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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 524 of 725

Negative / Null Result ReportMedicine

Dual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity.

Ekinci EI, Maldonado SG, Unseld A et al. · 2026 · Diabetes, obesity & metabolism

Aims This post hoc analysis evaluated the effect of survodutide on beta-cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and methods Trial 1404-0002 randomised 413 participants with…

View details →DOI: 10.1111/dom.70861
Negative / Null Result ReportMedicine

Comparison of the effect of internet-based and in-person cognitive behavioral therapy on the fear of childbirth in primiparous pregnant women: a randomized controlled trial.

Piri K, Gholamzadeh Jofreh M, Haghighizadeh MH et al. · 2026 · BMC psychology

Introduction Fear of childbirth (FOC) is a significant factor contributing to requests for elective cesarean sections. This study aimed to compare the effectiveness of internet-based cognitive behavioral therapy (ICBT) versus in-person…

View details →DOI: 10.1186/s40359-026-04903-w
Negative / Null Result ReportMedicine

Providing insight in resilience and recovery by using fatigability and its development over time in older adults after hip fracture surgery.

Dijksterhuis J, Hurmuz MZM, van Dartel D et al. · 2026 · European geriatric medicine

Purpose Older hip fracture patients are often frail, complicating their recovery trajectories. Insight into patients' resilience may help in getting more understanding of their predicted recovery and adjusting their treatment plan…

View details →DOI: 10.1007/s41999-026-01514-x
Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of Dotinurad in Patients with Advanced Chronic Kidney Disease.

Motomura T, Higashi M, Hattori A et al. · 2026 · Internal medicine (Tokyo, Japan)

Objective Hyperuricemia is associated with cardiovascular disease and chronic kidney disease (CKD). Dotinurad is a new uricosuric drug that has not been evaluated in clinical trials in patients with advanced CKD (CKD G3b-G5). This study…

View details →DOI: 10.2169/internalmedicine.5834-25
Negative / Null Result ReportMedicine

Learning and deskilling effects of artificial intelligence in colonoscopy among endoscopists with different levels of experience: a pragmatic, prospective trial.

Pedersen TA, Mori Y, Botteri E et al. · 2026 · Endoscopy

Background The effect of computer-aided detection (CADe) on performance of endoscopists with different experience levels is not well understood. This study assessed whether CADe use promotes learning or deskilling. Methods We performed a…

View details →DOI: 10.1055/a-2858-7084
Negative / Null Result ReportMedicine

Evaluation of preoperative screw planning and X-ray simulation for iliosacral and transsacral screw placement.

Hoskens S, Bamps K, Herteleer M · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Objectives The percutaneous placement of iliosacral (IS) and transsacral (TS) screws has become a standard practice for the treatment of pelvic fractures. Due to the complex sacral anatomy, accurate screw placement is essential to avoid…

View details →DOI: 10.1007/s00590-026-04768-0
Negative / Null Result Report

Efficacy of a Liposomal Ophthalmic Solution Containing Cross-Linked Hyaluronic Acid, Trehalose, and Stearylamine in Relieving Dry Eye-like Symptoms in Patients undergoing Multiple Intravitreal Treatments

Cagini C, Messina M, Fiore T et al. · 2026 · Preprint

Abstract Purpose This study investigates the efficacy of a liposomal ophthalmic solution containing cross-linked hyaluronic acid, trehalose, and stearylamine in reducing the occurrence of dry eye-like signs and symptoms in patients…

View details →DOI: 10.21203/rs.3.rs-9533021/v1
Negative / Null Result Report

Ethical Sensitivity and Moral Reasoning in Medical Students in Ecuador: Insights for Medical Education in Latin America

Moreira-Vera D, Solórzano MLP, Marín-Pérez AL · 2026 · Preprint

Abstract Introduction: Ethical decision-making is a core competency in medical training. However, evidence regarding moral reasoning and ethical sensitivity among medical students in Latin America remains limited, particularly in settings…

View details →DOI: 10.21203/rs.3.rs-9520858/v1
Negative / Null Result ReportMedicine

Inferior Vena Cava to Aorta Ratio in Children With Non-Hemorrhagic Shock After Fluid Bolus Using Point of Care Ultrasound.

Hamsika V, Batra P, Bhaskar V et al. · 2026 · Pediatric emergency care

Objective To compare IVC/Ao ratio, IVC collapsibility/distensibility indices before and after the administration of fluid bolus therapy in children with non-hemorrhagic shock using point of care ultrasound, and to correlate the changes in…

View details →DOI: 10.1097/pec.0000000000003626
Negative / Null Result ReportOpen accessMedicine

Engaging with Facebook Health Support Groups among Australian Culturally and Linguistically Diverse Populations.

Zein MMA, Win KT, Alananzeh I · 2026 · Healthcare informatics research

Objectives This study aims to explore the key factors that enhance engagement in Facebook health support groups among Australian culturally and linguistically diverse (CALD) communities. Methods A cross-sectional online survey was…

View details →DOI: 10.4258/hir.2026.32.1.14
Negative / Null Result ReportMedicine

Factors influencing the sensory profile in patients with autism spectrum disorder from 16 months to 14 years: results of an observational study.

