A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21191 results · page 44 of 707
Christopher G. Salib, Nicolas Reina, Kevin I. Perry et al. · 2019 · The Bone & Joint Journal
AIMS: Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total hip arthroplasty (THA). This study examines how differences in pelvic orientation of patients with spine fusions can increase…
Joon‐Tae Kim, Reza Jahan, Jeffrey L. Saver et al. · 2015 · Stroke
BACKGROUND AND PURPOSE: Sparse data are available regarding the association between hyperglycemia and outcomes in acute ischemic stroke patients receiving mechanical thrombectomy (MT). We investigated whether hyperglycemia affected the…
Kai Barron · 2020 · Experimental Economics
Abstract Bayes’ statistical rule remains the status quo for modeling belief updating in both normative and descriptive models of behavior under uncertainty. Some recent research has questioned the use of Bayes’ rule in descriptive models of behavior, presenting evidence that people overweight ‘good news’ relative to ‘bad news’ when updating ego-relevant beliefs. In this paper, we present experimental evidence testing whether this ‘good-news, bad-news’ effect is present in a financial decision making context (i.e. a domain that is important for understanding much economic decision making). We f
Kevin Kalinsky, Sandra Lee, Krista M. Rubin et al. · 2017 · Cancer
BACKGROUND KIT‐directed tyrosine kinase inhibitors such as imatinib have demonstrated benefits in KIT‐mutant (KIT+) mucosal, acral, vulvovaginal, and chronically sun‐damaged (CSD) melanoma. Dasatinib has superior preclinical activity in…
Marian E. Berryhill · 2014 · Frontiers in Psychology
The popularity of non-invasive brain stimulation techniques in basic, commercial, and applied settings grew tremendously over the last decade. Here, we focus on one popular neurostimulation method: transcranial direct current stimulation (tDCS). Many assumptions regarding the outcomes of tDCS are based on the results of stimulating motor cortex. For instance, the primary motor cortex is predictably suppressed by cathodal tDCS or made more excitable by anodal tDCS. However, wide-ranging studies testing cognition provide more complex and sometimes paradoxical results that challenge this heuristi
Sisay Demissew Beyene · 2023 · BMC Public Health
BACKGROUND: Food insecurity adversely affects human health, which means food security and nutrition are crucial to improving people's health outcomes. Both food insecurity and health outcomes are the policy and agenda of the 2030 Sustainable Development Goals (SDGs). However, there is a lack of macro-level empirical studies (Macro-level study means studies at the broadest level using variables that represent a given country or the whole population of a country or economy as a whole. For example, if the urban population (% of the total population) of XYZ country is 30%, it is used as a proxy va
Daniel A. Shoskes, Hannah Wang, A. Scott Polackwich et al. · 2016 · The Journal of Urology
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome is a common disorder with heterogeneous etiologies and clinical features. The gut microbiome is a metabolically active ecosystem linked to systemic conditions (gut-brain axis). We…
Jill E. Moore, Henry Pratt, Michael Purcaro et al. · 2020 · Genome biology
BACKGROUND: Many genome-wide collections of candidate cis-regulatory elements (cCREs) have been defined using genomic and epigenomic data, but it remains a major challenge to connect these elements to their target genes. RESULTS: To facilitate the development of computational methods for predicting target genes, we develop a Benchmark of candidate Enhancer-Gene Interactions (BENGI) by integrating the recently developed Registry of cCREs with experimentally derived genomic interactions. We use BENGI to test several published computational methods for linking enhancers with genes, including sign
N. J. Schweitzer, Michael J. Saks, Emily R. Murphy et al. · 2011 · Psychology Public Policy and Law
Recent developments in the neuropsychology of criminal behavior have given rise to concerns that neuroimaging evidence (such as MRI and functional MRI [fMRI] images) could unduly influence jurors. Across four experiments, a nationally…
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami et al. · 2021 · Nature Communications
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation. Paracrine IL11 activity stimulates hepatic stellate cells and causes fibrosis. In mouse models of NASH, hepatocyte-specific deletion of Il11ra1
Laura J. Wozniak, Michelle J. Hickey, Robert S. Venick et al. · 2015 · Transplantation
BACKGROUND: The role of donor-specific HLA antibodies (DSA) after pediatric liver transplantation (LTx) is not clearly established. We completed a cross-sectional study to characterize DSA in long-term survivors of pediatric LTx and assess…
Mary Wang · 2016 · PubMed
Anemia, defined as a hemoglobin level two standard deviations below the mean for age, is prevalent in infants and children worldwide. The evaluation of a child with anemia should begin with a thorough history and risk assessment.…
Sydney Ch’ng, Roman J. Skoracki, Jesse C. Selber et al. · 2014 · Head & Neck
BACKGROUND: Dental restoration is an integral part of head and neck cancer reconstruction. METHODS: We evaluated the success rate of osseointegrated implants in patients with head and neck cancer, comparing outcomes between implants placed…
M. Lukasiewicz, Stéphanie Gerard, Adeline Besnard et al. · 2013 · International Journal of Methods in Psychiatric Research
The aim of this analysis was to identify Young Mania Rating Scale (YMRS) meaningful benchmarks for clinicians (severity threshold, minimal clinically significant difference [MCSD]) using the Clinical Global Impressions Bipolar (CGI-BP)…
Lotte A van de Stadt, Wouter H Bos, Marlies Meursinge Reynders et al. · 2010 · Arthritis Research & Therapy
