Negative / Null Result ReportOpen accessMedicine
Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science
Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…
View details →DOI: 10.1016/j.bpsgos.2026.100692 Negative / Null Result Report
Mifune N · 2021 · Preprint
Whether intergroup conflict is a necessary condition for the evolution of human prosociality has been a matter of debate. At the center of the debate is the coevolutionary model of parochial altruism—that human cooperation with in-group…
View details →DOI: 10.21203/rs.3.rs-936427/v1 Negative / Null Result ReportOpen accessMedicine
Torkan A, Zoghi M, Foroughimehr N et al. · 2025 · Brain sciences
Background Research on the impact of 5G mobile phone electromagnetic exposure on corticospinal excitability and intracortical mechanisms is still poorly understood. Objective This randomized controlled pilot study explored the effects of…
View details →DOI: 10.3390/brainsci15111134 Negative / Null Result ReportMedicine
Galang CM, Obhi SS · 2023 · Experimental brain research
Previous research has shown that empathic pain observation can lead to motor facilitation in the form of faster reaction times. However, it is unclear whether participants are focusing on the others' pain or simply focusing on their own…
View details →DOI: 10.1007/s00221-022-06508-2 Negative / Null Result ReportMedicine
Rosenheck R, Kurtz SG, Anand ST et al. · 2023 · Psychiatry research
Multi-site randomized effectiveness trials evaluate treatments under real-world conditions. Whether results change practice is under-studied. A 6-month 26-site Veterans Health Administration (VHA) cooperative study published in 2011…
View details →DOI: 10.1016/j.psychres.2023.115071 Negative / Null Result ReportMedicine
Das S, Freedland SJ · 2023 · Cancer prevention research (Philadelphia, Pa.)
Statins are widely prescribed medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase and therefore reduce cholesterol synthesis. Given the key role of cholesterol in cancer, statins may therefore have…
View details →DOI: 10.1158/1940-6207.capr-22-0420 Negative / Null Result ReportOpen accessMedicine
Costa CL, Araujo-Menendez CEE, Lawrence A et al. · 2026 · Frontiers in aging neuroscience
Background High blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudied in groups who are at particularly high risk for dementia, such as…
View details →DOI: 10.3389/fnagi.2026.1729134 Negative / Null Result ReportMedicine
Chang MJ, Liu MT, Chen MR et al. · 2023 · Journal of medical virology
Systemic lupus erythematosus (SLE) characterized by immune dysfunction is possibly more vulnerable to herpes simplex virus (HSV) infection. The infection has been intensively considered a common onset and exacerbation of SLE. This study is…
View details →DOI: 10.1002/jmv.28649 Negative / Null Result Report
Rafiee Y, Jones BC, Shiramizu V · 2022 · Preprint
Objective: The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone.…
View details →DOI: 10.21203/rs.3.rs-2096405/v1 Negative / Null Result Report
Cotter KN, Crone D, Rodriguez-Boerwinkle R et al. · 2022 · Preprint
Visiting art museums has been associated with a range of flourishing outcomes. But there have been recent shifts towards increasing digital engagement with art, leading to a radical change in how people experience visual art. Given the now…
View details →DOI: 10.31234/osf.io/d638m Negative / Null Result Report
Enouy S, Desrochers J, Bossom I et al. · 2022 · Preprint
Objective: A recent meta-review of attentional bias research in eating disorders suggests that meta-analyses and systematic reviews include many low-quality and underpowered studies (Stott et al., 2021). As such, we examined whether…
View details →DOI: 10.31234/osf.io/w3nkv Negative / Null Result ReportMedicine
Martineau AR · 2023 · The Proceedings of the Nutrition Society
This review summarises evidence relating to a potential role for vitamin D supplementation in the prevention or treatment of coronavirus disease 2019 (COVID-19). Laboratory studies show that the active vitamin D metabolite…
View details →DOI: 10.1017/s0029665122002798 Negative / Null Result ReportOpen accessMedicine
Palepu K, Sadeghi K, Kleinschmidt DF et al. · 2023 · BMC neurology
Background Sleep spindle activity is commonly estimated by measuring sigma power during stage 2 non-rapid eye movement (NREM2) sleep. However, spindles account for little of the total NREM2 interval and therefore sigma power over the…
View details →DOI: 10.1186/s12883-023-03376-3 Negative / Null Result ReportOpen accessMedicine
Trombetta AB, Hanney WJ, Anderson AW et al. · 2026 · Muscles (Basel, Switzerland)
