Negative / Null Result ReportMedicine
Khajehzadehshoushtar S, Delfinis LJ, Rahman FA et al. · 2025 · The Journal of physiology
The degree to which mitochondrial-linked programmed cell death pathways contribute to skeletal muscle atrophy during cancer remains unknown. Here we combined a novel and robust mouse model of metastatic ovarian cancer with chronic…
View details →DOI: 10.1113/jp287912 Negative / Null Result ReportMedicine
Yin R, Fredenburgh JC, Weitz JI · 2025 · Journal of thrombosis and haemostasis : JTH
Background Milvexian, an oral factor (F)XIa inhibitor, is undergoing phase 3 evaluation for acute coronary syndrome. Such patients often require percutaneous coronary intervention (PCI). The PCI catheters trigger clotting by inducing…
View details →DOI: 10.1016/j.jtha.2025.06.028 Negative / Null Result ReportOpen accessMedicine
Drumeva GO, Plane AF, Petrenyov DR et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
View details →DOI: 10.1186/s40959-026-00469-z Negative / Null Result ReportOpen accessMedicine
Romanelli MA, Nogueira-Souza PD, Gomes DS et al. · 2026 · ACS omega
Snakebite-induced acute kidney injury (sAKI) is a severe clinical complication associated with Bothrops envenomation that can lead to kidney failure. Alternative therapies are needed due to the limitations of antivenom, including variable…
View details →DOI: 10.1021/acsomega.5c09974 Negative / Null Result Report
Gordon-Fennell L, Farero R, Jones J et al. · 2025 · Preprint
ABSTRACT Uncovering the neurobiological processes underlying substance use disorder informs future therapeutic interventions. Prior research implicates the corticotropin releasing factor (CRF) system as a major player in a wide variety of…
View details →DOI: 10.1101/2025.02.25.640140 Negative / Null Result ReportOpen accessMedicine
Vercalsteren E, Karampatsi D, Buizza C et al. · 2025 · Nutrients
Background/objectives : Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO 3 - )…
View details →DOI: 10.3390/nu17152434 Negative / Null Result Report
De Carli G, Giombini E, Colosi A et al. · 2025 · Preprint
To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…
View details →DOI: 10.20944/preprints202504.1296.v1 Negative / Null Result ReportMedicine
Gutfreund N, Tuppi M, Schäfer B et al. · 2025 · Reproduction (Cambridge, England)
In brief Induction of DNA double-strand breaks results in oocyte death caused by the activation of TAp63α. This study investigates which chemotherapeutic drugs activate p63 and which cause oocyte death without p63 activation. Abstract…
View details →DOI: 10.1530/rep-24-0225 Negative / Null Result ReportMedicine
Guzzo I, Becilli M, Cappoli A et al. · 2025 · Pediatric nephrology (Berlin, Germany)
Background High panel reactive antibody (PRA) titers are a significant challenge for patients undergoing kidney transplantation. Currently, no desensitization protocol has proven effective in preventing mid- and long-term graft loss. In…
View details →DOI: 10.1007/s00467-025-06884-1 Negative / Null Result Report
Salem Y, Leisengang S, Jakobs M et al. · 2025 · Preprint
Taste-immune associative learning has been shown to mimic immunopharmacological responses. Conditioned pharmacological effects may therefore be considered as controlled drug dose reduction strategy to maintain treatment efficacy. Against…
View details →DOI: 10.1101/2025.04.05.647348 Negative / Null Result Report
Ahn S, Goya B, Bertomo C et al. · 2025 · Preprint
ABSTRACT High dietary salt intake has powerful effects on cerebral blood vessels and has emerged as a risk factor for stroke and cognitive impairment. In mice, high salt diet (HSD) leads to reduced cerebral blood flow (CBF), tau…
View details →DOI: 10.1101/2025.02.27.640593 Negative / Null Result Report
Vilela WR, Platt N, Bechara LRG et al. · 2025 · Preprint
Abstract Microglia exhibit targeted responses to different stimuli, including lipids, which can differ depending on the environmental conditions they face. These responses involve inflammatory mediators and are crucial for maintaining…
View details →DOI: 10.21203/rs.3.rs-6058376/v1 Negative / Null Result ReportOpen accessMedicine
Hinks A, Vlemmix E, Power GA · 2025 · The journals of gerontology. Series A, Biological sciences and medical sciences
The age-related loss of muscle mass is partly driven by a reduction in serial sarcomere number (SSN), and further SSN loss occurs during immobilization. Serial sarcomere number is associated with optimal force and power production and…
View details →DOI: 10.1093/gerona/glaf082 Negative / Null Result ReportMedicine
Matienzo ME, Lee J, Lim S et al. · 2025 · American journal of physiology. Cell physiology
Glucocorticoids (GCs) are potent regulators of energy balance and adipose tissue function, making them attractive targets for obesity treatments. The local activation and inactivation of GCs are mediated by two key enzymes:…
View details →DOI: 10.1152/ajpcell.00978.2024 Negative / Null Result ReportOpen accessMedicine
Czarnota P, Gromowski T, Golda A et al. · 2026 · Cell communication and signaling : CCS
