIN2+, and analyzed the…

View details →DOI: 10.1186/s13027-026-00770-7
Negative / Null Result ReportMedicine

Efficacy and Safety of an Innovative Intraoral Cleaning Device-A Randomized Controlled Clinical Trial.

Steuber T, Graetz C, Springer C et al. · 2026 · International journal of dental hygiene

Objective This two-centre, double-blind, randomized, parallel-group study compared the efficacy and safety of a novel powered full-mouth cleaning device system (FMCD) with habitual toothbrushing (CG) in patients with generalized gingivitis…

View details →DOI: 10.1111/idh.70116
Negative / Null Result ReportMedicine

Comparing Clinical and Radiological Outcomes for a Three-Dimensional Printed Highly-Porous Cup and a Hydroxyapatite-Coated Non-Highly-Porous Cup in Total Hip Arthroplasty Using Propensity Score Matching.

Okazaki T, Imagama T, Matsuki Y et al. · 2026 · The Journal of arthroplasty

Background The use of highly-porous acetabular components in total hip arthroplasty (THA) has gained popularity. To elucidate the clinical and radiological outcomes of three-dimensional (3D)-printing highly porous cups, we compared…

View details →DOI: 10.1016/j.arth.2026.06.011
Negative / Null Result ReportMedicine

Determining the Impact of Race and Ethnicity on Diagnosis and Management of Vestibular Schwannoma.

Patel AA, Levi JR, Weber PC · 2026 · The Annals of otology, rhinology, and laryngology

Objective While prior literature has demonstrated that patients of lower socioeconomic groups may have larger tumors on presentation and poorer outcomes, there is limited literature on the impact of race and ethnicity on management of…

View details →DOI: 10.1177/00034894261453716
Negative / Null Result ReportMedicine

Hamstring-to-quadriceps ratio across menstrual cycle phases in physically active women: a repeated-measures study.

Heinrich C, Hofstaetter H, Puschkasch-Möck S et al. · 2026 · European journal of applied physiology

Objective To evaluate conventional hamstring-to-quadriceps ratio across the menstrual cycle in distinct angular velocities in an eumenorrheic, physically active population. Design Repeated measures within-subjects design. Methods…

View details →DOI: 10.1007/s00421-026-06279-6
Negative / Null Result ReportMedicine

Medium Cut-Off Versus High-Flux Dialyzers and Changes in Beck Depression Inventory Scores in Maintenance Hemodialysis: An Exploratory Observational Study.

Avsar FN, Erinc O, Sahutoglu T · 2026 · Hemodialysis international. International Symposium on Home Hemodialysis

Introduction Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle…

View details →DOI: 10.1111/hdi.70091
Negative / Null Result ReportMedicine

Acute cholecystitis in the robotic era: comparative safety and feasibility of robotic and laparoscopic cholecystectomy in an acute care surgery service.

Pontecorvo AA, Cornejo J, Tsenteradze T et al. · 2026 · Journal of robotic surgery

This study aimed to evaluate and compare perioperative outcomes of robotic versus laparoscopic cholecystectomy in patients with acute cholecystitis within an Acute Care Surgery setting. A retrospective cohort study was conducted including…

View details →DOI: 10.1007/s11701-026-03530-2
Negative / Null Result ReportMedicine

Real-World Outcomes of Nivolumab Plus Ipilimumab in Metastatic Melanoma: A Stratified Analysis of First- and Second-Line Treatment.

Iurchenkov A, Danilova A, Shilo P et al. · 2026 · Cancers

Background : Immune checkpoint inhibitors have significantly improved survival in metastatic melanoma. Combination nivolumab plus ipilimumab demonstrated superior efficacy in randomized trials, including CheckMate 067, but data beyond the…

View details →DOI: 10.3390/cancers18121994
Negative / Null Result Report

Day 7 clinical indicators for predicting discharge destination in patients with prolonged ICU stays: implications for time-limited trials

harada k, ikeda s, makino j · 2026 · Preprint

Abstract Background Prolonged intensive care unit (ICU) stays are associated with increased mortality and functional decline. Time-limited trials (TLTs) support decision-making under prognostic uncertainty; however, uncertainty may persist…

View details →DOI: 10.21203/rs.3.rs-9559184/v1
Negative / Null Result ReportMedicine

Interaction model of client health behavior-based nursing intervention improves outcomes in patients with pressure injury: A quasi-experimental study.

Guan X, Li X, Yue M et al. · 2026 · Scientific reports

Pressure injury (PI) prevention requires sustained nursing behaviors from patients, caregivers, and nurses. This single-center quasi-experimental, non-randomized, non-equivalent control group study enrolled 60 inpatients with PI or high PI…

View details →DOI: 10.1038/s41598-026-59843-7
Negative / Null Result ReportOpen accessMedicine

Combined Bisoprolol and Megestrol Acetate Improves Survival and Preserves Cardiac Performance in a Rat Model of Cancer Cachexia.

