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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 525 of 725

Negative / Null Result ReportMedicine

Generating structure in soft solids: heat stable milk chocolate

Holian JA, Bolton MD, Wilson DI · 2025 · Current Research in Food Science

Addition of small amounts of glycerol to milk chocolate during the tempering stage can yield a product which exhibits enhanced mechanical strength and retards motion of the continuous phase (cocoa butter, a mixture of fats) of this dense…

Negative / Null Result ReportMedicine

Beyond traditional sets: A longitudinal comparison of cluster and superset strength training in male basketball players.

Janicijevic D, Cuevas-Aburto J, Zhang X et al. · 2026 · Journal of sports sciences

This randomised study compared mid-term effects of supersets (SS) and cluster sets (CL) on neuromuscular performance in amateur male basketball players. Thirty participants were allocated to SS (n = 15) or CL (n = 15) and completed a…

View details →DOI: 10.1080/02640414.2026.2637204
Negative / Null Result ReportMedicine

Effect of Three Types of Specially-Designed Myopia Control Spectacle Lenses on Astigmatism: A Two-Year Result.

Wen K, Yang B, Liu L et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose This study sought to determine whether specially-designed myopia control spectacle lenses had any effect on astigmatism in clinical practice. Methods Medical records of 74 patients (age: 6 to 12 years old) involving the use of…

View details →DOI: 10.1007/s44402-026-00077-5
Negative / Null Result ReportMedicine

Age and sex differences in longitudinal CPAP adherence patterns.

Vodapally M, Chan-Golston AM, Sandhu J et al. · 2026 · Respiratory medicine

Study objective This study investigated long-term adherence to continuous positive airway pressure (CPAP) therapy among adult patients with obstructive sleep apnea (OSA), with a focus on identifying associations between age, sex, residual…

View details →DOI: 10.1016/j.rmed.2026.108755
Negative / Null Result ReportMedicine

Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study.

Wadström BN, Wulff AB, Pedersen KM et al. · 2026 · Atherosclerosis

Background and aims Elevated remnant lipoproteins are a causal risk factor for atherosclerotic cardiovascular disease. We tested the hypothesis that low-grade inflammation can explain part of the increased risk of peripheral artery disease…

View details →DOI: 10.1016/j.atherosclerosis.2026.120772
Negative / Null Result ReportOpen accessMedicine

Visceral adipose tissue and liver fat on 17-beta estradiol-dominant gender-affirming hormone therapy: A US-based cohort.

Talathi R, Juhasz V, Delgado M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Data on the metabolic effects of contemporaneous gender-affirming hormone therapy (GAHT) are limited. Objective To characterize the metabolic effects of GAHT ie, estradiol with anti-androgen therapy. Design Prospective…

View details →DOI: 10.1210/clinem/dgaf665
Negative / Null Result ReportMedicine

Active Aging: Learning English and Developing Fine Psychomotor Abilities.

Baranowska K, Dylewski R, Fugiel J et al. · 2026 · Experimental aging research

Background Recent studies highlight that cognitive processes involved in learning share neural pathways with those controlling fine motor skills. Building on this insight, the mini-EDUball method was developed to integrate cognitive and…

View details →DOI: 10.1080/0361073x.2026.2635284
Negative / Null Result ReportMedicine

Profession-Specific Ageism Changes Following a Two-Day Long-Term Care Placement in Dental Students.

Izumi M, Mizutani S, Fujimoto A et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Background Ageism among dental students can impede equitable geriatric care. Developing educational interventions to reduce profession-specific and general ageist attitudes is an urgent priority in aging societies. Objective To determine…

View details →DOI: 10.1111/eje.70116
Negative / Null Result ReportOpen accessMedicine

Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience.

Izadi N, Hill TD, Boe A et al. · 2025 · Frontiers in allergy

Background Across all age groups, asthma disproportionally affects inner-city underserved populations. Studies on the use of at-home spirometry and digital inhalers have limited real-world evaluation in pediatric asthma. Objectives In this…

View details →DOI: 10.3389/falgy.2025.1641312
Negative / Null Result ReportMedicine

Impact of Emicizumab on Coagulation Potential in Plasma From Healthy Women and Carriers of Haemophilia A During Late Pregnancy.

Takeyama M, Kimura F, Furukawa S et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Background Intra-cranial haemorrhage (ICH) in neonates with haemophilia A (HA) remains a serious perinatal complication. Prophylactic administration of emicizumab (Emi) to pregnant HA carriers has been discussed as a potential preventive…

View details →DOI: 10.1111/hae.70269
Null DatasetMedicine

Integrating systemic toxicity and toxicokinetic data to inform the need for subchronic dog studies in human health safety assessments of agrochemicals.

Murphy L, Mingoia R, Bianchi E et al. · 2026 · Regulatory toxicology and pharmacology : RTP

Regulatory testing for agrochemicals has traditionally included a 90-day toxicity study in a non-rodent species, usually the dog. With growing emphasis on the 3Rs-replacement, reduction, and refinement of animal use-and increased adoption…

View details →DOI: 10.1016/j.yrtph.2026.106081
Negative / Null Result ReportMedicine

A Video Analysis Study Examining Neuromuscular Training Warm-Up Practices in Youth Soccer.

