Negative / Null Result ReportOpen accessAgriculture
S.H. Hoseinifar email ; A.R. Mirvaghefi; B. Mojazi Amiri; H.A. Khoshbavar Rostami; M. Poor Amini; K. Darvish Bastami · 2011 · Majallah-i ̒Ilmī-i Shīlāt-i Īrān
The probiotic effects of inactive yeast, Saccharomyces cerevisiae var. ellipsoideus was studied on growth performance, survival and intestinal microbiota of beluga juveniles (Huso huso). The study was done in complete randomize design that included feeding of beluga juveniles with diets supplemented with 0 (control), 1, 2 and 5% yeast (4 treatments with 3 replicates). Beluga juveniles (11.40±0.56g) were randomly allocated in 12 oval tanks at a density of 35 fish per tank and triplicate group were fed with experimental diets. At the end of the trial, growth factors (final weight, weight gain,
Negative / Null Result ReportOpen accessMedicine (General)
Lee J, Jo D, Song S et al. · 2020 · Journal of Pain Research
Jongseok Lee,1 Daehyun Jo,2 Shinmi Song,1 Dahee Park,1 Dohyeong Kim,1 Jinyoung Oh1 1Department of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Pain Center, Pohang Wooridul Hospital, Pohang-si, Gyeongsangbuk-do, Republic of KoreaCorrespondence: Jinyoung OhDepartment of Anesthesiology and Pain Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-Ro, Gangnan-Gu, Seoul, Republic of KoreaTel +82-2-2019-3600Fax +82-2-2019-4833Email sgcms3@gmail.comPurpose: Dispersion of contrast media
Negative / Null Result ReportOpen accessMedicine
Yu-Hsuan Wu, Yi-Huei Chen, Ming-Hong Chang et al. · 2018 · PLoS ONE
To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia). The association between the onset of depression and levodopa equivalent dosage
View details →DOI: 10.1371/journal.pone.0192050 Negative / Null Result ReportOpen accessMedicine
WANG Yibo, HAN Yingdong, XIE Tiange, WU Juan, DI Hong, ZHANG Yun, ZENG Xuejun · 2025 · Jichu yixue yu linchuang
Objective To characterize the clinical features of the group of gout patients to facilitate earlier identification, and optimize the diagnosis and treatment of the condition. Methods The retrospective study analyzed 24 gout patients with shoulder joint(s) involved and consulted by physicians of Peking Union Medical College Hospital from March 2021 to April 2025, while 70 outpatient gout patients matched by clinical course duration and sex were enrolled as control group. Clinical data including medical history, laboratory tests, therapeutic interventions. Prognosis was systematically collected
View details →DOI: 10.16352/j.issn.1001-6325.2025.11.1485 Negative / Null Result ReportOpen accessSurgery
Leonardo de Castro Durães, Eliana Ferreira Ribeiro Durães, Pedro Felipe Silva de Freitas et al. · 2013 · Acta Cirúrgica Brasileira
PURPOSE: To evaluate the feasibility and safety of a new technique for laparoscopic segmental colectomy and primary anastomosis in the left colon of rats. METHODS: Thirty rats were randomly assigned to three groups of ten animals each. All animals underwent segmental resection of the left colon and end-to-end anastomosis. In Group I, the animals underwent laparoscopic surgery with carbon dioxide pneumoperitoneum at a pressure of 5 mmHg. In Group II, the animals underwent pneumoperitoneum with carbon dioxide at a pressure of 12 mmHg. In Group III, the control group, the animals underwent open s
Negative / Null Result ReportOpen accessInternal medicine
Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto et al. · 2022 · Acta Medica Indonesiana
Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on
Negative / Null Result ReportOpen accessMedicine (General)
Dalia M. Kamel, Nashwa S. Hamed, Neveen A. Abdel Raoof et al. · 2017 · Journal of Advanced Research
The aim of this study was to compare the effects of pulsed electromagnetic field versus pulsed ultrasound in treating patients with postnatal carpal tunnel syndrome. The study was a randomized, double-blinded trial. Forty postnatal female patients with idiopathic carpal tunnel syndrome were divided randomly into two equal groups. One group received pulsed electromagnetic field, with nerve and tendon gliding exercises for the wrist, three times per week for four weeks. The other group received pulsed ultrasound and the same wrist exercises. Pain level, sensory and motor distal latencies and con
