Negative / Null Result ReportMedicine
Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia
Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…
View details →DOI: 10.1016/j.bja.2025.09.019 Negative / Null Result ReportMedicine
Lin W, Zhang X, Zhuo Y et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Chronic postsurgical pain (CPSP) affects up to 60% of breast cancer surgery patients, substantially impairing quality of life. Although erector spinae plane block (ESPB) provides effective acute analgesia with superior safety…
View details →DOI: 10.1016/j.accpm.2025.101676 Negative / Null Result ReportMedicine
Dubreucq Guerif E, Agut S, Rousseau A et al. · 2026 · European journal of emergency medicine : official journal of the European Society for Emergency Medicine
Background and importance Vaso-occlusive crisis is the main reason for emergency department (ED) visits for patients with sickle cell disease. Therapeutic management involves multimodal analgesia, which often comprises the administration…
View details →DOI: 10.1097/mej.0000000000001282 Negative / Null Result ReportMedicine
Hofherr A, Mäki-Petäjä K, Selvarajah V et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points In 558 adults with type 2 diabetes and CKD, inhibition of IL-33 by tozorakimab was well tolerated. IL-33 signaling was blocked at all doses, eosinophil counts decreased, and urinary CC-chemokine ligand 2 decreased at the high…
View details →DOI: 10.1681/asn.0000000966 Negative / Null Result Report
Smoak CN, Gardner EN, Chua RN et al. · 2025 · Preprint
Adenosine deaminase acting on RNA 1 (ADAR1) edits double-stranded RNA (dsRNA) substrates by the deamination of adenosine to inosine in a process known as A-to-I editing. Modulation of ADAR1 expression and editing activity has previously…
View details →DOI: 10.1101/2025.08.08.669362 Negative / Null Result ReportMedicine
Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international
Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…
View details →DOI: 10.1177/10711007251344916 Negative / Null Result Report
Martínez RM, Goh KK, Fan Y et al. · 2025 · Preprint
Abstract Objective To evaluate the association between MS, work experience, and risky decision making, including its psychological and behavioral effects, on field-firefighters. Methods cross-sectional study was conducted using a sample of…
View details →DOI: 10.21203/rs.3.rs-7296428/v1 Negative / Null Result ReportMedicine
Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders
Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…
View details →DOI: 10.1016/j.jad.2025.120391 Negative / Null Result ReportMedicine
Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery
Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…
View details →DOI: 10.1093/bjs/znaf230 Negative / Null Result ReportMedicine
Bannink A, Kamstra-Brouwer H, van Wesemael D et al. · 2026 · Journal of dairy science
A feeding trial was conducted with 60 mid-lactation cows that were, on average, 116 DIM, parity 3.5, and with a fat- and protein-corrected milk (FPCM) yield of 34 kg/d. Cows were blocked based on cow traits and milk performance. Cows in…
View details →DOI: 10.3168/jds.2025-26616 Negative / Null Result ReportMedicine
Hiroki S, Fukasawa T, Yokogawa K et al. · 2025 · Journal of medical virology
Patients with type 2 diabetes have a higher risk of herpes zoster (HZ). Although metformin may reduce this risk via immunomodulatory effects, prior evidence is limited by confounding by indication and an unclear causal estimand. We aimed…
View details →DOI: 10.1002/jmv.70606 Negative / Null Result Report
DE BREK N, PEYROTTES A, DARIANE C et al. · 2025 · Preprint
Abstract Purpose: Penile fracture is a rare urological emergency treated by surgical exploration. However, the indication for intra-operative drainage remains debated due to limited evidence. This study aimed to assess the impact of…
View details →DOI: 10.21203/rs.3.rs-8071206/v1 Negative / Null Result ReportOpen accessMedicine
Gulersen M, Berghella V, Bornstein E · 2025 · Journal of clinical medicine
Singleton pregnancies complicated by a short cervical length (≤25 mm) are at significantly increased risk for spontaneous preterm birth. Several treatment strategies aimed at reducing this risk and improving perinatal outcomes have been…
View details →DOI: 10.3390/jcm14155544 Negative / Null Result ReportMedicine
Boff GA, Iepsen LB, Serighelli-Junior G et al. · 2025 · Veterinary research communications
This study aimed to evaluate the effects of magnesium sulfate on propofol requirements and perioperative analgesia in dogs undergoing ovariohysterectomy. Fourteen female dogs (2 ± 1 years, 17 ± 5 kg) were enrolled in this randomized and…
View details →DOI: 10.1007/s11259-025-11010-5 Negative / Null Result ReportMedicine
LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…
View details →DOI: 10.1093/jbmr/zjaf172 Negative / Null Result ReportMedicine