Liver cancer often arises in the setting of chronic liver disease and remains a major global health challenge with limited effective treatments. Isoprenylcysteine Carboxyl Methyltransferase (ICMT) is an enzyme that catalyzes the…
View details →DOI: 10.1186/s12964-026-02775-6 Negative / Null Result ReportMedicine
Ricalde A, Chen JW, Lim LJ et al. · 2025 · Pediatric dentistry
Purpose: To investigate the color difference between groups and changes over time of resin-modified glass ionomer (RMGI) restorations placed immediately after silver diammine fluoride (SDF) treatment. Methods: Thirty-six specimens were…
Negative / Null Result ReportMedicine
Berger L, Mulder E, Zange J et al. · 2025 · Medicine and science in sports and exercise
Purpose During spaceflight, countermeasures are crucial to counteract cardiorespiratory and musculoskeletal deconditioning, similar to effects seen after prolonged immobilization. Within a bed rest study simulating the effects of…
View details →DOI: 10.1249/mss.0000000000003803 Negative / Null Result ReportOpen accessMedicine
Breen DM, Saavedra-Peña RM, Joaquim S et al. · 2026 · Diabetes, obesity & metabolism
Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical…
View details →DOI: 10.1111/dom.70207 Negative / Null Result ReportMedicine
Jefferies S, Gilkison C, Duff P et al. · 2025 · Public health
Objectives Aotearoa New Zealand employed one of the most stringent public health pandemic responses internationally. We investigated whether ethnic health equity was achieved in the response and outcomes, from COVID-19 elimination in June…
View details →DOI: 10.1016/j.puhe.2025.105732 Negative / Null Result ReportMedicine
Park SJ, Park JS, Kang DH et al. · 2025 · Neurosurgery
Background and objectives Cement augmentation and hook fixation are popular prophylactic techniques against proximal junctional kyphosis (PJK) development. However, the efficacy of cement and hook has been inconsistent and conflicting.…
View details →DOI: 10.1227/neu.0000000000003454 Negative / Null Result ReportOpen accessMedicine
Plastina L, Gähwiler K, Gaertner VD et al. · 2025 · BMC pediatrics
Background To evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to…
View details →DOI: 10.1186/s12887-025-06104-7 Negative / Null Result ReportOpen accessMedicine
Grotemeyer A, Alexander S, Frieß L et al. · 2026 · NPJ Parkinson's disease
Neuroinflammation is deeply intertwined with dopaminergic (DA) neurodegeneration in Parkinson's disease (PD). We tested whether delphinidin, an anthocyanidin with reported inflammasome/NF-κB modulatory activity, alters neuroinflammation…
View details →DOI: 10.1038/s41531-025-01244-0 Negative / Null Result ReportOpen accessMedicine
Paulsson M, Ekholm C, Rolfson O et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after…
View details →DOI: 10.1177/21514593241280914 Negative / Null Result ReportOpen accessMedicine
Ponsford R, Meiksin R, Sturgess J et al. · 2026 · Journal of epidemiology and community health
Background Relationships and sex education (RSE) impacts some sexual behaviours but could be strengthened by incorporating whole-school approaches (eg, building engagement, providing contraception). These can prevent pregnancies and…
View details →DOI: 10.1136/jech-2025-225004 Negative / Null Result ReportMedicine
Cao J, Guo M, Wang J et al. · 2025 · Fish physiology and biochemistry
Plant-based essential oils have been considered to be used as fish anesthetics and as suitable alternatives to synthetic anesthetics. In this study, we evaluated the effect of Cinnamomum camphora var. linaloofera Fujita essential oil…
View details →DOI: 10.1007/s10695-025-01500-3 Failed Experiment Report
Castro-Cordova P, Lopez-Garcia OK, Orozco J et al. · 2025 · Preprint
The most common cause of healthcare-associated diarrhea and colitis in the U.S., is Clostridioides difficile , a spore-forming pathogen. Two toxins, TcdA and TcdB, are major virulence factors essential for disease manifestations, while C.…
View details →DOI: 10.1101/2025.01.29.635439 Failed Experiment Report
Henriksen K, Jørgensen A, Kaur S et al. · 2024 · Preprint
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
View details →DOI: 10.1101/2024.06.17.599254 Failed Experiment ReportMedicine
Pavicich MA, Maldonado ML, Nguyen TN et al. · 2025 · International journal of food microbiology
Apple fruit is widely consumed worldwide, but fungal contamination in the postharvest stage presents a significant food safety concern. This study evaluates the production and accumulation of Alternaria mycotoxins, including alternariol…
View details →DOI: 10.1016/j.ijfoodmicro.2025.111272 Negative / Null Result ReportOpen accessMedicine
Cifelli A, Butt Z, Cifelli E et al. · 2026 · Case reports in neurological medicine
We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage-gated calcium channel antibodies (VGCCAs) and was started…
View details →DOI: 10.1155/crnm/5563623 Negative / Null Result ReportMedicine
Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology
Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…
View details →DOI: 10.1016/j.vetimm.2025.110997 