View details →DOI: 10.1016/j.jare.2016.11.001 Failed Experiment ReportOpen accessDermatology
Stefan J. Jodl, Margitta Worm, Frauke Friedrichs et al. · 2025 · Dermatology and Therapy
Abstract Introduction Interleukin-1 receptor-associated kinase 4 (IRAK4) is expressed in various immune cells and regulates proinflammatory cytokine production. Its inhibition represents a novel, promising therapeutic option in the treatment of atopic dermatitis (AD). Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor that suppresses markers of local and systemic immune responses. This study aimed to evaluate the efficacy and safety of zabedosertib in adults with moderate-to-severe AD. Methods DAMASK was a randomized, double-blind, 12-week, placebo-controlled, phase 2a, proof-of-
View details →DOI: 10.1007/s13555-025-01505-z Failed Experiment ReportOpen accessTherapeutics. Pharmacology
Girish Parthan, Shobhit Bhansali, Anura V. Kurpad et al. · 2018 · BMC Pharmacology and Toxicology
Abstract Background Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control by promoting GLP1-mediated glucose-dependent insulin secretion and suppression of glucagon. Sitagliptin and vildagliptin have been shown to improve insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). However, these patients had uncontrolled blood glucose at inclusion; therefore, the improvement in insulin sensitivity observed in these studies could be attributed to the drug per se and/or reduction in glucotoxicity. This study examines the effect of linagliptin on insulin sensitivity and β-ce
View details →DOI: 10.1186/s40360-018-0228-z Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Christine Annaheim, Kerstin Hug, Caroline Stumm et al. · 2022 · Frontiers in Human Neuroscience
BackgroundFrontal brain dysfunction is a major challenge in neurorehabilitation. Neurofeedback (NF), as an EEG-based brain training method, is currently applied in a wide spectrum of mental health conditions, including traumatic brain injury.ObjectiveThis study aimed to explore the capacity of Infra-Low Frequency Neurofeedback (ILF-NF) to promote the recovery of brain function in patients with frontal brain injury.Materials and methodsTwenty patients hospitalized at a neurorehabilitation clinic in Switzerland with recently acquired, frontal and optionally other brain lesions were randomized to
View details →DOI: 10.3389/fnhum.2022.979723 Negative / Null Result ReportOpen accessEngineering (General). Civil engineering (General)
Weichuan Zhang, Mingxian Zhao, Zhongyan Yang et al. · 2024 · Developments in the Built Environment
A significant amount of waste is generated during the sandstone mining process. This study explores the use of red sandstone waste as a supplementary cementitious material to address environmental concerns in cement production. The experimental methods include isothermal calorimetry, compressive strength testing, thermogravimetric analysis, X-ray diffraction, infrared spectroscopy, scanning electron microscopy, high-temperature damage testing (200, 600, and 900 °C), and mesoscopic image analysis. The experimental findings reveal the following: (1) Red sandstone powder enhanced cement hydration
View details →DOI: 10.1016/j.dibe.2024.100346 Failed Experiment ReportOpen accessMedicine
Almira Ada Diken Türksayar, Simge Baytur · 2023 · Sabiad
Objective: The aim of this in vitro study was to compare the biaxial flexural strengths of permanent restorative materials produced by additive manufacturing and milling after thermal aging. Material and methods: For this study, three study groups were formed by producing disc-shaped specimens with a 3D printer (Form3, Formlabs) using permanent crown material (Permanent Crown, Somerville, MA) and two different resin-containing materials (Brilliant Crios,Coltene/ Whaledent; Cerasmart, GC Europe) by the milling method (n=10). The entire production process was carried out in accordance with the m
View details →DOI: 10.26650/jarhs2023-1200694 Negative / Null Result Report
D O Geavlete, C Beladan, D Deleanu et al. · 2019 · European Heart Journal
Abstract Introduction Different consequences concerning the cardiac function and structure in patients with renal artery stenosis (RAS) and completely different patterns of activation of the renin-angiotensin-aldosteron system were…
