Preoperative oral dextromethorphan does not reduce pain or morphine consumption after open cholecystectomy
Mahmoodzadeh Hossein; Movafegh Ali; Beigi Noshin · 2009 · Saudi Journal of Anaesthesia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Dextromethorphan, the D-isomer of the codeine analog levorphanol, is a weak, noncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist. It has been suggested that NMDA receptor antagonists induce preemptive analgesia when administered before tissue injury occurs, thus decreasing the subsequent sensation of pain. Materials and Methods: The study was conducted in the Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, between February 2005 and December 2006. In this study, 72 patients scheduled for elective cholesyctectomy were randomized into three g
Abstract by Mahmoodzadeh Hossein; Movafegh Ali; Beigi Noshin, Saudi Journal of Anaesthesia (2009) — licensed CC BY 4.0.
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