A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21216 results · page 56 of 708
Martin D. Hoffman, Julie L. Ingwerson, Ian R. Rogers et al. · 2012 · Wilderness and Environmental Medicine
OBJECTIVE: Very high blood creatine kinase (CK) concentrations have been observed among recent finishers of the 161-km Western States Endurance Run (WSER), and it has been suggested that there is a link between rhabdomyolysis and…
David Hodgson, Richard Pebody, Jasmina Panovska‐Griffiths et al. · 2020 · BMC Medicine
BACKGROUND: With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and new vaccines, it is likely that one or more of these will replace the current monoclonal Palivizumab programme. However, choosing the optimal intervention programme will require balancing the costs of the programmes with the health benefits accrued. METHODS: To compare the next generation of RSV prophylactics, we integrated a novel transmission model with an economic analysis. We estimated key epidemiological parameters by calibrating the model to 7 years of historical ep
Jeffrey Jensen Arnett · 2013 · Emerging Adulthood
This article addresses the question of whether today’s emerging adults are excessively “narcissistic” as claimed by Jean Twenge and others. The answer is a decisive “no.” There is no persuasive evidence that scores on the Narcissistic…
Caner Süsal, Dániel Wettstein, Bernd Döhler et al. · 2015 · Transplantation
BACKGROUND: The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority of studies were based on small numbers of patients with graft failure. METHODS: We…
Qilong Lu, Sebahattin Çirak, Terence A. Partridge · 2014 · Molecular Therapy — Nucleic Acids
On 20 September 2013, GlaxoSmithKline (GSK) and Prosensa announced that GSK's Phase III clinical trial (NCT01254019) of Drisapersen, an exon skipping drug for Duchenne muscular dystrophy (DMD), failed to meet the primary endpoint of a…
Theresa J. Ochoa, Jaime Zegarra, Luis Cam et al. · 2014 · The Pediatric Infectious Disease Journal
BACKGROUND: Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein. OBJECTIVE: To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian infants.…
Azra Fatima, Shao Kaifeng, Sven Dittmann et al. · 2013 · PLoS ONE
Long QT syndromes (LQTS) are heritable diseases characterized by prolongation of the QT interval on an electrocardiogram, which often leads to syncope and sudden cardiac death. Here we report the generation of induced pluripotent stems (iPS) cells from two patients with LQTS type 3 carrying a different point mutation in a sodium channel Nav1.5 (p.V240M and p.R535Q) and functional characterization of cardiomyocytes (CM) derived from them. The iPS cells exhibited all characteristic properties of pluripotent stem cells, maintained the disease-specific mutation and readily differentiated to CM. Th
Martin Michaelis, Bishr Agha, Florian Rothweiler et al. · 2015 · Scientific Reports
Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as highly flubendazole-sensitive cancer entity in a screen of 321 cell lines from 26 cancer entities. Flubendazole also reduced the viability of five primary neuroblastoma samples in nanomolar concentrations thought to be achievable in humans and inhibited vessel formation and neuroblastoma tumour growth in the chick chorioallantoic membrane assay. Resis
Yan Xu, Sam Schulman, Dar Dowlatshahi et al. · 2017 · CHEST Journal
BackgroundDirect oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin…
Denton Collins, William R. Pasewark, Mark E. Riley · 2012 · Accounting Horizons
SYNOPSIS: This archival study addresses whether the presence or absence of “bright lines” in a lease accounting standard influences the classification of leases as capital or operating. To the best of our knowledge, our study is the first…
Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
Roanna George, Stuart J. Moat · 2015 · Clinical Chemistry
BACKGROUND: The analysis of dried blood spots has been used routinely for newborn screening since the early 1970s, and the number of disorders screened has expanded substantially in recent years. However, there is a lack of evidence…
A. Sertaç Batıoğlu, Uğraş Şahin, Beril Gürlek et al. · 2011 · Gynecological Endocrinology
The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo…
Ralph Kober, Thanesvary Subraamanniam, John Watson · 2011 · Accounting and Finance
Abstract This paper examines whether the management accounting practice of total quality management (TQM) positively impacts on the financial performance of small and medium enterprises (SMEs). While research has investigated the impact of…
Karolina Partheen, Björg Kristjánsdóttir, Karin Sundfeldt · 2011 · Journal of Gynecologic Oncology
OBJECTIVE: Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the…
Katarzyna Jednoróg, Artur Marchewka, Irène Altarelli et al. · 2015 · Human Brain Mapping
The neural basis of specific reading disability (SRD) remains only partly understood. A dozen studies have used voxel-based morphometry (VBM) to investigate gray matter volume (GMV) differences between SRD and control children, however,…