View details →DOI: 10.1093/eurheartj/ehz745.0431 Negative / Null Result ReportOpen accessEducation (General)
Vincent Reynaert, Vincent Reynaert, Jalal Possik et al. · 2024 · Frontiers in Education
IntroductionThe field of poetry learning is currently facing significant challenges, primarily due to a lack of motivation and interest among students. This has resulted in educators encountering difficulties in identifying suitable educational alternatives. To address the latter issue, immersive learning has emerged as a potential solution, as it has been demonstrated to enhance motivation and learning outcomes in a multitude of fields.MethodsIn light of the aforementioned considerations, this field study seeks to examine the potential of virtual reality (VR) tools in enhancing the memorizati
View details →DOI: 10.3389/feduc.2024.1463635 Negative / Null Result ReportOpen accessDentistry
AHMAD ZAAZA, Nevien Mohamed, Gaffar El Halawani · 2025 · Alexandria Dental Journal
Introduction: Osseo-integrated dental implants were traditionally load-free for up to six months while they healed. Patients usually feel dissatisfied with the long loading times. Several studies have been conducted to improve osseointegration, decrease loading time, and increase patient satisfaction.Objectives: This study aimed to evaluate and compare both clinically and radiographically the effect of hyaluronic acid (HA) versus Titanium-Platelet Rich Fibrin (T-PRF) in enhancing osseointegration around anterior maxillary dental implants. Materials and Methods: Twelve patients with extracted m
View details →DOI: 10.21608/adjalexu.2024.282413.1497 Negative / Null Result ReportOpen accessMedicine
Elif Özdemir, Şeyda Türkölmez · 2020 · Ankara Medical Journal
INTRODUCTION: This study aims to disclose the frequency and clinical significance of incidental prostatic uptake during FDG PET imaging. METHODS: FDG PET images of 1839 male patients undergoing imaging for non-prostate and non-urinary bladder malignancy indications were retrospectively reviewed for the presence of incidental prostatic FDG uptake. Prostatic volume, calcification and the presence and pattern of FDG uptake were evaluated. Further follow-up prostatic evaluation results were comparatively assessed. RESULTS: Incidental prostatic FDG uptake was detected in 41 out of 1839 patients(2.2
View details →DOI: 10.5505/amj.2020.93653 Negative / Null Result ReportOpen accessMaterials of engineering and construction. Mechanics of materials
DUAN Peng, LIU Zong-de, TAO Xiang-qian, GU Shu-chao · 2021 · Cailiao Baohu
At present, the changes of microstructure and mechanical properties of T23 steel after served for more than 50 000 h have been less studied.In this work, with using the heat-delivery surface tubes of a 600 MW super-critical boiler as research object, the T23 steel final reheater tubes at various positions after about 80 000 h of service time were tested by microstructure analysis, tensile properties tests at room temperature and 525 ℃ temperature, and the deterioration degree and difference in mechanical properties between back and meet smoke side of tubes after long-term service were investig
View details →DOI: 10.16577/j.cnki.42-1215/tb.2021.01.008 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Eric V. Li, Sai K. Kumar, Jonathan A. Aguiar et al. · 2024 · BJUI Compass
Abstract Objective This study aimed to evaluate the association of dynamic contrast enhancement (DCE) with clinically significant prostate cancer (csPCa, Gleason Grade Group ≥2) and compare biparametric magnetic resonance imaging (bpMRI) and multiparametric MRI (mpMRI) nomograms. Subjects/patients and methods We identified a retrospective cohort of biopsy naïve patients who underwent pre‐biopsy MRI separated by individual MRI series from 2018 to 2022. csPCa detection rates were calculated for patients with peripheral zone (PZ) lesions scored 3–5 on diffusion weighted imaging (DWI) with availab
View details →DOI: 10.1002/bco2.415 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Takuji Yokoe, Takuya Tajima, Shuichi Kawagoe et al. · 2022 · BMC Musculoskeletal Disorders
