Negative / Null Result ReportMedicine
Daniel Brock Hewitt, Nicholas Nissen, Hassan Hatoum et al. · 2020 · Annals of Surgery
OBJECTIVES: To compare the efficacy and safety of algenpantucel-L [HyperAcute-Pancreas algenpantucel-L (HAPa); IND# 12311] immunotherapy combined with standard of care (SOC) chemotherapy and chemoradiation to SOC chemotherapy and…
View details →DOI: 10.1097/sla.0000000000004669Cited by 92 Negative / Null Result ReportOpen accessMedicine
Claudia Torino, Fabio Manfredini, Davide Bolignano et al. · 2014 · Kidney & Blood Pressure Research
BACKGROUND/AIMS: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. METHODS: We tested the…
View details →DOI: 10.1159/000355798Cited by 92 Negative / Null Result ReportOpen accessMedicine
Maximilian Salcher‐Konrad, Huseyin Naci, Courtney Davis · 2020 · Milbank Quarterly
Policy Points Regulatory agencies may have limited evidence on the clinical benefits and harms of new drugs when deciding whether new therapeutic agents are allowed to enter the market and under which conditions, including whether approval is granted under special regulatory pathways and obligations to address knowledge gaps through postmarketing studies are imposed. In a matched comparison of marketing applications for cancer drugs of uncertain therapeutic value reviewed by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), we found frequent discordance be
View details →DOI: 10.1111/1468-0009.12476Cited by 92 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Davide Fiore Bavaro, Alessandra Belati, Lucia Diella et al. · 2021 · Antibiotics
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients or in patients with post-surgical infections who had failed previous regimens. A total of 13 patients were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) patients were classified as critically ill, due to severe COVID-19 lung failure; 4/13 (31%) patients had post-surgical infections and 4/13 (31%) had severe infections in immunoc
View details →DOI: 10.3390/antibiotics10060652Cited by 92 Negative / Null Result ReportOpen accessMedicine
Marco Metra, Cathal O’Connor, Beth A. Davison et al. · 2011 · European Heart Journal
AIMS: Dyspnoea and pulmonary and/or peripheral congestion are the most frequent manifestations of acute heart failure (AHF) and are important targets for therapy. We have assessed changes in dyspnoea, their relationship with mortality, and…
View details →DOI: 10.1093/eurheartj/ehr042Cited by 92 Negative / Null Result ReportMedicine
Wentao Zhao, Fengliang Hu, Yuying Li et al. · 2012 · World Journal of Surgery
BACKGROUND: The aim of the present study was to investigate the usefulness of the transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer. METHODS: Between January 2007 and May…
View details →DOI: 10.1007/s00268-012-1812-9Cited by 92 Negative / Null Result ReportOpen accessNursing
Muhammed A. Usman, Daniel Callo-Concha · 2021 · Agricultural and Food Economics
Abstract Market access influences the dietary diversity and food security for smallholder households in many ways. In Ethiopia, most smallholders are subsistence farmers who have poor access to markets. This study used primary data from a household survey to examine the relationship between market access and the dietary diversity and food security for 324 smallholder households in the Yayu area of southwestern Ethiopia in early 2018. Multivariate regression analysis showed that households located far from market centers consumed not only less diverse foods but also spend less on food consumpti
View details →DOI: 10.1186/s40100-021-00190-8Cited by 92 Negative / Null Result ReportMedicine
Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →DOI: 10.1530/eje-10-0570Cited by 92 Negative / Null Result ReportOpen accessDecision Sciences
Ariella Kristal, Ashley V. Whillans, Max H. Bazerman et al. · 2020 · Proceedings of the National Academy of Sciences
Honest reporting is essential for society to function well. However, people frequently lie when asked to provide information, such as misrepresenting their income to save money on taxes. A landmark finding published in PNAS [L. L. Shu, N. Mazar, F. Gino, D. Ariely, M. H. Bazerman, Proc. Natl. Acad. Sci. U.S.A. 109, 15197–15200 (2012)] provided evidence for a simple way of encouraging honest reporting: asking people to sign a veracity statement at the beginning instead of at the end of a self-report form. Since this finding was published, various government agencies have adopted this practice.
