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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 543 of 725

Negative / Null Result ReportMedicine

Evaluation of Short-Term Stall Size Housing on the Behavior and Welfare of Domestic Horses (Equus caballus).

Outouil M, Daugherity EK, Warnick LD et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Single-stall housing is a common system used for horses in various settings, including racing stables, riding schools, teaching and research facilities. Adequate stall space is necessary for horses to lie down and make postural…

View details →DOI: 10.30802/aalas-jaalas-25-152
Negative / Null Result Report

The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae

Zwyssig M, Schneider J, Selten G et al. · 2026 · Preprint

The plant-beneficial bacterium Pseudomonas protegens CHA0 (CHA0) is widely studied for the biological control of soil-borne plant diseases. Beyond its root-colonising capabilities, CHA0 can also infect and kill insect larvae and thus…

View details →DOI: 10.64898/2026.03.19.712869
Negative / Null Result ReportMedicine

Is multimodal monitoring effective in detecting neurological changes in cases of severe idiopathic scoliosis after halo gravity traction?: a series of 70 patients.

Richard L, Vermersch AI, Saghbini E et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objective Severe scoliosis, defined by a Cobb angle exceeding 80°, requires surgical correction and is associated with a high risk of postoperative neurological complications. These complications may be reduced by halo gravity traction…

View details →DOI: 10.1016/j.neucli.2026.103144
Negative / Null Result ReportMedicine

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights.

Saravia DH, Silvan YA, Martinez JI · 2026 · Community mental health journal

Despite similar rates of mental illness, non-Latinx Whites (NLW) received care at higher rates compared to Latinxs (National Institute of Mental Health, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma…

View details →DOI: 10.1007/s10597-025-01584-4
Negative / Null Result ReportMedicine

Behavioral Incentives for Exercise and Intra-Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial.

Baker JF, Wysham KD, Quinones M et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA).…

View details →DOI: 10.1002/art.70176
Negative / Null Result ReportMedicine

Use of Er:YAG Laser for Disinfection of Infected Carious Dentin: Microbiological Evaluation and Scanning Electron Microscopy Analysis.

Marcondes Pinto MO, Arana-Chavez VE, Trevelin LT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Objective To evaluate the antimicrobial efficacy of Er:YAG laser for disinfection of softened carious dentin using subablative parameters. Background Current literature lacks robust scientific evidence supporting the use of Er:YAG laser…

View details →DOI: 10.1177/25785478261444876
Negative / Null Result ReportMedicine

Impact of Running Shoe Midsole Properties on Energy Cost of Running: Insights Into Midsole Stiffness and Resilience Properties.

Rodrigo-Carranza V, Alda-Blanco A, Kuzmeski J et al. · 2026 · International journal of sports physiology and performance

Purpose The mechanisms behind improvements in running economy (RE) from shoes with supercritical foams (SCF) compared with a traditional midsole material (ethylene vinyl acetate [EVA]) remain only partially understood. This study aimed to…

View details →DOI: 10.1123/ijspp.2025-0475
Negative / Null Result ReportMedicine

'Sawa Aqwa' (Stronger Together): A multi-site randomized controlled trial of a brief family systemic intervention for adolescent mental health in Lebanon.

Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…

View details →DOI: 10.1111/jcpp.70174
Negative / Null Result ReportMedicine

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Seidl E, Zikic A, Micic S et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Breath profile analysis of volatile organic compounds (VOCs) by electronic nose (eNose) technology can distinguish between healthy individuals and people with cystic fibrosis (pwCF). It remains, however, unclear whether CFTR…

View details →DOI: 10.1016/j.jcf.2026.03.014
Negative / Null Result ReportMedicine

Effect of Successive Bleaching Treatments Followed by Staining on Color, Whiteness, and Translucency of Polymer-Based CAD-CAM Materials.

Ramos AC, Mascaro BA, Dos Santos Nunes Reis JM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate differences in color, whiteness, and translucency of CAD-CAM materials after successive bleaching treatments and coffee immersion. Materials and methods Lava Ultimate (LU) and VITA Enamic (VE) were divided into four…

View details →DOI: 10.1111/jerd.70168
Negative / Null Result ReportMedicine

Three Decades of Evidence on Pulsatile Cardiopulmonary Bypass in Pediatrics: No Significant Clinical Benefit.