Hamid Seyedsayamdost · 2014 · Philosophical Psychology
In their paper titled “Gender and philosophical intuition,” Buckwalter and Stich argue that the intuitions of women and men differ significantly on various types of philosophical questions. Furthermore, men's intuitions, so the authors…
Bart J. Bronnenberg, Jean‐Pierre Dubé, Carl F. Mela · 2010 · Journal of Marketing Research
The authors analyze a multimillion dollar, three-year field study sponsored by five firms to assess whether enabling skipping of advertisements using digital video recorders (DVRs) affects consumers’ shopping behavior for advertised and…
Constance A. Mara, Robert A. Cribbie · 2012 · Communications in Statistics - Simulation and Computation
Equivalence tests are used when the objective is to find that two or more groups are nearly equivalent on some outcome, such that any difference is inconsequential. Equivalence tests are available for several research designs, however,…
Bill Hesselmar, Robert Saalman, Anna Rudin et al. · 2010 · Acta Paediatrica
OBJECTIVE: To investigate if the development of allergic diseases during the child's first 18 months of life is influenced by the time at which different food items were introduced into the child's diet. METHOD: A birth cohort of 184…
Elisa V. Bandera, Melony King, Urmila Chandran et al. · 2011 · BMC Women s Health
BACKGROUND: While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. METHODS: We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were
Junya Ako, Kiyoshi Hibi, Kenichi Tsujita et al. · 2019 · Circulation Journal
BACKGROUND: In patients with acute coronary syndrome (ACS), alirocumab reduced the risk of recurring ischemic events. ODYSSEY J-IVUS assessed the effect of alirocumab on coronary atheroma volume in Japanese patients recently hospitalized…
Klaus Wirth, Hagen Hartmann, André Sander et al. · 2015 · The Journal of Strength and Conditioning Research
Strength training-induced increases in speed strength seem indisputable. For trainers and athletes, the most efficient exercise selection in the phase of preparation is of interest. Therefore, this study determined how the selection of…
Lori G. Beaman, Dean Karlan, Bram Thuysbaert et al. · 2013 · American Economic Review
We conducted an experiment providing fertilizer grants to female rice farmers in Mali. We found that women who received fertilizer used both more fertilizer and more complementary inputs such as herbicides and hired labor. This shows that…
Jens Theysohn, Oliver Kraff, Stefan Maderwald et al. · 2011 · Journal of Magnetic Resonance Imaging
PURPOSE: To evaluate 7T MRI in the assessment of cerebrovascular alterations as seen in vascular dementia by means of detection of cerebral microbleeds (CMB) and depiction of white matter lesions (WML). 7T imaging was evaluated with…
Ziyauddin Khan, Mikhail Vagin, Xavier Crispin · 2020 · Advanced Science
Abstract In recent years, there has been an upsurge in the study of novel and alternative energy storage devices beyond lithium‐based systems due to the exponential increase in price of lithium. Sodium (Na) metal‐based batteries can be a…
Charles F. Manful, Eric Fordjour, Dasinaa Subramaniam et al. · 2025 · International Journal of Molecular Sciences
Reactive molecules, including oxygen and nitrogen species, serve dual roles in human physiology. While they function as essential signaling molecules under normal physiological conditions, they contribute to cellular dysfunction and damage when produced in excess by normal metabolism or in response to stressors. Oxidative/nitrosative stress is a pathological state, resulting from the overproduction of reactive species exceeding the antioxidant capacity of the body, which is implicated in several chronic human diseases. Antioxidant therapies aimed at restoring redox balance and preventing oxida
Abu Saleh Musa Miah, Jungpil Shin, Md. Al Mehedi Hasan et al. · 2022 · Applied Sciences
Sign language recognition is one of the most challenging applications in machine learning and human-computer interaction. Many researchers have developed classification models for different sign languages such as English, Arabic, Japanese, and Bengali; however, no significant research has been done on the general-shape performance for different datasets. Most research work has achieved satisfactory performance with a small dataset. These models may fail to replicate the same performance for evaluating different and larger datasets. In this context, this paper proposes a novel method for recogn
Britt Clynick, Tamera J. Corte, Helen E. Jo et al. · 2021 · European Respiratory Journal
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three…
Nathan Hendricks, Jeffrey M. Peterson, Hendricks, Nathan P. et al. · 2012 · AgEcon Search (University of Minnesota, USA)
Irrigation water demand is estimated using field-level panel data from Kansas over 16 years. The cost of pumping varies over time due to changes in energy prices and across space due to differences in the depth to water. Exploiting this…