View details →DOI: 10.1073/pnas.1911695117Cited by 92 Negative / Null Result ReportOpen accessMedicine
Ashley Woodcock, Eugene R. Bleecker, Jan Lötvall et al. · 2013 · CHEST Journal
BACKGROUND: The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to…
View details →DOI: 10.1378/chest.13-0178Cited by 92 Negative / Null Result ReportOpen accessNeuroscience
Alex I. Wiesman, Jennifer O’Neill, Mackenzie S. Mills et al. · 2018 · Brain
Combination antiretroviral therapies have revolutionized the treatment of HIV infection, and many patients now enjoy a lifespan equal to that of the general population. However, HIV-associated neurocognitive disorders (HAND) remain a major…
View details →DOI: 10.1093/brain/awy097Cited by 91 Negative / Null Result ReportOpen accessEnvironmental Science
Rahul Gondalia, Antoine Baldassari, Katelyn M. Holliday et al. · 2019 · Environment International
DNA methylation (DNAm) may contribute to processes that underlie associations between air pollution and poor health. Therefore, our objective was to evaluate associations between DNAm and ambient concentrations of particulate matter (PM)…
View details →DOI: 10.1016/j.envint.2019.03.071Cited by 91 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
R. Anand, Kartik Shah, Hengyao Niu et al. · 2011 · Nucleic Acids Research
DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication across these barriers,…
View details →DOI: 10.1093/nar/gkr836Cited by 91 Negative / Null Result ReportOpen accessMedicine
Rachna T. Shroff, Mark Yarchoan, Ashley O’Connor et al. · 2017 · British Journal of Cancer
BACKGROUND: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of…
View details →DOI: 10.1038/bjc.2017.119Cited by 91 Negative / Null Result ReportOpen accessMedicine
H Grubek-Jaworska, Magdalena Paplińska‐Goryca, Joanna Hermanowicz-Salamon et al. · 2012 · Respiration
BACKGROUND: IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as…
View details →DOI: 10.1159/000334900Cited by 91 Negative / Null Result ReportChemistry
Xiao‐Qiang Hu, Yuxing Zhang, Yixin Zhang et al. · 2020 · ChemCatChem
Abstract Ligand steric bulk is one of the most important parameters on determining activity, polymer molecular weight, and branching density in α‐diimine Ni(II) and Pd(II) catalyzed ethylene polymerization. In this contribution, we…
View details →DOI: 10.1002/cctc.202000141Cited by 91 Negative / Null Result ReportNeuroscience
Haifei Zhang, Yànhuá Lǐ, Jie‐Zhong Yu et al. · 2013 · NeuroImmunoModulation
Macrophages/microglia exhibit phenotypic and functional heterogeneity under physiological and pathological conditions. Owing to this heterogeneity, the polarization of macrophages/microglia is capable of effecting both detrimental and…
View details →DOI: 10.1159/000351221Cited by 91 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Elizabeth Nance, Siva P. Kambhampati, Elizabeth S. Smith et al. · 2017 · Journal of Neuroinflammation
Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain inflammation/injury both in vitro and in vivo using a Mecp2-null mouse model of Rett syndrome. To determine whether inflammation and immune dysregulation were potential targets for dendrimer-based therapeutics in R
View details →DOI: 10.1186/s12974-017-1004-5Cited by 91 Negative / Null Result Report
Kevin K. Beentjes, Arjen G. C. L. Speksnijder, Menno Schilthuizen et al. · 2019 · PeerJ
Background The heterogeneous nature of environmental DNA (eDNA) and its effects on species detection and community composition estimates has been highlighted in several studies in the past decades. Mostly in the context of spatial…
View details →DOI: 10.7717/peerj.7335Cited by 91 Negative / Null Result ReportOpen accessMedicine
Kelly A. Liebman, Steven T. Stoddard, Amy C. Morrison et al. · 2012 · PLoS neglected tropical diseases
BACKGROUND: Knowledge of spatial patterns of dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement of infected humans and mosquito vectors plays a role in the spread and persistence of virus, spatial dimensions of transmission can range from small household foci to large community clusters. Current understanding is limited because past analyses emphasized clinically apparent illness and did not account for the potentially large proportion of inapparent infections. In this study we analyzed both c