Ündar A, Lussier MJ, Rajesh S et al. · 2026 · World journal for pediatric & congenital heart surgery

BackgroundDrawing on more than 30 years of valuable expertise in in-vitro, in-vivo, and clinical trials, we report the key findings of our institutional research on pulsatile cardiopulmonary bypass (CPB).MethodsA detailed search was…

View details →DOI: 10.1177/21501351251412887
Negative / Null Result ReportOpen accessMedicine

Impact of adding a medical intern to the emergency department night shift.

Glass-Biran AH, Eyre A, Stein G et al. · 2026 · BMJ open quality

Objective To evaluate whether adding a fourth physician to the emergency department night shift would improve metrics. Methods This retrospective cohort study used data from the Meir Medical Centre emergency department, 1 January 2021 to…

View details →DOI: 10.1136/bmjoq-2025-003648
Negative / Null Result ReportMedicine

Evaluation of an Immune-guided Prevention Strategy Against CMV Among Intermediate-risk Kidney Transplant Recipients: A Quasi-experimental Study.

Caso JM, Fernández-Ruiz M, González E et al. · 2026 · Transplantation

Background Observational studies have shown that kidney transplant (KT) recipients who are cytomegalovirus (CMV)-seropositive (R+) but lack effective CMV-specific cell-mediated immunity (CMV-CMI) are at increased risk of CMV infection.…

View details →DOI: 10.1097/tp.0000000000005694
Negative / Null Result ReportOpen accessMedicine

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Ali R, Yazdi A, Collins K et al. · 2026 · International journal of critical illness and injury science

Background Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the…

View details →DOI: 10.4103/ijciis.ijciis_124_25
Negative / Null Result ReportMedicine

Euschistus heros RNase silencing: dsRNA stability and effects on RNAi susceptibility.

Quiroga-Murcia DE, Dos Santos ÉA, Schutter K et al. · 2025 · Journal of insect physiology

Nuclease (RNase) activity is a major limiting factor that reduces the effectiveness of RNAi-induced gene silencing across many insect species. In Euschistus heros, dsRNA degradation occurs predominantly upon contact with saliva, while…

View details →DOI: 10.1016/j.jinsphys.2025.104908
Negative / Null Result ReportMedicine

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy (MIP) for Primary Hyperparathyroidism With Concordant Localisation.

Chew BMH, Lim SSA, Gan TRX et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective There is increasing use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP). While ioPTH has improved cure rate, there is little evidence to suggest effectiveness in primary…

View details →DOI: 10.1002/ohn.70218
Negative / Null Result ReportMedicine

Influence of a Whisper Loading Test on the Vibration Mechanism of the Vocal Folds in the Context of Organic Dysphonia.

Hoppermann R, Kirsch J, Pilsl T et al. · 2026 · Journal of clinical medicine

Background/Objectives: Whispering has frequently been recommended to patients in order to avoid vocal overuse, particularly in those with organic dysphonia. However, there is controversy as to whether whispering may negatively affect vocal…

View details →DOI: 10.3390/jcm15051735
Negative / Null Result ReportMedicine

Biomechanical Comparison of Different Fixation Methods for Treating Jones Fracture of the Fifth Metatarsal.

Shih CM, Yen YC, Wang CH et al. · 2026 · Bioengineering (Basel, Switzerland)

Jones fractures are Zone 2 fractures of the fifth metatarsal. Biomechanical comparisons of fixation strategies for Jones fractures remain limited by the lack of standardized, head-to-head evaluations across major fixation methods. The…

View details →DOI: 10.3390/bioengineering13020135
Negative / Null Result ReportMedicine

Impact of eravacycline on fibrinogen.

Stevenson E, Ponder M, Daniels L et al. · 2026 · The Journal of antimicrobial chemotherapy

Objectives While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined.…

View details →DOI: 10.1093/jac/dkag030
Negative / Null Result ReportMedicine

There Is No Clinical and Radiological Difference between Suspensory and Cortical Button Fixation at the Treatment of Medial Meniscus Posterior Root Tear.

Sarikaya G, Paksoy AE, Karaşahin Ö et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study The purpose of this prospective study was to compare the two surgical techniques; (Transosseous Fixation with the Suspensory Fixation System technique and Pull Out Suture Repair) for clinical and radiologic scores and…

View details →DOI: 10.55095/achot2026/001
Negative / Null Result ReportMedicine

Vasopressors or Fluids in Early Septic Shock.

Peake SL, Macdonald SPJ, Howe BD et al. · 2026 · The New England journal of medicine

Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…

View details →DOI: 10.1056/nejmoa2516225