Abstract Background A number of studies have evaluated risk factors for lateral ankle sprain (LAS) or chronic lateral ankle instability (CLAI). However, the definitive risk factors for LAS or CLAI remain controversial. The purpose of this study was to evaluate whether the contralateral healthy ankles of subjects with ipsilateral mechanical lateral ankle laxity (group I) show greater lateral ankle laxity in comparison to the healthy ankles of bilateral healthy controls (group B). Methods From March 2020, anterior talofibular ligament (ATFL) lengths of young adult volunteers were cross-sectional
View details →DOI: 10.1186/s12891-022-05838-0 Negative / Null Result ReportOpen accessAnesthesiology
Mahmoodzadeh Hossein, Movafegh Ali, Beigi Noshin · 2009 · Saudi Journal of Anaesthesia
Background: Dextromethorphan, the D-isomer of the codeine analog levorphanol, is a weak, noncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist. It has been suggested that NMDA receptor antagonists induce preemptive analgesia when administered before tissue injury occurs, thus decreasing the subsequent sensation of pain. Materials and Methods: The study was conducted in the Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, between February 2005 and December 2006. In this study, 72 patients scheduled for elective cholesyctectomy were randomized into three g
Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Jeremy C Heard, Yunsoo A Lee, Nicholas D D'Antonio et al. · 2024 · Journal of Craniovertebral Junction and Spine
Objectives: To evaluate the (1) 90-day surgical outcomes and (2) 1-year revision rate of robotic versus nonrobotic lumbar fusion surgery. Methods: Patients >18 years of age who underwent primary lumbar fusion surgery at our institution were identified and propensity-matched in a 1:1 fashion based on robotic assistance during surgery. Patient demographics, surgical characteristics, and surgical outcomes, including 90-day surgical complications and 1-year revisions, were collected. Multivariable regression analysis was performed. Significance was set to P < 0.05. Results: Four hundred and fiftee
View details →DOI: 10.4103/jcvjs.jcvjs_145_23 Negative / Null Result ReportOpen accessMedicine
J Neves, P J Santos, I Azevedo et al. · 1999 · Acta Médica Portuguesa
Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: maternal age, parity, gestational age, the mode of delivery, the fetal weight, the maternal and fetal morbidity and mortality. The authors also reviewed the Literature on the incidence, the most frequent complications and the management in labour to compare with the results of the study
View details →DOI: 10.20344/amp.2145 Negative / Null Result ReportOpen accessMedicine
Leela McKinnon, David R Samson, Charles L Nunn et al. · 2022 · PLoS ONE
Sleep duration, quality, and rest-activity pattern-a measure for inferring circadian rhythm-are influenced by multiple factors including access to electricity. Recent findings suggest that the safety and comfort afforded by technology may improve sleep but negatively impact rest-activity stability. According to the circadian entrainment hypothesis, increased access to electric lighting should lead to weaker and less uniform circadian rhythms, measured by stability of rest-activity patterns. Here, we investigate sleep in a Maya community in Guatemala who are in a transitional stage of industria
View details →DOI: 10.1371/journal.pone.0277416 Negative / Null Result ReportOpen accessMicrobiology
Wang Linlin, Song Tingting, Du Yuejiao et al. · 2024 · BIO Web of Conferences
In order to find out the change rule of SPAD value in lettuce leaves and the rapid, non-destructive and more accurate detection method of chlorophyll content in lettuce leaves under intercropping mode, the effect of intercropping on SPAD value in lettuce leaves was studied and the correlation model between chlorophyll content and SPAD value was established. The results show that the SPAD value of lettuce leaves increases at first and then decreases slowly with the development of the days of aerosol culture, and intercropping has obvious advantage in the middle and late stages of aerosol cultur
View details →DOI: 10.1051/bioconf/202411103003 Negative / Null Result ReportOpen accessMedicine
Philipp Fuelkell, Soenke Langner, Nele Friedrich et al. · 2018 · PLoS ONE