INTRODUCTION: Ultrasonography (US) has better sensitivity than clinical evaluation for the detection of synovitis in early rheumatoid arthritis (RA). Patients presenting with arthralgia and a positive anti-citrullinated protein antibodies (ACPA) and/or Rheumatoid Factor (IgM-RF) status are at risk for developing RA. In the present study, US utility and predictive properties in arthralgia patients at risk for the development of arthritis were studied. METHODS: 192 arthralgia patients with ACPA and/or IgM-RF were included. Absence of clinical arthritis was confirmed by two physicians. US was per
Adrienne Lucas, Isaac Mbiti · 2014 · American Economic Journal Applied Economics
The most desirable Kenyan secondary schools are elite government schools that admit the best students from across the country. We exploit the random variation generated by the centralized school admissions process in a regression…
Jennifer L. Marti, Kunal Jain, Luc G.T. Morris · 2015 · Thyroid
INTRODUCTION: The long-term sequelae of radioactive iodine (RAI) for differentiated thyroid cancer (DTC) in pediatric and young adult patients are not well-defined. Epidemiologic analyses of second primary malignancy (SPM) risk have only…
Valter da Rocha Fernandes, Michelle L. Scipião Ribeiro, Thais Regina Ferreira de Melo et al. · 2016 · Frontiers in Psychology
The relationship between exercise and cognition is an important topic of research that only recently began to unravel. Here, we set out to investigate the relation between motor skills, cognitive function, and school performance in 45 students from 8 to 14 years of age. We used a cross-sectional design to evaluate motor coordination (Touch Test Disc), agility (Shuttle Run Speed-running back and forth), school performance (Academic Achievement Test), the Stroop test, and six sub-tests of the Wechsler Intelligence Scale for Children-IV (WISC-IV). We found, that the Touch Test Disc was the best p
Philip J. Mease, Chitra Karki, Jacqueline B. Palmer et al. · 2017 · Arthritis Care & Research
Objective To characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient‐reported outcomes. Methods Using the Corrona…
Michael Valenzuela, Carol Brayne, Perminder S. Sachdev et al. · 2011 · American Journal of Epidemiology
An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing…
Katri Korpela, María del Mar Delgado, Heikki Henttonen et al. · 2012 · Global Change Biology
Small rodents are key species in many ecosystems. In boreal and subarctic environments, their importance is heightened by pronounced multiannual population cycles. Alarmingly, the previously regular rodent cycles appear to be collapsing…
Emily A. P. Haigh, Michael Moore, Todd B. Kashdan et al. · 2010 · Assessment
Langer's theory of mindfulness proposes that a mindful person seeks out and produces novelty, is attentive to context, and is flexible in thought and behavior. In three independent studies, the factor structure of the Langer…
François Waldner, Diego de Abelleyra, Santiago R. Verón et al. · 2016 · International Journal of Remote Sensing
Accurate cropland information is of paramount importance for crop monitoring. This study compares five existing cropland mapping methodologies over five contrasting Joint Experiment for Crop Assessment and Monitoring (JECAM) sites of medium to large average field size using the time series of 7-day 250 m Moderate Resolution Imaging Spectroradiometer (MODIS) mean composites (red and near-infrared channels). Different strategies were devised to assess the accuracy of the classification methods: confusion matrices and derived accuracy indicators with and without equalizing class proportions, asse
Andrea Pescatori, Damiano Sandri, John Simon et al. · 2014 · IMF Working Paper
Using a novel empirical approach and an extensive dataset developed by the Fiscal Affairs Department of the IMF, we find no evidence of any particular debt threshold above which medium-term growth prospects are dramatically compromised.…
Kenneth Elpus · 2013 · Journal of Research in Music Education
This study examined the college entrance examination scores of music and non-music students in the United States, drawing data from the restricted-use data set of the Education Longitudinal Study of 2002 (ELS), a nationally representative…
Michael Asiamah, Daniel Ofori, Jacob Afful · 2019 · Journal of Asian Business and Economic Studies
Purpose The factors that determine foreign direct investment (FDI) are important to policy-makers, investors, the banking industry and the public at large. FDI in Ghana has received increased attention in recent times because its relevance in the Ghanaian economy is too critical to gloss over. The purpose of this paper is to examine the determinants of FDI in Ghana between the period of 1990 and 2015. Design/methodology/approach The study employed a causal research design. The study used the Johansen’s approach to cointegration within the framework of vector autoregressive for the data analysi
Aysegül Ilhan‐Mutlu, Matthias Osswald, Yunxiang Liao et al. · 2016 · Molecular Cancer Therapeutics
Patients with nonsquamous non-small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti-VEGF-A therapy may prevent the formation of nsNSCLC brain…
Vaibhav Sahai, Paul J. Catalano, Mark M. Zalupski et al. · 2018 · JAMA Oncology
Importance: Gemcitabine with platinum has limited efficacy for treatment of advanced cholangiocarcinoma, necessitating an evaluation of alternative drug combinations. Recent evidence suggests that paclitaxel may potentiate gemcitabine…
Beatrice Rammstedt, Richard F. Farmer · 2013 · Psychological Assessment
Acquiescence, or the tendency to respond to descriptions of conceptually distinct personality attributes with agreement/affirmation (acceptance acquiescence) or disagreement/opposition (counter-acquiescence), has been widely recognized as…
Jason W. Ridge, Federico Aime, Margaret A. White · 2013 · Strategic Management Journal
We integrate the seemingly contradictory theoretical predictions of behavioral and economic perspectives about the relationship between pay disparity and firm performance and show that tournament and social comparison theories are more…