Marani N, di Gennaro D, Garotti R et al. · 2026 · Frontiers in psychiatry

Introduction Sensory processing abnormalities represent a high-impact clinical feature in individuals with Autism Spectrum Disorder (ASD). Sensory alterations can be classified by modality and behavioral responses to stimuli. The…

View details →DOI: 10.3389/fpsyt.2026.1771832
Negative / Null Result ReportMedicine

Spondylolisthesis Reduction and Changes in Sagittal Alignment Following Single-Position Lateral Versus Lateral-Then-Prone Oblique Lumbar Interbody Fusion With Navigation-Assisted Posterior Percutaneous Instrumentation.

Ansari D, Bethel JA, Greeneway GP et al. · 2026 · Operative neurosurgery (Hagerstown, Md.)

Background and objectives Lateral interbody fusion represents a minimally-invasive approach to achieve indirect decompression via disc height restoration and alignment correction in patients with degenerative lumbar spondylolisthesis. If…

View details →DOI: 10.1227/ons.0000000000002019
Negative / Null Result ReportMedicine

Evaluation of organosilicone surfactants as synergists of Solenopsis invicta virus 3 in Solenopsis invicta.

White RL, Read QD, Valles SM · 2026 · Journal of invertebrate pathology

Solenopsis invicta virus 3 (SINV3) is a biological control agent against the red imported fire ant, S. invicta. We attempted to improve the virus' effectiveness with organosilicone adjuvants hydroxy trisiloxane [hydroxyTSX] and methoxy…

View details →DOI: 10.1016/j.jip.2026.108573
Negative / Null Result ReportMedicine

Tunable self-association of partially dephosphorylated beta-casein

Rasmussen PL, Rinnan Å, Nielsen SB et al. · 2026 · Food Hydrocolloids.

The utilization of bovine casein for creating casein micelles with properties resembling those in human milk presents an opportunity to bridge the nutritional gap between human milk and infant formula. However, the processing of these…

Negative / Null Result ReportMedicine

No Significant Impact of Preoperative Electrodiagnostic Testing on Short-Term Outcomes after Carpal Tunnel Release.

Williams AJ, Pum JM, Deyoung JK et al. · 2026 · The journal of hand surgery Asian-Pacific volume

Background: The purpose of this study was to compare Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) and PROMIS Pain Interference (PI) scores before and after carpal tunnel release (CTR) between…

View details →DOI: 10.1142/s2424835526500189
Failed Experiment Report

Assessment of the sensitivity of the RegCM5 model to physical parameterization schemes in precipitation simulation in the Bandama watershed (Côte d’Ivoire)

Doumbia M, Yoroba F, Koné B et al. · 2026 · Preprint

Abstract This study evaluates how different physical parameterization schemes affect precipitation simulation in the Bandama watershed (Côte d’Ivoire) using the RegCM5 regional climate model. Thirteen configurations were developed,…

View details →DOI: 10.21203/rs.3.rs-9997831/v1
Abandoned HypothesisMedicine

Examining autobiographical memory retrieval as an intervention to increase physical activity in adults aged 60 and older.

Smurzynska Z, Lerolland E, Siedlecki KL · 2026 · Memory (Hove, England)

Previous research examining the directive function in autobiographical memory in college-aged participants found that recalling autobiographical memories related to physical activity was associated with an increase in subsequent physical…

View details →DOI: 10.1080/09658211.2026.2680911
Negative / Null Result ReportMedicine

Mechanistic-statistical model for the expansion of ash dieback.

Fritsch C, Grosdidier M, Gégout-Petit A et al. · 2026 · Theoretical population biology

Hymenoscyphus fraxineus is an invasive forest fungal pathogen that induces severe dieback in European ash populations. The spread of the disease has been closely monitored in France by the forest health survey system which has made it…

View details →DOI: 10.1016/j.tpb.2026.06.006
Negative / Null Result Report

The Double-Edged Sword of Competition: How Organizational Effectiveness Mediates the Impact of Environmental Dynamism on SME Export Performance

Erfanikia A, Hajikarimi B, Nazari A et al. · 2026 · Preprint

Abstract This study investigates the complex interplay between strategic orientation, internal capabilities, and external environmental forces in shaping the export performance of Small and Medium-sized Enterprises (SMEs). Specifically, it…

View details →DOI: 10.21203/rs.3.rs-8924474/v1
Failed Experiment ReportMedicine

Social drivers of health and perioperative outcomes: Identifying domains and barriers with significant impact.

Edwards MA, Petty SB, Chawla K et al. · 2026 · American journal of surgery

Objectives This retrospective cohort of patients undergoing surgery from 2019 to 2023 evaluated the association between individual-level social drivers of health (SDoH) and postoperative outcomes (length of stay, 30-day mortality, 30-day…

View details →DOI: 10.1016/j.amjsurg.2026.116890