A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Christine Desmedt, Roberto Salgado, Marco Fornili et al. · 2017 · JNCI Journal of the National Cancer Institute
Background: Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after invasive ductal cancer (IDC). Here, we aimed at evaluating the prevalence, levels, and composition of tumor-infiltrating…
Fortune Ganda, K. Milondzo · 2018 · Sustainability
The impact of carbon emissions on corporate financial performance within the African corporate setting has remained open and inconclusive, owing primarily to the unavailability of data. However, this paper examines the effect of carbon emissions (Scope 1, Scope 2, and Scope 1 and 2) on the financial performance (ROE, ROI, and ROS) of 63 South African CDP companies for the 2015 fiscal year. Using multiple regression techniques, the paper found overwhelming evidence of a negative relationship between carbon emissions and corporate financial performance. Thus, results indicate that companies whic
Nathan A. Lewis, Nicholas A. Turiano, Brennan R. Payne et al. · 2016 · Aging Neuropsychology and Cognition
With an increasingly aging population, more work is needed to identify factors which may promote the maintenance of normal cognitive functioning. The current study tested the concurrent association between sense of purpose in life and the…
Anna Cieślak, Annette Vissing‐Jørgensen · 2020 · Review of Financial Studies
Abstract Since the mid-1990s, negative stock returns comove with downgrades to the Fed’s growth expectations and predict policy accommodations. Textual analysis of FOMC documents reveals that policy makers pay attention to the stock…
Isabel Holmbäck, Ulrika Ericson, Bo Gullberg et al. · 2010 · British Journal Of Nutrition
The role of eating frequency in obesity development is debated. Therefore, we investigated the association between eating frequency, BMI and waist circumference (WC), as well as how eating frequency is related to diet composition and…
Yann P. Kerevel, Lonna Rae Atkeson · 2013 · The Journal of Politics
Previous research suggests that women tend to be marginalized in legislatures or denied access to important agenda-setting resources that reduce their effectiveness as legislators after gaining office. However, previous studies have not…
Ida Moltke, Matteo Fumagalli, Thorfinn Sand Korneliussen et al. · 2014 · The American Journal of Human Genetics
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the am
Shaily Singh, Sherry Sandy, Samuel Wiebe · 2015 · Epilepsia
Summary Objective A major limitation of intracranial electroencephalography ( iEEG ) is recording from a confined region. This may falsely localize seizure onset if the distinction between ictal onset zone, proximity, and spread is…
Laura Salvador, Gunasekaran Singaravelu, Calvin B. Harley et al. · 2016 · Rejuvenation Research
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005)
Yu Liu, Qichun Wei, Guocan Yu et al. · 2014 · Database
Experience in clinical practice and research in systems pharmacology suggested the limitations of the current one-drug-one-target paradigm in new drug discovery. Single-target drugs may not always produce desired physiological effects on the entire biological system, even if they have successfully regulated the activities of their designated targets. On the other hand, multicomponent therapy, in which two or more agents simultaneously interact with multiple targets, has attracted growing attention. Many drug combinations consisting of multiple agents have already entered clinical practice, esp
Ronald A. Sherman · 2014 · Evidence-Based Complementary and Alternative Medicine
Medicinal maggots are believed to have three major mechanisms of action on wounds, brought about chemically and through physical contact: debridement (cleaning of debris), disinfection, and hastened wound healing. Until recently, most of…
Yaping Lin-Moshier, Michael V. Keebler, Robert Hooper et al. · 2014 · Proceedings of the National Academy of Sciences
The two-pore channels (TPC1 and TPC2) belong to an ancient family of intracellular ion channels expressed in the endolysosomal system. Little is known about how regulatory inputs converge to modulate TPC activity, and proposed activation…
John Alford, Sophie Yates · 2015 · Australian Journal of Public Administration
This article adds to the emerging empirical literature on citizen co‐production. Based on a telephone survey of 1000 Australian adults, it replicates a five‐country European study focusing on three policy domains: neighbourhood safety,…
Md Nadim Ferdous Hoque, Mengjin Yang, Zhen Li et al. · 2016 · ACS Energy Letters
Researchers have debated whether methylammonium lead iodide (MAPbI 3 ), with a perovskite crystal structure, is ferroelectric and therefore contributes to the current–voltage hysteresis commonly observed in hybrid perovskite solar cells…
Marcia J. Carlson, Natasha Pilkauskas, Sara McLanahan et al. · 2011 · Journal of Marriage and the Family
We used data from the Fragile Families and Child Wellbeing Study to examine how couple relationship quality and parental engagement are linked over children's early years-when they are infants, toddlers, and preschoolers. Our sample…
David M. Quinn · 2020 · Educational Evaluation and Policy Analysis
A vast research literature documents racial bias in teachers’ evaluations of students. Theory suggests bias may be larger on grading scales with vague or overly general criteria versus scales with clearly specified criteria, raising the…
Harry Horsley, James Malone‐Lee, David Holland et al. · 2013 · PLoS ONE
