A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21742 results · page 526 of 725
Robertson I, Taylor D, Chong J · 2025 · Journal of rehabilitation medicine
Background Rehabilitation is vital for optimizing recovery following neurological injuries. However, much of what is done for the paediatric population relies heavily on the adult literature or is based on expert opinion. No previous…
McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…
Helder M, Pandeya N, Seviiri M et al. · 2024 · Preprint
ABSTRACT With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell…
Snippe E, Elmer T, Ceulemans E et al. · 2024 · Journal of consulting and clinical psychology
Objective Despite the importance for understanding mechanisms of change, little is known about the order of change in daily life emotions, cognitions, and behaviors during treatment of depression. This study examined the within-person…
Jones GA · 2025 · Critical criminology
Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…
Al-Maghrabi M, Mamede S, Schmidt HG et al. · 2024 · Advances in medical education and practice
Background Literature suggest that physicians' high level of confidence has a negative impact on medical decisions, and this may lead to medical errors. Experimental research is lacking; however, this study investigated the effects of high…
Jeffrey CE, Andrews T, Godden SM et al. · 2024 · Journal of dairy science
The primary objective of this cross-sectional observational study was to determine whether bulk tank milk quality, udder health, udder hygiene, and milk production outcomes were associated with facility type on organic dairies. A secondary…
Vollebregt PF, Goh YL, Bagul A et al. · 2025 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Sacral neuromodulation (SNM) is considered the first-line surgical treatment in adults with refractory faecal incontinence (FI). However, its clinical efficacy has not been rigorously tested in a trial setting. Method Randomised,…
Bates KE, Smith ML, Farran EK et al. · 2024 · Journal of cognitive neuroscience
Mental imagery (MI) is the ability to generate visual phenomena in the absence of sensory input. MI is often likened to visual working memory (VWM): the ability to maintain and manipulate visual representations. How MI is recruited during…
Öster K, Tucker P, Söderström M et al. · 2024 · Scandinavian journal of work, environment & health
Objectives Quick returns ( Methods Of 225 nurses and assistant nurses who wore actigraphy wristbands and kept a diary of work and sleep for seven days, a subsample of 90 individuals with one observation of both a quick return and a control…
Rooney JPK, Geoghegan G, O'Reilly F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Introduction : Serum heat shock protein (HSP) concentrations have been reported as potential biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigate the role of serum HSP70, HSP90, and DNAJC7 as biomarkers for ALS. Methods…
Balouei F, Stefanon B, Martello E et al. · 2023 · Preprint
The gut-liver axis plays a pivotal role in the development of liver diseases, necessitating exploration into substances capable of modulating the microbiota to prevent dysbiosis. Over the past decade, diverse therapeutic approaches have…
Lenz KB, McDade J, Petrozzi M et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives Social determinants of health (SDOH) are associated with disparities in disease severity and in-hospital outcomes among critically ill children. It is unknown whether SDOH are associated with later outcomes. We evaluated…
Li C, Li X, Zhang Z · 2024 · Work (Reading, Mass.)
Background The involvement of Perchloroethylene (PCE) in the development of autoimmune diseases has been reported. However, few studies investigated immunotoxicity in PCE-exposed workers. Objective To study changes in the oxidative stress…
Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science
Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…
Zhao y, Xu F · 2023 · Preprint
Abstract Background: A few of cohort studies declared an converse association between pork intake and cardiovascular diseases, but the causal relationship is ambiguous. Objective: To evaluate the causal relationship between pork intake,…
McMullin MP, Cadotte NB, Fuchs EM et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives We aimed to implement a post-cardiac arrest targeted temperature management (TTM) bundle to reduce the percent of time with a fever from 7% to 3.5%. Design A prospective, quality improvement (QI) initiative utilizing the Method…
Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…
Rehe D, Subashchandran V, Zhang Y et al. · 2025 · Journal of clinical anesthesia
Study objective To determine whether preoperative LDL-C concentration affects the risk of perioperative major adverse cardiovascular or cerebrovascular events (MACCE) after noncardiac surgery. Design Single center retrospective cohort…
Dickerson JF, Clarke G, Weersing VR et al. · 2025 · American journal of epidemiology
The current study estimated effects of intervention dose (attendance) of a cognitive behavioral prevention (CBP) program on depression-free days (DFDs) in adolescent offspring of parents with a history of depression. As part of secondary…
De Gaudenzi M, Mozun R, Schlapbach LJ et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives Healthcare improvement studies indicate a potential to reduce cardiac arrests in the PICU through anticipatory care and shared awareness. We developed a structured risk-assessment and anticipation tool (i.e., the Airway,…
Yu S, Chen S, Tao T et al. · 2023 · Preprint
Background: Previous observational studies have found that negative moods are associated with cardiovascular diseases (CVDs). However, their causal association remains unclear. We aim to evaluate the causal associations of genetically…
Tlili S, Ghabi H, Mami I et al. · 2026 · World journal of nephrology
Background The outcome of renal transplantation is influenced by the occurrence of various complications, including urological. One of the most frequently occurring complications is lymphocele with an incidence of 0.6% to 51%. In fact,…
Castro CP, Diehl AG, Boyle AP · 2022 · Preprint
Understanding the genetic basis for complex, heterogeneous disorders, such as autism spectrum disorder (ASD), is a persistent challenge in human medicine. Owing to their phenotypic complexity, the genetic mechanisms underlying these…
Zahl-Olsen R, Gausel N, Tellefsen Håland Å et al. · 2022 · Preprint
Background: Routine Outcome Monitoring (ROM) systems have been used to monitor how a client’s life changes over the course of therapy. However, if a ROM system is to be used, the system should have sufficient construct validity to warrant…
Faghihian E, Ghobadi S, Rezaei R et al. · 2025 · The Saudi dental journal
The current study investigated the relationship between the first central deciduous tooth eruption time and serum levels of maternal alpha-fetoprotein and related multiple of the median (MoM). The cross-sectional study was performed on a…
Michel E, Garnier-Allain A, Kaliuzhna M et al. · 2026 · PloS one
Apathy and impulsivity are multidimensional constructs that shape goal-directed behavior. Although the motivational dopaminergic spectrum hypothesis frames them as opposing ends of a single continuum, questionnaire-based studies…
Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health
Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…
Kösem A, Dai B, McQueen JM et al. · 2023 · NeuroImage
During listening, brain activity tracks the rhythmic structures of speech signals. Here, we directly dissociated the contribution of neural envelope tracking in the processing of speech acoustic cues from that related to linguistic…
Bressan E, Zucchelli G, Tommasato G et al. · 2024 · Medicina (Kaunas, Lithuania)
Background and Objectives : The influence of the quantity and quality of peri-implant soft tissue on implant health and long-term maintenance is controversial. This consensus aimed to assess the importance of peri-implant soft tissue by…