Genetic effects influencing risk for major depressive disorder in China and Europe
Tim B. Bigdeli; Stephan Ripke; Roseann E. Peterson; Maciej Trzaskowski; S-A Bacanu; Abdel Abdellaoui; Till F. M. Andlauer; Aartjan T.F. Beekman · 2017 · Translational Psychiatry
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Abstract
Abstract Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying c
Abstract by Tim B. Bigdeli; Stephan Ripke; Roseann E. Peterson; Maciej Trzaskowski; S-A Bacanu; Abdel Abdellaoui; Till F. M. Andlauer; Aartjan T.F. Beekman, Translational Psychiatry (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/tp.2016.292