Bacterial urinary tract infections (UTI) are a major growing concern worldwide. Uropathogenic Escherichia coli has been shown to invade the urothelium during acute UTI in mice and humans, forming intracellular reservoirs that can evade antibiotics and the immune response, allowing recurrence at a later date. Other bacterial species, such as Staphylococcus saprophyticus, Klebsiella pneumonia and Salmonella enterica have also been shown to be invasive in acute UTI. However, the role of intracellular infection in chronic UTI causing more subtle lower urinary tract symptoms (LUTS), a particular pr
Deepak Malhotra · 2010 · Judgment and Decision Making
Abstract Prior research has found mixed evidence for the long-theorized link between religiosity and pro-social behavior. To help overcome this divergence, I hypothesize that pro-social behavior is linked not to religiosity per se, but…
Thomas N. Garavan, Alma McCarthy, Yanqing Lai et al. · 2020 · Human Resource Management Journal
Abstract Drawing on systems theory, we conducted a moderated meta‐analysis of the training and organisational performance relationship using 119 primary studies. We examined the moderating effects of quality versus quantity of training,…
Roisín M. Connolly, Fengmin Zhao, Kathy D. Miller et al. · 2021 · Journal of Clinical Oncology
PURPOSE Endocrine therapy resistance in advanced breast cancer remains a significant clinical problem that may be overcome with the use of histone deacetylase inhibitors such as entinostat. The ENCORE301 phase II study reported improvement…
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) · 2010 · EFSA Journal
The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion re-evaluating the safety of curcumin (E 100). Curcumin has been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives…
Dori Steinberg, Erica Levine, Sandy Askew et al. · 2013 · Journal of Medical Internet Research
BACKGROUND: Daily self-monitoring of diet and physical activity behaviors is a strong predictor of weight loss success. Text messaging holds promise as a viable self-monitoring modality, particularly among racial/ethnic minority populations. OBJECTIVE: This pilot study evaluated the feasibility of a text messaging intervention for weight loss among predominantly black women. METHODS: Fifty obese women were randomized to either a 6-month intervention using a fully automated system that included daily text messages for self-monitoring tailored behavioral goals (eg, 10,000 steps per day, no sugar
James H. Love, Stephen Roper, Priit Vahter · 2014 · Research Policy
Using a panel of Irish manufacturing plants over the period 1991–2008 we test for dynamic complementarities in the joint use of internal R&D and external knowledge sources. We find little evidence, either from considering successive cross-sectional waves of comparable surveys, or in terms of the strategy switch choices of specific plants, that there has been a systematic move towards the joint use of internal and external knowledge in innovation. We then test formally for the presence of complementarities in the joint use of internal R&D and external innovation linkages. In static terms we fin
Ethan Ligon, Badal Malick, Ketki Sheth et al. · 2019 · PLoS ONE
The availability of digital payment technologies (such as internet banking, mobile money, and credit/debit cards) has rapidly increased in the developing world, and is a cornerstone for financial inclusion initiatives in developing countries. Despite significant efforts to promote digital payments, rates of adoption remain modest in some low-income countries. In particular, the rate of adoption in India remains low despite significant efforts to promote adoption. In this paper, we consider possible reasons for the low rates of adoption among merchants in Jaipur, India with small fixed-location
Jean M. Twenge · 2013 · Emerging Adulthood
According to the empirical evidence, today’s emerging adults (Millennials/GenY, born after 1980) are more Generation Me than Generation We when compared to previous generations. Five data sets show a generational increase in narcissism,…
Selin Aviyente, Edward M. Bernat, Westley S. Evans et al. · 2010 · Human Brain Mapping
The temporal coordination of neural activity within structural networks of the brain has been posited as a basis for cognition. Changes in the frequency and similarity of oscillating electrical potentials emitted by neuronal populations…
Taciano L. Milfont, Elena Zubielevitch, Petar Milojev et al. · 2021 · Nature Communications
Abstract Accumulating evidence indicates that climate change awareness and concern has increased globally, but commentators suggest a climate change generation gap whereby younger people care more about climate change than older people.…
Samantha Stevenson, Baylor Fox-Kemper, Markus Jochum et al. · 2012 · Journal of Climate
Abstract The El Niño–Southern Oscillation (ENSO) response to anthropogenic climate change is assessed in the following 1° nominal resolution Community Climate System Model, version 4 (CCSM4) Coupled Model Intercomparison Project phase 5…
Clive S. Lennox · 2015 · The Accounting Review
ABSTRACT In 2005–2006, the PCAOB imposed restrictions on auditors' tax services in order to strengthen auditor independence and improve audit quality. The restrictions resulted in a significant drop in auditor-provided tax services (APTS).…
Min-Sun Kim, Yuan Yuan · 2015 · Episteme
Abstract In “Normativity and Epistemic Intuitions” (NEI), Weinberg, Nichols and Stich famously argue from empirical data that East Asians and Westerners have different intuitions about Gettier-style cases. We attempted to replicate their…