OBJECTIVES:To investigate acoustic noise reduction, image quality and white matter lesion detection rates of cranial magnetic resonance imaging (MRI) scans acquired with and without sequence-based acoustic noise reduction software. MATERIAL AND METHODS:Thirty-one patients, including 18 men and 13 women, with a mean age of 58.3±14.5 years underwent cranial MRI. A fluid-attenuated inversion recovery (FLAIR) sequence was acquired with and without acoustic noise reduction using the Quiet Suite (QS) software (Siemens Healthcare). During data acquisition, peak sound pressure levels were measured wit
View details →DOI: 10.1371/journal.pone.0206196 Negative / Null Result ReportOpen accessMedicine
Mujda Nooristani, Maxime Maheu, Marie-Soleil Houde et al. · 2019 · PLoS ONE
Noisy galvanic vestibular stimulation (nGVS) has been shown to enhance postural stability during stimulation, and the enhancing effect has been observed to persist for several hours post-stimulation. However, these effects were observed without proper control (sham condition) and the possibility of experimental bias has not been ruled out. The lasting effect of nGVS on postural stability therefore remains in doubt. We investigated the lasting effect of nGVS on postural stability using a control (sham) condition to confirm or infirm the possibility of experimental bias. 28 participants received
View details →DOI: 10.1371/journal.pone.0224619 Negative / Null Result ReportOpen accessSports medicine
Ayaka Yasuda, Shuhei Sasajima, Takehiro Kosaka et al. · 2023 · Journal of Physical Fitness and Sports Medicine
The purpose of this study was to investigate the effects of stimulation conditions (pressing force and frequency) and subcutaneous tissue properties (thickness and hardness) on the changes in tendon blood circulation caused by acupressure. Before and after acupressure, blood circulation of the Achilles tendon was measured using red laser lights. Acupressure was applied to the Achilles tendon for 3-min under three conditions. The following four conditions (including no stimulation condition) with different combinations of pressing forces and frequencies were established: 1) 50N and 1.5Hz, 2) 25
View details →DOI: 10.7600/jpfsm.12.147 Negative / Null Result ReportOpen accessGynecology and obstetrics
Yangyang Zhang, Yang Xu, Jiao Yu et al. · 2023 · Journal of Ovarian Research
Abstract Background A premature luteinizing hormone (LH) surge refers to an endogenous LH peak that occurs before follicle maturation or human chorionic gonadotropin injection in the process of controlled ovarian hyperstimulation. The effect of premature LH surge on pregnancy outcomes in fresh embryo transfer cycles is still controversial. The aim of this study was to explore the effect of a premature LH surge without elevated progesterone levels on the cumulative pregnancy rate (CPR) and cumulative live birth rate (CLBR) of patients during a flexible GnRH antagonist protocol. Methods A total
View details →DOI: 10.1186/s13048-023-01219-w Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Jia Lu, Yang Chen, Lili Shi et al. · 2023 · BioPsychoSocial Medicine
Abstract Background In Asia, the proportion of patients with irritable bowel syndrome (IBS) with abdominal discomfort alone is significantly higher than that in western countries. The purposes of this study are to understand the cognition of abdominal pain and abdominal discomfort in Chinese patients with IBS and to compare the clinical characteristics of patients with abdominal pain alone and with abdominal discomfort alone. Methods Patients with IBS with diarrhea (IBS-D) who met the Rome III diagnostic criteria and had episodes of at least one day/week were consecutively enrolled. The cognit
View details →DOI: 10.1186/s13030-023-00286-1 Negative / Null Result ReportOpen accessGeriatrics
Hong-Jhe Chen, Hsun Ou, Ru-Yih Chen et al. · 2025 · BMC Geriatrics
Abstract Background This study investigated the relationship between sleep disturbance, obstructive sleep apnea (OSA), and osteoporosis in older adults. Methods This cross-sectional study involved 326 older adults (mean age: 83.46 years) in elder care institutions in Taiwan. The presence of osteoporosis was assessed using dual-energy X-ray absorptiometry, while sleep quality and OSA risk were evaluated using the Pittsburgh Sleep Quality Index and STOP-Bang questionnaire, respectively. Heart rate variability (HRV) was measured to assess autonomic function. Logistic regression models, adjusted f
View details →DOI: 10.1186/s12877-025-06527-y 