Chen Z, Wang S, Palus S et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not…

View details →DOI: 10.1002/jcsm.70313
Negative / Null Result Report

Donor-source-specific competing risks of relapse and non-relapse mortality in adult B-ALL allogeneic hematopoietic stem cell transplantation

Choi D, Jung CW, Jang JH · 2026 · Preprint

Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a cornerstone of therapy for adult B-cell acute lymphoblastic leukemia (B-ALL), yet simultaneous comparisons across all four major donor categories…

View details →DOI: 10.21203/rs.3.rs-9480094/v1
Negative / Null Result ReportMedicine

Foetoscopic Laser Management of Triplet Pregnancies Complicated by Twin-Twin Transfusion Syndrome.

Vlachodimitropoulou E, Dagli SN, Huang GNY et al. · 2026 · Fetal diagnosis and therapy

Introduction Twin-twin transfusion syndrome (TTTS) may complicate triplet pregnancies with a monochorionic component; however, data on foetoscopic laser ablation (FLA) in this setting remain limited. This study evaluated perinatal outcomes…

View details →DOI: 10.1159/000551563
Negative / Null Result ReportMedicine

Imipramine: Do Metabolite Plasma Levels Affect Treatment Response?

Kasanmonadi RYN, Kamperman AM, Koch BCP et al. · 2026 · Journal of clinical psychopharmacology

Purpose/background Although combined plasma levels of imipramine and its metabolite desipramine are routinely assessed during therapeutic drug monitoring (TDM) of imipramine treatment, individual plasma levels are often overlooked.…

View details →DOI: 10.1097/jcp.0000000000002187
Negative / Null Result ReportMedicine

P-glycoprotein expression in sinonasal inverted papillomas and polyps: Marker or bystander?

Altan E, Küçüktağ Z, Arslankoz S et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: Sinonasal inverted papillomas (IPs) and nasal polyps (NPs) represent distinct benign lesions with different biological behaviors. P-glycoprotein (P-gp), a multidrug resistance transporter, has been implicated in inflammatory and…

View details →DOI: 10.1007/s00405-026-10220-0
Negative / Null Result ReportMedicine

Daily cost-efficiency of robotic liver resection over laparoscopic and open liver resection especially for complex liver resection procedures: An inverse probability of treatment weighting analysis.

Kano T, Kawaguchi Y, Nishioka Y et al. · 2026 · Surgery today

PURPOSE: To address our hypothesis that increased surgical costs for robotic liver resection would be compensated by reduced postoperative care expenses, we compared the economic outcomes of robotic, laparoscopic, and open liver resection…

View details →DOI: 10.1007/s00595-026-03293-1
Negative / Null Result ReportMedicine

Increased mortality and Acinetobacter baumannii predominance despite stable healthcare-associated infection rates during the COVID-19 pandemic.

Kaya G, Oskay PÖ, Mert NK et al. · 2026 · BMC infectious diseases

Background Coronavirus disease 2019 (COVID-19), first identified in Wuhan, China, in December 2019, rapidly evolved into a global pandemic with substantial morbidity and mortality. Severe COVID-19 cases, particularly those with pneumonia…

View details →DOI: 10.1186/s12879-026-13582-2
Negative / Null Result ReportMedicine

Association between iron status and inflammation markers with GDF15 and BMP6 in inflammatory bowel disease: a single center cross-sectional study.

Üstün Y, Yanık S, Uçar F et al. · 2026 · BMC gastroenterology

Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic disorders with relapsing and remitting disease courses. Several clinical indicators and biomarkers have been evaluated…

View details →DOI: 10.1186/s12876-026-04929-9
Negative / Null Result ReportOpen accessMedicine

Safety and Tolerability of Fractional CO<sub>2</sub> Lasers for Facial Rejuvenation Across Fitzpatrick Skin Phototypes I-IV: Retrospective Cohort Study.

Oloruntoba AI, Rodrigues M · 2026 · Journal of cosmetic dermatology

Background Fractional CO 2 laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO 2 laser systems include pulse modes such as HighPulse (HP),…

View details →DOI: 10.1111/jocd.70917
Negative / Null Result ReportMedicine

Child maltreatment recognition and reporting attitudes among pediatric nurses and physicians in Türkiye: A cross-sectional comparative study.

Çarikçi F, Girgin BA, Harmanci NF et al. · 2026 · Child abuse & neglect

Aim To examine and compare the proficiency of pediatric physicians and nurses in recognizing the signs of and risk factors for child maltreatment, as well as to determine the relationship between this proficiency and their reporting…

View details →DOI: 10.1016/j.chiabu.2026.108086
Negative / Null Result ReportMedicine

Safety and Efficacy of Oral Tacrolimus Induction Therapy in Elderly Patients with Ulcerative Colitis: A Subanalysis of a Large Multicenter Retrospective Cohort Study.

Inokuchi T, Hiraoka S, Oshima N et al. · 2026 · Gerontology

Introduction We previously reported the findings of a multicenter retrospective cohort study investigating the efficacy of oral tacrolimus induction therapy in patients with ulcerative colitis (UC). In this subanalysis, we specifically…

View details →DOI: 10.1159/000551622