Lutz D, van den Berg C, Neill MG et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

Objectives To investigate time spent completing neuromuscular training (NMT) exercises in youth soccer team warm-up across a season considering sex, level of play, session type, and coach exposure and awareness of NMT. Design…

View details →DOI: 10.1097/jsm.0000000000001423
Negative / Null Result ReportMedicine

Heroines: Limited Effects of an Educational Program With Counter-Stereotypical Female Role Models on Gender Schemas in Middle Childhood.

Endendijk JJ · 2025 · Psychological reports

Interventions in which people are exposed to counter-stereotypical role models are often used for breaking gender stereotypes. Most gender role-model interventions focus on adolescents and emerging adults. Yet, middle childhood might be a…

View details →DOI: 10.1177/00332941251409153
Negative / Null Result ReportMedicine

Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).

Pathak BK, Maurya M, Mishra N et al. · 2026 · Clinical pediatrics

Microcytic hypochromic anemia is common in severe acute malnutrition (SAM) children, but macrocytic anemia (vitamin B12/folate deficiency) is not uncommon. Vitamin B12 deficiency leads to anemia and developmental slowing. We looked for the…

View details →DOI: 10.1177/00099228251415045
Negative / Null Result ReportMedicine

Short-Term Variability in Duplex-Derived Carotid Flow Parameters in Symptomatic Patients Awaiting Carotid Endarterectomy.

Bodegom ME, Hissink RJ, El Moumni M et al. · 2026 · Annals of vascular surgery

Background Carotid stenosis is traditionally considered a relatively stable condition between symptom onset and carotid endarterectomy. However, short-term changes in duplex-derived hemodynamic parameters may occur during the waiting…

View details →DOI: 10.1016/j.avsg.2026.03.002
Negative / Null Result ReportMedicine

Multi-perspective spatial memory representation in the presence of others.

Li J, Wang Q, Xie N et al. · 2026 · Cognitive processing

In order to better adapt to spatial environments, individuals often establish a spatial frame of reference system to represent objects and their positions within a scene. This study utilized a partial scene recognition paradigm across…

View details →DOI: 10.1007/s10339-025-01327-z
Negative / Null Result ReportOpen accessMedicine

Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.

Beaudoin DL, Hassan AR, Shehu A et al. · 2026 · Communications biology

A fundamental feature of the visual system is its ability to detect image contrast. The contrast processing starts in the first synapse of the retina where parallel pathways are established to compute contrast to bright (ON pathway) and…

View details →DOI: 10.1038/s42003-026-09885-4
Negative / Null Result ReportMedicine

Effect of intravitreal injection of dexamethasone implant on the corneal morphology of young adults with central retinal vein occlusion.

Niu TT, Xin WJ · 2026 · International journal of ophthalmology

Aim To investigate the effect of intravitreal injection of dexamethasone (DEX) implants on the corneal morphology of young adults with central retinal vein occlusion (CRVO). Methods This was a retrospective study. The information of all…

View details →DOI: 10.18240/ijo.2026.05.10
Negative / Null Result ReportMedicine

Transient elastography in acute hospital inpatients with harmful alcohol use: a service evaluation.

Balston AJ, Conti I, Darko S et al. · 2026 · Alcohol and alcoholism (Oxford, Oxfordshire)

Aims Hospital admissions are frequently alcohol related and are an opportunity for health promotion. Transient Elastography (TE), an ultrasound-based method of assessing liver health, may be beneficial when used by inpatient Alcohol Care…

View details →DOI: 10.1093/alcalc/agaf079
Negative / Null Result ReportMedicine

Dietary Sodium Reduction Reveals Aldosterone Dysregulation in Patients With Essential Hypertension.

Duus CL, Nielsen SF, Hornstrup BG et al. · 2026 · Journal of clinical hypertension (Greenwich, Conn.)

Dietary sodium reduction affects blood pressure (BP), the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptides. Whether baseline levels of these hormones impact BP response to sodium reduction remains unknown. Aldosterone…

View details →DOI: 10.1111/jch.70229
Negative / Null Result ReportOpen accessMedicine

An Online Pilates Program for People with Hypermobility: A Pragmatic Clinical Trial Looking at Function, Interoception, Kinesiophobia, and Physical Activity Levels.

Russek LN, Di Bon J, Herbland A et al. · 2026 · Journal of multidisciplinary healthcare

Purpose This study evaluated whether an independent, online modified Pilates program alters function, interoception (internal body awareness), activity levels, and kinesiophobia (fear of movement) in people with symptomatic joint…

View details →DOI: 10.2147/jmdh.s564972
Negative / Null Result ReportMedicine

Variations in outcomes following burn injury and admission to an Australian or New Zealand intensive care unit: A retrospective data linkage cohort study.

Garside T, Udy A, Reade MC et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Introduction The Burns Registry of Australia and New Zealand (BRANZ) has been used to identify significant variation in burn injury management and outcomes across Australia and New Zealand. This study aimed to assess variation in clinical…

View details →DOI: 10.1016/j.burns.2026.107992
Negative / Null Result ReportMedicine

The Effect of a Mobile Game Developed for Children with Familial Mediterranean Fever on Disease Management and Quality of Life: A Randomized Controlled Trial.

Kaş Alay G, Mutlu B · 2026 · Games for health journal

Objective To determine the effect of training children with familial Mediterranean fever (FMF) using a mobile game (MG) or training booklet (TB) on self-efficacy, symptom management, and quality of life (HRQoL) compared with a control…

View details →DOI: 10.1177/2161783x251414694