Background Tensiomyography (TMG) offers a noninvasive means of evaluating skeletal muscle contractile properties, including muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts).…
View details →DOI: 10.3390/muscles5020030 Negative / Null Result ReportOpen accessMedicine
Errington TM, Mathur M, Soderberg CK et al. · 2021 · eLife
Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer…
View details →DOI: 10.7554/elife.71601 Negative / Null Result ReportMedicine
Giesen CG, Eder AB · 2022 · Cognition & emotion
The adaptation-by-binding account and the arousal-biased competition model suggest that emotional arousal increases binding effects for transient links between stimuli and responses. Two highly-powered, pre-registered experiments tested…
View details →DOI: 10.1080/02699931.2022.2130180 Negative / Null Result ReportMedicine
Ianni KM, Chernew ME, McWilliams JM · 2026 · Health services research
Objective To examine the effects of offering non-emergency medical transportation (NEMT) on care utilization among low-income and disabled beneficiaries in Medicare Advantage (MA). Study setting and design We leveraged the 2019 expansion…
View details →DOI: 10.1111/1475-6773.70086 Negative / Null Result ReportOpen accessMedicine
Jaeger B, Jones AL, Satchell L et al. · 2026 · International review of social psychology
The role of perceiver differences in impression formation remains relatively poorly understood. One line of research has tried to understand these differences by exploring the role of perceivers' needs and motivations, reasoning that…
View details →DOI: 10.5334/irsp.996 Negative / Null Result Report
Rafiee Y, Jones BC, Shiramizu VKM · 2022 · Preprint
The Compensatory Prophylaxis Hypothesis proposes that women will show increased pathogen disgust at points in the menstrual cycle when progesterone is high, compensating for the immunosuppressive effects of progesterone. However, evidence…
View details →DOI: 10.31234/osf.io/9fsgq Negative / Null Result ReportMedicine
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →DOI: 10.1016/j.semradonc.2025.07.002 Negative / Null Result ReportOpen accessMedicine
Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care
Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…
View details →DOI: 10.1186/s40560-026-00884-5 Negative / Null Result ReportOpen accessMedicine
Xu H, Yan Y, Niu J et al. · 2026 · BMC cancer
BACKGROUND: Metastatic colorectal cancer (mCRC) patients who progress following the standard chemotherapy have maintained a favourable performance status. Nevertheless, there are limited effective treatment options, particularly for a…
View details →DOI: 10.1186/s12885-026-15705-z Negative / Null Result ReportMedicine
Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
View details →DOI: 10.1007/s10147-025-02877-0 Negative / Null Result ReportMedicine
Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
View details →DOI: 10.1158/1078-0432.ccr-23-3936 Negative / Null Result ReportMedicine
Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
View details →DOI: 10.1007/s11910-024-01335-0 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 Negative / Null Result ReportMedicine
Asaithambi G, Castro-Pearson S, Meyer MK et al. · 2023 · Nutrition, metabolism, and cardiovascular diseases : NMCD
Background and aims Stroke is a major cause of mortality and disability, highlighting the importance of prevention. Clinical trials play an important role in evaluating interventions that can maximize stroke prevention. Traditional…
View details →DOI: 10.1016/j.numecd.2023.07.028 Negative / Null Result ReportMedicine
Poplin T, Kuplicki R, Walker EA et al. · 2025 · Biological psychiatry. Cognitive neuroscience and neuroimaging
Background Major depressive disorder (MDD) with comorbid anxiety presents significant treatment challenges, with high relapse rates and suboptimal outcomes. Transcranial direct current stimulation (tDCS) offers a scalable, noninvasive…
View details →DOI: 10.1016/j.bpsc.2025.10.020 Negative / Null Result ReportOpen accessMedicine
Webers C, Been M, van Tubergen A · 2023 · Current opinion in rheumatology
Purpose of review For almost a decade, treat-to-target (T2T) has been advocated as a management strategy for axial spondyloarthritis (axSpA), despite a lack of trial evidence. Recently, the first and only published T2T trial in axSpA did…
View details →DOI: 10.1097/bor.0000000000000941 Negative / Null Result ReportOpen accessMedicine
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
View details →DOI: 10.3390/cancers15123251 