Kimura K, Minagawa R, Iseda N et al. · 2025 · Anticancer research
Background/aim Pseudoaneurysm hemorrhage after pancreatectomy can be fatal. However, effective intraoperative preventive strategies remain unclear. This study evaluated the efficacy of fibrin glue combined with polyglycolic acid (PGA)…
View details →DOI: 10.21873/anticanres.17807 Negative / Null Result ReportMedicine
Kapur NK, Mangner N, Aghili N et al. · 2026 · Journal of the American College of Cardiology
Background Despite rapid percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), large infarcts contribute to heart failure and mortality. Left ventricular (LV) wall tension and load are major…
View details →DOI: 10.1016/j.jacc.2026.03.071 Negative / Null Result ReportOpen accessMedicine
Patel PY, Akhani MK, Rathod R et al. · 2025 · Cureus
Introduction and aim Laparoscopic cholecystectomy (LC) is the gold standard for gallstone disease, but conversion to open surgery may be required in difficult cases. The role of drain placement after cholecystectomy remains controversial.…
View details →DOI: 10.7759/cureus.93233 Negative / Null Result ReportMedicine
Tasci A, Tasci EDK, Turan CA et al. · 2026 · Journal of applied toxicology : JAT
Intravenous lipid emulsion (ILE) is an established antidote for local anesthetic systemic toxicity and has been tested in various lipophilic drug intoxications, but its efficacy in pioglitazone toxicity remains unclear. This study…
View details →DOI: 10.1002/jat.4939 Negative / Null Result ReportMedicine
Hovgaard HL, Vistisen ST, Enevoldsen J et al. · 2026 · Anesthesiology
Background Esophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy…
View details →DOI: 10.1097/aln.0000000000005919 Negative / Null Result ReportMedicine
Yan CL, Erben A, Sarmiento K et al. · 2025 · Quality management in health care
Background Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as an opportunity to address reasons for HF…
View details →DOI: 10.1097/qmh.0000000000000535 Negative / Null Result ReportMedicine
Vafaei A, Manavi MA, Toutounchian S et al. · 2025 · Neurochemical research
Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible…
View details →DOI: 10.1007/s11064-025-04584-8 Negative / Null Result ReportOpen accessMedicine
Shoubridge AP, Brass A, Crotty M et al. · 2025 · JAMA internal medicine
Importance Infectious outbreaks of respiratory viruses within long-term care facilities (LTCFs) for older adults are associated with high rates of hospitalization and death. Despite evidence that airborne transmission contributes…
View details →DOI: 10.1001/jamainternmed.2025.3388 Negative / Null Result ReportOpen accessMedicine
Qiao W, Liu L, Zhang X et al. · 2025 · BMC anesthesiology
Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block…
View details →DOI: 10.1186/s12871-025-02895-5 Negative / Null Result ReportOpen accessMedicine
Tomazini BM, Besen BAMP, Gales AC et al. · 2026 · Lancet regional health. Americas
Background Critically ill patients are at risk of nosocomial infections, acquisition of multidrug-resistant pathogens, and substantial antimicrobial consumption. We assessed whether bathing with chlorhexidine reduces these outcomes…
View details →DOI: 10.1016/j.lana.2026.101400 Negative / Null Result ReportMedicine
Beerse M, Bigelow KE, Barrios JA · 2025 · Exp Brain Res
The uncontrolled manifold analysis (UCM) is a useful technique for motor learning research enabling the classification of movement variability into solutions and errors. Less explored methodological considerations within the UCM framework…
Negative / Null Result ReportMedicine
Hald JD, Weir CJ, Keerie C et al. · 2026 · JAMA
Importance Osteogenesis imperfecta causes multiple fractures throughout life, causing substantial morbidity. Objective To determine whether the parathyroid hormone analogue teriparatide followed by zoledronic acid reduces the risk of…
View details →DOI: 10.1001/jama.2026.6889 Negative / Null Result ReportMedicine
Cancellier EL, Degryse F, da Silva RC et al. · 2025 · The Science of the total environment
The use of petroleum-based coatings in controlled-release fertilizers (CRFs) raises environmental concerns and it is unclear if, and to what extent, CRFs can improve P use efficiency. This study explored the synthesis of bio-based…
View details →DOI: 10.1016/j.scitotenv.2025.180403 Negative / Null Result ReportOpen accessMedicine
van den Brink DP, Hilderink BN, Kleinveld DJB et al. · 2026 · British journal of anaesthesia
Background During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while…
View details →DOI: 10.1016/j.bja.2025.08.060 Negative / Null Result ReportMedicine
Lopes LF, Favoretto VR, Evangelista AG et al. · 2025 · European food research & technology.
This study evaluated the efficacy of gaseous allyl isothiocyanate (AITC) in inhibiting Aspergillus parasiticus growth and aflatoxin production in soybeans and beans stored at 85% relative humidity for 35d. Samples of 50 g of soybeans or…