View details →DOI: 10.1371/journal.pntd.0001472Cited by 91 Negative / Null Result ReportMedicine
Sung‐Wan Kim, Joon‐An Yoo, S. Y. Lee et al. · 2010 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: This study compared the effectiveness of risperidone and olanzapine in the treatment of delirium. METHODS: This was a 7-day, randomized, comparative clinical trial of risperidone and olanzapine in patients with delirium. The…
View details →DOI: 10.1002/hup.1117Cited by 90 Negative / Null Result ReportOpen accessMedicine
Francesco Sclafani, Tae‐Yop Kim, David Cunningham et al. · 2015 · JNCI Journal of the National Cancer Institute
BACKGROUND: Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic target. We conducted a multicenter, randomized, double blind, phase…
View details →DOI: 10.1093/jnci/djv258Cited by 90 Negative / Null Result ReportOpen accessMedicine
Susan M. Smith, Tom Fahey, John Smucny et al. · 2017 · Cochrane Database of Systematic Reviews
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. Objectives To assess the effects of antibiotics in improving outcomes and to…
View details →DOI: 10.1002/14651858.cd000245.pub4Cited by 90 Negative / Null Result ReportMedicine
Edward S. Brewer, B. I. Reznikov, Rebecca F. Liberman et al. · 2010 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: The yield of head computed tomography (CT) for patients who suffered head trauma with a presenting Glasgow Coma Scale (GCS) score of 15 has been reported to be low, even in patients who are anticoagulated or on antiplatelet…
View details →DOI: 10.1097/ta.0b013e3181e5e286Cited by 90 Negative / Null Result ReportMedicine
Ali A. Farooqui, Bradley Hiser, Stephen L. Barnes et al. · 2013 · Journal of neurosurgery
OBJECT: Patients with traumatic brain injury (TBI) are at risk for development of thromboembolic disease. The use of chemoprophylaxis in this patient group has not fully been characterized. The authors hypothesize that early…
View details →DOI: 10.3171/2013.8.jns13424Cited by 90 Negative / Null Result ReportEngineering
Jonathan W. Byrnes, Wes McKamie, Christopher J. Swearingen et al. · 2011 · ASAIO Journal
Extracorporeal membrane oxygenation (ECMO) is a lifesaving therapy, which has been used for the support of children with a broad range of diseases. Two pumps of differing mechanisms have been used to generate the extracorporeal flow:…
View details →DOI: 10.1097/mat.0b013e31822e2475Cited by 90 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Santiago Acosta Ormaechea, Jiae Yoo, SAcosta Ormaechea@imf.org et al. · 2012 · IMF Working Paper
We investigate the relation between changes in tax composition and long-run economic growth using a new dataset covering a broad cross-section of countries with different income levels. We specifically consider 69 countries with at least…
View details →DOI: 10.5089/9781616355678.001Cited by 90 Negative / Null Result ReportOpen accessPsychology
Björn Philips, Peter Wennberg, Per Konradsson et al. · 2018 · European Addiction Research
AIMS: There is a scarcity of clinical trials on psychological treatments for concurrent borderline personality disorder (BPD) and substance use disorder (SUD). Mentalization-based treatment (MBT) have shown efficacy in several trials on…
View details →DOI: 10.1159/000485564Cited by 90 Negative / Null Result ReportOpen accessEngineering
Ananyananda Dasari, Sakthi Kumar Arul Prakash, László A. Jeni et al. · 2021 · npj Digital Medicine
This work investigates the estimation biases of remote photoplethysmography (rPPG) methods for pulse rate measurement across diverse demographics. Advances in photoplethysmography (PPG) and rPPG methods have enabled the development of contact and noncontact approaches for continuous monitoring and collection of patient health data. The contagious nature of viruses such as COVID-19 warrants noncontact methods for physiological signal estimation. However, these approaches are subject to estimation biases due to variations in environmental conditions and subject demographics. The performance of c
View details →DOI: 10.1038/s41746-021-00462-zCited by 90 Negative / Null Result ReportOpen accessMedicine
Syed Khalid, Ravi S. Nunna, Samantha Maasarani et al. · 2020 · Neurosurgical FOCUS
OBJECTIVE: Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than patients with normal bone…
View details →DOI: 10.3171/2020.5.focus20289Cited by 89 