Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome
Elizabeth Nance; Siva P. Kambhampati; Elizabeth S. Smith; Zhi Zhang; Fan Zhang; Sarabdeep Singh; Michael V. Johnston; Rangaramanujam M. Kannan · 2017 · Journal of Neuroinflammation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain inflammation/injury both in vitro and in vivo using a Mecp2-null mouse model of Rett syndrome. To determine whether inflammation and immune dysregulation were potential targets for dendrimer-based therapeutics in R
Abstract by Elizabeth Nance; Siva P. Kambhampati; Elizabeth S. Smith; Zhi Zhang; Fan Zhang; Sarabdeep Singh; Michael V. Johnston; Rangaramanujam M. Kannan, Journal of Neuroinflammation (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12974-017-1004-5